TimothyPatrickBrennanMD, PhD, MS

PubMed

• 165 citations
  Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.
  Zheng Wang, Evelyn E. Gurule, Timothy P. Brennan, Jeffrey M. Gerold, Kyungyoon J. Kwon, Nina N. Hosmane, Mithra Kumar, Subul A. Beg, Adam A. Capoferri, Stuart C. Ray, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Mar 13
• 34 citations
  Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors
  Maria Salgado, Timothy P. Brennan, Karen A. O'Connell, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, Joel N. Blankson> ;Retrovirology. 2010 Nov 8
• 102 citations
  Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma Virus
  Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, Joel N. Blankson> ;Journal of Virology. 2010 Jul 15
• 8 citations
  A Case of Seronegative HIV-1 Infection
  Adam M. Spivak, Timothy P. Brennan, Karen A. O'Connell, Emily Sydnor, Thomas M. Williams, Robert F. Siliciano, Joel E. Gallant, Joel N. Blankson> ;The Journal of Infectious Diseases. 2010 Feb 1
• 110 citations
  Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral T...
  Timothy P. Brennan, John O. Woods, Ahmad R. Sedaghat, Janet D. Siliciano, Robert F. Siliciano, Claus O. Wilke> ;Journal of Virology. 2009 Sep 1
• Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.
  Dinoso JB Kim SY Wiegand AM Palmer SE Gange SJ Cranmer L O'Shea A Callender M Spivak A Brennan T Kearney MF Proschan MA Mican JM Rehm CA Coffin JM Mello...> ;Proc Natl Acad Sci U S A. 2009 Jun 9
• 51 citations
  Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
  Justin R. Bailey, Timothy P. Brennan, Karen A. O'Connell, Robert F. Siliciano, Joel N. Blankson> ;Journal of Virology. 2009 Jan 1
• 10 citations
  Development of an aciclovir implant for the effective long-term control of herpes simplex virus type-1 infection in Vero cells and in experimentally infected SKH-1 mice
  Tory P. Johnson, Robin Frey, Melissa Modugno, Timothy P. Brennan, Barry J. Margulies> ;International Journal of Antimicrobial Agents. 2007 Nov 1
• 62 citations
  Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART.
  Ahmad R. Sedaghat, Janet D. Siliciano, Timothy P. Brennan, Claus O. Wilke, Robert F. Siliciano> ;Plos Pathogens. 2007 Aug 31
• 193 citations
  The HBV drug entecavir - effects on HIV-1 replication and resistance.
  Moira A. McMahon, Benjamin L. Jilek, Timothy P. Brennan, Lin Shen, Yan Zhou, Megan Wind-Rotolo, Sifei Xing, Shridhar Bhat, Braden R. Hale, Robert Hegarty, Curtis R. Ch...> ;The New England Journal of Medicine. 2007 Jun 21
• 343 citations
  Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circ...
  Justin R. Bailey, Ahmad R. Sedaghat, Tara L. Kieffer, Timothy P. Brennan, Patricia K. Lee, Megan Wind-Rotolo, Christine M. Haggerty, Ashrit R. Kamireddi, Yi Liu, Jessi...> ;Journal of Virology. 2006 Jul 1
• Limited protection from a pathogenic chimeric simian-human immunodeficiency virus challenge following immunization with attenuated simian immunodeficiency virus.
  Lewis MG, Yalley-Ogunro J, Greenhouse JJ, Brennan TP, Jiang JB, VanCott TC, Lu Y, Eddy GA, Birx DL> ;J. Virol.. 1999-02-01
• An automated multiplex oligonucleotide synthesizer: development of high-throughput, low-cost DNA synthesis.
  Lashkari DA, Hunicke-Smith SP, Norgren RM, Davis RW, Brennan T> ;Proc. Natl. Acad. Sci. U.S.A.. 1995-08-15
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Abstracts/Posters

• Detailed analysis of HIV-1 viremia and provirus from resting CD4+ T cells of patients on suppressive HAART support a model of release of virus from latent reservoirs w...
  Timothy Brennan, Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, WA, 2012
• Detailed analysis of HIV-1 viremia and provirus from resting CD4+ T cells of patients on suppressive HAART support a model of release of virus from latent reservoirs w...
  Timothy Brennan, 2011 annual American College of Physicians (ACP) Steps to Success Meeting, Bethesda, MD, 2011
• No evidence of evolution in HIV-1-infected patients receiving combination antiretroviral therapy
  Timothy Brennan, Keystone Symposia on Molecular and Cellular Biology – HIV Pathogenesis, Santa Fe, NM, 2010
• Analysis of HIV-1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy
  Timothy Brennan, Conference on Retroviruses and Opportunistic Infections (CROI), Montreal, Canada, 2010
• Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circ...
  Timothy Brennan, XVI International AIDS Conference, Toronto, Canada, 2006
• Understanding a Unique Plasma Population in HIV Infected Patients on HAART: Evidence of a Potential Second Latent Reservoir
  Timothy Brennan, Conference on Virology, University of Maryland, College Park, 2005
• Discovering an elusive receptor that interacts with a MCMV-encoded class I MHC homologue
  Timothy Brennan, Keystone conference on host-pathogen interactions, Taos, NM, 2004
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Lectures

• Analysis of HIV-1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy 
  Conference on Retroviruses and Opportunistic Infections (CROI) in Montreal, Canada - 2009