ThomasCappolaMDScM

Cardiology • Philadelphia, PA

Heart Failure & Transplantation, Interventional Cardiology, Cardiovascular Disease Genetics

Chief, Cardiovascular Medicine; William S. Smilow Professor

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Office
3400 Civic Center Blvd
Philadelphia, PA 19104
Phone+1 215-662-3140
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Education & Training

Johns Hopkins UniversityFellowship, Cardiovascular Disease, 1998 - 2002
Brigham and Women's HospitalResidency, Internal Medicine, 1995 - 1998
Harvard Medical SchoolClass of 1995

Certifications & Licensure

PA State Medical License 2002 - 2024
MD State Medical License 1999 - 2004
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Fellow, American Heart Association
Elected Member The American Society for Clinical Investigation, 2012
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy Start of enrollment: 2003 Jun 01
Withdrawn
Phase 1, Phase 2
IMAGE: A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant Rejection Start of enrollment: 2005 Jan 01
Completed
Not Applicable
Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure Start of enrollment: 2007 Mar 01
Completed
Phase 1, Phase 2
CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression Start of enrollment: 2011 Dec 01
Withdrawn
Phase 4
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Publications & Presentations

PubMed

Sex-Specific Effect of MTSS1 Downregulation on Dilated Cardiomyopathy.
Dongwook Choe, Megan Burke, Jeffrey A Brandimarto, Ingrid Marti-Pamies, Jaime Yob, Yifan Yang, Michael P Morley, Theodore G Drivas, Sharlene Day, Scott Damrauer, Xiao ...> ;Medrxiv. 2024 Mar 1
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.
Joe David Azzo, Marie-Joe Dib, Loukas Zagkos, Lei Zhao, Zhaoqing Wang, Ching-Pin Chang, Christina Ebert, Oday Salman, Sushrima Gan, Payman Zamani, Jordana B Cohen, Van...> ;Circulation. Heart Failure. 2024 Feb 1
Epistasis regulates genetic control of cardiac hypertrophy.
Wang, Q., Tang, T., Youlton, N., Weldy, C., Kenney, A., Ronen, O., Hughes, J., Chin, E., Sutton, S., Agarwal, A., Li, X., Behr, M., Kumbier, K., Moravec, C., Tang, W.,...> ;Research Square. 2023 Nov 20
Epistasis regulates genetic control of cardiac hypertrophy.
Qianru Wang, Tiffany M Tang, Nathan Youlton, Chad S Weldy, Ana M Kenney, Omer Ronen, J Weston Hughes, Elizabeth T Chin, Shirley C Sutton, Abhineet Agarwal, Xiao Li, Me...> ;Medrxiv. 2023 Nov 8
Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction.
Sushrima Gan, Lei Zhao, Oday Salman, Zhaoqing Wang, Christina Ebert, Joe David Azzo, Marie Joe Dib, Payman Zamani, Jordana B Cohen, Karl Kammerhoff, Peter Schafer, Die...> ;The American Journal of Cardiology. 2023 Nov 1
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum.
David S M Lee, Katie M Cardone, David Y Zhang, Sarah Abramowitz, John S DePaolo, Krishna G Aragam, Kiran Biddinger, Mitchell Conery, Ozan Dilitikas, Lily Hoffman-Andre...> ;Medrxiv. 2023 Oct 2
10 citations
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.
Guo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D., Ozcan, M., Chirinos, J., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K....> ;JACC. Basic to Translational Science. 2023 Mar 1
19 citations
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.
Michael G Levin, Noah L Tsao, Pankhuri Singhal, Chang Liu, Ha My T Vy, Ishan Paranjpe, Joshua D Backman, Tiffany R Bellomo, William P Bone, Kiran J Biddinger, Qin Hui,...> ;Nature Communications. 2022 Nov 14
9 citations
Genome-wide fetalization of enhancer architecture in heart disease.
Cailyn H Spurrell, Iros Barozzi, Michael Kosicki, Brandon J Mannion, Matthew J Blow, Yoko Fukuda-Yuzawa, Neil Slaven, Sarah Y Afzal, Jennifer A Akiyama, Veena Afzal, S...> ;Cell Reports. 2022 Sep 20
24 citations
Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.
Emily Flam, Cholsoon Jang, Danielle Murashige, Yifan Yang, Michael P Morley, Sunhee Jung, Daniel S Kantner, Hannah Pepper, Kenneth C Bedi Jr, Jeff Brandimarto, Benjami...> ;Nature Cardiovascular Research. 2022 Sep 1
5 citations
Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction.
Ali Javaheri, Ahmed Diab, Lei Zhao, Chenao Qian, Jordana B Cohen, Payman Zamani, Anupam Kumar, Zhaoqing Wang, Christina Ebert, Joseph Maranville, Erika Kvikstad, Micha...> ;Circulation. Heart Failure. 2022 Sep 1
5 citations
Sex Differences in Left Ventricular Assist Device-related Emergency Department Encounters in the United States.
Nosheen Reza, Jonathan J Edwards, Hannah Katcoff, Antara Mondal, Heather Griffis, Joseph W Rossano, Kimberly Y Lin, H Luise Holzhauser, Joyce W Wald, Thomas P Cappola,...> ;Journal of Cardiac Failure. 2022 Sep 1
3 citations
Mental Stress-Induced Myocardial Ischemia: When the Mind Controls the Fate of the Heart.
Paco E Bravo, Thomas P. Cappola> ;JAMA. 2021 Nov 9
32 citations
Truncated titin proteins in dilated cardiomyopathy
Quentin McAfee, Christina Yingxian Chen, Yifan Yang, Matthew A. Caporizzo, Michael Morley, Apoorva Babu, Sunhye Jeong, Jeffrey Brandimarto, Kenneth Bedi, Emily Flam, J...> ;Science Translational Medicine. 2021 Nov 3
6 citations
The genomics of heart failure: design and rationale of the HERMES consortium
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, J...> ;ESC Heart Failure. 2021 Sep 3
6 citations
Natriuretic Peptide Deficiency in Obese Individuals: Mechanistic Insights From Healthy Organ Donor Cohort
Vibhu Parcha, Nirav Patel, Kiran Musunuru, Kenneth B. Margulies, Thomas P. Cappola, Ganesh V. Halade, Thomas J. Wang, Garima Arora> ;Journal of the American College of Cardiology. 2021 Jun 22
52 citations
Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.
Rahul R. Goli, Jian Li, Jeff Brandimarto, Lisa D. Levine, Valerie Riis, Quentin McAfee, Steven R. DePalma, Alireza Haghighi, Jonathan G. Seidman, Christine E. Seidman,...> ;Circulation. 2021 May 11
14 citations
Chronobiology of Natriuretic Peptides and Blood Pressure in Lean and Obese Individuals.
Vibhu Parcha, Nirav Patel, Orlando M. Gutiérrez, Peng Li, Karen L. Gamble, Kiran Musunuru, Kenneth B. Margulies, Thomas P. Cappola, Thomas J. Wang, Garima Arora> ;Journal of the American College of Cardiology. 2021 May 11
49 citations
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
Parisha P. Shah, Wenjian Lv, Joshua H. Rhoades, Andrey Poleshko, Deepti Abbey, Matthew A. Caporizzo, Ricardo Linares-Saldana, Julie Heffler, Nazish Sayed, Dilip Thomas...> ;Cell Stem Cell. 2021 May 6
19 citations
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.
Sophie Garnier, Magdalena Harakalova, Stefan Weiss, Michal Mokry, Vera Regitz-Zagrosek, Christian Hengstenberg, Thomas P. Cappola, Richard Isnard, Eloisa Arbustini, St...> ;European Heart Journal. 2021 May 21
12 citations
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction
Thomas C. Hanff, Jordana B. Cohen, Lei Zhao, Ali Javaheri, Payman Zamani, Stuart B. Prenner, Ernst Rietzschel, Yi Jia, Alice M. Walsh, Joseph Maranville, Zhaoqing Wang...> ;JACC. Basic to Translational Science. 2021 Feb 1
6 citations
Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure.
Chia-Feng Liu, Ying Ni, Christine S. Moravec, Michael Morley, Euan A. Ashley, Thomas P. Cappola, Kenneth B. Margulies, W.H. Wilson Tang> ;Circulation. Genomic and Precision Medicine. 2021 Feb 1
426 citations
Patient Characteristics Associated With Telemedicine Access for Primary and Specialty Ambulatory Care During the COVID-19 Pandemic.
Lauren A. Eberly, Michael J. Kallan, Howard Julien, Norrisa Haynes, Sameed Ahmed M. Khatana, Ashwin S. Nathan, Christopher K. Snider, Neel P. Chokshi, Nwamaka D. Enean...> ;JAMA Network Open. 2020 Dec 1
7 citations
Genomic Context Differs Between Human Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy.
Megan J. Puckelwartz, Lorenzo L. Pesce, Lisa Dellefave-Castillo, Matthew T. Wheeler, Tess D. Pottinger, Avery C. Robinson, Samuel Kearns, Anthony Gacita, Zachary J. Sc...> ;Journal of the American Heart Association. 2021 Mar 25
Studying Heart Failure Through the Lens of Gene Regulation.
Thomas P. Cappola, Megan F. Burke> ;Circulation. Heart Failure. 2020 Sep 30
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