ThomasBarkerMD

Family Medicine • Yorba Linda, CA

Physician

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Office
18300 Yorba Linda Blvd
Suite 201
Yorba Linda, CA 92886
Phone+1 714-577-6000

Fax+1 714-572-9538
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Summary

Dr. Thomas Barker, MD is a family physician in Yorba Linda, California. He is currently licensed to practice medicine in California. He is affiliated with Placentia-Linda Hospital and Providence St. Jude Medical Center.

Education & Training

Dignity Health Northridge Hospital Medical CenterResidency, Family Medicine, 1981 - 1984
David Geffen School of Medicine at UCLAClass of 1981

Certifications & Licensure

CA State Medical License 1983 - 2025

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification PrimeSUITE EHR, Greenway Health, LLC, 2012-2013

Publications & Presentations

PubMed

33 citations
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion
Victoria L. Stefanelli, Shilpa Choudhury, Ping Hu, Yining Liu, Anja Schwenzer, Chiuan-Ren Yeh, Dwight M. Chambers, Kelly Pesson, Wei Li, Tatiana Segura, Kim S. Midwood...> ;Matrix Biology. 2019 Apr 17
62 citations
αvβ3 Integrin drives fibroblast contraction and strain stiffening of soft provisional matrix during progressive fibrosis
Vincent F. Fiore, Simon S. Wong, Coleen Tran, Chunting Tan, Wenwei Xu, Todd Sulchek, Eric S. White, James S. Hagood, Thomas H. Barker> ;JCI Insight. 2018 Oct 18
16 citations
LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol.
Dwight M. Chambers, Leandro Moretti, Jennifer J. Zhang, Spencer W. Cooper, Davis M. Chambers, Philip J. Santangelo, Thomas H. Barker> ;The Journal of Biological Chemistry. 2018 Oct 12
3 citations
Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo.
Elaissa T. Hardy, Yannan J. Wang, Sanathan Iyer, Robert G. Mannino, Yumiko Sakurai, Thomas H. Barker, Taiyun Chi, Yeojoon Youn, Hua Wang, Ashley C. Brown, Wilbur A. Lam> ;Lab on a Chip. 2018 Sep 26
15 citations
Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels.
Nicole Welsch, Ashley C. Brown, Thomas H. Barker, L. Andrew Lyon> ;Colloids and Surfaces. B, Biointerfaces. 2018 Jun 1
28 citations
Dynamic assembly of ultrasoft colloidal networks enables cell invasion within restrictive fibrillar polymers
Alison M. Douglas, Alexandros Fragkopoulos, Michelle K. Gaines, L. Andrew Lyon, Alberto Fernandez-Nieves, Thomas H. Barker> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Jan 18
55 citations
A novel platelet lysate hydrogel for endothelial cell and mesenchymal stem cell-directed neovascularization
Scott T. Robinson, Alison M. Douglas, Tatiana Chadid, Katie Kuo, Ajai Rajabalan, Haiyan Li, Ian B. Copland, Thomas H. Barker, Jacques Galipeau, Luke P. Brewster> ;Acta Biomaterialia. 2016 May 1
29 citations
Fibrin Network Changes in Neonates after Cardiopulmonary Bypass.
Ashley C. Brown, Riley H. Hannan, Lucas H. Timmins, Janet D. Fernandez, Thomas H. Barker, Nina A. Guzzetta> ;Anesthesiology. 2016 May 1
22 citations
Molecular interference of fibrin’s divalent polymerization mechanism enables modulation of multiscale material properties
Ashley C. Brown, Stephen R. Baker, Alison M. Douglas, Mark Keating, Martha B. Alvarez-Elizondo, Elliot L. Botvinick, Martin Guthold, Thomas H. Barker> ;Biomaterials. 2015 May 1
13 citations
The evolution of fibrin-specific targeting strategies
Victoria L. Stefanelli, Thomas H. Barker> ;Journal of Materials Chemistry. B. 2015 Feb 4
1 citations
One primer to rule them all: universal primer that adds BBa_B0034 ribosomal binding site to any coding standard 10 BioBrick.
Anton V. Bryksin, Haylee Bachman, Spencer W. Cooper, Tilak Balavijayan, Rachael M Blackstone, Haoli Du, Jackson P Jenkins, Casey L Haynes, Jessica L Siemer, Vincent F....> ;ACS Synthetic Biology. 2014 Dec 19
128 citations
Ultrasoft microgels displaying emergent platelet-like behaviours
Ashley C. Brown, Sarah E. Stabenfeldt, Byungwook Ahn, Riley T. Hannan, Kabir S. Dhada, Emily S. Herman, Victoria L. Stefanelli, Nina A. Guzzetta, Alexander Alexeev, Wi...> ;Nature Materials. 2014 Dec 1
137 citations
Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation
Yongzhi Qiu, Ashley C. Brown, David R. Myers, Yumiko Sakurai, Robert G. Mannino, Reginald Tran, Byungwook Ahn, Elaissa T. Hardy, Matthew F. Kee, Sanjay Kumar, Gang Bao...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct 7
41 citations
Environmental particulate (PM2.5) augments stiffness-induced alveolar epithelial cell mechanoactivation of transforming growth factor beta.
Marilyn M. Dysart, Boris Galvis, Armistead G. Russell, Thomas H. Barker> ;Plos One. 2014 Sep 16
40 citations
The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation.
Archana V. Boopathy, Pao Lin Che, Inthirai Somasuntharam, Vincent F. Fiore, E. Bernadette Cabigas, Kiwon Ban, Milton E. Brown, Yoshie Narui, Thomas H. Barker, Young Su...> ;Biomaterials. 2014 Sep 1
150 citations
Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level
Ashley C. Brown, Thomas H. Barker> ;Acta Biomaterialia. 2014 Apr 1
33 citations
Learning from nature – novel synthetic biology approaches for biomaterial design
Anton V. Bryksin, Ashley C. Brown, Michael M. Baksh, M. G. Finn, Thomas H. Barker> ;Acta Biomaterialia. 2014 Apr 1
1 citations
Biological biomaterials structure, function, property design across the molecular-nano-micro-macro scales.
Thomas H. Barker, Sarah C. Heilshorn> ;Acta Biomaterialia. 2014 Apr 1
26 citations
Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo
Lizhi Cao, Mark K. Zeller, Vincent F. Fiore, Patrick William Strane, Harry Bermudez, Thomas H. Barker> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 May 8
28 citations
Engineering fibrin polymers through engagement of alternative polymerization mechanisms.
Sarah E. Stabenfeldt, Merek Gourley, Laxminarayanan Krishnan, James B. Hoying, Thomas H. Barker> ;Biomaterials. 2012 Jan 1
24 citations
Modulation of fibrin matrix properties via knob:hole affinity interactions using peptide-PEG conjugates.
Allyson S.C. Soon, Christine S. Lee, Thomas H. Barker> ;Biomaterials. 2011 Jul 1
74 citations
Role of fibronectin in topographical guidance of neurite extension on electrospun fibers.
Vivek Mukhatyar, Manuel Salmerón-Sánchez, Soumon Rudra, Shoumit Mukhopadaya, Thomas H. Barker, Andrés J. García, Ravi V. Bellamkonda> ;Biomaterials. 2011 Jun 1
105 citations
The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine.
Thomas H. Barker> ;Biomaterials. 2011 Jun 1
27 citations
Engineering fibrin matrices: the engagement of polymerization pockets through fibrin knob technology for the delivery and retention of therapeutic proteins
Allyson S.C. Soon, Sarah E. Stabenfeldt, Wendy E. Brown, Thomas H. Barker> ;Biomaterials. 2010 Mar 1
47 citations
Polyketal microparticles for therapeutic delivery to the lung.
Vincent F. Fiore, Megan C. Lofton, Susanne Roser-Page, Stephen C. Yang, Jesse Roman, Niren Murthy, Thomas H. Barker> ;Biomaterials. 2010 Feb 1
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Hospital Affiliations

Placentia-Linda HospitalPlacentia, California
Providence St. Jude Medical CenterFullerton, California