StewartHLeckerMD

Nephrology • Boston, MA

Assistant Professor of Medicine, Beth Israel Deaconess Medical Center

Join to view full profile

Dr. Lecker is on Doximity

As a Doximity member you'll join over a million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Lecker's full profile

Already have an account?

Office
330 Brookline Avenue
BIDMC Renal Unit Libby 2
Boston, MA 02215
Phone(617) 632-9880
Is this information wrong?

Education & Training

Beth Israel Deaconess Medical CenterFELLOWSHIP
UCLA Medical CenterRESIDENCY
David Geffen School of Medicine at UCLAMEDICAL_SCHOOL

Certifications & Licensure

MA State Medical License 1996 - 2021
CA State Medical License 1993 - Present
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
Fellow (ASNF) American Society of Nephrology

Clinical Trials

An Exploratory Study to Evaluate FMX-8 to Treat Anemia in CKD Start of enrollment: 2014 Sep 01Albright, R.,Lecker, S.

Publications & Presentations

PubMed

Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications.
Poggio, E. D., McClelland, R. L., Blank, K. N., Hansen, S., Bansal, S., Bomback, A. S., Canetta, P. A., Khairallah, P., Kiryluk, K., Lecker, S. H., McMahon, G. M., Pal...> ;Clinical journal of the American Society of Nephrology : CJASN. 2020 Oct 17
Brugada phenocopy induced by hyperkalemia.
Zhuo, M., Li, J., Lecker, S. H.> ;Kidney international. 2019 Jan 23
The Glomerular Disease Study and Trial Consortium: A Grassroots Initiative to Foster Collaboration and Innovation.
Mehr, A. P., Sadeghi-Najafabadi, M., Chau, K., Messmer, J., Pai, R., Roy, N., Friedman, D., Pollak, M. R., Schlondorff, J., Naljayan, M., Singh, T., Lecker, S. H., Rod...> ;Kidney international reports. 2019 Jan 1
The Interdialytic Creatinine Rise is a novel marker of volume overload and mortality risk in hemodialysis patients.
Ilic, L. M., Davis, R. B., Brown, R. S., Lecker, S. H.> ;BMC nephrology. 2018 Aug 18
Diagnostic Use of Base Excess in Acid-Base Disorders.
Hoenig, M. P., Lecker, S. H., Zeidel, M. L.> ;The New England journal of medicine. 2018 Aug 3
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Martinelli, G. B.,Olivari, D.,Re Cecconi, A. D.,Talamini, L.,Ottoboni, L.,Lecker, S. H.,Stretch, C.,Baracos, V. E.,Bathe, O. F.,Resovi, A.,Giavazzi, R.,Cervo, L.,Picci...> ;Oncogene. 2016 May 24
20 citations
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Warren, S. A., Briggs, L. E., Zeng, H., Chuang, J., Chang, E. I., Terada, R., Li, M., Swanson, M. S., Lecker, S. H., Willis, M. S., Spinale, F. G., Maupin-Furlowe, J.,...> ;Circulation. 2012 Oct 26
42 citations
Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.
Lecker, S. H., Zavin, A., Cao, P., Arena, R., Allsup, K., Daniels, K. M., Joseph, J., Schulze, P. C., Forman, D. E.> ;Circulation. Heart failure. 2012 Sep 25
13 citations
Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.
Wing, S. S., Lecker, S. H., Jagoe, R. T.> ;Critical reviews in clinical laboratory sciences. 2011 Jun 28
63 citations
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
Chitalia, V. C., Foy, R. L., Bachschmid, M. M., Zeng, L., Panchenko, M. V., Zhou, M. I., Bharti, A., Seldin, D. C., Lecker, S. H., Dominguez, I., Cohen, H. T.> ;Nature cell biology. 2008 Sep 23
38 citations
Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes.
Menconi, M. J., Gonnella, P., Petkova, V., Lecker, S. H., Hasselgren, P.> ;Journal of cellular biochemistry. 2008 Jul 11
35 citations
Calpain activity and muscle wasting in sepsis.
Smith, I. J., Lecker, S. H., Hasselgren, P.> ;American journal of physiology. Endocrinology and metabolism. 2008 May 22
524 citations
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., Goldberg, A. L.> ;Cell metabolism. 2007 Dec 7
187 citations
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases.
Sacheck, J. M., Hyatt, J. P., Raffaello, A., Jagoe, R. T., Roy, R. R., Edgerton, V. R., Lecker, S. H., Goldberg, A. L.> ;FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Nov 23
6 citations
Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated with uterine smooth muscle involution in the postpartum period.
Bdolah, Y., Segal, A., Tanksale, P., Karumanchi, S. A., Lecker, S. H.> ;American journal of physiology. Regulatory, integrative and comparative physiology. 2006 Sep 30
269 citations
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
Lecker, S. H., Goldberg, A. L., Mitch, W. E.> ;Journal of the American Society of Nephrology : JASN. 2006 Jun 2
55 citations
Ubiquitin-protein ligases in muscle wasting.
Cao, P. R., Kim, H. J., Lecker, S. H.> ;The international journal of biochemistry & cell biology. 2005 Aug 30
113 citations
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling.
Skurk, C., Izumiya, Y., Maatz, H., Razeghi, P., Shiojima, I., Sandri, M., Sato, K., Zeng, L., Schiekofer, S., Pimentel, D. R., Lecker, S. H., Taegtmeyer, H., Goldberg,...> ;The Journal of biological chemistry. 2005 Mar 23
502 citations
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V. E., Bailey, J. L., Price, S. R., Mitch, W. E., Goldberg, A. L.> ;FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Jan 14
29 citations
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
Lecker, S. H.> ;Current opinion in clinical nutrition and metabolic care. 2003 Apr 12
7 citations
Slowing muscle atrophy: putting the brakes on protein breakdown.
Lecker, S. H., Goldberg, A. L.> ;The Journal of physiology. 2002 Dec 17
126 citations
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.
Jagoe, R. T., Lecker, S. H., Gomes, M., Goldberg, A. L.> ;FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 Nov 1
67 citations
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
Kwon, Y. T., Xia, Z., Davydov, I. V., Lecker, S. H., Varshavsky, A.> ;Molecular and cellular biology. 2001 Nov 2
Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.
Lecker, S. H., Solomon, V., Mitch, W. E., Goldberg, A. L.> ;J Nutr. 1999 Jan
The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle.
Solomon, V., Lecker, S. H., Goldberg, A. L.> ;J Biol Chem. 1998 Sep 25
Join now to see all

Press Mentions

Diagnostic Use of Base Excess in Acid–Base Disorders

Grant Support

Atrogin-1 And Muscle Protein BalanceNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2010
Molecular Basis For Muscle Protein Loss In CachexiaNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2003
Molecular Basis For Muscle Protein Loss In CachexiaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1997