TheodoreA.ChristopherMD

Emergency Medicine • Philadelphia, PA

Professor and Chair, Department of Emergency Medicine, Thomas Jefferson University and Hospitals

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Office
SKMC 1025 Walnut Street
Suite 300 College Bldg
Philadelphia, PA 19107
Phone+1 215-955-5105

Fax+1 215-503-5686
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Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Emergency Medicine, 1984 - 1986
Brown UniversityResidency, Internal Medicine, 1981 - 1984
Icahn School of Medicine at Mount SinaiClass of 1981

Certifications & Licensure

PA State Medical License 1981 - 2024
DE State Medical License 2015 - 2023
NJ State Medical License 2015 - 2021
American Board of Emergency Medicine Emergency Medicine
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

President, Pennsylvania Medical Society October, 2017
Fellow (FACEP) American College of Emergency Physicians
Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury.
Yunhui Du, Yanru Duan, Jianli Zhao, Caihong Liu, Zhen Zhang, John Zhang, Zhijun Meng, Xiaoliang Wang, Wayne Bond Lau, Dina Xie, Bernard L Lopez, Theodore A Christopher...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Dec 1
COVID-19 and cardiovascular complications: updates of emergency medicine.
Zhao, J., Xie, Y., Meng, Z., Liu, C., Wu, Y., Zhao, F., Ma, X., Lopez, B., Wang, Y., Christopher, T.> ;Emergency and Critical Care Medicine. 2023 Sep 1
2 citations
Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.
Zhijun Meng, Bin Liang, Yalin Wu, Caihong Liu, Han Wang, Yunhui Du, Lu Gan, Erhe Gao, Wayne B Lau, Theodore A Christopher, Bernard L Lopez, Walter J Koch, Xinliang Ma,...> ;Journal of Molecular and Cellular Cardiology. 2023 Sep 1
2 citations
Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic ...
Zhijun Meng, Zhen Zhang, Jianli Zhao, Caihong Liu, Peng Yao, Ling Zhang, Dina Xie, Wayne Bond Lau, Jumpei Tsukuda, Theodore A Christopher, Bernard Lopez, Di Zhu, Demin...> ;Circulation. 2023 Apr 11
5 citations
Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
Di Zhu, Zhen Zhang, Jianli Zhao, Demin Liu, Lu Gan, Wayne Bond Lau, Dina Xie, Zhijun Meng, Peng Yao, Jumpei Tsukuda, Theodore A Christopher, Bernard L Lopez, Erhe Gao,...> ;Circulation Research. 2022 Jul 8
7 citations
C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions.
Zheyi Yan, Chunfang Wang, Zhijun Meng, Lu Gan, Rui Guo, Jing Liu, Wayne Bond Lau, Dina Xie, Jianli Zhao, Bernard L Lopez, Theodore A Christopher, Ulhas P Naik, Xinlian...> ;Cells. 2022 Feb 23
20 citations
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function.
Lu Gan, Demin Liu, Dina Xie, Wayne Bond Lau, Jing Liu, Theodore A. Christopher, Bernard L. Lopez, Lian Liu, Hang Hu, Peng Yao, Yarong He, Erhe Gao, Walter J. Koch, Jia...> ;Circulation Research. 2021 Nov 12
14 citations
Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production
Demin Liu, Guoqiang Gu, Lu Gan, Wenjun Yan, Zhen Zhang, Peng Yao, Di Zhu, Wayne Bond Lau, Dina Xie, Sisi Wu, Zhijun Meng, Jumpei Tsukuda, Theodore A. Christopher, Bern...> ;Redox Biology. 2021 Mar 4
7 citations
C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19.
Yaoli Xie, Zhijun Meng, Jia Gao, Caihong Liu, Jing Wang, Rui Guo, Jianli Zhao, Bernard L. Lopez, Theodore A. Christopher, Daniel Lee, Xinliang Ma, Yajing Wang> ;Proteomes. 2021 Mar 1
11 citations
Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat
Guizhi Jia, Zhijun Meng, Caihong Liu, Xinliang Ma, Jia Gao, Jing Liu, Rui Guo, Zheyi Yan, Theodore A. Christopher, Bernard L. Lopez, Wenxia Liu, Hongliang Dai, Wayne B...> ;Life Sciences. 2020 Sep 15
7 citations
Adiponectin inhibits cardiac arrest/cardiopulmonary resuscitation‑induced apoptosis in brain by increasing autophagy involved in AdipoR1‑AMPK signaling.
Yarong He, Bofu Liu, Peng Yao, Yuming Shao, Yan-Wei Cheng, Jie Zhao, Jiang Wu, Zhiwei Zhao, Wen Huang, Theodore A. Christopher, Bernard L. Lopez, Xinliang Ma, Yu Cao> ;Molecular Medicine Reports. 2020 May 22
20 citations
C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling.
Jing Liu, Zhijun Meng, Lu Gan, Rui Guo, Jia Gao, Caihong Liu, Di Zhu, Demin Liu, Ling Zhang, Zhen Zhang, Dina Xie, Xiangying Jiao, Wayne Bond Lau, Bernard L. Lopez, Th...> ;Redox Biology. 2020 Feb 24
29 citations
miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders.
Yunhui Du, Xiao Wang, Linyi Li, Wenjing Hao, Huina Zhang, Yu Li, Yanwen Qin, Shaoping Nie, Theodore A. Christopher, Bernard L. Lopez, Wayne Bond Lau, Yajing Wang, Xin-...> ;Circulation Research. 2020 Jan 17
79 citations
Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/R...
Lu Gan, Dina Xie, Jing Liu, Wayne Bond Lau, Theodore A. Christopher, Bernard L. Lopez, Ling Zhang, Erhe Gao, Walter J. Koch, Xinliang Ma, Yajing Wang> ;Circulation. 2020 Mar 24
16 citations
Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK
Dina Xie, Jianli Zhao, Rui Guo, Liyuan Jiao, Yanqing Zhang, Wayne Bond Lau, Bernard L. Lopez, Theodore A. Christopher, Erhe Gao, Jimin Cao, Xinliang Ma, Yajing Wang> ;Scientific Reports. 2020 Jan 8
14 citations
Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling.
Rui Guo, Lu Gan, Wayne Bond Lau, Zheyi Yan, Dina Xie, Erhe Gao, Theodore A. Christopher, Bernard L. Lopez, Xin-Liang Ma, Yajing Wang> ;Circulation Journal. 2019 Jun 20
24 citations
Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress.
Zheyi Yan, Rui Guo, Lu Gan, Wayne Bond Lau, Xiaoming Cao, Jianli Zhao, Xin-Liang Ma, Theodore A. Christopher, Bernard L. Lopez, Yajing Wang> ;Life Sciences. 2018 Oct 15
18 citations
Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling
Yunhui Du, Rui Li, Wayne Bigond Lau, Jianli Zhao, Bernard L. Lopez, Theodore A. Christopher, Xin-Liang Ma, Yajing Wang> ;Plos One. 2016 Mar 29
18 citations
High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation.
Gaizhen Liu, Bin Liang, Wayne Bond Lau, Yang Wang, Jianli Zhao, Rui Li, Xi Wang, Yuexing Yuan, Bernard L. Lopez, Theodore A. Christopher, Chuanshi Xiao, Xin-Liang Ma, ...> ;Free Radical Biology & Medicine. 2015 Dec 1
36 citations
C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform
Yuexing Yuan, Wayne Bond Lau, Hui Su, Yang Sun, Wei Yi, Yunhui Du, Theodore A. Christopher, Bernard L. Lopez, Yajing Wang, Xin-Liang Ma> ;American Journal of Physiology. Endocrinology and Metabolism. 2015 May 15
87 citations
The development of the emergency medicine milestones
Michael S. Beeson, Wallace A. Carter, Theodore A. Christopher, Jonathan W. Heidt, James H. Jones, Lynne Meyer, Susan B. Promes, Kevin G. Rodgers, Philip Shayne, Susan ...> ;Academic Emergency Medicine. 2013 Jul 1
63 citations
Emergency medicine milestones.
Michael S. Beeson, Wallace A. Carter, Theodore A. Christopher, Jonathan W. Heidt, James H. Jones, Lynne Meyer, Susan B. Promes, Kevin G. Rodgers, Philip Shayne, Mary J...> ;Journal of Graduate Medical Education. 2013 Apr 4
6 citations
Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion.
Wayne Bond Lau, Yanqing Zhang, Jianli Zhao, Baojiang Liu, Xiaoliang Wang, Yuexing Yuan, Theodore A. Christopher, Bernard L. Lopez, Erhe Gao, Walter J. Koch, Xin-Liang ...> ;American Journal of Physiology. Endocrinology and Metabolism. 2013 Mar 15
162 citations
C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway
Qijun Zheng, Yuexing Yuan, Wei Yi, Wayne Bond Lau, Yajing Wang, Xiaoliang Wang, Yang Sun, Bernard L. Lopez, Theodore A. Christopher, Jonathan M. Peterson, G. William W...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2011 Nov 1
9 citations
Expectations of an emergency medicine clerkship director.
Robert L. Rogers, David A. Wald, Michelle Lin, Leslie S. Zun, Theodore A. Christopher, David E. Manthey> ;Academic Emergency Medicine. 2011 Apr 26
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Press Mentions

Philadelphia Doctor Stabbed Multiple Times in Head and Face by PatientFebruary 24th, 2021
Pennsylvania Removes Prior Authorization for Opioid TreatmentOctober 13th, 2018
Pennsylvania Insurers Eliminate Prior Authorization for Substance Abuse TreatmentOctober 12th, 2018
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Professional Memberships

Hospital Affiliations

Thomas Jefferson University HospitalPhiladelphia, Pennsylvania