ThomasMichelMD

PubMed

• D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress.
  Fotios Spyropoulos, Thomas Michel> ;Current Opinion in Chemical Biology. 2024 Apr 1
• FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure.
  Ruby Guo, Fotios Spyropoulos, Thomas Michel> ;Free Radical Biology & Medicine. 2024 May 1
• 1 citations
  Adult and neonatal models of chemogenetic heart failure caused by oxidative stress.
  Fotios Spyropoulos, Apabrita Ayan Das, Markus Waldeck-Weiermair, Shambhu Yadav, Arvind K Pandey, Ruby Guo, Taylor A Covington, Venkata Thulabandu, Kosmas Kosmas, Benja...> ;The Journal of Clinical Investigation. 2024 Mar 14
• 15 citations
  Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
  Rui Miao, Cong Jiang, Winston Y Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G Liang, Junbing Zhang...> ;Immunity. 2023 Nov 14
• 4 citations
  Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines.
  Shambhu Yadav, Markus Waldeck-Weiermair, Fotios Spyropoulos, Roderick Bronson, Arvind K Pandey, Apabrita Ayan Das, Alexander C Sisti, Taylor A Covington, Venkata Thula...> ;Nature Communications. 2023 May 29
• 3 citations
  Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins.
  Markus Waldeck-Weiermair, Shambhu Yadav, Jonas Kaynert, Venkata Revanth Thulabandu, Arvind K Pandey, Fotios Spyropoulos, Taylor Covington, Apabrita Ayan Das, Christina...> ;Redox Biology. 2022 Dec 1
• 2 citations
  Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells.
  Arvind K Pandey, Markus Waldeck-Weiermair, Quinn S Wells, Wusheng Xiao, Shambhu Yadav, Emrah Eroglu, Thomas Michel, Joseph Loscalzo> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2022 Sep 1
• 12 citations
  Metabolomic and transcriptomic signatures of chemogenetic heart failure.
  Fotios Spyropoulos, Andrea Sorrentino, Jiska van der Reest, Peiran Yang, Markus Waldeck-Weiermair, Benjamin Steinhorn, Emrah Eroglu, Seyed Soheil Saeedi Saravi, Paul Y...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2022 Mar 1
• 6 citations
  Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology
  Benjamin Steinhorn, Emrah Eroglu, Thomas Michel> ;Annual Review of Pharmacology and Toxicology. 2022 Jan 6
• 9 citations
  Dissecting in vivo and in vitro redox responses using chemogenetics.
  Markus Waldeck-Weiermair, Shambhu Yadav, Fotios Spyropoulos, Christina Krüger, Arvind K. Pandey, Thomas Michel> ;Free Radical Biology & Medicine. 2021 Nov 6
• 6 citations
  Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting.
  Yusuf Ceyhun Erdogan, Hamza Yusuf Altun, Melike Secilmis, Busra Nur Ata, Gulsah Sevimli, Zeynep Cokluk, Asal Ghaffari Zaki, Serap Sezen, Tuba Akgul Caglar, İlker Sevge...> ;Free Radical Biology & Medicine. 2021 Oct 20
• 7 citations
  Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria.
  Christopher J. Herbert, Sylvie Labarre-Mariotte, David Cornu, Cyrielle Sophie, Cristina Panozzo, Thomas Michel, Geneviève Dujardin, Nathalie Bonnefoy> ;Nucleic Acids Research. 2021 Nov 8
• 6 citations
  Directed evolution predicts cytochrome b G37V target site modification as probable adaptive mechanism towards the QiI fungicide fenpicoxamid in Zymoseptoria tritici.
  Guillaume Fouché, Thomas Michel, Anaïs Laleve, Nick X. Wang, David Young, Brigitte Meunier, Danièle Debieu, Sabine Fillinger, Anne Sophie Walker> ;Environmental Microbiology. 2021 Sep 16
• 8 citations
  The importance of aquaporin-8 for cytokine-mediated toxicity in rat insulin-producing cells
  Christina Krüger, Anne Jörns, Jonas Kaynert, Markus Waldeck-Weiermair, Thomas Michel, Matthias Elsner, Sigurd Lenzen> ;Free Radical Biology & Medicine. 2021 Aug 4
• 1 citations
  Feeding guild determines strength of top-down forces in multitrophic system experiencing bottom-up constraints.
  Christine Becker, Peng Han, Mateus R. Campos, Philippe Béarez, Eva Thomine, Jacques Le Bot, Stéphane Adamowicz, Richard Brun, Xavier Fernandez, Nicolas Desneux, Thomas...> ;The Science of the Total Environment. 2021 Jun 19
• 1 citations
  Design, synthesis, and biological evaluation of multiple targeting antimalarials.
  Yiqing Yang, Tang Tongke, Xiaolu Li, Thomas Michel, Liqin Ling, Zhenghui Huang, Maruthi Mulaka, Yue Wu, Hongying Gao, Liguo Wang, Jing Zhou, Brigitte Meunier, Hangjun ...> ;Acta Pharmaceutica Sinica. B. 2021 May 20
• 7 citations
  Anti-breast cancer potential of Anonidium mannii (Oliv.) Engl. & Diels barks ethanolic extract: UPLC-ESI-QTOF-MS detection of anticancer alkaloids.
  Francine Azegha Mefegue, Thomas Michel, Eutrophe Le Doux Kamto, Larissa Vanelle Kenmogne, Charline Florence Awounfack, Xavier Siwe Noundou, Derek Tantoh Ndinteh, Dieud...> ;Journal of Ethnopharmacology. 2021 Apr 21
• 17 citations
  AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells.
  Christina Krüger, Markus Waldeck-Weiermair, Jonas Kaynert, Thomas Pokrant, Yesaswini Komaragiri, Oliver Otto, Thomas Michel, Matthias Elsner> ;Redox Biology. 2021 Apr 1
• 26 citations
  Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
  John A. Collins, Maryna Kapustina, Jesalyn A. Bolduc, James F.W. Pike, Brian O. Diekman, Kimberlee S. Mix, Susan Chubinskaya, Emrah Eroglu, Thomas Michel, Leslie B. Po...> ;Free Radical Biology & Medicine. 2021 Feb 16
• Author Correction: Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction.
  Benjamin Steinhorn, Andrea Sorrentino, Sachin L. Badole, Yulia A. Bogdanova, Vsevolod V. Belousov, Thomas Michel> ;Nature Communications. 2021 Jan 7
• 2 citations
  Revisiting the mode of action of the antimalarial proguanil using the yeast model.
  Pierre Mounkoro, Thomas Michel, Brigitte Meunier> ;Biochemical and Biophysical Research Communications. 2021 Jan 1
• 4 citations
  A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione.
  Pierre Mounkoro, Thomas Michel, Marie-Pierre Golinelli-Cohen, Stéphanie Blandin, Elisabeth Davioud-Charvet, Brigitte Meunier> ;Free Radical Biology & Medicine. 2021 Jan 1
• 2 citations
  Untargeted metabolomic and molecular network approaches to reveal tomato root secondary metabolites.
  Souhila Messaili, Yanyan Qu, Laëtitia Fougère, Cyril Colas, Nicolas Desneux, Anne-Violette Lavoir, Emilie Destandau, Thomas Michel> ;Phytochemical Analysis. 2021 Sep 1
• 4 citations
  New Isoflavones with Antioxidant Activity Isolated from Cornulaca monacantha.
  Rania Mhiri, Imed Koubaa, Rachid Chawech, Florence Auberon, Noureddine Allouche, Thomas Michel> ;Chemistry & Biodiversity. 2020 Nov 8
• 49 citations
  Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
  Virginie Montiel, Ramona Bella, Lauriane Y. M. Michel, Hrag Esfahani, Delphine De Mulder, Emma L. Robinson, Jean-Philippe Deglasse, Malte Tiburcy, Pak Hin Chow, Jean-C...> ;Science Translational Medicine. 2020 Oct 7
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Journal Articles

• Chemogenetic generation of hydrogen peroxide (H2O2) in the heart induces severe cardiac dysfunction  
  Steinhorn B, Sorrentino A, Badole S, Belousov V, Michel T, Nature Comm, 1/1/2018
• Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH oxidase isoforms NOX2 and NOX4  
  Steinhorn B, Sartoretto J, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T, Free Radic Biol Med, 1/1/2017
• The future of vascular medicine  
  Kinlay S, Michel T, Leopold J, Circulation, 1/1/2016
• Nitric oxide mediates glial-induced neurodegeneration in Alexander disease  
  Wang L, Hageman TL, Kalwa H, Michel T, Messing A, and Feany MB, Nature Communications, 1/1/2015
• Rondo in E: Nitroglycerin, nitric oxide, and endothelial therapeutics  
  Steinhorn B, Loscalzo J and Michel T, New England Journal of Medicine, 1/1/2015
• Phosphatidylcholine Transfer Protein interacts with Thioesterase Superfamily Member 2 to attenuate insulin signaling  
  Ersoy B, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD and Cohen DE, Science Signaling, 1/30/2013
• R is for Arginine  
  Michel T, Circulation, 1/1/2013
• Thiol-metabolizing proteins and endothelial redox state: Differential modulation of eNOS and biopterin pathways  
  Sugiyama T and Michel T, Am J Physiol Heart Circ Phys, 1/1/2010
• Cellular signaling and NO production  
  Michel T and Vanhoutte PM, Pflugers Archiv Pharm, 1/1/2010
• NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart  
  Michel T, Circulation, 1/1/2010
• PPAR-gamma in the endothelium regulates metabolic responses to high-fat diet in mice  
  Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J, J Clin Invest, 1/1/2009
• Regulation of Rac1 by simvistatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-Beta  
  Kou R, Sartoretto J and Michel T, J Biol Chem, 1/1/2009
• Tetrahydrobiopterin recycling: a key determinant of eNOS-dependent signaling pathways in vascular endothelium  
  Sugiyama T, Levy B and Michel T, J Biol Chem, 1/1/2009
• Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-induced AMP-activated protein kinase activation in endothelial cells  
  Jin B, Sartoretto J, Gladyshev V, and Michel T, Proc Natl Acad Sci USA, 1/1/2009
• Regulation of VASP phosphorylation in cardiac myocytes: Differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic...  
  Sartoretto J, Jin B, Bauer M, Gertler F, Liao R and Michel T, Am J Physiol Heart Circ Phys, 1/1/2009
• Sphingosine 1-phosphate and control of vascular tone  
  Igarashi J and Michel T, Cardiovascular Research, 1/1/2009
• ANP-initiated cGMP pathways regulate VASP phosphorylation and angiogenesis in vascular endothelium  
  Chen H, Levine Y, Golan DE, Michel T, and Lin AJ, J Biol Chem, 1/1/2008
• The enigma of sphingosine 1-phosphate synthesis: A novel role for endothelial sphingosine kinases  
  Igarashi J and Michel T, Circulation Research, 1/1/2008
• S1P and eNOS regulation  
  Igarashi J, Michel T, Biochim Biophys Acta, 1/1/2008
• Agonist-modulated regulation of AMPK-activated protein kinase in endothelial cells: Evidence for an AMPK-Rac1-Akt-eNOS pathway  
  Levine Y, Li GK and Michel T, J Biol Chem, 1/1/2007
• Epinephrine regulation of eNOS: roles of Rac1 and Beta3-adrenergic receptors in endothelial NO signaling  
  Kou R and Michel T, J Biol Chem, 1/1/2007
• The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo  
  Atochin D et al, J Clin Invest, 1/1/2007
• Effects of S-nitrosation of nitric oxide synthase  
  Mitchell, DA, Michel T and Marletta M, Adv Exp Biol, 1/1/2007
• Life history of eNOS: Partners and pathways  
  Dudzinski D and Michel T, Cardiovascular Research, 1/1/2007
• Nitric oxide signaling comes of age: 20 years and thriving  
  Lamas, S, Lowenstein CJ and Michel T, Cardiovascular Research, 1/1/2007
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Books/Book Chapters

• Hemostasis and Thrombosis 
  Chapter: The vascular biology of nitric oxide and NO synthases. 
  Page 536 - 548Maron BA and Michel TEditors: W. Baird.Lippincott Williams and Wilkins, PhiladelphiaEdition 5th,2012
• Goodman and Gilman's Pharmacological Basis of Therapeutics 
  Chapter: Treatment of myocardial ischemia and hypertension. 
  Page 745 - 788Michel T and Hoffman BBEditors: L. Brunton.McGraw Hill, NYEdition 12th,2010
• Hemostasis and Thrombosis 
  Chapter: Vascular biology of nitric oxide and NO synthases. 
  Page 653 - 657Dudzinski D and Michel TEditors: L. Clowes.Lippincott Williams and Wilkins, PhiladelphiaEdition 4th,2006
• Goodman and Gilman's Pharmacological Basis of Therapeutics 
  Chapter: Treatment of myocardial ischemia. 
  Page 823 - 844Michel TEditors: L Brunton.McGraw Hill, New YorkEdition 11th,2005
• Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy 
  Chapter: Pharmacology of Vascular Tone 
  Page 317 - 334Yeh DC and Michel TEditors: DE Golan, et al.Lippincott Williams and Wilkins, Baltimore, MD2004
• Bioluminescence & Chemiluminescence: Progress & Current Applications 
  Chapter: Mechanism of firefly flash control: NO inhibition of oxygen consumption in lantern mitochondria is reversed by light. 
  Page 25 - 28Aprille JR, Lagace CJ, Lewis SM, Michel T, Modica-Napolitano JS, Trimmer BA and Zayas RMEditors: Stanley PE & Kricka LJ.World Scientific Publishing, Singapore2002
• Melmon and Morelli's Clinical Pharmacology: Basic Principles in Therapeutics 
  Chapter: Stable coronary artery disease: angina and atherosclerosis. 
  Page 114 - 131Michel T and Weinfeld MSEditors: Melmon KL, et al.McGraw Hill, New YorkEdition 4th,2000
• Coronary Artery Spasm 
  Chapter: Regulatory mechanisms of endothelial nitric oxide synthase. 
  Page 19 - 25Sase K and Michel TEditors: Yasue H.Axel Springer, Tokyo, Japan2000
• Nitric Oxide and the Cardiovascular System 
  Chapter: Cell and molecular biology of nitric oxide synthases. 
  Page 11 - 32Feron O and Michel TEditors: J. Loscalzo and J. A. Vita.Humana Press, Totowa, NJ2000
• Textbook of Molecular Medicine 
  Chapter: Endothelium-derived nitric oxide and the control of vascular tone. 
  Michel T and Lamas SEditors: Jameson L.Blackwell, Cambridge, MA1999
• Endothelium, Nitric Oxide and Atherosclerosis 
  Chapter: Molecular and cellular regulation of endothelial nitric oxide synthase. 
  Page 29 - 37Downey W and Michel TEditors: Goodman R and Panda J.Futura, NY1999
• Molecular Biology of Cardiovascular Disease 
  Chapter: Molecular regulation of nitric oxide synthases. 
  Page 141 - 160Michel T, Sase K and Lamas SEditors: Marks A and Taubman M.Marcel Dekker, NY1997
• Methods in Nitric Oxide Research 
  Chapter: Molecular biological analysis of nitric oxide synthases. 
  Page 161 - 176Michel T, Xie QW, Nathan CEditors: Feelisch M and Stamler J.Wiley1996
• Nitric Oxide and the Lung 
  Chapter: Molecular biological features of the nitric oxide synthases. 
  Page 59 - 68Lamas S and Michel TEditors: Zapol W.Marcel Dekker, NY1996
• Therapy of Heart Failure: Basic Science and Clinical Aspects 
  Chapter: Endothelial cell-derived vasoactive and inotropic paracrine factors. 
  Page 515 - 536Michel T, Kramer BK, Kelly RAEditors: Gwathmey J.Marcel Dekker1992
• Biochemical Actions of Hormones 
  Chapter: Regulation of adenylate cyclase by adrenergic receptors. 
  Page 43 - 68Michel T, Hoffman BB, Lefkowitz RJEditors: Litwack G.1982
• The Biology of Nitric Oxide 
  Chapter: The constitutive endothelial NO synthase gene: implications for its evolution and cellular regulation. 
  Page 1 - 4Robinson LJ, Morton CC and Michel TEditors: S. Moncada.Portland Press, London
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Other

• Nitric oxide synthase 3. 
  Michel, T., UCSD-Nature Molecule Pages
  1/1/2009
• Strategic Advisory Group on Education White Paper. 
  Michel T, Platt O, et al, Harvard Medical School (pp. 1-29)
  hms.harvard.edu/public/strategy/sage.pdf
  Boston MA - 1/1/2008
• Identification and mathematical modeling of basic transport processes in eutrophic lake systems. 
  Michel J, Michel T, Bossert WH, Harvard Lake Study, Division of Engineering and Applied Physics (pp. 1-135)
  Harvard University, Cambridge, MA - 1/1/1976
• Squam Lakes Study Report. 
  Lewis SM, D'Asaro EA and Michel T, Harvard Lake Study, Division of Engineering and Applied Physics (pp. 1-102)
  Harvard University, Cambridge, MA - 1/1/1976
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