TimothyWayneBrothertonMD

Oncology • Hillsborough, NC

Associate Professor at University of North Carolina, Hillsborough Campus

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Office
460 Waterstone Drive
Hillsborough, NC 27278
Phone+1 919-595-5900

Fax+1 919-595-5988
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Education & Training

University of Iowa Hospitals and ClinicsFellowship, Hematology and Medical Oncology, 1984 - 1987
University of Iowa Hospitals and ClinicsResidency, Internal Medicine, 1982 - 1984
University of Iowa Roy J. and Lucille A. Carver College of MedicineClass of 1982

Certifications & Licensure

NC State Medical License 2007 - 2024
VA State Medical License 1991 - 2018
IA State Medical License 1982 - 2001
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

AOA
CMS Meaningful Use Stage 1 Certification OncoEMR, Altos Solutions, Inc., 2012

Clinical Trials

Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma Start of enrollment: 2010 Mar 15
Active, not recruiting
Phase 1, Phase 2

Publications & Presentations

PubMed

51 citations
Use of trastuzumab in the treatment of metastatic endometrial cancer.
Elizabeth L. Jewell, Angeles Alvarez Secord, T. Brotherton, Andrew Berchuck> ;International Journal of Gynecological Cancer. 2006 May 1
8 citations
Discrete regions of the avian β-globin gene cluster have tissue-specific hypersensitivity to cleavage by sonication in nuclei
Jeffrey S. Reneker, Timothy W. Brotherton> ;Nucleic Acids Research. 1991 Sep 11
6 citations
Postsynthetic methylation of core histones in K562 cells is associated with bulk acetylation but not with transcriptional activity.
Jeff Reneker, Timothy W. Brotherton> ;Biochemistry. 1991 Aug 27
26 citations
Avian nuclear matrix proteins bind very tightly to cellular DNA of the beta-globin gene enhancer in a tissue-specific fashion.
Timothy W. Brotherton, David W. Zenk, Stephen Kahanic, Jeff Reneker> ;Biochemistry. 1991 Jun 18
25 citations
A nuclear matrix protein binds very tightly to DNA in the avian beta-globin gene enhancer.
David W. Zenk, Gordon D. Ginder, Timothy W. Brotherton> ;Biochemistry. 1990 Jun 5
10 citations
Binding of HMG 17 to mononucleosomes of the avian β-globin gene cluster in erythroid and non-erythroid cells
Timothy W. Brotherton, Jeff Reneker, Gordon D. Ginder> ;Nucleic Acids Research. 1990 Apr 25
4 citations
Bovine pancreatic DNase I binds very tightly to DNA fragments and may be mistaken for putative endogenous nuclear proteins convalently bound to DNA
Timothy W. Brotherton, David W. Zenk> ;Biochemical and Biophysical Research Communications. 1990 Jan 15
13 citations
Heparin binds to intact mononucleosomes and induces a novel unfolded structure.
Timothy W. Brotherton, M. V. Jagannadham, Gordon D. Ginder> ;Biochemistry. 1989 Apr 18
Topoisomerase II activity is not involved in the maintenance of active beta-globin chromatin structure in avian reticulocytes.
Timothy W. Brotherton, David W. Zenk, Bennett Jp, Gordon D. Ginder> ;Progress in Clinical and Biological Research. 1989 Jan 1
1 citations
Nuclear matrix attachment regions of the chicken beta-type globin gene cluster.
Bennett Jp, Timothy W. Brotherton, Gordon D. Ginder> ;Progress in Clinical and Biological Research. 1989 Jan 1
20 citations
Preferential in vitro binding of high mobility group proteins 14 and 17 to nucleosomes containing active and DNase I sensitive single-copy genes.
Timothy W. Brotherton, Gordon D. Ginder> ;Biochemistry. 1986 Jun 3
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Professional Memberships

American College of Physicians - ACP
Member
American Society of Clinical Oncology - ASCO
Member

Hospital Affiliations

University of North Carolina HospitalsChapel Hill, North Carolina