ToddShaneCrocenziMD

Director of gastrointestinal oncology research at the Robert W. Franz Cancer Research Center principal investigator with the Columbia River Oncology Program

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Office
4805 Ne Glisan St
6n40
Portland, OR 97213
Phone+1 503-215-5696

Fax+1 503-215-5695
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Education & Training

Dartmouth-Hitchcock/Mary Hitchcock Memorial HospitalFellowship, Hematology and Medical Oncology, 2001 - 2004
University of MarylandResidency, Internal Medicine, 1994 - 1997
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1994

Certifications & Licensure

PA State Medical License Current
OR State Medical License 2005 - 2024

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2009-2013
Portland Monthly Magazine Castle Connolly, 2011
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Clinical Trials

Anti-OX40, Cyclophosphamide (CTX) and Radiation in Patients With Progressive Metastatic Prostate Cancer Start of enrollment: 2010 Oct 14
Completed
Phase 1
Study of Imprime PGG® in Combination With Cetuximab in Subjects With Recurrent or Progressive KRAS Wild Type Colorectal Cancer Start of enrollment: 2011 Apr 01
Terminated
Phase 3
Immunochemoradiotherapy in Patients With Pancreatic Cancer Start of enrollment: 2011 Jan 01
Completed
Phase 1
Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma. Start of enrollment: 2011 Jul 01
Active, not recruiting
Phase 2
Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C) Start of enrollment: 2013 Sep 01
Completed
Phase 2
Chemoimmunotherapy and Radiation in Pancreatic Cancer Start of enrollment: 2013 Jul 01
Completed
Phase 1
Combination Vaccine Immunotherapy (DRibbles) for Patients With Definitively-Treated Stage III Non-small Cell Lung Cancer Start of enrollment: 2013 Jul 01
Completed
Phase 2
Phase I Study of Safety and Immunogenicity of ADU-623 Start of enrollment: 2014 Jan 08
Completed
Phase 1
Safety and Efficacy of Combination Listeria/GVAX Pancreas Vaccine in the Pancreatic Cancer Setting Start of enrollment: 2014 Feb 05
Completed
Phase 2
Immunoscore in Rectal Cancer Start of enrollment: 2014 Jan 24
Completed
A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread Start of enrollment: 2014 Mar 12
Active, not recruiting
Phase 2
Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma Start of enrollment: 2014 May 08
Completed
Phase 1
α-TEA in Advanced Cancer Start of enrollment: 2014 Aug 04
Completed
Phase 1
Pilot Study of DRibble Vaccine for Prostate Cancer Patients Start of enrollment: 2014 Oct 24
Completed
Phase 1
Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma Start of enrollment: 2014 Oct 01
Completed
Phase 1
ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer Start of enrollment: 2016 Mar 24
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848.
Leila T Tchelebi, Kathryn A Winter, Ross A Abrams, Howard P Safran, William F Regine, Susan McNulty, Abraham Wu, Kevin L Du, Samantha A Seaward, Shelly X Bian, Raid Al...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Jan 1
1 citations
ASO Visual Abstract: Drug-Eluting Beads with Irinotecan Therapy of Unresectable Intrahepatic Cholangiocarcinoma (DELTIC) with Concomitant Systemic Gemcitabine and Cisp...
Robert C G Martin 2nd, Kerri A Simo, Paul Hansen, Flavio Rocha, Prejesh Philips, Kelly M McMasters, Clifton M Tatum, Lawrence R Kelly, Michael Driscoll, Vivek R Sharma...> ;Annals of Surgical Oncology. 2022 Sep 1
14 citations
Drug-Eluting Bead, Irinotecan Therapy of Unresectable Intrahepatic Cholangiocarcinoma (DELTIC) with Concomitant Systemic Gemcitabine and Cisplatin.
Robert C G Martin 2nd, Kerri A Simo, Paul Hansen, Flavio Rocha, Prejesh Philips, Kelly M McMasters, Clifton M Tatum, Lawrence R Kelly, Michael Driscoll, Vivek R Sharma...> ;Annals of Surgical Oncology. 2022 Sep 1
97 citations
TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking.
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel E Fox, Michaela Phillips, Alejandro F Alice, Tiffany C. Blair, Mark H. Whiteford, David P. O'Brien, Reha...> ;Nature Communications. 2020 Apr 9
63 citations
Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer.
Takahiro Tsujikawa, Todd S. Crocenzi, Jennifer N. Durham, Elizabeth A. Sugar, Annie A. Wu, Beth Onners, Julie M. Nauroth, Robert A. Anders, Elana J. Fertig, Daniel A. ...> ;Clinical Cancer Research. 2020 Jul 15
500 citations
Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164
Dung T. Le, Tae Won Kim, Eric Van Cutsem, Ravit Geva, Dirk Jäger, Hiroki Hara, Matthew Burge, Bert H. O'Neil, Petr Kavan, Takayuki Yoshino, Rosine Guimbaud, Hiroya Tan...> ;Journal of Clinical Oncology. 2020 Jan 1
130 citations
Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic...
Dung T. Le, Vincent J. Picozzi, Andrew H. Ko, Zev A. Wainberg, Hedy L. Kindler, Andrea Wang-Gillam, Paul E. Oberstein, Michael A. Morse, Herbert J. Zeh, Colin D. Weeke...> ;Clinical Cancer Research. 2019 Sep 15
98 citations
Expert Consensus Document on Pulmonary Metastasectomy.
John R. Handy, Ross M. Bremner, Todd S. Crocenzi, Frank C. Detterbeck, Hiran C. Fernando, Panos Fidias, Scott Firestone, Candice Johnstone, Michael Lanuti, Virginia R....> ;The Annals of Thoracic Surgery. 2019 Feb 1
13 citations
Safety and antitumor activity of pembrolizumab in patients with advanced microsatellite instability–high (MSI-H) colorectal cancer: KEYNOTE-164
Dung T. Le, Petr Kavan, Tae Hwan Kim, Matthew Burge, E. Van Cutsem, Hiroki Hara, Patrick McKay Boland, J.-L. Van Laethem, Ravit Geva, Hiroya Taniguchi, Todd S. Crocenz...> ;Annals of Oncology. 2018 Jun 1
4213 citations
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Dung T. Le, Jennifer N. Durham, Kellie N. Smith, Hao Wang, Bjarne Bartlett, Laveet K. Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon Luber, Fay Wong, Nilofer S...> ;Science. 2017 Jul 28
2731 citations
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
Anthony B. El-Khoueiry, Bruno Sangro, Thomas Yau, Todd S. Crocenzi, Masatoshi Kudo, Chiun Hsu, Tae You Kim, Su Pin Choo, Jörg Trojan, Theodore H. Welling, Tim Meyer, Y...> ;Lancet. 2017 Jun 24
74 citations
A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic...
Todd S. Crocenzi, Benjamin Cottam, Pippa Newell, Ronald F. Wolf, Paul D. Hansen, Chet W. Hammill, Matthew C. Solhjem, Yue-Yun To, Amy Greathouse, Garth W. Tormoen, Zel...> ;Journal for Immunotherapy of Cancer. 2016 Aug 16
2 citations
Comparison of local reactions to oxaliplatin infusions by peripheral versus central venous administration
Yue-Yun To, Kimberly J Sutcliffe, Helena M. Hoen, Ramona A Swaney, Justin D Nicholls, Todd S. Crocenzi> ;Journal of Oncology Pharmacy Practice. 2016 Apr 1
95 citations
Randomized controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver-limited metastasis.
Robert C.G. Martin, Charles R. Scoggins, Marshall T. Schreeder, William S. Rilling, Christopher J. Laing, Clifton M. Tatum, Lawrence R. Kelly, Ricardo Garcia-Monaco, V...> ;Cancer. 2015 Oct 15
2357 citations
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, Hao Wang, Bjarne R Bartlett, Holly Kemberling, Aleksandra D Eyring, Andrew D Skora, Brandon S Luber, Nilofer S Azad, Dan Laheru, Barbara Bi...> ;The New England Journal of Medicine. 2015 Jun 25
398 citations
Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer
Dung T. Le, Andrea Wang-Gillam, Vincent J. Picozzi, Tim F. Greten, Todd S. Crocenzi, Gregory M. Springett, Michael A. Morse, Herbert J. Zeh, Deirdre Jill Cohen, Robert...> ;Journal of Clinical Oncology. 2015 Apr 20
12 citations
A phase II, randomized, double blind trial of calcium aluminosilicate clay versus placebo for the prevention of diarrhea in patients with metastatic colorectal cancer ...
Bryan K. Kee, Jeffrey S. Morris, Rebecca Slack, Todd Crocenzi, Lucas Wong, Ben Esparaz, Michael J. Overman, Katrina Y. Glover, Desiree Jones, Sijin Wen, Michael J. Fisch> ;Supportive Care in Cancer. 2015 Jan 1
74 citations
Durable responses and reversible toxicity of high-dose interleukin-2 treatment of melanoma and renal cancer in a Community Hospital Biotherapy Program
Roxanne Payne, Lyn A. Glenn, Helena M. Hoen, Beverley Richards, Robert Lufkin, Todd S. Crocenzi, Walter J. Urba, Brendan D. Curti> ;Journal for Immunotherapy of Cancer. 2014 May 14
343 citations
OX40 is a potent immune-stimulating target in late-stage cancer patients.
Brendan D. Curti, Magdalena Kovacsovics-Bankowski, Nicholas P. Morris, Edwin B. Walker, Lana Chisholm, Kevin Floyd, Joshua M. Walker, Iliana Gonzalez, Tanisha Meeuwsen...> ;Cancer Research. 2013 Dec 15
86 citations
A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resec...
Michael A. Morse, Donna Niedzwiecki, John L. Marshall, Christopher R. Garrett, David Z. Chang, Mebea Aklilu, Todd S. Crocenzi, David J. Cole, Sophie Dessureault, Amy H...> ;Annals of Surgery. 2013 Dec 1
23 citations
A phase II study of bevacizumab and high-dose interleukin-2 in patients with metastatic renal cell carcinoma: a Cytokine Working Group (CWG) study.
Uday B. Dandamudi, Musie Ghebremichael, Jeffrey A. Sosman, Joseph I. Clark, David F. McDermott, Michael B. Atkins, Janice P. Dutcher, Walter J. Urba, Meredith M. Regan...> ;Journal of Immunotherapy. 2013 Nov 1
3 citations
Circulating and intratumoral macrophages in patients with hepatocellular carcinoma: Correlation with therapeutic approach
Pippa Newell, Ben Cottam, Talicia Savage, Chet W. Hammill, Ronald L. Wolf, Carlo Bifulco, Hong D. Xiao, Todd S. Crocenzi, Paul D. Hansen, Marka R. Crittenden, Michael ...> ;American Journal of Surgery. 2013 May 1
A dendritic cell-based vaccine effects on T-cell responses compared with a viral vector vaccine when administered to patients following resection of colorectal metasta...
Lyerly HK, Hobeika A, Niedzwiecki D, Osada T, Marshall J, Garrett CR, Chang DZ, Aklilu M, Crocenzi TS, Cole DJ, Dessureault S, Hsu SD, Bulusu A, Clary BM, Annechiarico...> ;J. Clin. Oncol.. 2011-05-20
Survival rates among patients vaccinated following resection of colorectal cancer metastases in a phase II randomized study compared with contemporary controls.
Morse M, Niedzwiecki D, Marshall J, Garrett CR, Chang DZ, Aklilu M, Crocenzi TS, Cole DJ, Dessureault S, Hobeika A, Osada T, Clary BM, Hsu SD, Devi G, Bulusu A, Annech...> ;J. Clin. Oncol.. 2011-05-20
14 citations
Cytokine Working Group Study of Lymphodepleting Chemotherapy, Interleukin-2, and Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Metastatic Melanoma:...
Krishna S Gunturu, Kenneth R. Meehan, Todd A. MacKenzie, Todd S. Crocenzi, David F. McDermott, Edward J. Usherwood, Kim Margolin, Nancy A. Crosby, Michael B. Atkins, M...> ;Journal of Clinical Oncology. 2010 Mar 1
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