TimLekicMDPhD

PubMed

• 13 citations
  Geographic Analysis of Mobile Stroke Unit Treatment in a Dense Urban Area: The New York City METRONOME Registry
  Benjamin R Kummer, Mackenzie P. Lerario, Madeleine D Hunter, Xian Wu, Elizabeth S Efraim, Setareh Salehi Omran, Monica L. Chen, Iván Díaz, Daniel Sacchetti, Tim Lekic,...> ;Journal of the American Heart Association. 2019 Dec 17
• 10 citations
  Clinical Information Systems Integration in New York City's First Mobile Stroke Unit.
  Benjamin R Kummer, Michael P Lerario, Babak B. Navi, Adam C. Ganzman, Daniel S. Ribaudo, Saad Mir, Sammy Pishanidar, Tim Lekic, Olajide Williams, Hooman Kamel, Randolp...> ;Applied Clinical Informatics. 2018 Jan 1
• 4 citations
  Letter re: Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE.
  Jose Gutierrez, Tim Lekic> ;Neurology. 2017 Nov 14
• 3 citations
  Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury.
  Cherine H. Kim, Devin W. McBride, Prativa Sherchan, Carl E. Person, Eric C.K. Gren, Wayne Kelln, Tim Lekic, William K. Hayes, Jiping Tang, John H. Zhang> ;Neurobiology of Disease. 2017 Nov 1
• 3 citations
  Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach.
  Tim Lekic, Damon Klebe, Pilar Pichon, Katarina Brankov, Sally Sultan, Devin W. McBride, Darlene Casel, Alhamza Al-Bayati, Yan Ding, Jiping Tang, John H. Zhang> ;Current Drug Targets. 2017 Aug 31
• 25 citations
  α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage
  Paul R. Krafft, Devin W. McBride, William B. Rolland, Tim Lekic, Jerry J. Flores, John H. Zhang> ;Biomed Research International. 2017 Apr 26
• 5 citations
  A composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats.
  Devin W. McBride, Derek Nowrangi, Harpreet Kaur, Guangyong Wu, Lei Huang, Tim Lekic, Jiping Tang, John H. Zhang> ;Journal of Cerebral Blood Flow and Metabolism. 2017 Mar 20
• 18 citations
  Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups.
  Damon Klebe, Jerry J. Flores, Devin W. McBride, Paul R. Krafft, William B. Rolland, Tim Lekic, John H. Zhang> ;Journal of Cerebral Blood Flow and Metabolism. 2017 Sep 1
• 4 citations
  Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury.
  Cherine H. Kim, Devin W. McBride, Ronak Raval, Prativa Sherchan, Karen L. Hay, Eric C.K. Gren, Wayne Kelln, Tim Lekic, William K. Hayes, Brian S. Bull, Richard Lee App...> ;Scientific Reports. 2017 Jan 19
• 18 citations
  Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups.
  William B. Rolland, Paul R. Krafft, Tim Lekic, Damon Klebe, Julia Legrand, Abby J. Weldon, Liang Xu, John H. Zhang> ;Journal of Neurochemistry. 2017 Jan 1
• 59 citations
  PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats.
  Jerry J. Flores, Damon Klebe, William B. Rolland, Tim Lekic, Paul R. Krafft, John H. Zhang> ;Neurobiology of Disease. 2016 Mar 1
• 1 citations
  Remote Ischemic Postconditioning (RIPC) After GMH in Rodents.
  Tim Lekic, Damon Klebe, Jerry J. Flores, Regina Peters, William B. Rolland, Jiping Tang, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 1 citations
  Brain Volume Determination in Subarachnoid Hemorrhage Using Rats
  Tim Lekic, Maurice Hardy, Mutsumi Fujii, Devin W. McBride, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 4 citations
  Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats
  Tim Lekic, Paul R. Krafft, Damon Klebe, William B. Rolland, Jerry J. Flores, Jiping Tang, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 8 citations
  Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage.
  Tim Lekic, Jerry J. Flores, Damon Klebe, Desislava Doycheva, William B. Rolland, Jiping Tang, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• Exsanguination Postconditioning of ICH (EPIC-H) Using the Lancet for Brain Bleed in Rodents, Preliminary Study
  Tim Lekic, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 5 citations
  PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage.
  Tim Lekic, Paul R. Krafft, Damon Klebe, Jerry J. Flores, William B. Rolland, Jiping Tang, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 3 citations
  Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats.
  Devin W. McBride, Christine Jacob, Desislava Doycheva, Brandon Dixon, Jay Malaguit, Tim Lekic, Jiping Tang, John H. Zhang> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 3 citations
  Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage
  Jay Malaguit, Darlene Casel, Brandon Dixon, Desislava Doycheva, Jiping Tang, John H. Zhang, Tim Lekic> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 4 citations
  Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia
  Brandon Dixon, Jay Malaguit, Darlene Casel, Desislava Doycheva, Jiping Tang, John H. Zhang, Tim Lekic> ;Acta Neurochirurgica. Supplement. 2016 Jan 1
• 16 citations
  Protease-Activated Receptor 1 and 4 Signal Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury
  Tim Lekic, Damon Klebe, Devin W. McBride, Anatol Manaenko, William B. Rolland, Jerry J. Flores, Orhan Altay, Jiping Tang, John H. Zhang> ;Stroke. 2015 Jun 1
• 25 citations
  Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
  Tim Lekic, Damon Klebe, Roy Poblete, Paul R. Krafft, William B. Rolland, Jiping Tang, John H. Zhang> ;Current Medicinal Chemistry. 2015 Mar 31
• 34 citations
  Imatinib Preserves Blood-Brain Barrier Integrity Following Experimental Subarachnoid Hemorrhage in Rats
  Yan Zhan, Paul R. Krafft, Tim Lekic, Qingyi Ma, Rhonda Souvenir, John H. Zhang, Jiping Tang> ;Journal of Neuroscience Research. 2015 Jan 1
• 32 citations
  Acute and Delayed Deferoxamine Treatment Attenuates Long-Term Sequelae After Germinal Matrix Hemorrhage in Neonatal Rats
  Damon Klebe, Paul R. Krafft, Clotilde Hoffmann, Tim Lekic, Jerry J. Flores, William B. Rolland, John H. Zhang> ;Stroke. 2014 Aug 1
• 51 citations
  Correlation between subacute sensorimotor deficits and brain edema in two mouse models of intracerebral hemorrhage.
  Paul R. Krafft, Devin W. McBride, Tim Lekic, William B. Rolland, Charles E. Mansell, Qingyi Ma, Jiping Tang, John H. Zhang> ;Behavioural Brain Research. 2014 May 1
• Join now to see all

Journal Articles

• Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury  
  Kim CH, McBride DW, Raval R, Sherchan P, Hay KL, Gren EC, Kelln W, Lekic T, Hayes WK, Bull BS, Applegate R, Tang J, Zhang JH, Sci Rep, 1/19/2017
• Crotalus Atrox Venom Preconditioning Increases Plasma Fibrinogen and Reduces Perioperative Hemorrhage in a Rat Model of Surgical Brain Injury  
  Tim Lekic, Richard Applegate, Brian S Bull, Ronak Raval, Nature
• Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury  
  Kim CH, McBride DW, Sherchan P, Person CE, Gren EC, Kelln W, Lekic T, Hayes WK, Tang J, Zhang JH, Neurobiol Dis, 1/9/2017
• Fingolimod Confers Neuroprotection through Activation of Rac1 after Experimental Germinal Matrix Hemorrhage in Rat Pups  
  Rolland WB, Krafft PR, Lekic T, Klebe D, LeGrand J, Weldon AJ, Xu L, Zhang JH, J Neurochem, 1/5/2017
• alpha7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage  
  Krafft PR, McBride D, Rolland WB, Lekic T, Flores JJ, Zhang JH, Biomed Res Int, 1/1/2017
• composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats  
  McBride DW, Nowrangi D, Kaur H, Wu G, Huang L, Lekic T, Tang J, Zhang JH, J Cereb Blood Flow Metab, 1/1/2017
• Aligning animal models of clinical germinal matrix hemorrhage, from basic correlation to therapeutic approach  
  Lekic T, Klebe DW, Pichon P, Brankov K, Sultan S, McBride DW, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, Curr Drug Targets, 1/14/2016
• Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups  
  Klebe D, Flores JJ, McBride DW, Krafft PR, Rolland WB, Lekic T, Zhang JH, J Cereb Blood Flow Metab, 1/1/2016
• PPARgamma-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats  
  Flores JJ, Klebe D, Rolland WB, Lekic T, Krafft PR, Zhang JH, Neurobiol Dis, 1/1/2016
• Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia  
  Dixon B, Malaguit J, Casel D, Doycheva D, Tang J, Zhang JH, Lekic T, Acta Neurochir Suppl, 1/1/2016
• Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage  
  Malaguit J, Casel D, Dixon B, Doycheva D, Tang J, Zhang JH, Lekic T, Acta Neurochir, 1/1/2016
• PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage  
  Lekic T, Krafft PR, Klebe D, Flores J, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage  
  Lekic T, Flores J, Klebe D, Doycheva D, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats  
  Lekic T, Krafft PR, Klebe D, Rolland WB, Flores J, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats  
  McBride DW, Jacob C, Doycheva D, Dixon BJ, Malaguit J, Lekic T, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Brain Volume Determination in Subarachnoid Hemorrhage Using Rats  
  Lekic T, Hardy M, Fujii M, McBride DW, Zhang JH, Acta Neurochir, 1/1/2016
• Remote Ischemic Postconditioning (RIPC) After GMH in Rodents  
  Lekic T, Klebe D, Flores J, Peters R, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Exsanguination Postconditioning of ICH (EPIC-H) Using the Lancet for Brain Bleed in Rodents, Preliminary Study  
  Lekic T, Zhang JH, Acta Neurochir, 1/1/2016
• Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network  
  Lekic T, Klebe D, Poblete R, Krafft PR, Rolland WB, Tang J, Zhang JH, Curr Med Chem, 1/1/2015
• Imatinib preserves blood-brain barrier integrity following experimental subarachnoid hemorrhage in rats  
  Zhan Y, Krafft PR, Lekic T, Ma Q, Souvenir R, Zhang JH, Tang J, J Neurosci Res, 1/1/2015
• Small molecule inhibitors in the treatment of cerebral ischemia  
  Flores JJ, Zhang Y, Klebe DW, Lekic T, Fu W, Zhang JH, Expert Opin. Pharmacother., 1/1/2014
• Inhibition of transforming growth factor-Beta attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage  
  Manaenko A, Lekic T, Barnhart M, Hartman R, Zhang JH, Stroke, 1/1/2014
• Pontine hemorrhage Response  
  Lekic T, Rolland W, Krafft PR, Suzuki H, Tang J, Zhang JH, Kamper JE, Hartman RE, J. Neurosurg., 1/1/2013
• Splenic Immune Cells In Experimental Neonatal Hypoxia-Ischemia  
  Fathali N, Ostrowski RP, Hasegawa Y, Lekic T, Tang J, Zhang JH, Transl. Stroke Res., 1/1/2013
• Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage  
  Rolland WB, Lekic T, Krafft PR, Hasegawa Y, Altay O, Hartman R, Ostrowski R, Manaenko A, Tang J, Zhang JH, Exp. Neurol., 1/1/2013
• Join now to see all

Other

• Experimental models of brain hemorrhage using clostridial collagenase (Dissertation)