
Steven E Nissen MD
Preventive Cardiology
Professor of Medicine, Cleveland Cl College of Medicine/Case West Res Chief Academic Officer - Heart, Vascular, and Thoracic Institute
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9500 Euclid AveCleveland, OH 44195
Phone+1 800-223-2273
Fax+1 216-445-6855
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Summary
- Dr. Steven Nissen is a cardiologist in Cleveland, OH and is affiliated with Cleveland Clinic. He received his medical degree from University of Michigan Medical School and has been in practice 39 years. He specializes in preventive cardiology and is experienced in general cardiology, lipid disorders, preventive cardiology, hypertension, and coronary artery disease. He has more than 500 publications and over 90,000 citations.
Education & Training
University of Kentucky College of MedicineFellowship, Cardiovascular Disease, 1981 - 1983
University of Michigan Medical SchoolClass of 1978
Certifications & Licensure
OH State Medical License 1992 - 2026
CA State Medical License 1980 - 1993
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2016
- CMS Meaningful Use Stage 1 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2016
- America's Top Doctors Castle Connolly, 2004-2014
Clinical Trials
- Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia Start of enrollment: 2014 Oct 30
- The Role of F-18 Florbetapir in the Early Detection of Cardiac Amyloidosis Start of enrollment: 2017 Jan 01
- Supplements, Placebo, or Rosuvastatin Study Start of enrollment: 2021 Apr 23
Publications & Presentations
PubMed
- In vivo gene editing for lipid management: An early perspective from ANGPTL3-targeted CRISPR-Cas9 therapy.Luke J Laffin, Steven E Nissen
Molecular Therapy. 2026-02-04 - Inaccurate information regarding cardiovascular disease prevention enabled by generative artificial intelligence.Astefanos Al-Dalakta, Bianca Honnekeri, Fatima Rodriguez, Luke Laffin, Vikas Sunder
American Journal of Preventive Cardiology. 2026-02-01 - 1 citationsCost-Effectiveness of Bempedoic Acid in High Cardiovascular Risk Patients with Statin Intolerance: An Analysis of the CLEAR Outcomes Trial.Stephen J Nicholls, Kausik K Ray, A Michael Lincoff, Evelyn Sarnes, Kristin K Gillard
American Journal of Cardiovascular Drugs. 2026-01-01
Journal Articles
- Coronary Revascularization StrategiesSteven E Nissen, Faisal G Bakaeen, JAMA
- Effect of C-reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients with High-Risk Vascular DiseaseSteven E Nissen, Jeffrey S Riesmeyer, JAMA Cardiology
- Original Investigation Effect of Evolocumab on Coronary Plaque CompositionSteven E Nissen, Ransi Somaratne, Rishi Puri, Christie M Ballantyne, ScienceDirect
Authored Content
- Coronary Revascularization StrategiesJuly 2020
- Effect of C-reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients with High-Risk Vascular DiseaseJuly 2020
- Effect of C-reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients with High-Risk Vascular DiseaseJuly 2020
Press Mentions
First Human Trial of a CRISPR-Based Treatment Significantly Lowered Cholesterol and TriglyceridesNovember 17th, 2025
CRISPR-Cas9 Gene Editing for Refractory Dyslipidemia Shows Safety and Preliminary EfficacyNovember 10th, 2025
Fish Oil Halves CV Risk in Patients on Dialysis: PISCESNovember 10th, 2025
Professional Memberships
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