TerzahM.HortonMDPh.D.

PubMed

• MRD at the End of Induction and EFS in T-cell Lymphoblastic Lymphoma: Children's Oncology Group Trial AALL1231.
  Robert J Hayashi, Michelle L Hermiston, Brent L Wood, David Trent Teachey, Meenakshi Devidas, Zhiguo Chen, Robert D Annett, Barbara L Asselin, Keith August, Steve Cho,...> ;Blood. 2024 Mar 8
• 1 citations
  Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia.
  Aram Lyu, Ryan S Humphrey, Seo Hee Nam, Tyler A Durham, Zicheng Hu, Dhivya Arasappan, Terzah M Horton, Lauren I R Ehrlich> ;Nature Communications. 2023 Oct 7
• 1 citations
  Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
  Katherine Tarlock, Xiaowei Liu, Emasenyie A Isikwei, Joel M Reid, Terzah M Horton, Elizabeth Fox, Brenda J Weigel, Todd Cooper, Minard, C.> ;Pediatric Blood & Cancer. 2023 Dec 1
• Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: ...
  Fieke W Hoff, Yihua Qiu, Brandon D Brown, Robert B Gerbing, Amanda R Leonti, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Edward Anders Kolb, Todd A Alonzo, Soheil Mes...> ;Proteomics. Clinical Applications. 2023 Nov 1
• DNA Damage Response-Related Proteins Are Prognostic for Outcome in Both Adult and Pediatric Acute Myelogenous Leukemia Patients: Samples from Adults and from Children ...
  Stefan E Hubner, Eduardo S de Camargo Magalhães, Fieke W Hoff, Brandon D Brown, Yihua Qiu, Terzah M Horton, Steven M Kornblau> ;International Journal of Molecular Sciences. 2023 Mar 20
• Reverse Phase Protein Array Profiling Identifies Recurrent Protein Expression Patterns of DNA Damage-Related Proteins across Acute and Chronic Leukemia: Samples from A...
  Fieke W Hoff, Ti'ara L Griffen, Brandon D Brown, Terzah M Horton, Jan Burger, William Wierda, Stefan E Hubner, Yihua Qiu, Steven M Kornblau> ;International Journal of Molecular Sciences. 2023 Mar 13
• 4 citations
  Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells.
  Francesco Maura, Bachisio Ziccheddu, Jenny Z Xiang, Bhavneet Bhinder, Joel Rosiene, Federico Abascal, Kylee H Maclachlan, Kenneth Wha Eng, Manik Uppal, Feng He, Wei Zh...> ;Blood Cancer Discovery. 2023 May 1
• 4 citations
  IL-10 and TNFα are associated with decreased survival in low-risk pediatric acute myeloid leukemia; a children's oncology group report.
  Alexandra M Stevens, Terzah M Horton, Chana L Glasser, Robert B Gerbing, Richard Aplenc, Todd A Alonzo, Michele S Redell> ;Pediatric Hematology and Oncology. 2023 Mar 1
• 40 citations
  Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma.
  David T Teachey, Meenakshi Devidas, Brent L Wood, Zhiguo Chen, Robert J Hayashi, Michelle L Hermiston, Robert D Annett, J Hunter Archer, Barbara L Asselin, Keith J Aug...> ;Journal of Clinical Oncology. 2022 Jul 1
• 5 citations
  Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
  Lauren K Meyer, Cristina Delgado-Martin, Phillip P Sharp, Benjamin J Huang, Dustin McMinn, Tiffaney L Vincent, Theresa Ryan, Terzah M Horton, Brent L Wood, David T Tea...> ;British Journal of Haematology. 2022 Jul 1
• 21 citations
  Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
  Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha ...> ;Nature Communications. 2022 May 19
• 8 citations
  Clinical relevance of proteomic profiling inpediatric acute myeloid leukemia: a Children's Oncology Group study.
  Fieke W Hoff, Anneke D Van Dijk, Yihua Qiu, Chenyue W Hu, Rhonda E Ries, Andrew Ligeralde, Gaye N Jenkins, Robert B Gerbing, Alan S Gamis, Richard Aplenc, E Anders Kol...> ;Haematologica. 2022 Oct 1
• Reverse phase protein arrays in acute leukemia: investigative and methodological challenges.
  Fieke W Hoff, Terzah M Horton, Steven M Kornblau> ;Expert Review of Proteomics. 2021 Dec 1
• 3 citations
  Bortezomib is significantly beneficial for de novo pediatric AML patients with low phosphorylation of the NF-κB subunit RelA.
  Anneke D. van Dijk, Fieke W Hoff, Yihua Qiu, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye Jenkins, Eveline ...> ;Proteomics. Clinical Applications. 2021 Nov 1
• 7 citations
  Gene expression-based model predicts outcome in children with intermediate-risk classical Hodgkin lymphoma
  Rebecca L. Johnston, Anja Mottok, Fong Chun Chan, Aixiang Jiang, Arjan Diepstra, Lydia Visser, Adele Telenius, Randy D. Gascoyne, Debra L. Friedman, Cindy L. Schwartz,...> ;Blood. 2021 Oct 18
• 6 citations
  Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia.
  Jeremy M. Schraw, John P. Woodhouse, Melanie Brooke Bernhardt, Olga A. Taylor, Terzah M. Horton, Michael E. Scheurer, M. Fatih Okcu, Karen R. Rabin, Philip J. Lupo, Au...> ;Scientific Reports. 2021 Oct 4
• 6 citations
  Rational biomarker development for the early and minimally invasive monitoring of AML
  Sherif Abdelhamed, John T. Butler, Seul Jung, Ding-Wen Chen, Gaye Jenkins, Lina Gao, Jeong Y. Lim, Jeffery M. Klco, Terzah M. Horton, Peter Kurre> ;Blood Advances. 2021 Nov 9
• 4 citations
  Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency.
  Monika Perez, Oscar Sias-Garcia, Alfred Daramola, Helen Wei, Maci Terrell, Raushan Rashid, Woojun D Park, Kevin Duong, Terzah M. Horton, Feng Li, Nikitha Cherayil, Jos...> ;Blood Advances. 2021 Dec 14
• 5 citations
  The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma.
  Jennifer Foster, Eveline Barbieri, Linna Zhang, Kathleen A. Scorsone, Myrthala Moreno-Smith, Peter E. Zage, Terzah M. Horton> ;International Journal of Molecular Sciences. 2021 Jun 18
• 6 citations
  The effects of sample handling on proteomics assessed by reverse phase protein arrays (RPPA): Functional proteomic profiling in leukemia.
  Terzah M. Horton, Fieke W Hoff, Anneke D. van Dijk, Gaye Jenkins, Debra J. Morrison, Teena Bhatla, Laura Hogan, Eleny Romanos-Sirakis, Julia Meyer, William L. Carroll,...> ;Journal of Proteomics. 2021 Feb 20
• 8 citations
  Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia
  A. D. van Dijk, Fieke W Hoff, Yihua Qiu, Joya Chandra, Elias Jabbour, E. S. J. M. de Bont, Terzah M. Horton, Steven M. Kornblau> ;Clinical Epigenetics. 2021 Jan 28
• 6 citations
  Defining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma.
  Jennifer E. Agrusa, Brooks Scull, Harshal Abhyankar, Howard Lin, Nmazuo W. Ozuah, Rikhia Chakraborty, Olive S. Eckstein, Nitya Gulati, Elmoataz Abdel Fattah, Nader Kim...> ;Cancers. 2020 Dec 2
• 13 citations
  Tumor-associated myeloid cells provide critical support for T-ALL.
  Aram Lyu, Todd A. Triplett, Seo Hee Nam, Zicheng Hu, Dhivya Arasappan, Wesley H. Godfrey, Rachel Y. Ames, Adviti Sarang, Hilary J. Selden, Chang-Han Lee, George Georgi...> ;Blood. 2020 Oct 15
• 8 citations
  Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report.
  Fieke W Hoff, Anneke D. van Dijk, Yihua Qiu, Peter P. Ruvolo, Robert B. Gerbing, Amanda R. Leonti, Gaye Jenkins, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A....> ;Blood. 2021 Feb 25
• 81 citations
  Bortezomib with standard chemotherapy for children with acute myeloid leukemia does not improve treatment outcomes: a report from the Children's Oncology Group.
  Richard Aplenc, Soheil Meshinchi, Lillian Sung, Todd A. Alonzo, John K. Choi, Brian T. Fisher, Robert B. Gerbing, Betsy A. Hirsch, Terzah M. Horton, Samir B. Kahwash, ...> ;Haematologica. 2020 Jul 1
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Journal Articles

• Transmissible ER Stress Reconfigures the AML Bone Marrow Compartment  
  Saman K Hashmi, Peter Kurre, Terzah M Horton, Nature
• Phase 1/ 2 trial of brentuximab vedotin in combination with gemcitabine for pediatric and young adult patients with relapsed or refractory Hodgkin Lymphoma: A report f...  
  Cole, PD, K McCarten, Q Pei, M Spira, ML Metzger, RA Drachtman, TM Horton, R Bush, SM Blaney, BJ Weidel, KM Kelly, Lancet Oncology, 1/1/2018
• Investigating the biology of relapsed acute leukemia: Proceedings of the therapeutic advances for childhood leukemia and lymphoma (TACL) consortium biology working group  
  Bhojwani, D., MJ Burke, T Horton, DS Ziegler, ML Sulis, KR Schultz, S Izraeli, BH Chang, Pediatric Hematology and Oncology, 1/1/2017
• Analysis of NF- kappaB Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome�A Children's Oncology Group Study  
  TM Horton,�AM Sheehan,�D Lopez-Terrada,�RE Hutchison,�S Narendra,�M-F Wu,�and H Liu, Lymphoma, 1/1/2012
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Books/Book Chapters

• New Agents for the Treatment of Acute Lymphoblastic Leukaemia 
  Chapter: Trial Designs for the Evaluation of New Agents in Acute Lymphoblastic Leukaemia 
  J. Whitlock and TM HortonEditors: Vaskar Saha and Pamela Kearns.Springer, Manchester, England, United Kingdom
• UpToDate 
  Chapter: Overview of Diagnosis and Presentation of Acute Lymphocytic Leukemia in children I 
  TM Horton and CP SteuberEditors: Rose BD.Wellesley, MA
• UpToDate 
  Chapter: Overview of Diagnosis and Presentation of Acute Lymphocytic Leukemia in children II 
  TM Horton and CP SteuberEditors: Rose BD.Wellesley, MA
• UpToDate 
  Chapter: Overview of the treatment and outcome of acute lymphoblastic leukemia in children-I 
  TM Horton and CP SteuberEditors: Rose BD.Wellesley, MA
• UpToDate 
  Chapter: Overview of the treatment and outcome of acute lymphoblastic leukemia in children-II 
  TM Horton and CP SteuberEditors: Rose BD.Wellesley, MA
• Perspectives on Childhood Cancer 
  Chapter: New drugs in Pediatric Leukemia 
  TM Horton and SL BergEditors: David Poplack.Edition 3rd,
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Abstracts/Posters

• Leukemic Stress Targets the mTOR Pathway to Suppress Residual HSC in the BM Microenvironment
  Terzah M Horton, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a ChildrenÍs Onc...
  Terzah M Horton, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability
  Terzah M Horton, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Comprehensive Cell Specific Transcriptome Profiling of a Pediatric Hodgkin Lymphoma Cohort
  Terzah M Horton, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Proteomic Landscape of Acute Leukemia: A Comparison between ALL and AML in Adults
  Terzah M Horton, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Proteomic profiling of the unfolded protein response identifies patients benefiting from bortezomib in pediatric acute myeloid leukemia
  Hoff, FW, Y Qiu, W Hu, AA Qutub, AS Gamis, R Aplenc A Kolb, TA Alonzo, ES deBont, SM Kornblau, TM Horton, American Association of Cancer Research, 1/15/2018
• Proteomic landscape of de novo pediatric acute myeloid leukemia
  Hoff, FW, Y Qiu, W Hu,AA Qutub, AS Gamis, R Aplenc, EA Kolb, TA Alonzo, ES deBont, TM Horton, SM Kornblau, American Association of Cancer Research, 1/15/2018
• Pediatric Acute Myeloid leukemia: an evolving proteomic landscape
  Hoff FW, Y Qui, CS Hu, AA Qutub, AS Gamis, R Aplenc EA Kolb TA Alonzo, ESMJK de Bont, SM Kornblau, TM Horton, American Society of Hematology (ASH), 1/4/2018
• AraC-Daunorubicin-Etoposide (ADE) response prediction in pediatric AML patients using a computation biology modeling (CBM) based precision medicine workflow
  NK Singh, M Sauban, RK Raman, R Vidva, A Tyagi, AA Talawdekar, A Kas, S Vali, CR Cogl, SM Kornblau, TM Horton, T Abbasi, American Society of Hematology (ASH), 1/4/2018
• RPPA-profiling identified patients with low phosphorylation of HSF1 at serine 326 as potential candidate for bortezomib treatment in addition to standard therapy in pe...
  Hoff FW, SWM Bruggeman, Y Qiu, AS. Gamis, R Aplenc, EA Kolb, TA Alonzo, EJM de Bont, SM Kornblau, TM Horton, American Society of Hematology (ASH), 1/3/2018
• Signatures of Histone modification marks and proteins in pediatric AML: A comparison to adults
  Kijk, AD, FW Hoff, CW Hu, ESJM de Bont, YH Qiu, AA Qutub, TM Horton, SM Kornblau, American Society of Hematology (ASH), 1/3/2018
• AXL expression in pediatric AML is associated with putative LSC and correlates with a distinct set of proteins including PD-L1
  Ruvolo, PP, FW Hoff, YH Qiu, A Gaiccia, M Andreeff, ESJM deBont, TM Horton, SM Kornblau, American Society of Hematology (ASH), 1/2/2018
• Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance Through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia
  LK Meyer, BJ Huang, R Roy, A Hechmer, AM Wandler, C Delgado-Martin, A Olshen, TM Horton, DT Teachey, KM Shannon, ML Hermiston, American Society of Hematology (ASH), 1/2/2018
• Detection of biomarkers using xMAP technology for high-risk Hodgkin Lymphoma in the setting of a cooperative group Phase III clinical trial
  Dave, H, S VanPelt, G Jenkins, TM Horton, S Alibhani, Q Pei, R Keller, S Castellino, K Kelly, C Bollard, ISCAYAHL meeting, 1/1/2017
• Recognition of Recurrent Protein Expression Patterns in Pediatric Acute Myeloid Leukemia Suggests New Therapeutic Targets
  Fieke W Hoff, Chenyue W Hu, Yihua Qiu, Suk-Young Yoo, Amina Qutub, Eveline S. de Bont, Terzah M. Horton and Steven M. Kornblau, Blood, 1/1/2016
• Recurrent Patterns of Protein Expression Signatures in Pediatric Acute Lymphoblastic Leukemia: Recognition and Therapeutic Guidance
  Fieke W Hoff, Chenyue W Hu, Yihua Qiu, Suk-Young Yoo, Amina Qutub, TM. Horton and Steven M. Kornblau, Blood, 1/1/2016
• Prediction of primary treatment response and outcome in pediatric Hodgkin lymphoma using digital gene expression profiling
  Mottok A. Johnston, RL, FC Chan, DW Scott, DL Friedman, CL Schwartz, KM Kelly, TM Horton, C Steidl, ISHL, 1/1/2016
• Correlating RPPA data with clinical features in pediatric acute Leukemia
  J Sab, SM Kornblau, W Love, TM Horton, Dan L. Duncan Research Symposium, 1/1/2015
• Targeting NEDD8: a novel approach to treating neuroblastoma
  J. Foster, L. Zhang, K. Scorsone, E Barbiere, J. Muscal, G. Jenkins, P. Zage, S. Berg, TM Horton, 1/1/2015
• Identifying proteins for detecting activation of the unfolded protein response
  G. Oyekanmi, Jenkins, G, TM Horton, NCI-Diversity Supplement program, 1/1/2015
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Lectures

• The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Proteasome Inhibitor therapy for the treatment of hematologic malignancies 
  1/8/2018
• Taking out the Trash: Proteasome inhibitor therapy for hematologic malignancies 
  1/13/2014
• Update on relapsed leukemia and AML COG protocols 
  1/1/2010
• Chemotherapy Combinations for Relapsed/ Refractory HL 
  1/30/2009
• New drugs for the Treatment of Hodgkin Lymphoma 
  1/17/2008
• Toxicity and DLT Attribution in the context of relapsed ALL therapy 
  1/2/2008
• PARP Inhibition and Proteasome Inhibitors: Potential use in Pediatric Hematologic Malignancies 
  1/1/2008
• Temozolomide and PARP inhibition: Bench to Bedside and Back 
  1/1/2008
• Preclinical models of novel drugs in pediatric Hodgkin lymphoma 
  1/27/2007
• New Drug Development for Pediatric Leukemias & Lymphomas 
  1/20/2007
• In vitro Evaluation of the PARP Inhibitor ABT-888 in Combination with Temozolomide for the Treatment of Pediatric Leukemia 
  1/1/2007
• Innovative therapies of childhood malignancies: new pharmacologic agents 
  1/1/2007
• Translation for hematology-oncology patients and their families 
  1/11/2006
• A Phase I study of Bortezomib (PS-341, VELCADE) in Pediatric Patients with Relapsed or Refractory Leukemia 
  1/3/2006
• Preclinical applications of basic research 
  1/1/2006
• Childhood Cancer 
  1/1/2006
• Anemia of Childhood 
  1/1/2006
• Management of Childhood Leukemia 
  1/1/2006
• Ubiquitination and Proteasome Inhibition in Pediatric Hematologic Malignancies 
  1/25/2004
• Metabolism of cyclosporine in patient with histocytic lymphohistiocytosis (HLH) 
  1/21/2004
• Introduction to Cancer Chemotherapy 
  1/10/2004
• Novel Agents for the treatment of pediatric malignancies 
  Houston, TX - 1/1/2004
• Idiopathic thrombotic thrombocytopenia masquerading as hemolytic uremic syndrome 
  1/1/2004
• Sickle Cell Crises 
  1/6/2003
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Other

• Overview of the outcome of acute lymphoblastic leukemia in children 
  Horton TM, Steuber CP
  http://www.uptodate.com/contents/overview-of-the-outcome-of-acute-lymphoblastic-leukemia-in-children
  UpToDate, Wolters Kluwer Health - 2012-10-19
• Overview of the presentation and classification of acute lymphoblastic leukemia in children 
  Horton TM, Steuber CP
  http://www.uptodate.com/contents/overview-of-the-presentation-and-classification-of-acute-lymphoblas
  UpToDate, Wolters Kluwer Health - 2012-12-08
• Overview of the treatment of acute lymphoblastic leukemia in children 
  Horton TM, Steuber CP
  http://www.uptodate.com/contents/overview-of-the-treatment-of-acute-lymphoblastic-leukemia-in-childr
  UpToDate, Wolters Kluwer Health - 2012-11-21
• Risk group stratification and prognosis for acute lymphoblastic leukemia in children 
  Horton TM, Steuber CP
  http://www.uptodate.com/contents/risk-group-stratification-and-prognosis-for-acute-lymphoblastic-leu
  UpToDate, Wolters Kluwer Health - 2013-04-11
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