ThomasOrtelMD

Hematology • Durham, NC

Professor of Medicine, Duke University

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Office
40 Duke Medicine Cir
Durham, NC 27710
Phone+1 919-684-5350
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Education & Training

Duke University HospitalFellowship, Hematology and Medical Oncology, 1988 - 1991
Duke University HospitalResidency, Internal Medicine, 1985 - 1988
Indiana University School of MedicineClass of 1985

Certifications & Licensure

NC State Medical License 1989 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2008-2014
Whos Who in Medicine and Healthcare Marquis Whos Who
Top MD Consumers Checkbook

Clinical Trials

Optimal Platelet Dose Strategy for Management of Thrombocytopenia Start of enrollment: 2004 Jul 01
Completed
Phase 3
Fresh-Frozen Plasma Infusions to Reduce Risk of Bleeding Related to Invasive Procedures Start of enrollment: 2006 Mar 01
Withdrawn
Phase 3
Risk of Developing Antibodies to Heparin-PF4 After Heart Surgery Start of enrollment: 2006 Jun 01
Completed
Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome Start of enrollment: 2006 Jun 01
Recruiting
Pharmacokinetic Study of Fondaparinux in Outpatients With Renal Dysfunction Start of enrollment: 2007 Aug 01
Withdrawn
Not Applicable
Evaluating the Presence of Blood Clots in People With Heparin-Induced Thrombocytopenia (HIT) (The HOT Study) Start of enrollment: 2008 Jan 01
Terminated
Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study) Start of enrollment: 2009 Jul 01
Completed
Phase 3
Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP) Start of enrollment: 2009 Apr 01
Terminated
Phase 3
Clinical Decision Rule Validation Study to Predict Low Recurrent Risk in Patients With Unprovoked Venous Thromboembolism Start of enrollment: 2008 Nov 01
Completed
Phase 4
Red Cell Storage Duration Study Start of enrollment: 2010 Jan 01
Completed
Phase 3
Initial Treatment of Patients With Immune Thrombocytopenic Purpura Start of enrollment: 2010 Jan 01
Terminated
Phase 3
"Pharmacokinetic Study of Fondaparinux in Inpatients With Renal Dysfunction" Start of enrollment: 2010 May 01
Completed
Phase 1
Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study Start of enrollment: 2010 Jun 01
Completed
A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP) Start of enrollment: 2017 Oct 13
Recruiting
Phase 3
Roles: Principal Investigator
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura Start of enrollment: 2021 Apr 14
Recruiting
Phase 3
Roles: Principal Investigator
A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) Start of enrollment: 2023 Mar 21
Recruiting
Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

37 citations
2023 ACR/EULAR antiphospholipid syndrome classification criteria.
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tats...> ;Annals of the Rheumatic Diseases. 2023 Oct 1
40 citations
The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria.
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tats...> ;Arthritis & Rheumatology. 2023 Oct 1
1 citations
Anticoagulation in Patients With COVID-19 Pneumonia-What Is the Optimal Intensity?
Richard C Becker, Thomas L Ortel> ;JAMA Internal Medicine. 2023 Jun 1
8 citations
Effect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
Tracy Y Wang, Abdus S Wahed, Alison Morris, Lisa Baumann Kreuziger, John G Quigley, Gervasio A Lamas, Alexandra J Weissman, Jose Lopez-Sendon, M Margaret Knudson, Debo...> ;Annals of Internal Medicine. 2023 Apr 1
26 citations
Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management.
Jason S Knight, D Ware Branch, Thomas L Ortel> ;BMJ. 2023 Feb 27
1 citations
Peri-procedure management of antithrombotic agents and thrombocytopenia for common procedures in oncology: Guidance from the SSC of the ISTH.
Tzu-Fei Wang, Kristen M Sanfilippo, James Douketis, Anna Falanga, John Karageorgiou, Anthony Maraveyas, Thomas L Ortel, Gerald Soff, Suresh Vedantham, Jeffrey I Zwicker> ;Journal of Thrombosis and Haemostasis. 2022 Dec 1
1 citations
Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina.
Ibrahim Saber, Alys Adamski, Maragatha Kuchibhatla, Karon Abe, Michele Beckman, Nimia Reyes, Ryan Schulteis, Bhavana Pendurthi Singh, Andrea Sitlinger, Elizabeth H Tha...> ;Research and Practice in Thrombosis and Haemostasis. 2022 Jul 1
An antiplatelet response gene expression signature is associated with bleeding.
Kevin A Friede, Rachel A Myers, Ilya Zhbannikov, Thomas L Ortel, Svati H Shah, William E Kraus, Geoffrey S Ginsburg, Deepak Voora, Gales, J.> ;Cardiovascular Research. 2023 Mar 31
Exploring the Applicability of Using Natural Language Processing to Support Nationwide Venous Thromboembolism Surveillance: Model Evaluation Study.
Aaron Wendelboe, Ibrahim Saber, Justin Dvorak, Alys Adamski, Natalie Feland, Nimia Reyes, Karon Abe, Thomas Ortel, Gary Raskob> ;JMIR Bioinformatics and Biotechnology. 2022 May 8
7 citations
New methods facilitated the process of prioritizing questions and health outcomes in guideline development.
Wojtek Wiercioch, Robby Nieuwlaat, Yuan Zhang, Pablo Alonso-Coello, Philipp Dahm, Alfonso Iorio, Veena Manja, Reem A. Mustafa, Ignacio Neumann, Thomas L. Ortel, Bram R...> ;Journal of Clinical Epidemiology. 2021 Nov 26
1 citations
Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.
Rachel A. Myers, Thomas L. Ortel, Geoffrey S. Ginsburg, Alexander Waldrop, Sandeep S. Dave, Deepak Voora> ;British Journal of Clinical Pharmacology. 2021 Oct 27
79 citations
Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Michael B. Streiff, Bjorn Holmstrom, Dana Angelini, Aneel A. Ashrani, Amro Elshoury, John Fanikos, Kleber Yotsumoto Fertrin, Annemarie E. Fogerty, Shuwei Gao, Samuel Z...> ;Journal of the National Comprehensive Cancer Network. 2021 Oct 15
9 citations
Anticoagulant Therapy in Patients Hospitalized With COVID-19.
Lana Wahid, Thomas L. Ortel> ;JAMA Internal Medicine. 2021 Oct 7
9 citations
How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines
Robby Nieuwlaat, Wojtek Wiercioch, Jan Brozek, Nancy Santesso, Robert Kunkle, Pablo Alonso-Coello, David Anderson, Shannon M. Bates, Mary Cushman, Philipp Dahm, Alfons...> ;Blood Advances. 2021 Nov 23
2 citations
Meta-analysis and systematic review of randomized controlled trials assessing the role of thromboprophylaxis after vascular surgery.
Tarek Haykal, Yazan Zayed, Josiane Kerbage, Smit Deliwala, Chandler A. Long, Thomas L. Ortel> ;Journal of Vascular Surgery. Venous and Lymphatic Disorders. 2021 Sep 8
56 citations
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Gowthami M Arepally, Thomas L Ortel> ;Blood. 2021 Jul 29
18 citations
Andexanet alfa and four-factor prothrombin complex concentrate for reversal of apixaban and rivaroxaban in patients diagnosed with intracranial hemorrhage
Mark L Vestal, Kimberly L. Hodulik, Jennifer Mando-Vandrick, Michael L. James, Thomas L. Ortel, Matthew Fuller, Maria Notini, Mark D Friedland, Ian J. Welsby> ;Journal of Thrombosis and Thrombolysis. 2021 Jun 8
Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): What We Know and Don't Know.
Gowthami M. Arepally, Thomas L. Ortel> ;Blood. 2021 Jun 1
5 citations
Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines
Wojtek Wiercioch, Robby Nieuwlaat, Philipp Dahm, Alfonso Iorio, Reem A. Mustafa, Ignacio Neumann, Bram Rochwerg, Veena Manja, Pablo Alonso-Coello, Thomas L. Ortel, Nan...> ;Journal of Clinical Epidemiology. 2021 May 13
Is the use of warfarin becoming obsolete
Tarek Haykal, Smit Deliwala, Thomas L. Ortel> ;Journal of Community Hospital Internal Medicine Perspectives. 2021 May 10
6 citations
Thromboprophylaxis for orthopedic surgery; An updated meta-analysis.
Tarek Haykal, Soheir S. Adam, Areeg Bala, Yazan Zayed, Smit Deliwala, Josiane Kerbage, Anoosha Ponnapalli, Srikanth Malladi, Varun Samji, Thomas L. Ortel> ;Thrombosis Research. 2021 Mar 1
Successful Management of Catastrophic Thrombotic Storm in a Young Boy: A Case Report From Northern India.
Ankur Kumar Jindal, Jasmina Ahluwalia, Rajiv Suku, Deepti Suri, Karen Nuytemans, Thomas L. Ortel, Margaret A. Pericak-Vance, Jeffery M. Vance, Surjit Singh> ;Journal of Pediatric Hematology/oncology. 2021 Feb 3
50 citations
Development of new international antiphospholipid syndrome classification criteria phase I/II report : generation and reduction of candidate criteria
Medha Barbhaiya, Stéphane Zuily, Yasaman Ahmadzadeh, Mary-Carmen Amigo, Tadej Avcin, Maria Laura Bertolaccini, D. Ware Branch, Guilherme Ramires de Jesus, Katrien Devr...> ;Arthritis Care & Research. 2021 Sep 2
4 citations
Platelet reactivity in response to aspirin and ticagrelor in African-Americans and European-Americans.
Margaret Infeld, Kevin A Friede, Tan Ru San, Holly J. Knickerbocker, Geoffrey S. Ginsburg, Thomas L. Ortel, Deepak Voora> ;Journal of Thrombosis and Thrombolysis. 2021 Feb 1
169 citations
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostas...
Katrien Devreese, Philip G. de Groot, Bas de Laat, Doruk Erkan, Emmanuel J. Favaloro, Ian J. Mackie, Marta Martinuzzo, Thomas L. Ortel, Vittorio Pengo, Jacob H. Rand, ...> ;Journal of Thrombosis and Haemostasis. 2020 Nov 1
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Journal Articles

Automated Versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults
David Gallagher, Juliessa M Pavon, Harvey J Cohen, Thomas L Ortel, Applied Clinical Informatics

Abstracts/Posters

Cancer- Associated Venous Thromboembolism (VTE) Characteristics in Blacks Compared to Whites in Durham County, North Carolina
Thomas L. Ortel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Risk Factors Associated with 6-Month Recurrent VTE Among Patients in Two Large Population-Based Surveillance Systems
Thomas L. Ortel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

Hemostasis and Thrombosis
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Laboratory Criteria for Antiphospholipid Syndrome: Reply
American Society of Hematology (ASH), Hollywood, California - 10/12/2012

Other

Laboratory Criteria for Antiphospholipid Syndrome: Reply
Thomas Ortel, MD, Journal of Thrombosis and Haemostasis
https://www.doximity.com/articles/9d2ed495-af3c-4907-8efa-27b82eedb4cc
UpToDate, Wolters Kluwer Health - 2012-03-19

Press Mentions

HEP-COVID: Therapeutic-Dose Heparin Effective in Non-ICU PatientsOctober 12th, 2021
Tackle the Triglycerides to Reduce ASCVD Risk, ACC SaysJuly 28th, 2021
Drug Problems: Hematologic Complications of Illicit Drug UseNovember 15th, 2019
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Hospital Affiliations

Duke University HospitalDurham, North Carolina