ThemistoclesLAssimesMD

PubMed

• Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.
  Karl Smith-Byrne, Åsa Hedman, Marios Dimitriou, Trishna Desai, Alexandr V Sokolov, Helgi B Schioth, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Joshua Atkins, Ric...> ;Nature Communications. 2024 Apr 29
• Development and utility of a clinical research informatics application for participant recruitment and workflow management for a return of results pilot trial in famil...
  Charles A Brunette, Thomas Yi, Morgan E Danowski, Mark Cardellino, Alicia Harrison, Themistocles L Assimes, Joshua W Knowles, Kurt D Christensen, Amy C Sturm, Yan V Su...> ;JAMIA Open. 2024 Apr 1
• Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.
  Johanna L Smith, Catherine Tcheandjieu, Ozan Dikilitas, Kruthika Iyer, Kazuo Miyazawa, Austin Hilliard, Julie Lynch, Jerome I Rotter, Yii-Der Ida Chen, Wayne Huey-Hern...> ;Circulation. Genomic and Precision Medicine. 2024 Feb 21
• A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes.
  Peter Saliba-Gustafsson, Johanne M Justesen, Amanda Ranta, Disha Sharma, Ewa Bielczyk-Maczynska, Jiehan Li, Laeya A Najmi, Maider Apodaka, Patricia Aspichueta, Hanna M...> ;Medrxiv. 2024 Feb 4
• 1 citations
  Diet Quality and Epigenetic Aging in the Women's Health Initiative.
  Reynolds, L., Houston, D., Skiba, M., Stewart, J., Li, Y., Horvath, S., Bhatti, P., Baccarelli, A., Tooze, J., Vitolins, M., Whitsel, E., Assimes, T., Zannas, A.> ;Journal of the Academy of Nutrition and Dietetics. 2024 Jan 11
• 1 citations
  Cardiorespiratory fitness and risk of heart failure with preserved ejection fraction.
  Kokkinos, P., Pittaras, A., Samuel, I., Lamonte, M., Franklin, B., Murphy, R., Zhang, J., Sui, X., Myers, J., Faselis, C., Lavie, C., Assimes, T., Vargas, J.> ;European Journal of Heart Failure. 2023 Dec 28
• Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and in...
  Karlijn A C Meeks, Amy R Bentley, Themistocles L Assimes, Nora Franceschini, Adebowale A Adeyemo, Charles N Rotimi, Ayo P Doumatey> ;Genome Medicine. 2023 Dec 4
• Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation.
  Lars Lind, Olga Titova, Rui Zeng, Daniela Zanetti, Martin Ingelsson, Stefan Gustafsson, Johan Sundström, Johan Ärnlöv, Sölve Elmståhl, Karl Michaëlsson, Themistocles A...> ;Circulation. Genomic and Precision Medicine. 2023 Dec 1
• CXCL12 regulates coronary artery dominance in diverse populations and links development to disease.
  Pamela E Rios Coronado, Daniela Zanetti, Jiayan Zhou, Jeffrey A Naftaly, Pratima Prabala, Pik Fang Kho, Azalia M Martínez Jaimes, Austin T Hilliard, Saiju Pyarajan, Da...> ;Medrxiv. 2023 Oct 27
• Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention (PCI) in the Million Veterans Program.
  Catherine Chanfreau-Coffinier, Kevin A Friede, Mary E Plomondon, Kyung Min Lee, Zhenyu Lu, Julie A Lynch, Scott L DuVall, Jason L Vassy, Stephen W Waldo, John H Cleato...> ;Medrxiv. 2023 Oct 26
• 6 citations
  Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.
  Maryam Kavousi, Maxime M Bos, Hanna J Barnes, Christian L Lino Cardenas, Doris Wong, Haojie Lu, Chani J Hodonsky, Lennart P L Landsmeer, Adam W Turner, Minjung Kho, Na...> ;Nature Genetics. 2023 Oct 1
• Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts.
  Mohammad Yaser Anwar, Mariaelisa Graff, Heather M Highland, Roelof Smit, Zhe Wang, Victoria L Buchanan, Kristin L Young, Eimear E Kenny, Lindsay Fernandez-Rhodes, Simi...> ;Human Genetics. 2023 Oct 1
• Carriers of rare damaginggenetic variants are at lower risk of atherosclerotic disease.
  Marios K Georgakis, Rainer Malik, Natalie R Hasbani, Gabrielle Shakt, Alanna C Morrison, Noah L Tsao, Renae Judy, Braxton D Mitchell, Huichun Xu, May E Montasser, Ron ...> ;Medrxiv. 2023 Aug 16
• Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.
  Corinne Carland, Grace Png, Anders Malarstig, Pik Fang Kho, Stefan Gustafsson, Karl Michaelsson, Lars Lind, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis...> ;Clinical Proteomics. 2023 Aug 7
• 1 citations
  Genetic insights into resting heart rate and its role in cardiovascular disease.
  Yordi J van de Vegte, Ruben N Eppinga, M Yldau van der Ende, Yanick P Hagemeijer, Yuvaraj Mahendran, Elias Salfati, Albert V Smith, Vanessa Y Tan, Dan E Arking, Ioanna...> ;Nature Communications. 2023 Aug 2
• 25 citations
  A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.
  Aniruddh P Patel, Minxian Wang, Yunfeng Ruan, Satoshi Koyama, Shoa L Clarke, Xiong Yang, Catherine Tcheandjieu, Saaket Agrawal, Akl C Fahed, Patrick T Ellinor, , Phili...> ;Nature Medicine. 2023 Jul 1
• Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.
  Rodrigo Guarischi-Sousa, Elias Salfati, Pik Fang Kho, Kruthika R Iyer, Austin T Hilliard, David M Herrington, Philip S Tsao, Shoa L Clarke, Themistocles L Assimes> ;Circulation. Genomic and Precision Medicine. 2023 Oct 1
• 7 citations
  Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.
  Anurag Verma, Jennifer E Huffman, Alex Rodriguez, Mitchell Conery, Molei Liu, Yuk-Lam Ho, Youngdae Kim, David A Heise, Lindsay Guare, Vidul Ayakulangara Panickan, Hele...> ;Medrxiv. 2023 Jun 29
• Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts.
  Daniela Zanetti, Laurel Stell, Stefan Gustafsson, Fahim Abbasi, Philip S Tsao, Joshua W Knowles, , Björn Zethelius, Johan Ärnlöv, Beverley Balkau, Mark Walker, Laura C...> ;Diabetologia. 2023 Sep 1
• 2 citations
  A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.
  Johanna L Smith, Catherine Tcheandjieu, Ozan Dikilitas, Kruthika Lyer, Kazuo Miyazawa, Austin Hilliard, Julie Lynch, Jerome I Rotter, Yii-Der Ida Chen, Wayne Huey-Hern...> ;Medrxiv. 2023 Jun 6
• 2 citations
  Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
  Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W Winkler, Adam E L...> ;Nature. 2023 Jun 1
• Mendelian randomization analyses clarify the effects of height on cardiovascular diseases.
  Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M Damrauer, Themistocles L Assimes, Christopher S Thom, Benjamin F Voight> ;Medrxiv. 2023 May 5
• 12 citations
  Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program.
  Jason L Vassy, Daniel C Posner, Yuk-Lam Ho, David R Gagnon, Ashley Galloway, Vidisha Tanukonda, Serena C Houghton, Ravi K Madduri, Benjamin H McMahon, Philip S Tsao, S...> ;JAMA Cardiology. 2023 Jun 1
• 3 citations
  Cardiovascular Disease and Mortality in Black Women Carrying the Amyloidogenic V122I Transthyretin Gene Variant.
  Bernhard Haring, Rebecca P Hunt, Aladdin H Shadyab, Charles Eaton, Robert Kaplan, Lisa Warsinger Martin, Gurusher Panjrath, Lewis H Kuller, Themistocles Assimes, Charl...> ;JACC. Heart Failure. 2023 Sep 1
• 1 citations
  Evaluation of the association between circulating IL-1β and other inflammatory cytokines and incident atrial fibrillation in a cohort of postmenopausal women.
  Sofia E Gomez, Justin Parizo, Simon Ermakov, Joseph Larson, Robert Wallace, Themistocles Assimes, Mark Hlatky, Marcia Stefanick, Marco V Perez> ;American Heart Journal. 2023 Apr 1
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Journal Articles

• Original Investigation Editorial Comment Making the Most Out of Mendel’s Laws in Complex Coronary Artery Disease∗  
  Themistocles Assimes, MD, ScienceDirect

Lectures

• Future Hub: Precision Cardiology: Polygenic Risk Scores 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019