TsungHLinMD

PubMed

• 38 citations
  Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
  Brian S. Gerstenberger, Catherine M. Ambler, Eric P. Arnold, Mary-Ellen Banker, Matthew Frank Brown, James D. Clark, Alpay Dermenci, Martin E. Dowty, Andrew Fensome, S...> ;Journal of Medicinal Chemistry. 2020 Aug 25
• 5 citations
  Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences.
  Brian S. Gerstenberger, Mary Ellen Banker, James D. Clark, Martin E. Dowty, Andrew Fensome, Roger S. Gifford, Matthew C. Griffor, Martin Hegen, Brett D. Hollingshead, ...> ;Scientific Reports. 2020 Jun 2
• 7 citations
  Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1
  Andrew Fensome, Catherine M. Ambler, Eric P. Arnold, Mary Ellen Banker, James D. Clark, Martin E. Dowty, Ivan Viktorovich Efremov, Andrew C. Flick, Brian S. Gerstenber...> ;Bioorganic & Medicinal Chemistry. 2020 May 15
• 57 citations
  Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition
  Martin E. Dowty, Tsung H. Lin, Michael I. Jesson, Martin Hegen, David Martin, Vaibhav Katkade, Sujatha Menon, Jean-Baptiste Telliez> ;Pharmacology Research & Perspectives. 2019 Nov 15
• 57 citations
  PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.
  Hua Xu, Michael I. Jesson, Uthpala Seneviratne, Tsung H. Lin, M Nusrat Sharif, Liang Xue, Chuong Nguyen, Robert A. Everley, John I. Trujillo, Douglas S. Johnson, Gary ...> ;ACS Chemical Biology. 2019 May 13
• 98 citations
  Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino...
  Andrew Fensome, Catherine M. Ambler, Eric P. Arnold, Mary Ellen Banker, Matthew Frank Brown, Jill Chrencik, James D. Clark, Martin E. Dowty, Ivan Viktorovich Efremov, ...> ;Journal of Medicinal Chemistry. 2018 Aug 16
• 85 citations
  Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Tr...
  Michael L. Vazquez, Neelu Kaila, Strohbach Joseph Walter, John David Trzupek, Matthew Frank Brown, Mark Edward Flanagan, Mark J. Mitton-Fry, Johnson Timothy Allan, Ten...> ;Journal of Medicinal Chemistry. 2018 Jan 23
• 63 citations
  Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
  Tsung H. Lin, Martin Hegen, Elizabeth Quadros, Cheryl Nickerson-Nutter, Kenneth C. Appell, Andrew G. Cole, Yuefei Shao, Steve Tam, Michael Ohlmeyer, Bojing Wang, Debra...> ;Arthritis and Rheumatism. 2010 Aug 1
• 11 citations
  2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
  Andrew G. Cole, Adolph Bohnstedt, Vidyadhar M. Paradkar, Celia Kingsbury, Jorge Quintero, Haengsoon Park, Yingchun Lu, Ming You, Irina Neagu, David J. Diller, Jeffrey ...> ;Bioorganic & Medicinal Chemistry Letters. 2009 Dec 1
• 22 citations
  Cell Cycle Progression Following Naive T Cell Activation Is Independent of Jak3/Common γ-Chain Cytokine Signals
  Min Shi, Tsung H. Lin, Kenneth C. Appell, Leslie J. Berg> ;Journal of Immunology. 2009 Oct 1
• 97 citations
  Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.
  Min Shi, Tsung H. Lin, Kenneth C. Appell, Leslie J. Berg> ;Immunity. 2008 Jun 13
• 6 citations
  Identification and characterization of small-molecule inhibitors of Tie2 kinase.
  Jinqi Liu, Tsung H. Lin, Andrew G. Cole, Rong Wen, Lian Zhao, Marc Raleigh Brescia, Biji Jacob, Zahid Hussain, Kenneth C. Appell, Ian Henderson, Maria L. Webb> ;FEBS Letters. 2008 Mar 5
• 11 citations
  Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.
  Tsung H. Lin, Axel Metzger, David J. Diller, Madhuri Desai, Ian Henderson, Gulzar Ahmed, Earl F. Kimble, Elizabeth Quadros, Maria L. Webb> ;The Journal of Pharmacology and Experimental Therapeutics. 2006 Aug 1
• 3 citations
  Successful screening of large encoded combinatorial libraries leading to the discovery of novel p38 MAP kinase inhibitors.
  Axel Metzger, David J. Diller, Tsung H. Lin, Ian Henderson, Maria L. Webb> ;Combinatorial Chemistry & High Throughput Screening. 2006 May 31
• 30 citations
  The discovery of novel chemotypes of p38 kinase inhibitors.
  David J. Diller, Tsung H. Lin, Axel Metzger> ;Current Topics in Medicinal Chemistry. 2005 Aug 31
• 31 citations
  The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
  Katerina Leftheris, Gulzar Ahmed, Ran Chan, Alaric J. Dyckman, Zahid Hussain, Kan Ho, John Hynes, Jeffrey J. Letourneau, Wei Li, Shuqun Lin, Axel Metzger, Kevin J. Mor...> ;Journal of Medicinal Chemistry. 2004 Nov 6
• Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, Mandelic acids, and the...
  Winstead MB, Dougherty DA, Lin TH, Khentigan A, Lamb JF, Winchell HS> ;J. Med. Chem.. 1978-02-01
• Relationship of chemical structure and solvent to in vivo scintigraphic distribution patterns of 11C compounds. II. 11C aminonitriles.
  Winstead MB, Widner PJ, Means JL, Engstrom MA, Graham GE, Khentigan A, Lin TH, Lamb JF, Winchell HS> ;J. Nucl. Med.. 1975-11-01
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