TimothyLouisFrankelMD

PubMed

• A Comparison of Spatial and Phenotypic Immune Profiles of Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions.
  Thomas Enzler, Jiaqi Shi, Jake McGue, Brian D Griffith, Lei Sun, Vaibhav Sahai, Hari Nathan, Timothy L Frankel> ;International Journal of Molecular Sciences. 2024 Mar 3
• The Aryl Hydrocarbon Receptor: Impact on the Tumor Immune Microenvironment and Modulation as a Potential Therapy.
  Griffith, B., Frankel, T.> ;Cancers. 2024 Jan 23
• WITHDRAWN: Oncogenic KRASextrinsically induces an immunosuppressive microenvironment in lung adenocarcinoma.
  Lasse-Opsahl, E., Baliira, R., Barravecchia, I., McLintock, E., Lee, J., Ferris, S., Espinoza, C., Hinshaw, R., Cavanaugh, S., Robotti, M., Brown, K., Donahue, K., Abd...> ;Biorxiv. 2024 Feb 6
• 2 citations
  Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression.
  Debasmita Mukherjee, Srija Chakraborty, Lena Bercz, Liliana D'Alesio, Jessica Wedig, Molly A Torok, Timothy Pfau, Hannah Lathrop, Shrina Jasani, Abigail Guenther, Jake...> ;Iscience. 2023 Aug 18
• 6 citations
  Multiplex Immunohistochemistry and Immunofluorescence: A Practical Update for Pathologists.
  Paul W Harms, Timothy L Frankel, Myrto Moutafi, Arvind Rao, David L Rimm, Janis M Taube, Dafydd Thomas, May P Chan, Liron Pantanowitz> ;Modern Pathology. 2023 Jul 1
• 31 citations
  Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.
  Gaopeng Li, Jae Eun Choi, Ilona Kryczek, Yilun Sun, Peng Liao, Shasha Li, Shuang Wei, Sara Grove, Linda Vatan, Reagan Nelson, Grace Schaefer, Steven G Allen, Kamya San...> ;Cancer Cell. 2023 Feb 13
• 1 citations
  Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer.
  Brian D Griffith, Jenny Lazarus, Jake McGue, Santhoshi Krishnan, Michael I D'Angelica, Jinru Shia, Irina Dobrosotskaya, Jaiqi Shi, Jacob Edwards, Arvind Rao, Timothy L...> ;Frontiers in Immunology. 2023 Jan 1
• Multiplex Fluorescent Immunohistochemistry for Preservation of Tumor Microenvironment Architecture and Spatial Relationship of Cells in Tumor Tissues.
  Jake J McGue, Jacob J Edwards, Brian D Griffith, Timothy L Frankel> ;Methods in Molecular Biology. 2023 Jan 1
• Towards the characterization of the tumor microenvironment through dictionary learning-based interpretable classification of multiplexed immunofluorescence images.
  Santhoshi N Krishnan, Souptik Barua, Timothy L Frankel, Arvind Rao> ;Physics in Medicine and Biology. 2022 Dec 21
• 19 citations
  Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer.
  Hannah N Bell, Amanda K Huber, Rashi Singhal, Navyateja Korimerla, Ryan J Rebernick, Roshan Kumar, Marwa O El-Derany, Peter Sajjakulnukit, Nupur K Das, Samuel A Kerk, ...> ;Cell Metabolism. 2023 Jan 3
• 4 citations
  MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment.
  Brian D Griffith, Simon Turcotte, Jenny Lazarus, Fatima Lima, Samantha Bell, Lawrence Delrosario, Jake McGue, Santhoshi Krishnan, Morgan D Oneka, Hari Nathan, J Joshua...> ;Cancers. 2022 Aug 24
• 10 citations
  DNA-PK Inhibition and Radiation Promote Antitumoral Immunity through RNA Polymerase III in Pancreatic Cancer.
  Weiwei Wang, Matthew T McMillan, Xinyi Zhao, Zhuwen Wang, Long Jiang, David Karnak, Fatima Lima, Joshua D Parsels, Leslie A Parsels, Theodore S Lawrence, Timothy L Fra...> ;Molecular Cancer Research. 2022 Jul 6
• 1 citations
  Cellular engagement and interaction in the tumor microenvironment predict non-response to PD-1/PD-L1 inhibitors in metastatic non-small cell lung cancer.
  Angel Qin, Fatima Lima, Samantha Bell, Gregory P Kalemkerian, Bryan J Schneider, Nithya Ramnath, Madelyn Lew, Santhoshi Krishnan, Shariq Mohammed, Arvind Rao, Timothy ...> ;Scientific Reports. 2022 May 31
• 3 citations
  GaWRDenMap: a quantitative framework to study the local variation in cell-cell interactions in pancreatic disease subtypes.
  Santhoshi N Krishnan, Shariq Mohammed, Timothy L Frankel, Arvind Rao> ;Scientific Reports. 2022 Mar 8
• 5 citations
  Immune sensing of microbial metabolites: Action at the tumor.
  Timothy L Frankel, Marina Pasca di Magliano> ;Immunity. 2022 Feb 8
• 13 citations
  Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming.
  Ashley Velez-Delgado, Katelyn L Donahue, Kristee L Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E Menjivar, Emily L Lasse Opsahl, Nina G Steele, Stephanie The, Jen...> ;Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 1
• 47 citations
  IFNγ signaling integrity in colorectal cancer immunity and immunotherapy.
  Wan Du, Timothy L. Frankel, Michael D. Green, Weiping Zou> ;Cellular & Molecular Immunology. 2021 Aug 12
• 51 citations
  Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages
  Samantha Kemp, Nina Steele, Eileen S. Carpenter, Katelyn Donahue, Grace G. Bushnell, Aaron H. Morris, Sophia M Orbach, Veerin Sirihorachai, Zeribe C. Nwosu, Carlos Esp...> ;Life Science Alliance. 2021 Mar 29
• 18 citations
  Immunotherapy for pancreatic ductal adenocarcinoma.
  Eileen S. Carpenter, Sarah Nelson, Filip Bednar, Clifford S. Cho, Hari Nathan, Vaibhav Sahai, Marina Pasca di Magliano, Timothy L. Frankel> ;Journal of Surgical Oncology. 2021 Mar 1
• 5 citations
  Association of RAS Mutation Location and Oncologic Outcomes After Resection of Colorectal Liver Metastases.
  Thomas Boerner, Debra A. Goldman, Mithat Gonen, Timothy L. Frankel, Efsevia Vakiani, T. Peter Kingham, William R. Jarnagin, Alice C. Wei, Kevin C. Soares, David B. Sol...> ;Annals of Surgical Oncology. 2021 Feb 1
• 114 citations
  Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer.
  Nina Steele, Giulia Biffi, Samantha Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E. Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Ha...> ;Clinical Cancer Research. 2021 Apr 1
• 24 citations
  Immune determinants of Barrett’s progression to esophageal adenocarcinoma
  Kiran H. Lagisetty, Dyke P. McEwen, Derek J. Nancarrow, Johnathon G Schiebel, Daysha Ferrer-Torres, Dipankar Ray, Timothy L. Frankel, Jules Lin, Andrew C. Chang, Laura...> ;JCI Insight. 2021 Jan 11
• 1 citations
  CGAT: Cell Graph ATtention Network for Grading of Pancreatic Disease Histology Images.
  Mayank Baranwal, Santhoshi Krishnan, Morgan Oneka, Timothy L. Frankel, Arvind Rao> ;Frontiers in Immunology. 2021 Jan 1
• 36 citations
  Telehealth for Cancer Care in Veterans: Opportunities and Challenges Revealed by COVID
  Cindy Y Jiang, Nadeem T El-Kouri, David Elliot, Jenna Shields, Megan E.V. Caram, Timothy L. Frankel, Nithya Ramnath, Vida Almario Passero> ;JCO Oncology Practice. 2021 Jan 1
• 48 citations
  Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma
  Loryn Holokai, Jayati Chakrabarti, Joanne Lundy, Daniel Croagh, Pritha Adhikary, Scott S. Richards, Chantal Woodson, Nina Steele, R. K. Kuester, Aaron Scott, Mohammad ...> ;Cancers. 2020 Dec 17
• Join now to see all