TimothyMCrombleholmeMD

Pediatric (General) Surgery • Hartford, CT

Fetal Surgery

Director, Fetal Care Center at Connecticut Children's

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Office
282 Washington Street
Hartford, CT 06106
Phone+1 860-545-9830
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Education & Training

Tufts-New England Medical CenterFellowship, Pediatric Surgery, 1991 - 1993
University of California (San Francisco)Residency, Surgery, 1984 - 1991
Tufts University School of MedicineClass of 1984
University of PennsylvaniaCollege of Arts and Sciences: B.A., 1977 - 1980

Certifications & Licensure

CT State Medical License 2020 - 2025
MO State Medical License 2020 - 2023
TX State Medical License 2018 - 2023
CO State Medical License 2011 - 2019
OH State Medical License 2004 - 2013
PA State Medical License 1995 - 2004
NJ State Medical License 1996 - 2003
American Board of Surgery Surgery
American Board of Surgery Pediatric Surgery

Clinical Trials

Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Start of enrollment: 2002 Mar 01
Unknown status
Not Applicable
Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM) Start of enrollment: 2008 Apr 01
Terminated
Phase 1, Phase 2
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science Start of enrollment: 2005 Jun 01
Recruiting
Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Start of enrollment: 2011 Apr 19
Completed
Not Applicable
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Publications & Presentations

PubMed

17 citations
IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3.
Walker D Short, Emily Steen, Xinyi Wang, Oluyinka O Olutoye 2nd, Hima V Vangapandu, Natalie Templeman, Alexander J Blum, Chad M Moles, Daria A Narmoneva, Timothy M Cro...> ;FASEB Journal. 2022 Jul 1
2 citations
Amniotic Fluid microRNA in Severe Twin-Twin Transfusion Syndrome Cardiomyopathy-Identification of Differences and Predicting Demise.
Eleanor L Schuchardt, Shelley D Miyamoto, Timothy Crombleholme, Anis Karimpour-Fard, Armin Korst, Bonnie Neltner, Lisa W Howley, Bettina Cuneo, Carmen C Sucharov> ;Journal of Cardiovascular Development and Disease. 2022 Jan 23
Prenatal Recognition of Hepatopulmonary Fusion in Right-Sided Congenital Diaphragmatic Hernia for Successful Operative Planning.
Kristy L Terp, Bailey K Roberts, Rachel M Pevsner Crum, Timothy Crombleholme, S Pinar Karakas, Fuad Alkhoury, Alonso, D.> ;Fetal Diagnosis and Therapy. 2022 Jan 1
20 citations
Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene.
Lu Qiao, Le Xu, Lan Yu, Julia Wynn, Rebecca Hernan, Xueya Zhou, Christiana Farkouh-Karoleski, Usha Krishnan, Julie Khlevner, Aliva De, Annette Zygmunt, Timothy M. Crom...> ;American Journal of Human Genetics. 2021 Oct 7
4 citations
Pediatric mediastinal mass algorithm: A quality improvement initiative to reduce time from presentation to biopsy.
Jamie M Fleming, Savannah Ross, Lindsey Hoffman, Rebecca L Coughlin, Timothy M. Crombleholme, David A. Mong, Joanne M. Hilden, Kelly W. Maloney, Gee Mei Tan> ;Paediatric Anaesthesia. 2021 Aug 1
19 citations
Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes.
Lu Qiao, Julia Wynn, Lan Yu, Rebecca Hernan, Xueya Zhou, Vincent Duron, Gudrun Aspelund, Christiana Farkouh-Karoleski, Annette Zygumunt, Usha Krishnan, Shannon N. Nees...> ;Genetics in Medicine. 2020 Jul 28
1 citations
Maternal-fetal surgery during the coronavirus disease 2019 pandemic.
Timothy M. Crombleholme, Kenneth J. Moise> ;American Journal of Obstetrics & Gynecology MFM. 2020 May 18
20 citations
Comparative outcomes of right versus left congenital diaphragmatic hernia: A multicenter analysis.
Alexey Abramov, Weijia Fan, Rebecca Hernan, Ariela L. Zenilman, Julia Wynn, Gudrun Aspelund, Julie Khlevner, Usha Krishnan, Foong-Yen Lim, George B. Mychaliska, Brad W...> ;Journal of Pediatric Surgery. 2020 Jan 1
6 citations
Error traps in fetal surgery.
Jose L. Peiro, Timothy M. Crombleholme> ;Seminars in Pediatric Surgery. 2019 Jun 1
2 citations
Indomethacin Dosing and Constriction of the Ductus Arteriosus During Open Fetal Surgery for Myelomeningocele Repair.
Lisa Howley, Debnath Chatterjee, Sonali S. Patel, Bettina F. Cuneo, Timothy M. Crombleholme, Nicholas Behrendt, Michael V. Zaretsky, Ahmed I. Marwan, Jeannie Zuk, Henr...> ;Fetal Diagnosis and Therapy. 2019 Jan 1
80 citations
De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders.
Hongjian Qi, Lan Yu, Xueya Zhou, Julia Wynn, Haoquan Zhao, Yicheng Guo, Na Zhu, Alexander Kitaygorodsky, Rebecca Hernan, Gudrun Aspelund, Foong-Yen Lim, Timothy M. Cro...> ;Plos Genetics. 2018 Dec 10
11 citations
Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep
R. Blair Dodson, Kyle N Powers, Jason Gien, Paul J. Rozance, Gregory J. Seedorf, David P. Astling, Kenneth Lloyd Jones, Timothy M. Crombleholme, Steven H. Abman, Crist...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2018 May 3
9 citations
Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair
Scott Deeney, Lisa Howley, Maggie M. Hodges, Kenneth W. Liechty, Ahmed I. Marwan, Jason Gien, John Kinsella, Timothy M. Crombleholme> ;The Journal of Pediatrics. 2018 Jan 1
17 citations
Modified Hysterotomy Closure Technique for Open Fetal Surgery.
Michael V. Zaretsky, Kenneth W. Liechty, Henry L. Galan, Nicholas Behrendt, Shane Reeves, Ahmed I. Marwan, C. Corbett Wilkinson, Michael H. Handler, Megan Lagueux, Tim...> ;Fetal Diagnosis and Therapy. 2017 Sep 6
28 citations
Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11.
Tracy Funk, Young H. Lim, Ann M. Kulungowski, Lori Prok, Timothy M. Crombleholme, Keith A. Choate, Anna L. Bruckner> ;JAMA Dermatology. 2016 Sep 1
Case report of myometrial window following fetoscopic treatment of twin-twin transfusion syndrome: indications of underlying collagen vascular disease?
Michael V. Zaretsky, David K. Manchester, Henry L. Galan, Nicholas Behrendt, Ahmed I. Marwan, Kenneth W. Liechty, Timothy M. Crombleholme> ;Clinical Case Reports. 2017 May 9
5 citations
Twin pregnancy complicated by esophageal atresia, duodenal atresia, gastric perforation, and hypoplastic left heart structures in one twin: a case report and review of...
Mohamad K. Abou Chaar, Mariana L. Meyers, Bethany D. Tucker, Henry L. Galan, Kenneth W. Liechty, Timothy M. Crombleholme, Ahmed I. Marwan> ;Journal of Medical Case Reports. 2017 Mar 18
6 citations
A definition of gentle ventilation in congenital diaphragmatic hernia: A survey of neonatologists and pediatric surgeons
Christiana Farkouh-Karoleski, Tasnim Najaf, Julia Wynn, Gudrun Aspelund, Wendy K. Chung, Charles J.H. Stolar, George B. Mychaliska, Brad W. Warner, Amy J. Wagner, Robe...> ;Journal of Perinatal Medicine. 2017 Dec 20
3 citations
Pediatric Intraocular Immature Teratoma Associated With Sacrococcygeal Teratoma.
Kristen Zhelnin, Grant M. Gebhard, David M. Mirsky, Scott C N Oliver, Mark A. Lovell, Csaba Galambos, Timothy M. Crombleholme, Emily A. McCourt> ;Pediatric and Developmental Pathology. 2017 Jan 25
17 citations
Fetal origins of adult cardiac disease: a novel approach to prevent fetal growth restriction induced cardiac dysfunction using insulin like growth factor.
Tarek Alsaied, Khaled Omar, Jeanne James, Robert B. Hinton, Timothy M. Crombleholme, Mounira Habli> ;Pediatric Research. 2017 Jan 18
5 citations
Ex utero Intrapartum Treatment to Ventricular Pacing: A Novel Delivery Strategy for Complete Atrioventricular Block with Severe Bradycardia.
Bettina F. Cuneo, Max B. Mitchell, Ahmed I. Marwan, Matthew Green, Johannes C. von Alvensleben, Regina M. Reynolds, Timothy M. Crombleholme, Henry L. Galan> ;Fetal Diagnosis and Therapy. 2017 Jan 1
45 citations
Fetal Treatment 2017: The Evolution of Fetal Therapy Centers - A Joint Opinion from the International Fetal Medicine and Surgical Society (IFMSS) and the North America...
Anita J. Moon-Grady, Ahmet Baschat, Darrell L. Cass, Mahesh Choolani, Joshua A. Copel, Timothy M. Crombleholme, Jan Deprest, Stephen P. Emery, Mark I. Evans, Francois ...> ;Fetal Diagnosis and Therapy. 2017 Jan 1
8 citations
Effects of Maternal Valium Administration on Fetal MRI Motion Artifact: A Comparison Study at High Altitude.
Mariana L. Meyers, David M. Mirsky, Kimberly A. Dannull, Suhong Tong, Timothy M. Crombleholme> ;Fetal Diagnosis and Therapy. 2017 Jan 1
15 citations
Use of an Amnioport to Maintain Amniotic Fluid Volume in Fetuses with Oligohydramnios Secondary to Lower Urinary Tract Obstruction or Fetal Renal Anomalies
William Polzin, Foong Y. Lim, Mounira Habli, James Van Hook, Melissa Minges, Ronald Jaekle, Timothy M. Crombleholme> ;Fetal Diagnosis and Therapy. 2017 Jan 1
41 citations
Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling.
Swathi Balaji, Xinyi Wang, Alice King, Louis D. Le, Sukanta S. Bhattacharya, Chad M. Moles, Manish J. Butte, Vinicio A. de Jesus Perez, Kenneth W. Liechty, Thomas N. W...> ;FASEB Journal. 2017 Mar 1
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Journal Articles

Indomethacin Dosing and Constriction of the Ductus Arteriosus During Open Fetal Surgery for Myelomeningocele Repair
Bettina F Cuneo, Timothy M Crombleholme, Ahmed I Marwan, Lisa W Howley, Michael V Zaretsky, Henry L Galan, Debnath Chatterjee, Sonali S Patel, Nicholas Behrendt, Crist..., Fetal Diagnosis and Therapy

Press Mentions

New Center for High Risk Babies to Provide Higher Level of Care, Save LivesApril 3rd, 2023
Courtney D. Stephenson, DO, an Obstetrician-Gynecologist and Maternal-Fetal Medicine Specialist with CharlotteFebruary 18th, 2020
The Surgeon Who Works on Babies Before They’re BornOctober 10th, 2018
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Grant Support

Endothelial Progenitor Cell Recruitment In Diabetic MiceNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2008
Endothelial Progenitor Cell Biology In Type 1 DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2008
Dermal-Epidermal Interactions In Diabetic Wound HealingNational Institute Of Diabetes And Digestive And Kidney Diseases2004
Twin-Twin Transfusion Syndrome TrialNational Center For Research Resources2004
Twin-Twin Transfusion Syndrome TrialEunice Kennedy Shriver National Institute Of Child Health &Human Development2004
Twin-Twin Transfusion Syndrome TrialEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2003
Dermal-Epidermal Interactions In Diabetic Wound HealingNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2003