ThomasDMeekMD

PubMed

• 41 citations
  Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
  Anneliese S. Ashhurst, Arthur H Tang, Pavla Fajtová, Michael C Yoon, Anupriya Aggarwal, Max J. Bedding, Alexander Stoye, Laura Beretta, Dustin Pwee, Aleksandra Drelich...> ;Journal of Medicinal Chemistry. 2021 Nov 3
• 4 citations
  Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.
  Drake M. Mellott, Dan Torres, Inna Krieger, Scott A. Cameron, Zahra Moghadamchargari, Arthur Laganowsky, James C. Sacchettini, Thomas D. Meek, Lawrence Harris> ;Journal of the American Chemical Society. 2021 Oct 27
• 6 citations
  Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease.
  D Chase Pectol, Christopher R DeLaney, Jiyun Zhu, Drake M. Mellott, Ardala Katzfuss, Zane W. Taylor, Thomas D. Meek, Marcetta Y. Darensbourg> ;Chemical Communications. 2021 Aug 19
• 15 citations
  Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
  Linfeng Li, Balachandra Chenna, Kai S Yang, Taylor R. Cole, Zachary T Goodall, Miriam A. Giardini, Zahra Moghadamchargari, Elizabeth Alvarez Hernandez, Jana Gomez, Cla...> ;Journal of Medicinal Chemistry. 2021 Aug 12
• 58 citations
  A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
  Drake M. Mellott, Chien Te K. Tseng, Aleksandra Drelich, Pavla Fajtová, Balachandra Chenna, Demetrios H. Kostomiris, Jason C. Hsu, Jiyun Zhu, Zane W. Taylor, Klaudia I...> ;ACS Chemical Biology. 2021 Apr 16
• 5 citations
  Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid.
  Truc Viet Pham, Drake M. Mellott, Zahra Moghadamchargari, Kevin Chen, Inna Krieger, Arthur Laganowsky, James C. Sacchettini, Thomas D. Meek> ;ACS Chemical Biology. 2021 Mar 10
• 12 citations
  Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
  Tejas R. Karhadkar, Thomas D. Meek, Richard H. Gomer> ;The Journal of Pharmacology and Experimental Therapeutics. 2021 Jan 1
• 6 citations
  Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L
  Anneliese S. Ashhurst, Arthur H Tang, Pavla Fajtová, Michael Yoon, Anupriya Aggarwal, Alexander Stoye, Mark Larance, Laura Beretta, Aleksandra Drelich, Danielle E. Ski...> ;Biorxiv. 2020 Dec 25
• 14 citations
  A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
  Drake M. Mellott, Chien-Te K Tseng, Aleksandra Drelich, Pavla Fajtová, Balachandra Chenna, Kostomiris Dh, Hsu J, Jiyun Zhu, Zane W. Taylor, Tat, Ardala Katzfuss, Li Li...> ;Biorxiv. 2020 Oct 24
• 14 citations
  Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity
  Balachandra Chenna, Linfeng Li, Drake M. Mellott, Xiang Zhai, Jair L. Siqueira-Neto, Claudia Calvet Alvarez, Jean A. Bernatchez, Emily Desormeaux, Elizabeth Alvarez He...> ;Journal of Medicinal Chemistry. 2020 Mar 3
• Enhanced Antibiotic Discovery by PROSPECTing.
  Vern L. Schramm, Thomas D. Meek> ;Biochemistry. 2019 Aug 20
• 18 citations
  Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease.
  Yuying Ma, Linfeng Li, He Shuai, Chengyou Shang, Yang Sun, Ning Liu, Thomas D. Meek, Yaxin Wang, Luqing Shang> ;Journal of Medicinal Chemistry. 2019 Jun 11
• 20 citations
  Catalytic Mechanism of Cruzain from Trypanosoma cruzi As Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics.
  Xiang Zhai, Thomas D. Meek> ;Biochemistry. 2018 Jan 16
• 97 citations
  Mechanistic enzymology in drug discovery: a fresh perspective.
  Geoffrey A Holdgate, Thomas D Meek, Rachel L Grimley> ;Nature Reviews. Drug Discovery. 2018 Jan 1
• Mechanistic Enzymology in Drug Discovery: A Fresh Perspective
  Thomas Meek, MD> ;Nature. 2017 Dec 02
• 25 citations
  Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
  Truc Viet Pham, Andrew S. Murkin, Margaret M. Moynihan, Lawrence Harris, Peter C. Tyler, Nishant D. Shetty, James C. Sacchettini, Hsiao-ling Huang, Thomas D. Meek> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Jul 18
• 36 citations
  Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36
  Myles B. Poulin, Jessica L. Schneck, Rosalie Matico, Patrick McDevitt, Michael J. Huddleston, Wangfang Hou, Johnson Neil W, Sara H. Thrall, Thomas D. Meek, Vern L. Sch...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb 2
• 5 citations
  Will nanomedicine deliver on its promise of changing therapeutics or remain an interesting and important research tool in cell biology and physiology
  Richard Kirsh, Steve R. Hood, Christopher S. Brook, Aidan Gilmartin, Philip C. Dell'orco, Thomas D. Meek> ;International Journal of Pharmaceutics. 2013 Sep 15
• 17 citations
  Development of a High-Throughput Screen to Detect Inhibitors of TRPS1 Sumoylation
  Martin Brandt, Lawrence M. Szewczuk, Hong Zhang, Xuan Hong, Patricia M. McCormick, Tia Lewis, Taylor I Graham, Sunny T Hung, Amber D Harper-Jones, John J. Kerrigan, Da...> ;Assay and Drug Development Technologies. 2013 Jun 17
• 12 citations
  The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
  Jon K. Rubach, Guanglei Cui, Jessica L. Schneck, Amy N. Taylor, Baoguang Zhao, Angela Smallwood, Neysa Nevins, David D. Wisnoski, Sara H. Thrall, Thomas D. Meek> ;Biochemistry. 2012 Sep 13
• 25 citations
  On the catalytic mechanism of human ATP citrate lyase.
  Fan Fan, Howard J. Williams, Joseph Boyer, Taylor L. Graham, Huizhen Zhao, Ruth Lehr, Hongwei Qi, Benjamin Schwartz, Frank M. Raushel, Thomas D. Meek> ;Biochemistry. 2012 Jun 15
• 2 citations
  Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
  Rachel D. Totoritis, Chaya Duraiswami, Amy N. Taylor, John J. Kerrigan, Nino Campobasso, Katherine J. Smith, Paris Ward, Bryan W. King, Monique Murrayz-Thompson, Amber...> ;Biochemistry. 2011 Jun 28
• 9 citations
  Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1
  Jessica L. Schneck, Jacques Briand, Stephanie Chen, Ruth Lehr, Patrick McDevitt, Baoguang Zhao, Angela Smallwood, Nestor O. Concha, Khyati Oza, Robert B. Kirkpatrick, ...> ;Biochemistry. 2010 Jul 30
• 25 citations
  Chemical Mechanism of a Cysteine Protease, Cathepsin C, As Revealed by Integration of both Steady-State and Pre-Steady-State Solvent Kinetic Isotope Effects
  Jessica L. Schneck, James P. Villa, Patrick McDevitt, Michael S. McQueney, Sara H. Thrall, Thomas D. Meek> ;Biochemistry. 2008 Jul 26
• 44 citations
  Highly Potent Inhibitors of Methionine Aminopeptidase-2 Based on a 1,2,4-Triazole Pharmacophore†
  Joseph P. Marino, P.W. Fisher, Glenn A. Hofmann, Robert B. Kirkpatrick, Cheryl A. Janson, Randall K. Johnson, C. Ma, Michael R. Mattern, Thomas D. Meek, Ryan, C. Schul...> ;Journal of Medicinal Chemistry. 2007 Jul 18
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