StevenYChangMDPhD

Critical Care Medicine

Clinical Professor of Medicine, MICU Director, David Geffen School of Medicine at UCLA, Ronald-Reagan UCLA Medical Center

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Office
757 Westwood Plz
Los Angeles, CA 90095
Phone(310) 267-9643
Fax(562) 766-2008
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Education & Training

University of ChicagoFellowship, Pulmonary Disease and Critical Care Medicine, 2002
New York Presbyterian Hospital - Columbia CampusResidency, Internal Medicine, 1999
New York Presbyterian Hospital - Columbia CampusInternship, Internal Medicine, 1996 - 1997
University of Chicago Pritzker School of MedicineClass of 1996
University of ChicagoPhD, Pharmacological & Physiological Sciences, 1992 - 1995
Miami UniversityB.A., Zoology, Magna Cum Laude, 1985 - 1989

Certifications & Licensure

CA State Medical License 2013 - 2021
NJ State Medical License 2006 - 2015
IL State Medical License 1999 - 2008
NY State Medical License 1997 - Present
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Nominated for Golden Apple Teaching Award Rutgers-NJMS, 2008, 2011-2013
Faculty Teaching Award North Shore University Hospital, Department of Medicine, 2004
Faculty Teaching Award North Shore University Hospital, Division of Pulmonary & Critical Care Medicine, 2004
Harry Ginsburg Memorial Award University of Chicago, 1995
Phi Beta Kappa 1989
University Honors Miami University, 1989
Herbert Ray Brauchla Scholar Leader Miami University, 1988
National Merit Scholar 1985
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Clinical Trials

Severe ARDS: Generating Evidence Start of enrollment: 2016 Oct 01Nida Qadir, MD, Pauline Park, MD, Raquel Bartz, MD, and Michelle N Gong, MD
Reevaluation Of Systemic Early Neuromuscular Blockade Start of enrollment: 2015 Dec 01David A. Schoenfeld, PhD
Vitamin D to Improve Outcomes by Leveraging Early Treatment Boyd Taylor Thompson, MD
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis David Alan Schoenfeld, PhD
Vitamin C, Thiamine, and Steroids in Sepsis Jonathan Sevransky, MD, MHS

Publications & Presentations

PubMed

Perioperative Considerations in Liver Transplantation.
Barjaktarevic, I.,Cortes Lopez, R.,Steadman, R.,Wray, C.,Qadir, N.,Chang, S. Y.,Wang, T.> ;Semin Respir Crit Care Med. 2018 Nov 30
Acute Respiratory Failure and Pulmonary Complications in End-Stage Liver Disease.
Qadir, N.,Wang, T.,Barjaktarevic, I.,Chang, S. Y.> ;Semin Respir Crit Care Med. 2018 Nov 30
Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients.
Seethala, R. R.,Hou, P. C.,Aisiku, I. P.,Frendl, G.,Park, P. K.,Mikkelsen, M. E.,Chang, S. Y.,Gajic, O.,Sevransky, J.> ;Ann Intensive Care. 2017 Jan 25
Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.
Checkley W Martin GS Brown SM Chang SY Dabbagh O Fremont RD Girard TD Rice TW Howell MD Johnson SB O'Brien J Park PK Pastores SM Patil NT Pietropaoli AP ...> ;Crit Care Med. 2014 Feb
Contemporary ventilator management in patients with and at risk of ALI/ARDS.
Chang SY Dabbagh O Gajic O Patrawalla A Elie MC Talmor DS Malhotra A Adesanya A Anderson HL 3rd Blum JM Park PK Gong MN> ;Respir Care. 2013 Apr
Protocols in the management of critical illness.
Chang, S. Y., Sevransky, J., Martin, G. S.> ;Crit Care. 2011 Mar 16
Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study.
Gajic O Dabbagh O Park PK Adesanya A Chang SY Hou P Anderson H 3rd Hoth JJ Mikkelsen ME Gentile NT Gong MN Talmor D Bajwa E Watkins TR Festic E Yilmaz M...> ;Am J Respir Crit Care Med. 2011 Feb 15
Regional ICU care: the future is now.
Chang, S.Y., Merwin, S.L., Fein, J., Fein, A.M.> ;J Intensive Care Med. 2010-05-01
Critical care organization.
Chang, S. Y.,Multz, A. S.,Hall, J. B.> ;Crit Care Clin. 2005 Jan
CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex.
Cormet-Boyaka, E., Di, A., Chang, S.Y., Naren, A.P., Tousson, A., Nelson, D.J., Kirk, K.L.> ;Proc Natl Acad Sci U S A. 2002 Sep 17
Mechanisms of CFTR regulation by syntaxin 1A and PKA.
Chang, S. Y., Di, A., Naren, A. P., Palfrey, H. C., Kirk, K. L., Nelson, D. J.> ;J Cell Sci. 2002 Feb 15
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Journal Articles

Protocols and hospital mortality in critically ill patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study (USCIITG-CIOS)
Sevransky, J.E., W. Checkley, P. Herrera, B.W. Pickering, J. Barr, S.M.Brown, S.Y. Chang, D. Chong, D. Kaufman, R.D. Fremont, T.D. Girard, J. Hoag, S.B. Johnson, M.P. ..., Critical Care Medicine, 1/24/2015
Structure, process and annual ICU mortality across 69 centers: United Sates Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Checkley, W., G.S. Martin, S. Brown, S.Y. Chang, O. Dabbagh, R.D. Fremont, T.D. Girard, M.D. Howell, S. Johnson, J. O’Brien, P.K. Park, S. Pastores, N.T. Patil, A.P. P..., Critical Care Medicine, 1/1/2014
Contemporary Ventilator Management in Patients with and at risk of ALI/ARDS
Chang, S.Y., O. Dabbagh, O. Gajic, A. Patrawalla, M-C Elie, D. Talmor,A. Malhotra, A. Adesanya, H.L. Anderson III, J.M. Blum, P.K. Park, and M.N. Gong on behalf of the..., Respiratory Care, 1/1/2013
Protocols in the management of critical illness
Chang, S.Y., J. Sevransky, G.S. Martin, Critical Care, 1/1/2012
Early identification of patients at risk of acute lung injury: Evaluation of Lung Injury Prediction Score in a Multicenter Cohort Study
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Regional ICU Care: The future is now
Chang, S.Y., S.L. Merwin, J.F. Fein, A.M. Fein, Journal of Intensive Care Medicine, 1/1/2010
Critical Illness in the Obese Patient
Chang, S.Y., J.P. Kress, and J.B. Hall, Current Respiratory Medicine Reviews, 1/1/2008
Critical Care Organization
Chang, S.Y., A.S. Multz, and J.B. Hall, Critical Care Clinics, 1/1/2005
Mechanisms of CFTR regulation by Syntaxin 1A and PKA
Chang, S.Y., A. Di, A.P. Naren, H.C. Palfrey, K.L. Kirk and D.J. Nelson, Journal of Cell Science, 1/1/2002
CFTR chloride channels are regulated by a SNAP 23/Syntaxin 1A complex
Cormet-Boyaka, E., A. Di, S.Y. Chang, A.P. Naren, A. Tousson, D.J. Nelson, and K.L. Kirk, Proceedings of the National Academy of Sciences, 1/1/2002
Modal behavior of the mu1 Na+ channel and effects of coexpression of the beta1-subunit
Chang, S.Y., J. Satin, and H.A. Fozzard, Biophysical Journal, 1/1/1996
Co-expression of beta1 cardiac Na channel alpha subunits in oocytes decreases lidocaine block
Makielski, J.C., J.T. Limberis, S.Y. Chang, Z. Fan, and J.W. Kyle, Molecular Pharmacology, 1/1/1996
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Books/Book Chapters

Pulmonary Examination and Board Review
Chapter: HIV and the Lung
Arredondo, A, R. Huynh, and S.Y. ChangMcGraw-Hill, New York, NY2015
Clinical Management of Pulmonary Arterial Hypertension
Chapter: Pulmonary Hypertension in the ICU
Chang, S.Y.Editors: J. Klinger, A. Talwar, A. Fein.Professional Communications Inc2015
Manual of Critical Care
Chapter: The Systemic Inflammatory Response Syndrome and Septic Shock
Chang, S.Y., J. Edelson, and A.M. FeinEditors: S. Raoof.McGraw-Hill2009
Just the Facts: Critical Care
Chapter: Echocardiography in the critically ill patient
Chang, S.Y.Editors: J.B. Hall & G.A. Schmidt.McGraw-Hill, New York, NY2007
Irwin and Rippe’s Intensive Care Medicine
Chapter: Defining and measuring patient safety in the critical care unit
Fein, A.M., S.Y. Chang, D. Ost, J.E. Heffner, and S.L. MerwinEditors: R.S.S. Irwin & J.M. Rippe.Lippincott Williams & WilliamsEdition 6th,2007
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Abstracts/Posters

Sepsis
Chang, S.Y., Rutgers-NJMS – Medical Housestaff; UCLA – Pulmonary & Critical Care Fellows, 1/1/2015
Management of ARDS
Chang, S.Y., Rutgers-NJMS – Medical Housestaff; UCLA – Pulmonary & Critical Care Fellows; UCLA - Multidisciplinary Critical Care Conference, 1/1/2015
Ventilator Waveforms
Chang, S.Y., UCLA – Pulmonary & Critical Care Fellows; UCLA - Department of Respiratory Therapy, 1/1/2015
Sedation & Spontaneous Breathing Trials
Chang, S.Y., UCLA - Internal Medicine Housestaff Monthly MICU Lectures, 1/1/2015
Improving mechanical ventilator bundle compliance: A quality improvement project
Albores, J., and S. Chang, American Journal of Respiratory and Critical Care Medicine, 1/1/2015
Association between clinical protocols and hospital mortality in critically ill patients: United States Critical Illness and Injury Trials Group-Critical Illness Outco...
Sevransky, J.E., W. Checkley, P.E. Morris, B.W. Pickering, J.B. Hoag, S. Shahul, M.P. Kerlin, M. Putman, N. Patil, J. Guzman, S.M. Brown, S. Pastores, R. Fremont, L. R..., American Journal of Respiratory and Critical Care Medicine, 1/1/2014
Critical Illness Outcomes Study: An Observational Cohort of Critically Ill Patients
Sevransky, J.E., W. Checkley, T.D. Girard, S.M. Pastores, S. Shahul, A. Martinez, S. Brown, N. Patil, T. O’Keffe, B. Pickering, J. Liebler, P. Park, J. , S. Chang, J. ..., American Journal of Respiratory and Critical Care Medicine, 1/1/2012
Use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers and clinical outcomes among patients at risk for Acute Lung Injury
Watkins, T., L.B. Lemos-Filho, O. Dabbagh, S.Y. Chang, P.K. Park, M.N. Gong, American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Early cumulative fluid balance and development of acute lung injury
Park, P., N.O. Birkmeyer, N. Gentile, S.Y. Chang, O. Dabbagh., O. Gajic, American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Organizational structure of 27 intensive care units in the United States: 10 Critical Illness Outcomes Study (CIOS)
Checkly, W., G.S. Martin, S. Brown, S.Y. Chang, O. Dabbagh, R. Fremont, T.D. Girard, M. Howell, S. Johnson, J. O’Brien, P.K. Park, S. Pastores, N. Patil, A. Pietropaol..., American Journal of Respiratory and Critical Care Medicine, 1/1/2011
ALI/ARDS in Emergency Surgery: The U.S. Critical Illness and Injury Trials Group (USCIITG) Lung Injury Prevention Study Cohort
Park, P., S. Chang, O. Gajic, O. Dabbagh, A Adesanya, J. Hoth, H. Anderson, on behalf of the U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Stud..., American Association for the Surgery in Trauma conference, 1/1/2010
Towards prevention of acute lung injury: identification of patients at risk at the time of hospital admission
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2010
Frequency and outcome of acute lung injury in hospitalized patients at risk: a multicenter cohort study
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2010
Interpretation of PFTs
Chang, S.Y., Rutgers-NJMS – Medical Housestaff, 1/1/-1
Management of ALI/ARDS
Chang, S.Y., NYU School of Medicine – Medical Housestaff, 1/1/2005
Pathophysiology of Sepsis
Chang, S.Y., NYU School of Medicine – 2nd Year Medical Students, 1/1/2005
Pulmonary Manifestations of Rheumatologic Disease
Chang, S.Y., NYU School of Medicine – CME Course, 1/1/2005
Etiology of prolonged mechanical ventilation in tertiary setting
Quinones, A., R. Ali-Permell, R. Russo, S. Chang, E. Hussain, M. Nelson, A. Fein., Chest, 1/1/2003
Disruption of direct Syntaxin 1A-CFTR interaction results in increased channel activity in human airway epithelia
Chang, S.Y., A. Di, A.P. Naren, K.L. Kirk, and D.J. Nelson, American Journal of Respiratory and Critical Care Medicine, 1/1/2001
Regulation of ICFTR by Syntaxin 1A occurs predominantly via direct protein-protein interactions
Di, A. S.Y. Chang, A.P. Naren, K.L. Kirk, and D. Nelson, Biophysical Journal, 1/1/2001
CFTR cooperatively interacts with SNAP-23 and Syntaxin 1A
Cormet-Boyaka, E., S. Chang, A. Di, A.P. Naren, D.J. Nelson, and K.L. Kirk, Pediatric Pulmonology, 1/1/2000
A putative interaction between HCLC-3 and CFTR
Huang, P., A. Di, M.A. Kaetzel, K. Kirk, S. Chang, X.D. Johnson, and D.J. Nelson, Biophysical Journal, 1/1/2000
Beta1-subunit expressed with adult rat skeletal muscle Na channel alpha-subunit restores a native-like fast gating mode
Chang, S., J. Satin, J. Kyle and H. Fozzard, Biophysical Journal, 1/1/1995
Na channel beta1 association with cardiac Na channel alpha subunits demonstrated by lidocaine block
Makielski, J.C., J.T. Limberis, S.Y. Chang, Z. Fan, and J.W. Kyle, Biophysical Journal, 1/1/1995
Rat brain beta1 Na channel subunit interacts with rat brain IIa, skeletal muscle (gamma1), and rat heart (RH1) alpha-subunits
Kyle, J.W., S.Y. Chang, J. Satin, J.M. Fang, H.A. Fozzard, and R.B. Rogart, Biophysical Journal, 1/1/1993
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Lectures

Ventilator Waveforms
1/1/2015
Pulmonary & Critical Care Core Lecture Series
1/1/2013
The Acute Respiratory Distress Syndrome
Queens, NY - 1/1/2013
Severe Sepsis and Septic Shock in 2007
1/1/2007
Critical Care – Critical Care Core Lecture Series
1/1/2005
Innovations in diagnosis and treatment of pulmonary embolism
San Diego, CA - 1/1/2005
Right ventricular dysfunction in critical illness
Orlando, FL - 1/1/2004
Critical Care Lectures Series for Fellows
1/1/-2
Housestaff Lectures Series – Topics in Critical Care
1/1/-3
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