ThaliaAndreaFaraziMDPh.D.

Pediatric Hematology & Oncology • Brisbane, CA

Senior Medical Director Clinical Development Cell Therapy, Bristol Myers Squibb

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Office
1000 Sierra Point Parkway
Bristol Myers Squibb
Brisbane, CA 94005
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Education & Training

Rockefeller UniversityMS, Clinical Investigation, 2011 - 2014
New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 2005 - 2009
New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 2005 - 2008
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 2002 - 2005
Washington University in St. Louis School of MedicineClass of 2002

Certifications & Licensure

CA State Medical License 2019 - 2025
NY State Medical License 2013 - 2020
CT State Medical License 2008 - 2013
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL) Start of enrollment: 2020 Jul 14
Active, not recruiting
Phase 2

Publications & Presentations

PubMed

6 citations
Statistical Assessment of Depth Normalization for Small RNA Sequencing.
Li-Xuan Qin, Jian Zou, Jiejun Shi, Ann Lee, Aleksandra Mihailovic, Thalia A. Farazi, Thomas Tuschl, Samuel Singer> ;JCO Clinical Cancer Informatics. 2020 Jun 29
36 citations
Deciphering human ribonucleoprotein regulatory networks
Neelanjan Mukherjee, Hans-Hermann Wessels, Svetlana Lebedeva, Marcin Sajek, Mahsa Ghanbari, Aitor Garzia, Alina Munteanu, Dilmurat Yusuf, Thalia A. Farazi, Jessica I. ...> ;Nucleic Acids Research. 2019 Jan 25
44 citations
Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies.
Andrew E. Place, Kelly C. Goldsmith, Jean-Pierre Bourquin, Mignon L. Loh, Lia Gore, Daniel A. Morgenstern, Yeshwant D. Sanzgiri, David Hoffman, Ying Zhou, Jeremy A. Ro...> ;Future Oncology. 2018 Mar 29
30 citations
The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression
Xavier Rambout, Cécile Detiffe, Jonathan Bruyr, Emeline Mariavelle, Majid Cherkaoui, Sylvain Brohée, Pauline Demoitié, Marielle Lebrun, Romuald Soin, Bart Lesage, Kati...> ;Nature Structural & Molecular Biology. 2016 Jul 1
38 citations
Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS.
Marianna Teplova, Thalia A. Farazi, Thomas Tuschl, Dinshaw J. Patel> ;Quarterly Reviews of Biophysics. 2015 Sep 8
39 citations
Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets
Thalia A. Farazi, Carl S. Leonhardt, Neelanjan Mukherjee, Aleksandra Mihailovic, Song Li, Klaas E.A. Max, Cindy Meyer, Masashi Yamaji, Pavol Cekan, Nicholas C. Jacobs,...> ;RNA. 2014 May 23
20 citations
Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis
Irene Y. Cheung, Thalia A. Farazi, Irina Ostrovnaya, Hong Xu, Hoa Tran, Aleksandra Mihailovic, Thomas Tuschl, Nai-Kong V. Cheung> ;Genes, Chromosomes & Cancer. 2014 Oct 1
156 citations
Human CLP1 mutations alter tRNA biogenesis affecting both peripheral and central nervous system function
Ender Karaca, Stefan Weitzer, Davut Pehlivan, Hiroshi Shiraishi, Tasos Gogakos, Toshikatsu Hanada, Shalini N. Jhangiani, Wojciech Wiszniewski, Marjorie Withers, Ian M....> ;Cell. 2014 Apr 24
57 citations
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
Thalia A. Farazi, Jelle ten Hoeve, Miguel Brown, Aleksandra Mihailovic, Hugo M. Horlings, Marc J. van de Vijver, Thomas Tuschl, Lodewyk F. A. Wessels> ;Genome Biology. 2014 Jan 7
68 citations
PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding s...
Jessica I. Spitzer, Markus Hafner, Markus Landthaler, Manuel Ascano, Thalia A. Farazi, Greg S. Wardle, Jeff Nusbaum, Mohsen Khorshid, Lukas Burger, Mihaela Zavolan, Th...> ;Methods in Enzymology. 2014 Jan 1
34 citations
Mammalian miRNA curation through next-generation sequencing
Miguel Brown, Hemant Suryawanshi, Markus Hafner, Thalia A. Farazi, Thomas Tuschl> ;Frontiers in Genetics. 2013 Aug 2
5 citations
An Arrayed RNA Interference Genome-Wide Screen Identifies Candidate Genes Involved in the MicroRNA 21 Biogenesis Pathway
David Shum, Bhavneet Bhinder, Christina N. Ramirez, Constantin Radu, Paul Calder, Lesslie Beauchamp, Thalia A. Farazi, Markus Landthaler, T. Tuschi, Susan Magdaleno, H...> ;Assay and Drug Development Technologies. 2013 Apr 5
589 citations
microRNAs in Human Cancer
Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl> ;Advances in Experimental Medicine and Biology. 2013 Jan 1
98 citations
Barcoded cDNA library preparation for small RNA profiling by next-generation sequencing
Markus Hafner, Neil Renwick, Thalia A. Farazi, Aleksandra Mihailovic, John Pena, Thomas Tuschl> ;Methods. 2012 Oct 1
50 citations
Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing
Thalia A. Farazi, Miguel Brown, Pavel Morozov, Jelle ten Hoeve, Iddo Z. Ben-Dov, Volker Hovestadt, Markus Hafner, Neil Renwick, Aleksandra Mihailovic, Lodewyk F. A. We...> ;Methods. 2012 Oct 1
16 citations
An image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathway.
David Shum, Bhavneet Bhinder, Constantin Radu, Paul Calder, Christina N. Ramirez, Hakim Djaballah> ;Combinatorial Chemistry & High Throughput Screening. 2012 Jul 31
270 citations
RNA targets of wild-type and mutant FET family proteins
Jessica I. Hoell, Erik Larsson, Simon Runge, Jeffrey Nusbaum, Sujitha Duggimpudi, Thalia A. Farazi, Markus Hafner, Arndt Borkhardt, Chris Sander, Thomas Tuschl> ;Nature Structural & Molecular Biology. 2011 Dec 1
276 citations
MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
Thalia A. Farazi, Hugo M. Horlings, Jelle ten Hoeve, Aleksandra Mihailovic, Hans Halfwerk, Pavel Morozov, Miguel Brown, Markus Hafner, Fabien Reyal, Marieke van Kouwen...> ;Cancer Research. 2011 Jul 1
768 citations
miRNAs in human cancer.
Thalia A. Farazi, Jessica I. Spitzer, Pavel Morozov, Thomas Tuschl> ;The Journal of Pathology. 2011 Jan 1
321 citations
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
Thalia A. Farazi, Stefan Juranek, Thomas Tuschl> ;Development. 2008 Apr 1
396 citations
The biology and enzymology of protein N-myristoylation.
Thalia A. Farazi, Gabriel Waksman, Jeffrey I. Gordon> ;The Journal of Biological Chemistry. 2001 Oct 26
21 citations
Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis.
Thalia A. Farazi, Jill K. Manchester, Gabriel Waksman, Jeffrey I. Gordon> ;Biochemistry. 2001 Aug 7
61 citations
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
Thalia A. Farazi, Gabriel Waksman, Jeffrey I. Gordon> ;Biochemistry. 2001 May 29
17 citations
Transient-state kinetic analysis of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase reveals that a step after chemical transformation is rate limi...
Thalia A. Farazi, Jill K. Manchester, Jeffrey I. Gordon> ;Biochemistry. 2000 Dec 1
95 citations
Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs
Rajiv S. Bhatnagar, Klaus Fütterer, Thalia A. Farazi, Sergey Korolev, Clare L. Murray, Emily Jackson-Machelski, George W. Gokel, Jeffrey I. Gordon, Gabriel Waksman> ;Nature Structural Biology. 1998 Dec 1
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