SusanMoodyMD

PubMed

• Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling.
  Chen Liu, Hengyu Lu, Hongyun Wang, Alice Loo, Xiamei Zhang, Guizhi Yang, Colleen Kowal, Scott Delach, Ye Wang, Silvia Goldoni, William D. Hastings, Karrie Wong, Hui Ga...> ;Clinical Cancer Research. 2021 Jan 1
• 2 citations
  Safety and efficacy of nazartinib (EGF816) in adults with EGFR-mutant non-small-cell lung carcinoma: a multicentre, open-label, phase 1 study.
  Daniel Shao-Weng Tan, Natasha B. Leighl, Gregory J. Riely, James Chih-Hsin Yang, Lecia V. Sequist, Juergen Wolf, Takashi Seto, Enriqueta Felip, Santiago Ponce Aix, Mau...> ;The Lancet Respiratory Medicine. 2020 Jan 15
• Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers.
  Huai-Xiang Hao, Hongyun Wang, Chen Liu, Steven Kovats, Roberto Velazquez, Hengyu Lu, Bhavesh Pant, Matthew D. Shirley, Matthew J. Meyer, Minying Pu, Joanne Lim, Michae...> ;Molecular Cancer Therapeutics. 2019 Aug 22
• 9 citations
  SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors.
  Hengyu Lu, Chen Liu, Roberto Velazquez, Hongyun Wang, Lukas Manuel Dunkl, Malika Kazic-Legueux, Anne Haberkorn, Eric Billy, Eusebio Manchado, Saskia M. Brachmann, Susa...> ;Molecular Cancer Therapeutics. 2019 Jul 1
• 6 citations
  Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in L...
  Zofia Piotrowska, Mehlika Hazar-Rethinam, Coleen Rizzo, Brandon Nadres, Emily E. Van Seventer, Heather A. Shahzade, Inga T. Lennes, Anthony J. Iafrate, Dora Dias-Santa...> ;JCO precision oncology. 2018 Jul 16
• SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
  Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw, Satoshi Yoda, Grainne Kerr, Kristine Yu, Jinsheng Liang, Yichen Cao, Yan Chen, Michael S. ...> ;Nature Medicine. 2018 Mar 5
• PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
  Nina Ilic, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Bar...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 25
• PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling
  Susan Moody, Anna C. Schinzel, Shambhavi Singh, Francesca Izzo, Matthew R. Strickland, Leo Y. Luo, Sapana R. Thomas, Jesse S. Boehm, So Young Kim, Zhigang C. Wang, Wil...> ;Oncogene. 2015 Apr 16
• Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit
  Zehua Zhu, Amir R. Aref, Travis J. Cohoon, Thanh U. Barbie, Yu Imamura, Shenghong Yang, Susan Moody, Rhine R. Shen, Anna C. Schinzel, Tran C. Thai, Jacob B. Reibel, Pa...> ;Cancer Discovery. 2014 Jan 20
• Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers.
  Maria B. Raeder, Even Birkeland, Jone Trovik, Camilla Krakstad, Shyemaa Shehata, Steven E. Schumacher, Travis I. Zack, Antje Krohn, Henrica M.J. Werner, Susan Moody, E...> ;PLOS ONE. 2013 Feb 5
• Functional genomics and cancer drug target discovery.
  Susan Moody, Jesse S. Boehm, David A. Barbie, William C. Hahn> ;Current Opinion in Molecular Therapeutics. 2010 Jun 1
• Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
  David A. Barbie, Pablo Tamayo, Jesse S. Boehm, So Young Kim, Susan Moody, Ian F. Dunn, Anna C. Schinzel, Peter Sandy, Etienne Meylan, Claudia Scholl, Stefan Fröhling, ...> ;Nature. 2009 Nov 5
• Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
  Christopher J. Sarkisian, Blaine A. Keister, Douglas B. Stairs, Robert B. Boxer, Susan E. Moody, Lewis A. Chodosh> ;Nature Cell Biology. 2007 May 1
• 10 citations
  Hormone-Induced Protection against Mammary Tumorigenesis Is Conserved in Multiple Rat Strains and Identifies a Core Gene Expression Signature Induced by Pregnancy
  Collin M. Blakely, Alexander J. Stoddard, George K. Belka, Katherine D. Dugan, Kathleen L. Notarfrancesco, Susan E. Moody, Celina M. D'Cruz, Lewis A. Chodosh> ;Cancer Research. 2006 Jun 15
• Defective neuromuscular synaptogenesis in mice expressing constitutively active ErbB2 in skeletal muscle fibers.
  Olga Ponomareva, Hualong Ma, Vita M. Vock, Elaine L. Ellerton, Susan E. Moody, Ramzi Dakour, Lewis A. Chodosh, Mendell Rimer> ;Molecular and Cellular Neuroscience. 2006 Feb 1
• Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary Gland
  Celina M. D'Cruz, Susan E. Moody, Stephen R. Master, Jennifer L. Hartman, Elizabeth A. Keiper, Marcin Imielinski, James D. Cox, James Y. Wang, Seung I. Ha, Blaine A. K...> ;Molecular Endocrinology. 2002 Sep 1
• Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis.
  Stephen R. Master, Jennifer L. Hartman, Celina M. D'Cruz, Susan E. Moody, Elizabeth A. Keiper, Seung I. Ha, James D. Cox, George K. Belka, Lewis A. Chodosh> ;Molecular Endocrinology. 2002 Jun 1
• c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
  Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golan...> ;Nature Medicine. 2001 Feb 1
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