ThomasMichaelRaffayMDFAAP

Neonat/Perinatology • Cleveland, OH

Neonatal Respiratory Failure & Lung Development

Neonatologist at Rainbow Babies and Children's Hospital/Case Western Reserve University

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Office
UH Rainbow Babies and Children's Hospital
11100 Euclid Ave Department of Pediatrics-Neonatology
Cleveland, OH 44106
Phone+1 216-844-3387

Fax+1 216-844-3380
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Education & Training

Case Western Reserve Univ/Univ Hosps Cleveland Med Ctr/Rainbow Babies and Childrens HospitalFellowship, Neonatal-Perinatal Medicine, 2010 - 2013
Nationwide Children's Hospital/Ohio State UniversityResidency, Pediatrics, 2008 - 2011
Ohio State University College of MedicineClass of 2007

Certifications & Licensure

OH State Medical License 2007 - 2026
American Board of Pediatrics Pediatrics
American Board of Pediatrics Neonatal-Perinatal Medicine

Clinical Trials

Inhaled Treatment for Bronchopulmonary Dysplasia Start of enrollment: 2024 Aug 01
Suspended
Phase 1

Publications & Presentations

PubMed

Predicting Extubation Readiness in Preterm Infants Utilizing Machine Learning: A Diagnostic Utility Study.
Mandy Brasher, Alexandr Virodov, Cody Bumgardner, Elie G Abu Jawdeh, Thomas M Raffay, Henrietta S Bada, M Douglas Cunningham> ;The Journal of Pediatrics. 2024 Mar 30
Elevated Urine Hyaluronan Concentrations Are Associated with an Unfavorable Respiratory Outcome in Preterm Neonates at 40 Weeks Postmenstrual Age.
Peter Mathew MacFarlane, Zhengyi Chen, Nori Minich, Catherine Ann Mayer, Richard John Martin, Juliann Marie Di Fiore, Thomas Michael Raffay, Anna Maria Hibbs> ;Neonatology. 2024 Mar 14
Association between Intermittent Hypoxemia and NICU Length of Stay in Preterm Infants.
Anna Maria Hibbs, Zhengyi Chen, Nori M Minich, Richard J Martin, Thomas M Raffay, Peter M MacFarlane, Juliann M Di Fiore> ;Neonatology. 2024 Mar 4
2 citations
Hypoxemia events in preterm neonates are associated with urine oxidative biomarkers.
Thomas M Raffay, Juliann M Di Fiore, Zhengyi Chen, Ángel Sánchez-Illana, Maximo Vento, José David Piñeiro-Ramos, Julia Kuligowski, Richard J Martin, Curtis Tatsuoka, N...> ;Pediatric Research. 2023 Oct 1
3 citations
Intermittent Hypoxemia and Bronchopulmonary Dysplasia: Manifestations of Immature Respiratory Control and the Preterm Lung.
Juliann M. Di Fiore, Richard J. Martin, Thomas M. Raffay> ;American Journal of Respiratory and Critical Care Medicine. 2021 Nov 15
7 citations
Aerosolized Surfactant for Preterm Infants with Respiratory Distress Syndrome
Mandy Brasher, Thomas M. Raffay, M. Douglas Cunningham, Elie G. Abu Jawdeh> ;Children. 2021 Jun 10
2 citations
Response to first dose of inhaled albuterol in mechanically ventilated preterm infants.
Thomas M. Raffay, Mandy Brasher, Brooke C Place, Abhijit Patwardhan, Peter J. Giannone, Henrietta S. Bada, Philip M. Westgate, Elie G. Abu Jawdeh> ;Journal of Perinatology. 2021 May 25
15 citations
The relationship between intermittent hypoxemia events and neural outcomes in neonates
Juliann M. Di Fiore, Thomas M. Raffay> ;Experimental Neurology. 2021 May 10
2 citations
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5.
Thomas M. Raffay, Koby Bonilla-Fernandez, Anjum Jafri, Ramadan B Sopi, Laura Smith, Feifei Cui, Maureen O'Reilly, Rongli Zhang, Craig A. Hodges, Peter M. MacFarlane, G...> ;American Journal of Respiratory Cell and Molecular Biology. 2021 Jul 9
13 citations
Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome.
Arielle L. Olicker, Thomas M. Raffay, Rita M. Ryan> ;Children. 2021 Mar 23
5 citations
Extubation Readiness in Preterm Infants: Evaluating the Role of Monitoring Intermittent Hypoxemia
Elie G. Abu Jawdeh, Amrita Pant, Aayush Gabrani, M. Douglas Cunningham, Thomas M. Raffay, Philip M. Westgate> ;Children. 2021 Mar 18
3 citations
Prenatal Maternal Lipopolysaccharide and Mild Newborn Hyperoxia Increase Intrapulmonary Airway but Not Vessel Reactivity in a Mouse Model.
Margaret Kuper-Sassé, Peter M. MacFarlane, Catherine A. Mayer, Richard J. Martin, Y. S. Prakash, Christina M. Pabelick, Thomas M. Raffay> ;Children. 2021 Mar 5
10 citations
Prematurity and postnatal alterations in intermittent hypoxaemia
Juliann M. Di Fiore, Vidhi Shah, Abhijit Patwardhan, Abdus Sattar, Shengxuan Wang, Thomas M. Raffay, Richard J. Martin, Elie G. Abu Jawdeh> ;Archives of Disease in Childhood. Fetal and Neonatal Edition. 2021 Feb 17
6 citations
The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.
Vidhi Shah, Thomas M. Raffay, Richard J. Martin, Máximo Vento, Ángel Sánchez-Illana, José David Piñeiro-Ramos, Julia Kuligowski, Juliann M. Di Fiore> ;Neonatology. 2020 Aug 14
1 citations
Caffeine prevents prostaglandin E1-induced disturbances in respiratory control in neonatal rats: implications for infants with critical congenital heart disease.
L J Mitchell, Catherine A. Mayer, A Mayer, J. M. Di Fiore, S L Shein, Thomas M. Raffay, Peter M. MacFarlane> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2020 Aug 1
16 citations
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis
Julianne N.P. Smith, Matthew D Witkin, Alvin P. Jogasuria, Kelsey F. Christo, Thomas M. Raffay, Sanford D. Markowitz, Amar Desai> ;Scientific Reports. 2020 Jul 15
2 citations
Preemie Brains Don't Like Mechanical Ventilation!
Thomas M. Raffay, Richard J. Martin> ;The Journal of Pediatrics. 2020 Jun 7
9 citations
Intermittent hypoxia and bronchial hyperreactivity.
Thomas M. Raffay, Richard J. Martin> ;Seminars in Fetal & Neonatal Medicine. 2020 Apr 1
8 citations
S-Nitrosylation of CHIP Enhances F508Del-CFTR Maturation.
Khalequz Zaman, Julia Knight, Faraaz Hussain, Ruofan Cao, Samuel K. Estabrooks, Ghaith Altawallbeh, Kristopher Holloway, Anjum Jafri, Victoria Sawczak, Yuejin Li, Paul...> ;American Journal of Respiratory Cell and Molecular Biology. 2019 Nov 27
7 citations
Rodent models of respiratory control and respiratory system development—Clinical significance
Andrew M. Dylag, Thomas M. Raffay> ;Respiratory Physiology & Neurobiology. 2019 Jul 14
2 citations
Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper-relaxant responses to S-nitrosoglutathione in a hyperoxic murine model.
Helly J Einisman, Benjamin Gaston, Christiaan Wijers, Laura Smith, Tristan H. Lewis, Stephen J. Lewis, Thomas M. Raffay> ;Pediatric Pulmonology. 2019 Sep 4
11 citations
Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants.
Ángel Sánchez-Illana, Vidhi Shah, José David Piñeiro-Ramos, Juliann M. Di Fiore, Guillermo Quintás, Thomas M. Raffay, Peter M. MacFarlane, Richard J. Martin, Julia Kul...> ;Free Radical Biology & Medicine. 2019 Oct 1
51 citations
Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age
Thomas M. Raffay, Andrew M. Dylag, Abdus Sattar, Elie G. Abu Jawdeh, Shufen Cao, Benjamin Michael Pax, Kenneth A. Loparo, Richard J. Martin, Juliann M. Di Fiore> ;Pediatric Research. 2019 Feb 1
29 citations
Early inspired oxygen and intermittent hypoxemic events in extremely premature infants are associated with asthma medication use at 2 years of age
Juliann M. Di Fiore, Andrew M. Dylag, Ryan D. Honomichl, Anna Maria Hibbs, Richard J. Martin, Curtis Tatsuoka, Thomas M. Raffay> ;Journal of Perinatology. 2019 Feb 1
2 citations
Pulse Oximetry Targets in Extremely Premature Infants and Associated Mortality: One-Size May Not Fit All.
Thomas M. Raffay, Michele C. Walsh> ;Journal of Nature and Science. 2018 Jun 10
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Press Mentions

Pulmonary Hypertension Linked to Worse Bronchopulmonary Dysplasia Outcomes in InfantsNovember 16th, 2023

Grant Support

R03 GSNO Metabolism in Tracheal AspiratesNIH NHLBI2021–2023
K08 S-Nitrosoglutathione in BPDNIH NHLBI2017–2023
U01 PreVENTNIH NHLBI2016–2021
S-Nitrosoglutathione Reductase Inhibition in PAHATS Foundation Research Award2017–2019