TimothyCKennedyMD

PubMed

• 16 citations
  Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia
  Daniel T. Merrick, Michael G. Edwards, Wilbur A. Franklin, Michio Sugita, Robert L. Keith, York E. Miller, Micah Friedman, Lori D. Dwyer-Nield, Meredith A. Tennis, Mar...> ;Cancer Research. 2018 Sep 1
• 26 citations
  PERSISTENCE OF BRONCHIAL DYSPLASIA IS ASSOCIATED WITH DEVELOPMENT OF INVASIVE SQUAMOUS CELL CARCINOMA
  Daniel T. Merrick, Dexiang Gao, York E. Miller, Robert L. Keith, Anna E. Barón, William J. Feser, Timothy C. Kennedy, Patrick J. Blatchford, Sarah Braudrick, Fred R. H...> ;Cancer Prevention Research. 2016 Jan 1
• 14 citations
  Endobronchial miRNAs as biomarkers in lung cancer chemoprevention
  Céline Mascaux, William J. Feser, Marina T. Lewis, Anna E. Barón, Christopher D. Coldren, Daniel T. Merrick, Timothy C. Kennedy, John I. Eckelberger, Leslie Rozeboom, ...> ;Cancer Prevention Research. 2013 Feb 1
• 136 citations
  Non-invasive Breath Analysis of Pulmonary Nodules
  Nir Peled, Marwan Hakim, Paul A. Bunn, York E. Miller, Timothy C. Kennedy, Jane Mattei, John D. Mitchell, Fred R. Hirsch, Hossam Haick> ;Journal of Thoracic Oncology. 2012 Oct 1
• 77 citations
  Defining a Gene Promoter Methylation Signature in Sputum for Lung Cancer Risk Assessment
  Shuguang Leng, Kieu Do, Christin M. Yingling, Maria A. Picchi, Holly J. Wolf, Timothy C. Kennedy, William J. Feser, Anna E. Barón, Wilbur A. Franklin, Malcolm V. Brock...> ;Clinical Cancer Research. 2012 Jun 15
• 76 citations
  Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers
  Robert L. Keith, Patrick J. Blatchford, John Kittelson, John D. Minna, Karen Kelly, Pierre P. Massion, Wilbur A. Franklin, Jenny T. Mao, David O. Wilson, Daniel T. Mer...> ;Cancer Prevention Research. 2011 Jun 1
• 41 citations
  The Detection of Chromosomal Aneusomy by Fluorescence In situ Hybridization in Sputum Predicts Lung Cancer Incidence
  Marileila Varella-Garcia, Aline P. Schulte, Holly J. Wolf, William J. Feser, Chan Zeng, Sarah Braudrick, Xiang Yin, Fred R. Hirsch, Timothy C. Kennedy, Robert L. Keith...> ;Cancer Prevention Research. 2010 Apr 1
• 22 citations
  A Randomized Phase II Chemoprevention Trial of 13-CIS Retinoic Acid with Or without α Tocopherol or Observation in Subjects at High Risk for Lung Cancer
  Karen Kelly, John Kittelson, Wilbur A. Franklin, Timothy C. Kennedy, Catherine E. Klein, Robert L. Keith, Edward C. Dempsey, Marina T. Lewis, Mary Jackson, Fred R. Hir...> ;Cancer Prevention Research. 2009 May 1
• 82 citations
  Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical Trial
  Eric S. Edell, Stephen Lam, Harvey I. Pass, York E. Miller, Thomas G. Sutedja, Timothy C. Kennedy, Gregory M. Loewen, Robert L. Keith> ;Journal of Thoracic Oncology. 2009 Jan 1
• 34 citations
  Chromosomal Aneusomy in Bronchial High-Grade Lesions Is Associated with Invasive Lung Cancer
  Steinn Jonsson, Marileila Varella-Garcia, York E. Miller, Holly J. Wolf, Tim Byers, Sarah Braudrick, Porntip Kiatsimkul, Marina T. Lewis, Timothy C. Kennedy, Robert L....> ;American Journal of Respiratory and Critical Care Medicine. 2008 Feb 1
• 23 citations
  Sputum cytologic atypia predicts incident lung cancer: defining latency and histologic specificity.
  Tim Byers, Holly J. Wolf, Wilbur A. Franklin, Sarah Braudrick, Daniel T. Merrick, Kenneth R. Shroyer, Fred R. Hirsch, Chan Zeng, Anna E. Barón, Paul A. Bunn, York E. M...> ;Cancer Epidemiology, Biomarkers & Prevention. 2008 Jan 1
• 22 citations
  Bronchial Epithelial Ki-67 Index Is Related to Histology, Smoking, and Gender, but Not Lung Cancer or Chronic Obstructive Pulmonary Disease
  York E. Miller, Patrick J. Blatchford, Dae Sung Hyun, Robert L. Keith, Timothy C. Kennedy, Holly J. Wolf, Tim Byers, Paul A. Bunn, Marina T. Lewis, Wilbur A. Franklin,...> ;Cancer Epidemiology, Biomarkers & Prevention. 2007 Nov 1
• 66 citations
  Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
  Timothy C. Kennedy, Annette McWilliams, Eric S. Edell, Tom G. Sutedja, Gordon H. Downie, Rex C. Yung, Adi F. Gazdar, Praveen N. Mathur> ;Chest. 2007 Sep 1
• 23 citations
  Spectral Karyotyping Detects Chromosome Damage in Bronchial Cells of Smokers and Patients with Cancer
  Marileila Varella-Garcia, Lin Chen, Roger Powell, Fred R. Hirsch, Timothy C. Kennedy, Robert L. Keith, York E. Miller, John D. Mitchell, Wilbur A. Franklin> ;American Journal of Respiratory and Critical Care Medicine. 2007 Sep 1
• 34 citations
  Treatment trends and factors associated with survival in T1aN0 and T1bN0 breast cancer patients.
  Timothy C. Kennedy, Andrew K. Stewart, Karl Y. Bilimoria, Lina Patel-Parekh, Stephen F. Sener, David P. Winchester> ;Annals of Surgical Oncology. 2007 Jul 20
• 59 citations
  Analysis of c-ErbB1/Epidermal Growth Factor Receptor and c-ErbB2/HER-2 Expression in Bronchial Dysplasia: Evaluation of Potential Targets for Chemoprevention of Lung C...
  Daniel T. Merrick, John Kittelson, R. Winterhalder, Georgia Kotantoulas, Steen Ingeberg, Robert L. Keith, Timothy C. Kennedy, York E. Miller, Wilbur A. Franklin, Fred ...> ;Clinical Cancer Research. 2006 Apr 1
• 18 citations
  High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia.
  Timothy C. Kennedy, Wilbur A. Franklin, Sheila A. Prindiville, Robert Cook, Edward C. Dempsey, Robert L. Keith, Fred R. Hirsch, Thomas A. Merrick, Kenneth R. Shroyer, ...> ;Lung Cancer. 2005 Aug 1
• 20 citations
  Using molecular markers in sputum for the early detection of lung cancer: A review
  Timothy C. Kennedy, Fred R. Hirsch> ;Lung Cancer. 2004 Aug 1
• 5 citations
  High prevalence of endobronchial malignancy in high-risk patients with moderate dysplasia in sputum.
  Timothy C. Kennedy, Wilbur A. Franklin, Sheila A. Prindiville, Robert Cook, Edward C. Dempsey, Robert L. Keith, Fred R. Hirsch, Thomas A. Merrick, Kenneth R. Shroyer, ...> ;Chest. 2004 May 1
• 166 citations
  Fluorescence Versus White-Light Bronchoscopy for Detection of Preneoplastic Lesions: a Randomized Study
  Fred R. Hirsch, Sheila A. Prindiville, York E. Miller, Wilbur A. Franklin, Edward C. Dempsey, James Murphy, Paul A. Bunn, Timothy C. Kennedy> ;Journal of the National Cancer Institute. 2001 Sep 19
• 56 citations
  Review of Recent Advances in Fluorescence Bronchoscopy in Early Localization of Central Airway Lung Cancer
  Timothy C. Kennedy, Stephen Lam, Fred R. Hirsch> ;The Oncologist. 2001 Jun 1
• 117 citations
  Angiogenic Squamous Dysplasia in Bronchi of Individuals at High Risk for Lung Cancer
  Robert L. Keith, York E. Miller, Robert M. Gemmill, Harry A. Drabkin, Edward C. Dempsey, Timothy C. Kennedy, Sheila A. Prindiville, Wilbur A. Franklin> ;Clinical Cancer Research. 2000 May 1
• 32 citations
  Screening for lung cancer revisited and the role of sputum cytology and fluorescence bronchoscopy in a high-risk group
  Timothy C. Kennedy, York E. Miller, Sheila Prindiville> ;Chest. 2000 Apr 1
• 23 citations
  Efficacy of two sputum collection techniques in patients with air flow obstruction.
  Timothy C. Kennedy, Susan P. Proudfoot, Steven Piantadosi, Lee Wu, Geno Saccomanno, Thomas L. Petty, Melvyn S. Tockman> ;Acta Cytologica. 1999 Jul 1
• 356 citations
  Localization of Bronchial Intraepithelial Neoplastic Lesions by Fluorescence Bronchoscopy
  Stephen Lam, Timothy C. Kennedy, Michael Unger, York E. Miller, David Gelmont, Valerie W. Rusch, Bruce Gipe, David Howard, Jean C. LeRiche, Andrew Coldman, Adi F. Gazdar> ;Chest. 1998 Mar 1
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Journal Articles

• The Detection of Chromosomal Aneusomy by Fluorescence in Situ Hybridization in Sputum Predicts Lung Cancer Incidence  
  Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin,X, Hirsch FR, Kennedy TC, Keith RL, Baron AE, Belinsky SA, Miller YE, Byers, T, Franklin WA, Cancer Prevention Research, 1/1/2010
• Sputum Cytologic Atypia Predicts Incident Lung Cancer: Defining Latency and Histologic Specificity  
  Byers, T., Wolf, H.J., Franklin W.A., Braudrick, S., Merrick, D.T., Shroyer, K.R., Hirsch, F.R., Zeng, C., Baron, A.E., Bunn, P.A., Miller, Y.E., Timothy C. Kennedy, Cancer Epidemiology Biomarkers Prevention, 1/1/2008
• Bronchial Epithelial Ki-67 Index Is Related to Histology, Smoking and Gender, but Not Lung Cancer or Chronic Obstructive Pulmonary Disease  
  Miller YE, Blatchford P, Hyun DS, Keith RL, Kennedy TC, Wolf H, Byers T, Bunn PA Jr., Lewis MT, Franklin WA, Hirsch FR, Kittelson J., Cancer Epidemiology Biomarkers Prevention, 1/1/2007
• Bronchial Intraepithelial Neoplasia/early Central Airways Lung Cancer: ACCP Evidence-based Clinical Practice Guidelines  
  Timothy C. Kennedy, Annette McWilliams, Eric Edell,, Tom Sutedja, Gordon Downie, Rex Yung, Adi Gazdar, and Praveen N. Mathur, Chest, 1/1/2007
• Spectral Karyotyping Detects Chromosome Damage in Bronchial Cells of Smokers and Patients with Cancer  
  Marileila Vareilla-Garcia, Lin Chen, Roger L Powel, Fred R. Hirsch, Timothy C. Kennedy, Robert Keith, York E. Miller, John D. Mitchell, Wilbur A. Franklin, American Journal of Respiratory and Critical Care Medicine, 1/1/2007
• Lack of Association between Sputum Atypia and Chronic Obstructive Pulmonary Disease Mortality  
  Miller, Y.E., Vu, K.O., Kennedy, T.C., Hirsch, F.R., Petty, T.L., Bunn, P.A., Keith, R.L., Franklin, W.A., Wolf, H.J., Prindville, S., Byers, T., J. Thoracic Oncology, 1/1/2006
• High Prevalence of Occult Endobronchial Malignancy in High Risk Patients with Moderate Sputum Atypia  
  Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA Jr., Miller YE., Lung Cancer, 1/1/2005
• Multi-target Interphase Fluorescence in Situ Hybridization Assay Increases Sensitivity of Sputum Cytology as a Predictor of Lung Cancer  
  Varella-Garcia M, Kittelson J, Schulte AP, Vu KO, Wolf HJ, Zeng C, Hirsch FR, Byers T, Kennedy T, Miller YE, Keith RL, Franklin WA, Cancer Detect Prev, 1/1/2004
• Angiogenic Activity in Bronchial Dysplasia and Invasive Lung Cancer: Features of Vascular Endothelial Growth Factor (VEGF) Expression  
  Merrick DT, Haney J, Sugita M, Keith RL, Kennedy TC, Miller YE, Franklin WA, Lung Cancer Supplement, 1/1/2003
• Angiogenic Squamous Dysplasia (ASD): A Biomarker Highly Associated with Squamous Cell Lung Carcinoma  
  Keith RL, Miller YE, Kennedy TC, Hirsch FR, Kittelson J, Bunn PA, Kelly K, Franklin WA, Lung Cancer Supplement, 1/1/2003
• Fluorescence versus White-light Bronchoscopy for Detection of Pre-neoplastic Lesions: A Randomized Study  
  Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA, Jr, Kennedy TC, J National Cancer Institute, 1/1/2001
• Screening for Lung Cancer Revisited and the Role of Sputum Cytology and Fluorescence Bronchoscopy in a High Risk Group  
  Kennedy TC, Prindiville SA, Miller Y, Chest, 1/1/2000
• Angiogenic Squamous Dysplasia in Bronchi of Patients at High Risk for Lung Cancer  
  Keith RL, Miller YE, Gemmill R, Dempsey EC, Kennedy TC, Franklin WA, Clinical Cancer Research, 1/1/2000
• Efficacy of Two Sputum Collection Techniques in Patients with Air Flow Obstruction  
  Kennedy TC, Proudfoot SP, Piantadosi S, Wu L, Saccomanno G, Petty TL, Tockman MS, Acta Cytologica, 1/1/1999
• Localization of Bronchial Intraepithelial Neoplastic Lesions by Fluorescence Bronchoscopy  
  Lam S, Kennedy TC, Unger M, Miller YE, Gelmont D, Rusch V, Gipe, B, Howard D, LeRiche JC, Coldman A, Gazdar AF, Chest, 1/1/1998
• Widely Dispersed p53 Mutation in Respiratory Epithelium A Novel Mechanism for Field Carcinogenesis  
  Franklin WA, Gazdar AF, Haney J, Wistuba II, LaRosa FG, Kennedy TC, Ritchey DM, Miller YE, Journal of Clinical Investigation, 1/1/1997
• Airflow Obstructed Patients with Significant Smoking Histories Show High Prevalence of Sputum Cellular Dysplasia  
  Kennedy, TC. Proudfoot S., Franklin W, Saccomanno G, Miller Y., Chest, 1/1/1996
• Expansion of Bronchial Epithelial Cell Populations by in Vitro Culture of Explants from Dysplastic and Histologically Normal Sites  
  Franklin WA, Folkvord JM, Varella-Garcia M, Kennedy TC, Proudfoot S, Cook R, Dempsey EC, Helm K, Bunn PA, Miller YE., American Journal Respiratory and Cellular Biology, 1/1/1996
• Expression of Epidermal Growth Factor Receptor, Neural Cell Adhesion Molecule, Ki-67 and Transferrin Receptor by Dysplastic Bronchial Epithelium  
  Franklin WA, Kennedy TC, Miller Y, Meyer A, Folkvoord J, Garza-Williams S, Parks T, Bunn P., Internation Journal of Cancer, 1/1/1996
• Characterization of Epithelia Cells Cultured from Human Endobronchial Explants  
  FranklinWA, Folkvord J, Kennedy TC, Lung Cancer, 1/1/1994
• Characterization of Apparently Normal Tissue Adjacent to Suspicious Lesions Identified under Fluorescence Bronchoscopy  
  Kennedy TC, Franklin WA, Cook, R, Proudfoot S, Lung Cancer, 1/1/1994
• Establishment of Regional Screening System to Identify Dysplastic Patients for SPORE Lung Cancer Trials  
  Lung Cancer, 1/1/1994
• Establishment of Regional Sputum Screening System to Identify Dysplastic Patients for SPORE Lung Cancer Trials  
  TC Kennedy, Proudfoot S, Franklin W, 7th World Conference of the International Association for the Study of Lung Cancer, 1/1/1994
• Characterization of Apparently Normal Tissue Adjacent to Suspicious Lesions Identified under Fluorescence Bronchoscopy  
  TC Kennedy, Schwartz JS, Franklin W, Cook R, 7th World Conference of the International Association for the Study of Lung Cancer, NCI SPORE in Lung Cancer , 1/1/1994
• Pulmonary Hypertension Associated with Long Term Inhalation of "Crank" Methamphetamine  
  Schaiberger PH, Kennedy, TC, Miller, FC, Gal, J, Petty TL, Chest, 1/1/1993
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Books/Book Chapters

• Current Therapy of Internal Medicine 
  Chapter: High Altitude Diseases 
  Editors: Kassirer.Edition 3.0,1991
• Current Therapy of Respiratory Diseases 
  Chapter: High Altitude Diseases 
  Editors: Cherniak, RM.Edition 3.0,1989

Abstracts/Posters

• Very Low Sepsis Mortality with Aggressively Implemented Goal-directed Sepsis Bundle Program by 24 Hour On-site Critical Care Service in a Community Teaching Hospital
  Timothy C. Kennedy, Michele Kilbourne, Howard Shapiro, Elizabeth Aronsen, Andras Bodoni, Timothy Clark, Juliana Sutarik, Eric Yeager, Jeffery Schwartz, American Thoracic Society International Conference, Toronto, Canada, 1/1/2008
• Structural and Numerical Chromosomal Abnormalities in Bronchial Cells from Heavy Smokers
  Varella-Garcia M., Chen, L., Chan, Z., Baron, A., Hirsch, F.R., Kennedy, T.C., Keith, R.L., Miller, Y.E., Mitchell, J., Franklin, W.A., Lung Cancer SPORE Winter Meeting Proceedings, 1/1/2006
• Endobronchial CIS: Aneuploidy Reflects Natural History of Untreated Lesions
  Miller, Y.E., Varella-Garcia, M., Jonsson S., Keith R.L., Hirsch, F.R., Merrick D.T., Kennedy, T.C., Franklin W.A., Lung Cancer SPORE Winter Meeting Proceedings, 1/1/2006
• Ki67 Bronchial Epithelial Proliferation Rate and Lung Cancer Risk
  Miller YE, Hyun DS, Blatchford P, Lewis M, Kennedy TC, Keith RL, Wolf H, Franklin WA, Kittelson, J, Hirsch FR, 11th World Congress on Lung Cancer, Lung Cancer Supplement, 11th World Conference on Lung Cancer, Barcelona, Spain, 1/1/2005
• Elevated Vascular Endothelial Growth Factor Expression in Bronchial Dysplasia Demonstrated by Quantitative RNA Analysis
  Merrick DT, Haney J, Sugita M, Miller Y, Keith R, Kennedy T, Franklin WA, Lung Cancer, 1/1/2005
• High Prevalence of Endobronchial Malignancy in High-risk Patients Who Have Moderate Dysplasia in Sputum
  Kennedy TC, Franklin WA, Keith RL, Hirsch FR, Merrick TA, Shroyer K, Petty TL, Byers T, Bunn PA Jr, Miller YE, Lung Cancer Supplement, 1/1/2003
• Aberrant DNA Methylation and Sputum Atypia Predict Lung Cancer- Preliminary Report from the University of Colorado Lung Cancer SPORE High Risk Cohort Study
  Hirsch FR, Belinski SA, Kennedy TC, Miller YE, Franklin WA, Wolf HJ, Bunn PA, Byers T, Lung Cancer Supplement, 1/1/2003
• Micropapillary Squamous Metaplasia/dysplasia: A Lesion Reflecting Angiogenesis in Bronchial Mucosa of Smokers
  Franklin WA, Kennedy TC, Dempsey EJ, Miller YE, 1/1/1998
• A Regional Pulmonary Network to Collect Pre-neoplastic Specimens in High Risk Subjects for Lung Cancer. Sputum and Fluorescent Bronchoscopy Specimens
  TC Kennedy & Proudfoot S, 1st Annual SPORE Lung Cancer Meeting: NCI, Reston Virginia, 1/1/1993
• Two Sputum Collection Techniques for Evaluation of Sputum Cytology
  TC Kennedy, Proudfoot S, Saccomanno G, Symposium: Innovations in Mulitimodality Therapy for Lung Cancer, Denver, Colorado, 1/1/1992
• Comparison of Early Morning Cough with Induced Sputum Technique for the Purposes of Evaluating Sputum Cytology
  TC Kennedy, Proudfoot S, Petty TL, Saccomanno G, American Thoracic Society, Annual Meeting, Miami, Florida, 1/1/1992
• Natural History of Untreated Endobronchial Carcinoma in Situ
  Miller YE, Keith RL, Franklin WA, Dempsey EC, Hirsch FR, Kennedy TC, 11th World Congress on Lung Cancer, Lung Cancer Supplement, Barcelona, Spain, 1/3./2005
• Evaluation of Bronchial Histology as an Endpoint in a Phase II Chemoprevention Trial of 13-Cis Retinoic Acid
  Kittelson JM, Kelly KK, Lambert-Kerzner A, Hirsch FR, Franklin W, Keith RL, Kennedy TC, Miller YE, Bunn PA Jr, Winter Lung Spore Meeting, Pittsburg, PA, 1/13/2004
• Morphologic and Genetic Abnormalities in the Bronchial Epithelium of High Risk Smokers
  Keith RL, Varella-Garcia M, Gemmill RM, Haney J, Fox MW, Anderson JS, Wiest J, Otstott T, Kennedy TC, Miller Y, Franklin WA, ALA/ATS International Conference, 1/28/1998
• Fluorescence Bronchoscopy Compared to White Light Bronchoscopy in the Detection of High Grade Bronchial Dysplasia
  Prindiville S, Miller Y, Cook R, Dempsey E, Franklin W, Kelly K, Folkvord J, Proudfoot S and Kennedy TC, Am Assoc Can Res Annual Meeting, 1/28/1998
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Other

• Interpretation of Arterial Blood Gas Software 
  C. Oxentenco, J. O. Broughton, T. C. Kennedy, P. Corsello, Computerized Pulmonary Services
  1/1/1978