TimothyYeatmanMD

Colon & Rectal Surgery, Hepatobiliary Surgery, Surgical Oncology (Other than Breast)

Director and President Gibbs Cancer Center & Research Institute Founding President and Chief Scientific Officer Guardian Research Network

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Office
101 E Wood St
3rd Floor
Spartanburg, SC 29303
Phone+1 813-745-7292

Fax+1 813-745-7204
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Education & Training

University of Texas Health Science Center at Houston/M D Anderson Cancer CenterFellowship, Hematology and Medical Oncology, 1990 - 1992
University of FloridaResidency, Surgery, 1984 - 1990
Emory University School of MedicineClass of 1984

Certifications & Licensure

FL State Medical License 1985 - 2025
UT State Medical License 2018 - 2024
SC State Medical License 2012 - 2019
TX State Medical License 1991 - 1992
AL State Medical License 1990 - 1990

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
James IV Travelling Scholar James IVth Association, 2001
British Journal of Surgery Lectureship British J of Surgery, 2000
Fellow (FACS) American College of Surgeons
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Clinical Trials

Lymphatic Mapping and Sentinel Lymph Node Biopsy in the Treatment of Colorectal Cancer Start of enrollment: 1999 Jun 01
Completed
Not Applicable

Publications & Presentations

PubMed

61 citations
Evaluation of cell-free DNA approaches for multi-cancer early detection.
Arash Jamshidi, Minetta C Liu, Eric A Klein, Oliver Venn, Earl Hubbell, John F Beausang, Samuel Gross, Collin Melton, Alexander P Fields, Qinwen Liu, Nan Zhang, Eric T...> ;Cancer Cell. 2022 Dec 12
2 citations
Ras Pathway Activation and MEKi Resistance Scores Predict the Efficiency of MEKi and SRCi Combination to Induce Apoptosis in Colorectal Cancer.
Thomas Benjamin Davis, Shilpa Gupta, Mingli Yang, Lance Pflieger, Malini Rajan, Heiman Wang, Ramya Thota, Timothy J Yeatman, Warren Jackson Pledger> ;Cancers. 2022 Mar 11
7 citations
APC and TP53 Mutations Predict Cetuximab Sensitivity across Consensus Molecular Subtypes
Ramya Thota, Mingli Yang, Lance Pflieger, Michael J. Schell, Malini Rajan, Thomas B. Davis, Heiman Wang, Angela P. Presson, Warren Jack Pledger, Timothy J. Yeatman> ;Cancers. 2021 Oct 27
2 citations
Impact of rurality on melanoma diagnosis in Utah.
Tawnya L. Bowles, Carol Sweeney, John Snyder, Jesse Gygi, Brad Bott, Daniel Wray, Timothy J. Yeatman, William T. Sause> ;Melanoma Management. 2021 Mar 4
30 citations
Telehealth Is a Sustainable Population Health Strategy to Lower Costs and Increase Quality of Health Care in Rural Utah.
Ramya Thota, David Gill, Jamie Brant, Timothy J. Yeatman, Derrick S. Haslem> ;JCO Oncology Practice. 2020 May 28
Assessment of Treatment Cost-effectiveness Using a Colorectal Cancer Mutation Profile
Timothy J. Yeatman, Michael J. Schell, William T. Sause> ;JAMA Network Open. 2020 Mar 2
8 citations
PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC
Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger> ;Oncotarget. 2019 Nov 26
12 citations
Repurposing EGFR Inhibitor Utility in Colorectal Cancer in Mutant APC and TP53 Subpopulations
Mingli Yang, Michael J. Schell, Andrey Loboda, Michael Nebozhyn, Jiannong Li, Jamie K. Teer, W. Jack Pledger, Timothy J. Yeatman> ;Cancer Epidemiology, Biomarkers & Prevention. 2019 Apr 23
1 citations
Whole Genome Sequencing Analysis of a Stage IV Colon Cancer Patient with a 10-Year Disease-Free Survival following Systemic Chemotherapy/Bevacizumab.
Timothy J. Yeatman, Mingli Yang, Domenico Coppola> ;Case Reports in Gastroenterology. 2018 Nov 28
16 citations
PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation
Thomas B. Davis, Mingli Yang, Michael J. Schell, Heiman Wang, Le Ma, W. Jack Pledger, Timothy J. Yeatman> ;Scientific Reports. 2018 Jun 18
290 citations
lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling
Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L. Franklin, Jing Wang, Huaying Hu, Tian-Ying Wei, Mingli Yang, Tim...> ;Nature Medicine. 2017 Oct 16
33 citations
Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.
Cunxi Li, Bhuminder Singh, Ramona Graves-Deal, Haiting Ma, Alina Starchenko, William Fry, Yuanyuan Lu, Yang Wang, Galina Bogatcheva, Mohseen P. Khan, Ginger L. Milne, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 4
20 citations
Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer
Bernard Omolo, Mingli Yang, Fang Yin Lo, Michael J. Schell, Sharon Austin, Kellie Howard, Anup Madan, Timothy J. Yeatman> ;BMC Medical Genomics. 2016 Oct 19
40 citations
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer.
Yajuan Li, Mattia Lauriola, Donghwa Kim, Mirko Francesconi, Gabriele D'Uva, Dave Shibata, Mokenge P. Malafa, Timothy J. Yeatman, Domenico Coppola, Rossella Solmi, Jin ...> ;Oncogene. 2016 Sep 1
143 citations
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
Michael J. Schell, Mingli Yang, Jamie K. Teer, Fang Yin Lo, Anup Madan, Domenico Coppola, Alvaro N.A. Monteiro, Michael Nebozhyn, Binglin Yue, Andrey Loboda, Gabriel A...> ;Nature Communications. 2016 Jun 15
29 citations
A composite gene expression signature optimizes prediction of colorectal cancer metastasis and outcome
Michael J. Schell, Mingli Yang, Edoardo Missiaglia, Mauro Delorenzi, Charlotte Soneson, Binglin Yue, Michael Nebozhyn, Andrey Loboda, Gregory C. Bloom, Timothy J. Yeatman> ;Clinical Cancer Research. 2016 Feb 1
19 citations
Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil
Victoria L. Bryant, Roy M. Elias, Susan McCarthy, Timothy J. Yeatman, Mark G. Alexandrow> ;Molecular Cancer Research. 2015 Sep 1
33 citations
Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era.
Richard D. Kim, Michael J. Schell, Jamie K. Teer, Danielle M. Greenawalt, Mingli Yang, Timothy J. Yeatman> ;Plos One. 2015 May 14
37 citations
Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation.
Nishi Kothari, Richard B. Kim, Robert N. Jorissen, Jayesh Desai, Jeanne Tie, Hui-Li Wong, Ian Farragher, Ian T. Jones, Fiona Day, Shan Li, Anuratha Sakthinandeswaren, ...> ;Acta Oncologica. 2015 Mar 22
36 citations
A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary m...
Jennifer Permuth-Wey, Y. Ann Chen, Kate Fisher, Susan McCarthy, Xiaotao Qu, Mark C. Lloyd, Agnieszka Kasprzak, Michelle Fournier, Vonetta L. Williams, Kavita M. Ghia, ...> ;Plos One. 2015 Jan 21
21 citations
Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas.
Domenico Coppola, Lodovico Balducci, Dung-Tsa Chen, Andrey Loboda, Michael Nebozhyn, Aileen Staller, William J. Fulp, William S. Dalton, Timothy J. Yeatman, Steven Brem> ;Journal of Geriatric Oncology. 2014 Oct 1
22 citations
Comparison of KRAS mutation analysis of colorectal cancer samples by standard testing and next-generation sequencing.
Nishi Kothari, Michael J. Schell, Jamie K. Teer, Timothy J. Yeatman, David Shibata, Richard Kim> ;Journal of Clinical Pathology. 2014 Sep 1
58 citations
MicroRNA-147 Induces a Mesenchymal-To-Epithelial Transition (MET) and Reverses EGFR Inhibitor Resistance
Chang Gong Lee, Susan McCarthy, Mike Gruidl, Cindy R. Timme, Timothy J. Yeatman> ;Plos One. 2014 Jan 15
28 citations
Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells
Cindy R. Timme, Mike Gruidl, Timothy J. Yeatman> ;Apoptosis. 2013 Jul 26
69 citations
miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular carcinoma.
J. M. Hernandez, A. Elahi, C. W. Clark, Jia-Wang Wang, L. A. Humphries, Barbara A. Centeno, G.C. Bloom, Bryan C. Fuchs, Timothy J. Yeatman, David Shibata> ;Annals of Surgical Oncology. 2013 Jul 18
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Lectures

Leveraging the integrated EHR for trial matching across a nationwide network.
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/25/2020

Press Mentions

Intermountain Cancer Care Is Praised and New Cancer Answers Hotline LaunchedNovember 13th, 2019
Gibbs Cancer Center and Research Institute Taking on State-of-the-Art AppearanceAugust 25th, 2019
Groundbreaking for Cancer Research Center in GreerMay 18th, 2016
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