ThomasCSheaMD

Oncology • Chapel Hill, NC

Professor of Medicine, University of North Carolina School of Medicine

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Office
101 Manning Dr
Chapel Hill, NC 27599
Phone+1 919-966-7746

Fax+1 919-966-7748
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Education & Training

Beth Israel Deaconess Medical CenterFellowship, Hematology and Medical Oncology, 1982 - 1985
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1981 - 1982
University of North Carolina at Chapel Hill School of MedicineClass of 1978

Certifications & Licensure

CA State Medical License 1988 - Present
NC State Medical License 1979 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

High-Dose Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Metastatic Breast Cancer Start of enrollment: 1997 Sep 01
Completed
Phase 2
SWOG-9704 Chemoradiotherapy and Peripheral Stem Cell Transplantation Compared With Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma Start of enrollment: 1997 Jul 01
Completed
Phase 3
Fludarabine and Cyclophosphamide Followed by Peripheral Stem Cell Transplant in Treating Patients With Leukemia or Lymphoma Start of enrollment: 2001 Feb 01
Completed
Phase 2
Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Non-Hodgkin's Lymphoma Start of enrollment: 2004 Apr 01
Completed
Phase 2
Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Bortezomib, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory Low-Grade, Follicular, or Mantle Cell Non-Hodgkin's Lymphoma Start of enrollment: 2006 Jul 01
Completed
Phase 1
Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease Start of enrollment: 2011 Jan 07
Completed
Phase 2
Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen Start of enrollment: 2005 Oct 01
Completed
Phase 1, Phase 2
Efalizumab in Treating Patients With Graft-Versus-Host Disease of the Skin That Did Not Respond to Previous Steroids Start of enrollment: 2006 Dec 01
Terminated
Not Applicable
Clofarabine and Gemtuzumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2007 Nov 01
Terminated
Phase 1
Blood Stem Cell Transplant With Low Dose Chemotherapy for Relapsed Follicular Non-Hodgkin's Lymphoma (BMT CTN 0701) Start of enrollment: 2009 Apr 01
Completed
Phase 2
Bortezomib and Romidepsin in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Start of enrollment: 2010 Apr 26
Completed
Phase 1
Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801) Start of enrollment: 2010 Apr 01
Completed
Phase 2, Phase 3
Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702) Start of enrollment: 2010 May 01
Completed
Phase 3
Reduced Intensity Regimen vs Myeloablative Regimen for Myeloid Leukemia or Myelodysplastic Syndrome (BMT CTN 0901) Start of enrollment: 2011 Jun 01
Terminated
Phase 3
Standard of Care +/- Midostaurin to Prevent Relapse Post Stem Cell Transplant in Patients With FLT3-ITD Mutated AML Start of enrollment: 2014 Feb 06
Completed
Phase 2
Allo vs Hypomethylating/Best Supportive Care in MDS (BMTCTN1102) Start of enrollment: 2013 Dec 16
Completed
Phase 2
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203) Start of enrollment: 2014 Aug 01
Completed
Phase 2
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Publications & Presentations

PubMed

1 citations
Anti-CD30 CAR T cells as consolidation after autologous haematopoietic stem-cell transplantation in patients with high-risk CD30lymphoma: a phase 1 study.
Natalie S Grover, George Hucks, Marcie L Riches, Anastasia Ivanova, Dominic T Moore, Thomas C Shea, Mary Beth Seegars, Paul M Armistead, Kimberly A Kasow, Anne W Beave...> ;The Lancet. Haematology. 2024 Mar 28
1 citations
Impact of patient and clinical characteristics on cognitive changes after allogeneic hematopoietic stem cell transplantation.
Zev M. Nakamura, Hillary M. Heiling, Eliza M. Park, Allison M. Deal, Laura J. Quillen, Stephanie A. Chien, Kate E. Stanton, William A. Wood, Bradley N. Gaynes, Tim A. ...> ;Bone Marrow Transplantation. 2021 Oct 2
14 citations
Adjuvanted recombinant zoster vaccine in adult autologous stem cell transplant recipients : polyfunctional immune responses and lessons for clinical practice
Edward A. Stadtmauer, Keith M. Sullivan, Mohamed El Idrissi, Bruno Salaun, Aránzazu Alonso Alonso, Charalambos Andreadis, Veli-Jukka Anttila, Adrian Bloor, Raewyn Broa...> ;Human Vaccines & Immunotherapeutics. 2021 Aug 18
4 citations
A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation
Zev M. Nakamura, Allison M. Deal, Eliza M. Park, Laura J. Quillen, Stephanie A. Chien, Kate E. Stanton, Sean McCabe, Hillary M. Heiling, William A. Wood, Thomas C. She...> ;Journal of Psychosomatic Research. 2021 Apr 27
2 citations
Collaborative care for depression and anxiety in the bone marrow transplant population: A pilot feasibility study
Anureet C. Copeland, Xianming Tan, Rebekah P. Nash, Emily G. Holmes, Janell Markey, Thomas C. Shea, William A. Wood, Eliza M. Park> ;Psycho-Oncology. 2021 Jan 1
3 citations
Cognitive function in patients prior to undergoing allogeneic hematopoietic stem cell transplantation
Zev M. Nakamura, Allison M. Deal, Donald L. Rosenstein, Laura J. Quillen, Stephanie A. Chien, William A. Wood, Thomas C. Shea, Eliza M. Park> ;Supportive Care in Cancer. 2021 Apr 1
5 citations
Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma
Sarah A. Holstein, Vera J. Suman, Kouros Owzar, Katelyn Santo, Don M. Benson, Thomas C. Shea, Thomas Martin, Margarida Silverman, Luis Isola, Ravi Vij, Bruce D. Cheson...> ;Biology of Blood and Marrow Transplantation. 2020 Aug 1
182 citations
Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma.
Carlos A. Ramos, Natalie S Grover, Anne W. Beaven, Premal Lulla, Meng Fen Wu, Anastasia Ivanova, Tao Wang, Thomas C. Shea, Cliona M. Rooney, Christopher Dittus, Steven...> ;Journal of Clinical Oncology. 2020 Jul 23
2 citations
Design of a randomized placebo controlled trial of high dose intravenous thiamine for the prevention of delirium in allogeneic hematopoietic stem cell transplantation.
Zev M. Nakamura, Allison M. Deal, Donald L. Rosenstein, Laura J. Quillen, Stephanie A. Chien, William A. Wood, Thomas C. Shea, Eliza M. Park> ;Contemporary Clinical Trials. 2020 Jun 30
17 citations
ABVD followed by BV consolidation in risk-stratified patients with limited-stage Hodgkin lymphoma
Steven I. Park, Thomas C. Shea, Oludamilola Olajide, Nishitha Reddy, Lihua E. Budde, Nilanjan Ghosh, Allison M. Deal, Jeanne F. Noe, Stephen M. Ansell> ;Blood Advances. 2020 Jun 9
15 citations
Pilot randomized trial of an electronic symptom monitoring and reporting intervention for hospitalized adults undergoing hematopoietic stem cell transplantation.
Ashley Leak Bryant, Erin M. Coffman, Brett Phillips, Xianming Tan, Elizabeth Bullard, Rachel Hirschey, Joshua Bradley, Antonia V. Bennett, Angela M. Stover, Lixin Song...> ;Supportive Care in Cancer. 2020 Mar 1
18 citations
Lessons learned from a pilot randomized clinical trial of home-based exercise prescription before allogeneic hematopoietic cell transplantation.
William A. Wood, Mark A. Weaver, Abbie E. Smith-Ryan, Erik D. Hanson, Thomas C. Shea, Claudio L. Battaglini> ;Supportive Care in Cancer. 2020 Feb 28
Evaluation of mobilization efficacy with an extended interval following plerixafor administration
Sarah E. Stump, Morgan Trepte, J. Ryan Shaw, Tatjana Grgic, Jonathan R. Ptachcinski, Andrew Sharf, Marcie L. Riches, Thomas C. Shea, Yara A. Park, Maurice Alexander> ;Journal of Oncology Pharmacy Practice. 2020 Feb 16
17 citations
Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients.
Jing Zhu, Tejendra Patel, Jordan A Miller, Chad Torrice, Mehak Aggarwal, Margaret R Sketch, Maurice Alexander, Paul M. Armistead, James M. Coghill, Tatjana Grgic, Kata...> ;International Journal of Molecular Sciences. 2020 Jan 29
17 citations
Five-year outcomes of the S1106 study of R-hyper-CVAD vs R-bendamustine in transplant-eligible patients with mantle cell lymphoma
Manali Kamdar, Hongli Li, Robert W. Chen, Lisa M. Rimsza, Michael LeBlanc, Timothy S. Fenske, Thomas C. Shea, Paul M. Barr, Tycel Phillips, John P. Leonard, Brad S. Ka...> ;Blood Advances. 2019 Oct 22
8 citations
Influence of Treating Facility, Provider Volume, and Patient-Sharing on Survival of Patients With Multiple Myeloma
Ashley T. Freeman, May Kuo, Lei Zhou, Justin G. Trogdon, Chris D. Baggett, Sascha A. Tuchman, Thomas C. Shea, William A. Wood> ;Journal of the National Comprehensive Cancer Network. 2019 Sep 1
10 citations
Successful treatment of hepatitis C virus infection with direct-acting antivirals during hematopoietic cell transplant.
Hayley E. Cunningham, Thomas C. Shea, Tatjana Grgic, Anne M. Lachiewicz> ;Transplant Infectious Disease. 2019 Jun 1
67 citations
Allogeneic Hematopoietic Cell Transplantation Compared to Chemotherapy Consolidation in older Acute Myeloid Leukemia (AML) Patients 60–75 Years in First Complete Remis...
Celalettin Ustun, Jennifer Le-Rademacher, Hai-Lin Wang, Megan Othus, Zhuoxin Sun, Brittny Major, Mei-Jie Zhang, Elizabeth Storrick, Jacqueline M. Lafky, Selina Chow, K...> ;Leukemia. 2019 Nov 1
19 citations
Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort.
Matthew Painschab, Edwards Kasonkanji, Takondwa Zuze, Bongani Kaimila, Tamiwe Tomoka, Richard Nyasosela, Ruth Nyirenda, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chi...> ;British Journal of Haematology. 2019 Feb 1
9 citations
Evaluation of a Test Dose Strategy for Pharmacokinetically-Guided Busulfan Dosing for Hematopoietic Stem Cell Transplantation
Jessica M. Davis, Anastasia Ivanova, Yunro Chung, J. Ryan Shaw, Kamakshi V. Rao, Jonathan R. Ptachcinski, Andrew Sharf, Jonathan S. Serody, Paul M. Armistead, William ...> ;Biology of Blood and Marrow Transplantation. 2019 Feb 1
10 citations
Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis
Zeina Al-Mansour, Hongli Li, James R. Cook, Louis S. Constine, Stephen Couban, Douglas A. Stewart, Thomas C. Shea, Pierluigi Porcu, Jane N. Winter, Brad S. Kahl, Sonal...> ;Leukemia & Lymphoma. 2019 Jan 10
18 citations
Effect of Antihuman T Lymphocyte Globulin on Immune Recovery after Myeloablative Allogeneic Stem Cell Transplantation with Matched Unrelated Donors: Analysis of Immune...
Mahasweta Gooptu, Haesook T. Kim, Yi Bin Chen, Witold B. Rybka, Andrew S. Artz, Michael Boyer, Laura Johnston, Joseph P. McGuirk, Thomas C. Shea, Madan Jagasia, Paul J...> ;Biology of Blood and Marrow Transplantation. 2018 Nov 1
32 citations
A Phase II Trial of Bortezomib and Vorinostat in Mantle Cell Lymphoma and Diffuse Large B-cell Lymphoma
Victor Yazbeck, Danielle Shafer, Edward B. Perkins, Domenico Coppola, Lubomir Sokol, Kristy L. Richards, Thomas B. Shea, Jia Ruan, Samir Parekh, Roger Strair, Christop...> ;Clinical Lymphoma, Myeloma & Leukemia. 2011 Nov 18
2 citations
Country-Level Macroeconomic Indicators Predict Early Post-Allogeneic Hematopoietic Cell Transplantation Survival in Acute Lymphoblastic Leukemia: A CIBMTR Analysis
William A. Wood, Ruta Brazauskas, Zhen-Huan Hu, Hisham Abdel-Azim, Ibrahim Ahmed, Mahmoud Aljurf, Sherif M. Badawy, Amer Beitinjaneh, Biju George, David Buchbinder, Ja...> ;Biology of Blood and Marrow Transplantation. 2018 Sep 1
195 citations
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Pa...
Robert J. Soiffer, Haesook T. Kim, Joseph P. McGuirk, Mitchell E. Horwitz, Laura Johnston, Mrinal M. Patnaik, Witold B. Rybka, Andrew S. Artz, David L. Porter, Thomas ...> ;Journal of Clinical Oncology. 2017 Oct 17
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Journal Articles

Mature Outcomes and Prognostic Indices in Diffuse Large B‐Cell Lymphoma in Malawi: A Prospective Cohort
Thomas C Shea, Yuri Fedoriw, British Journal of Haematology

Abstracts/Posters

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizu...
Thomas C. Shea, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Press Mentions

Management of Recurrent Prostate Cancer After Radiotherapy: Long-Term Results from CALGB 9687 (Alliance), a Prospective Multi-Institutional Salvage Prostatectomy SeriesNovember 1st, 2018

Grant Support

Cancer And Leukemia Group BNational Cancer Institute1994–2012
Core--Protocol Review And Monitoring SystemNational Cancer Institute2005–2009
Pharmacodynamic Modeling Of Oral Etoposide In Relapsed NON HodgkinsNational Center For Research Resources1999–2002
Filgrastim Alone Or In Combination W/ R Methuscf In Breast CancerNational Center For Research Resources1999–2002
Core--Clinical ProtocolNational Cancer Institute2000
High Dose Carboplatin And Paclitaxel With G-CSF In Non-Small Cell Lung CancerNational Center For Research Resources1998–1999
Blood Progenitor Cell Mobilization By R-Methuscf &R-Methug-Csf In Breast CancerNational Center For Research Resources1997
Peripheral Blood Stem Cells And High Dose ChemotherapyNational Cancer Institute1992