ThomasEMerchantDOPhD

Radiation Oncology • Memphis, TN

Pediatric Radiation Oncology

Member and Chair, Department of Radiation Oncology, St. Jude Children's Research Hospital

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Office
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
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Education & Training

Memorial Sloan Kettering Cancer CenterResidency, Radiation Oncology, 1991 - 1994
University of UtrechtPhD, Experimental Pathology, Cum Laude, 1989 - 1992
Chicago College of Osteopathic Medicine at Midwestern UniversityClass of 1989
University of MichiganBS, Nuclear Engineeering, 1980 - 1983

Certifications & Licensure

TN State License 1996 - 2025
IL State License 1990 - 1991
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2021
Memphis Magazine: Top Doctors Castle Connolly, 2006-2021

Clinical Trials

Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma Start of enrollment: 2003 Aug 01
Completed
Phase 2
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects Start of enrollment: 1997 Jun 01
Completed
Phase 2
Planning Margin Requirements for Pediatric Radiation Oncology Start of enrollment: 2008 Mar 01
Completed
A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma or Observation After Radical Resection Start of enrollment: 2011 Aug 22
Active, not recruiting
Phase 2
A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma Start of enrollment: 2014 May 07
Active, not recruiting
Phase 2
A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection Start of enrollment: 2016 Jun 22
Recruiting
Phase 2
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Publications & Presentations

PubMed

Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort.
Fang Wang, Lu Lu, Carmen L Wilson, Daniel M Green, Thomas E Merchant, Deo Kumar Srivastava, Angela Delaney, Rebecca M Howell, John L Jefferies, Leslie L Robison, Kirst...> ;Journal of Clinical Oncology. 2024 Mar 20
PENTEC Organ-Specific Report: Brain and Brain Stem Necrosis After Reirradiation for Recurrent Childhood Primary Central Nervous System Tumors: A PENTEC Comprehensive R...
Ajithkumar, T., Avanzo, M., Yorke, E., Tsang, D., Milano, M., Olch, A., Dieckmann, K., Fuji, H., Timmermann, B., Bentzen, S., Jackson, A., Merchant, T., Mahajan, A., P...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Feb 1
Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma.
Julianna Sienna, Lisa S Kahalley, Donald Mabbott, David Grosshans, Anna Theresa Santiago, Arnold Dela Cruz Paulino, Thomas E Merchant, Gohar S Manzar, Hitesh Dama, Dav...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 30
Shifting Strategies in the Treatment of Pediatric Craniopharyngioma.
Segev Gabay, Thomas E Merchant, Frederick A Boop, Jonathan Roth, Shlomi Constantini> ;Current Oncology Reports. 2023 Dec 1
Setup Uncertainty of Pediatric Brain Tumor Patients Receiving Proton Therapy: A Prospective Study.
Jared Becksfort, Jinsoo Uh, Andrew Saunders, Julia A Byrd, Hannah M Worrall, Matt Marker, Christian Melendez-Suchi, Yimei Li, Jenghwa Chang, Kavitha Raghavan, Thomas E...> ;Cancers. 2023 Nov 20
1 citations
Social cognition and adjustment in adult survivors of pediatric central nervous system tumors.
Chiara Papini, Victoria W Willard, Amar Gajjar, Thomas E Merchant, Deokumar Srivastava, Gregory T Armstrong, Melissa M Hudson, Kevin R Krull, Tara M Brinkman> ;Cancer. 2023 Oct 1
Social determinants of cognitive outcomes in survivors of pediatric brain tumors treated with conformal radiation therapy.
Taylor N Mule', Jason Hodges, Shengjie Wu, Yimei Li, Jason M Ashford, Thomas E Merchant, Heather M Conklin> ;Neuro-Oncology. 2023 Oct 3
5 citations
Proton therapy and limited surgery for paediatric and adolescent patients with craniopharyngioma (RT2CR): a single-arm, phase 2 study.
Thomas E Merchant, Mary Ellen Hoehn, Raja B Khan, Noah D Sabin, Paul Klimo, Frederick A Boop, Shengjie Wu, Yimei Li, Elizabeth A Burghen, Niki Jurbergs, Eric S Sandler...> ;The Lancet. Oncology. 2023 May 1
2 citations
Tackling Pediatric Low-Grade Gliomas: A Global Perspective.
Daniel C Moreira, Catherine G Lam, Nickhill Bhakta, Frederick A Boop, Jason Chiang, Thomas E Merchant, Carlos Rodriguez-Galindo, Amar Gajjar, Ibrahim Qaddoumi> ;JCO Global Oncology. 2023 Apr 1
Development of a log file analysis tool for proton patient QA, system performance tracking, and delivered dose reconstruction.
Ozgur Ates, Fakhriddin Pirlepesov, Li Zhao, Chia-Ho Hua, Thomas E Merchant> ;Journal of Applied Clinical Medical Physics. 2023 Jul 1
3 citations
Pediatric Craniopharyngioma: The Effect of Visual Deficits and Hormone Deficiencies on Long-Term Cognitive Outcomes After Conformal Photon Radiation Therapy.
Thomas E Merchant, Sonal Dangda, Mary Ellen Hoehn, Shengjie Wu, Yimei Li, Fang Wang, Haitao Pan, Frederick A Boop, Niki Jurbergs, Heather M Conklin> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Mar 1
3 citations
Conformal Radiation Therapy for Ependymoma at Age ≤3 Years: A 25-Year Experience.
Gabrielle N Howe, Drucilla Y Edmonston, Grace C Dirks, Frederick A Boop, Thomas E Merchant> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Jul 15
1 citations
Hypogonadism After Treatment for Medulloblastoma: Results From the SJMB03 Trial of Risk-Adapted Radiation Therapy.
Thomas E Merchant, Shengjie Wu, Arzu Onar-Thomas, Amar Gajjar, Angela Delaney> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Jul 1
Novel Monthly Quality Assurance Regimen and 5-Year Analysis Using a Proton Metrology System.
Ates, O., Faught, J., Pirlepesov, F., Sobczak, D., Hua, C., Merchant, T.> ;International Journal of Particle Therapy. 2023 Jan 1
Endocrinopathy After Treatment for Medulloblastoma: Results From the SJMB03 Trial of Risk-Adapted Radiation Therapy.
Thomas E Merchant, Shengjie Wu, Arzu Onar-Thomas, Angela Delaney, Amar Gajjar> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Jul 1
Three-dimensional dose and LETprediction in proton therapy using artificial neural networks.
Fakhriddin Pirlepesov, Lydia Wilson, Vadim P Moskvin, Alex Breuer, Franz Parkins, John T Lucas Jr, Thomas E Merchant, Austin M Faught> ;Medical Physics. 2022 Dec 1
6 citations
Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 a...
Anthony P Y Liu, Sandeep K Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C Bowers, Tim Hassal...> ;Acta Neuropathologica. 2022 Oct 1
4 citations
Physical function, body mass index, and fitness outcomes in children, adolescents, and emerging adults with craniopharyngioma from proton therapy through five years of...
Robyn E Partin, Matthew D Wogksch, Rikeenkumar Dhaduk, Jason M Ashford, Daniel J Indelicato, Heather M Conklin, Thomas E Merchant, Kirsten K Ness> ;Journal of Neuro-Oncology. 2022 Sep 1
1 citations
Design of a novel 5-camera surface guidance system with multiple imaging isocenters.
Ozgur Ates, Li Zhao, David Sobczak, Fakhriddin Pirlepesov, Chia-Ho Hua, Ben Waghorn, Thomas E Merchant> ;Journal of Applied Clinical Medical Physics. 2022 Oct 1
10 citations
Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321).
Ira J Dunkel, Jin Piao, Guillermo L Chantada, Anuradha Banerjee, Sherif Abouelnaga, Jeffrey C Buchsbaum, Thomas E Merchant, Meaghan M Granger, Rima F Jubran, Joanna L ...> ;Journal of Clinical Oncology. 2022 Nov 20
1 citations
Lifetime attributable risk of radiation induced second primary cancer from scattering and scanning proton therapy - A model for out-of-field organs of paediatric patie...
Mikaela Dell'Oro, Michala Short, Puthenparampil Wilson, Dylan Peukert, Chia-Ho Hua, Thomas E Merchant, Eva Bezak> ;Radiotherapy and Oncology. 2022 Jul 1
4 citations
Image-based data mining applies to data collected from children.
Lydia J Wilson, Abigail Bryce-Atkinson, Andrew Green, Yimei Li, Thomas E Merchant, Marcel van Herk, Eliana Vasquez Osorio, Austin M Faught, Marianne C Aznar> ;Physica Medica. 2022 Jul 1
Accuracy of stopping power ratio calculation and experimental validation of proton range with dual-layer computed tomography.
Vadim P Moskvin, Fakhriddin Pirlepesov, Yue Yan, Ozgur Ates, William J Myers, Jinsoo Uh, Li Zhao, Nadav Shapira, Yoad Yagil, Thomas E Merchant, Chia-Ho Hua> ;Acta Oncologica. 2022 Jul 1
1 citations
Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemot...
John T Lucas, Christopher L Tinkle, Jie Huang, Arzu Onar-Thomas, Sudharsan Srinivasan, Parker Tumlin, Jared B Becksfort, Paul Klimo, Frederick A Boop, Giles W Robinson...> ;Neuro-Oncology. 2022 Jul 1
2 citations
Limited surgery and conformal photon radiation therapy for pediatric craniopharyngioma: long-term results from the RT1 protocol.
Drucilla Y Edmonston, Shengjie Wu, Yimei Li, Raja B Khan, Frederick A Boop, Thomas E Merchant> ;Neuro-Oncology. 2022 Dec 1
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Journal Articles

Computerized Assessment of Cognitive Impairment Among Children Undergoing Radiation Therapy for Medulloblastoma
Giles W Robinson, Thomas E Merchant, Amar Gajjar, Heather M Conklin, Journal of Neuro-Oncology
Heterogeneity Within the PF-EPN-B Ependymoma Subgroup
Andrew Grossbach, Vijay Ramaswamy, Benjamin Lu, Mariarita Santi, Caterina Giannini, Linda M Liau, Terri S Armstrong, Sarah Leary, Matthias A Karajannis, Kenneth Aldape..., Acta Neuropathologica
Molecular Heterogeneity and CXorf67 Alterations in Posterior Fossa Group A (PFA) Ependymomas
Noah D Sabin, Amar Gajjar, Thomas E Merchant, David W Ellison, Ryan Lee, Paul Klimo, Acta Neuropathologica

Press Mentions

The Promise (And Limits) of Pediatric Proton RadiationSeptember 8th, 2022
The Promise (And Limits) of Pediatric Proton Radiation -News ForestAugust 19th, 2022
Three New Research Teams Aim to Improve Therapies for Difficult-to-Treat Pediatric CancersOctober 19th, 2020
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Hospital Affiliations

St. Jude Children's Research HospitalMemphis, Tennessee