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Office
3400 Spruce Street
3 Silverstein Building
Philadelphia, PA 19104Phone+1 215-662-3487Fax+1 215-349-5534- Is this information wrong?
Summary
- I serve as the Chief of Neurosurgical Oncology and Co-Director of the Penn Brain Tumor Center at the Hospital of the University of Pennsylvania. My clinical focus is to obtain the best possible outcomes in patients presenting with complex brain tumors, harnessing the current technology of neuroimaging, computer-guided surgery, and brain mapping. I work with an expert team of nurses, nurse practitioners, residents and colleagues in Anesthesiology, Medical Oncology, Neurology, Neuroradiology, Neuropathology and Radiation Oncology. Current clinical trials include electrical field therapy, vaccine therapy, anti-angiogenesis therapy, and sophisticated brain mapping (connectomics).
Education & Training
- Harvard Medical SchoolCertificate, Surgical Leadership, 2018 - 2019
- Massachusetts General HospitalResidency, Neurological Surgery, 1980 - 1981
- New York Presbyterian Hospital (Cornell Campus)Residency, Neurological Surgery, 1979 - 1980
- Massachusetts General HospitalResidency, Neurological Surgery, 1977 - 1979
- Massachusetts General HospitalResidency, Neurological Surgery, 1973 - 1974
- Massachusetts General HospitalInternship, Transitional Year, 1972 - 1973
- Harvard Medical SchoolClass of 1972
- Rutgers UniversityBA, Magna Cum Laude, 1964 - 1968
Certifications & Licensure
- PA State Medical License 2011 - 2024
- NJ State Medical License 2016 - 2021
- FL State Medical License 1995 - 2012
- IL State Medical License 1990 - 2002
- NY State Medical License 1980 - 1992
- American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2007-2018
- America's Top Doctors for Cancer Castle Connolly, 2005-2013
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
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Clinical Trials
- Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma Start of enrollment: 1999 Mar 01
- Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
- Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Start of enrollment: 2009 Jun 01
Publications & Presentations
PubMed
- 90 citationsPhase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastomaSteven Brem, Stuart A. Grossman, Kathryn A. Carson, Pamela New, Surasak Phuphanich
Neuro-Oncology. 2005-07-01 - 181 citationsInhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.Steven Brem, David Zagzag, Ana-Maria C. Tsanaclis, Stephen T. Gately, M.-P. Elkouby
The American Journal of Pathology. 1990-11-01 - 53 citationsPhase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastomaPrakash Chinnaiyan, Sajeel Chowdhary, Lisa Potthast, Antony Prabhu, Ya Yu Tsai
Neuro-Oncology. 2012-01-01
Journal Articles
- Three‐Dimensional Echo Planar Spectroscopic Imaging for Differentiation of True Progression from Pseudoprogression in Patients with GlioblastomaArati Desai, Ronald L Wolf, MacLean Nasrallah, Suyash Mohan, Steven Brem, NMR in Biomedicine
- Pervasive within-mitochondrion single-nucleotide variant heteroplasmy as revealed by single-mitochondrion sequencingMorris J, Na Y-J, Zhu H, Lee J-H, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O’Rourke DM, Wolf JA, Grady MS, Sul J-Y, Kim J, Eberwine J., Cell Reports, 1/1/2017
- commentary to Bonney PA et al A simplified method of accurate postprocessing of diffusion tensor imaging for use in brain tumor resectionsBrem S, Operative Neurosurgery, 1/1/2017
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Books/Book Chapters
Abstracts/Posters
- IMCT-15*Pilot study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastomaO’Rourke DM, Desai A, Morrissette JD, Martinez-Lage M, Nasrallah M, Brem S, Maloney E, Shen A, Mohan S, Wang S, Verma G, Lacey S, Melenhorst J, Navenot J-M, Zheng Z, L..., Neuro-Oncology, 1/1/2015
- Chemical Shift Imaging (CSI) for detection of 2-hydroxyglutarate (2HG) in human gliomas at 3T.Verma G, Poptani H, Nasrallah M, Thomas A, Brem S, Mohan S, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
- Two-dimensional localized correlated spectroscopy (2D L-COSY) at 7T for detection of 2-hydroxyglutarate in gliomas with IDH mutations.Verma G, Mohan S, Nasrallah M, Thomas MA, Desai A, Desiderio L, Poptani H, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
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Lectures
- Advances in the Management of Brain TumorsFt. Lauderdale - 1/1/2007
- Early detection of brain tumor response to shaped beam radiosurgery using b-value diffusion-weighted MRI in patients with cerebral metastases: A pilot study in 20 pati...Kyoto, Japan - 1/1/2006
- Angiogenesis and Immunotherapy: Scientific Horizons in the Treatment of Brain TumorsFt. Lauderdale - 1/1/2005
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Other
- Studies on the Host Response to a Human Brain Tumor. Honors ThesisBrem S, Harvard Medical School
1/1/1972 - Electrophysiological Studies of the Thermoregulatory System in Two Invertebrates. Biology Honors ThesisBrem S, Rutgers University
1/1/1964 - Turning Point: The Race Against CancerPeter Jennings, Host, ABC News
1/29/1998
Press Mentions
- Northwest Biotherapeutics: Data Is Done, Just Wait for ApprovalNovember 23rd, 2022
- Brain Tumor Second Opinion Consults by TelemedicineDecember 20th, 2018
- Penn Medicine Telemedicine Pilots Second Opinions to Brain Tumor PatientsDecember 19th, 2018
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Grant Support
- Approaches To Brain Tumor TherapyNational Cancer Institute1999–2002
- Approaches To Brain Tumor TherapyNational Cancer Institute1998
- Copper And Angiogenesis Control Of CNS MalignancyNational Cancer Institute1992
Professional Memberships
- Member
- Fellow
- Member
Other Languages
- French, Hebrew, Spanish
Hospital Affiliations
- Pennsylvania HospitalPhiladelphia, Pennsylvania
- Doylestown HealthDoylestown, Pennsylvania
- Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
- Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
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