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Steven Brem, MD, Neurosurgery, Philadelphia, PA, Pennsylvania Hospital

StevenBremMD

Neurosurgery Philadelphia, PA

Brain & Spinal Tumor, Pituitary Surgery, Skull Base

Professor of Neurosurgery and Senior Member, Penn Brain Tumor Center

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  • Office

    3400 Spruce Street
    3 Silverstein Building
    Philadelphia, PA 19104
    Phone+1 215-662-3487
    Fax+1 215-349-5534
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Summary

  • I serve as the Chief of Neurosurgical Oncology and Co-Director of the Penn Brain Tumor Center at the Hospital of the University of Pennsylvania. My clinical focus is to obtain the best possible outcomes in patients presenting with complex brain tumors, harnessing the current technology of neuroimaging, computer-guided surgery, and brain mapping. I work with an expert team of nurses, nurse practitioners, residents and colleagues in Anesthesiology, Medical Oncology, Neurology, Neuroradiology, Neuropathology and Radiation Oncology. Current clinical trials include electrical field therapy, vaccine therapy, anti-angiogenesis therapy, and sophisticated brain mapping (connectomics).

Education & Training

  • Harvard Medical School
    Harvard Medical SchoolCertificate, Surgical Leadership, 2018 - 2019
  • Massachusetts General Hospital
    Massachusetts General HospitalResidency, Neurological Surgery, 1980 - 1981
  • New York Presbyterian Hospital (Cornell Campus)
    New York Presbyterian Hospital (Cornell Campus)Residency, Neurological Surgery, 1979 - 1980
  • Massachusetts General Hospital
    Massachusetts General HospitalResidency, Neurological Surgery, 1977 - 1979
  • Massachusetts General Hospital
    Massachusetts General HospitalResidency, Neurological Surgery, 1973 - 1974
  • Massachusetts General Hospital
    Massachusetts General HospitalInternship, Transitional Year, 1972 - 1973
  • Harvard Medical School
    Harvard Medical SchoolClass of 1972
  • Rutgers University
    Rutgers UniversityBA, Magna Cum Laude, 1964 - 1968

Certifications & Licensure

  • PA State Medical License
    PA State Medical License 2011 - 2024
  • NJ State Medical License
    NJ State Medical License 2016 - 2021
  • FL State Medical License
    FL State Medical License 1995 - 2012
  • IL State Medical License
    IL State Medical License 1990 - 2002
  • NY State Medical License
    NY State Medical License 1980 - 1992
  • American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

  • America's Top Doctors Castle Connolly, 2007-2018
  • America's Top Doctors for Cancer Castle Connolly, 2005-2013
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Three‐Dimensional Echo Planar Spectroscopic Imaging for Differentiation of True Progression from Pseudoprogression in Patients with Glioblastoma  
    Arati Desai, Ronald L Wolf, MacLean Nasrallah, Suyash Mohan, Steven Brem, NMR in Biomedicine
  • Pervasive within-mitochondrion single-nucleotide variant heteroplasmy as revealed by single-mitochondrion sequencing  
    Morris J, Na Y-J, Zhu H, Lee J-H, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O’Rourke DM, Wolf JA, Grady MS, Sul J-Y, Kim J, Eberwine J., Cell Reports, 1/1/2017
  • commentary to Bonney PA et al A simplified method of accurate postprocessing of diffusion tensor imaging for use in brain tumor resections  
    Brem S, Operative Neurosurgery, 1/1/2017
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Books/Book Chapters

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Abstracts/Posters

  • IMCT-15*Pilot study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma
    O’Rourke DM, Desai A, Morrissette JD, Martinez-Lage M, Nasrallah M, Brem S, Maloney E, Shen A, Mohan S, Wang S, Verma G, Lacey S, Melenhorst J, Navenot J-M, Zheng Z, L..., Neuro-Oncology, 1/1/2015
  • Chemical Shift Imaging (CSI) for detection of 2-hydroxyglutarate (2HG) in human gliomas at 3T.
    Verma G, Poptani H, Nasrallah M, Thomas A, Brem S, Mohan S, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
  • Two-dimensional localized correlated spectroscopy (2D L-COSY) at 7T for detection of 2-hydroxyglutarate in gliomas with IDH mutations.
    Verma G, Mohan S, Nasrallah M, Thomas MA, Desai A, Desiderio L, Poptani H, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
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Lectures

  • Advances in the Management of Brain Tumors 
    Ft. Lauderdale - 1/1/2007
  • Early detection of brain tumor response to shaped beam radiosurgery using b-value diffusion-weighted MRI in patients with cerebral metastases: A pilot study in 20 pati... 
    Kyoto, Japan - 1/1/2006
  • Angiogenesis and Immunotherapy: Scientific Horizons in the Treatment of Brain Tumors 
    Ft. Lauderdale - 1/1/2005
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Other

  • Studies on the Host Response to a Human Brain Tumor. Honors Thesis 
    Brem S, Harvard Medical School
    1/1/1972
  • Electrophysiological Studies of the Thermoregulatory System in Two Invertebrates. Biology Honors Thesis 
    Brem S, Rutgers University
    1/1/1964
  • Turning Point: The Race Against Cancer 
    Peter Jennings, Host, ABC News
    1/29/1998

Press Mentions

  • Northwest Biotherapeutics: Data Is Done, Just Wait for Approval
    Northwest Biotherapeutics: Data Is Done, Just Wait for ApprovalNovember 23rd, 2022
  • Brain Tumor Second Opinion Consults by Telemedicine
    Brain Tumor Second Opinion Consults by TelemedicineDecember 20th, 2018
  • Penn Medicine Telemedicine Pilots Second Opinions to Brain Tumor Patients
    Penn Medicine Telemedicine Pilots Second Opinions to Brain Tumor PatientsDecember 19th, 2018
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Grant Support

  • Approaches To Brain Tumor TherapyNational Cancer Institute1999–2002
  • Approaches To Brain Tumor TherapyNational Cancer Institute1998
  • Copper And Angiogenesis Control Of CNS MalignancyNational Cancer Institute1992

Professional Memberships

Other Languages

  • French, Hebrew, Spanish

Hospital Affiliations