UdoRudloffMD

General Surgery • Bethesda, MD

Surgical Oncology (Other than Breast)

Physician

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Office
Center For Cancer Research Ccr Nci Nih
Hatfield Center, Room 4-5940, 10 Center Drive
Bethesda, MD 20892
Phone+1 301-496-3098

Fax+1 301-402-1788
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Education & Training

NYU Grossman School of MedicineResidency, Surgery, 2005 - 2007
University of Heidelberg Faculty of MedicineClass of 1997

Certifications & Licensure

VA State Medical License 2013 - 2026
MD State Medical License 2018 - 2025
NM State Medical License 2007 - 2014
American Board of Surgery Surgery

Clinical Trials

Surgery for Pancreatic Tumors and Collection of Tumor Tissue for Study Start of enrollment: 2004 Dec 21
Terminated
The Natural History of Solid Organ Cancer Stem Cells (SOCSC) Start of enrollment: 2009 Feb 09
Terminated
Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial Start of enrollment: 2009 Jul 22
Completed
Phase 3
Lapatinib in Stage IV Melanoma With ERBB4 Mutations Start of enrollment: 2011 May 20
Terminated
Phase 2
Drosophila-generated CTL Start of enrollment: 2011 Apr 15
Terminated
Phase 2
Regional Chemotherapy in Locally Advanced Pancreatic Cancer: RECLAP Trial Start of enrollment: 2011 Jan 26
Completed
Phase 1
TKM 080301 for Primary or Secondary Liver Cancer Start of enrollment: 2011 Aug 26
Completed
Phase 1
Selumetinib Sulfate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12R Mutations Start of enrollment: 2017 Jul 21
Completed
Phase 2
M7824 (MSB0011359C) in Combination With Gemcitabine in Adults With Previously Treated Advanced Adenocarcinoma of the Pancreas Start of enrollment: 2018 May 17
Terminated
Phase 1, Phase 2
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors Start of enrollment: 2020 Oct 27
Recruiting
Phase 1
Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer Start of enrollment: 2021 Jun 15
Terminated
Phase 1, Phase 2
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Publications & Presentations

PubMed

Determination of metarrestin (ML-246) in human plasma for a first-in-human clinical pharmacokinetic application by a simple and efficient uHPLC-MS/MS assay.
William J Richardson, Sara M Zimmerman, Annieka Reno, Natalia Corvalan Cabanas, Oluwatobi Arisa, Udo Rudloff, William D Figg, Cody J Peer> ;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2023 May 30
4 citations
A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice.
Anghesom Ghebremedhin, Ahmad Bin Salam, Benjamin Adu-Addai, Steve Noonan, Richard Stratton, Md Shakir Uddin Ahmed, Chandra Khantwal, George R Martin, Huixian Lin, Chri...> ;Cells. 2023 Apr 26
2 citations
Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies.
Saifun Nahar, Yue Huang, Bethany A Nagy, John A Zebala, Dean Y Maeda, Udo Rudloff, Joost J Oppenheim, De Yang> ;Cancers. 2023 Apr 19
1 citations
Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signal...
Dandan Li, Anne M Miermont, Rushikesh Sable, Humair S Quadri, Lesley A Mathews Griner, Scott E Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S Powers, Stephen...> ;Molecular Cancer Research. 2023 Apr 1
3 citations
Emerging kinase inhibitors for the treatment of pancreatic ductal adenocarcinoma.
Udo Rudloff> ;Expert Opinion on Emerging Drugs. 2022 Sep 1
4 citations
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
Frankowski, K., Patnaik, S., Wang, C., Southall, N., Dutta, D., De, S., Li, D., Dextras, C., Lin, Y., Bryant-Connah, M., Davis, D., Wang, F., Wachsmuth, L., Shah, P., ...> ;Journal of Medicinal Chemistry. 2022 Jun 23
4 citations
Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translat...
Jessica M Faupel-Badger, Amanda L Vogel, Shadab F Hussain, Christopher P Austin, Matthew D Hall, Elizabeth Ness, Philip Sanderson, Pramod S Terse, Xin Xu, Krishna Bala...> ;Journal of Clinical and Translational Science. 2022 Jan 1
8 citations
T Cell-Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer.
Dandan Li, Nicholas J. Schaub, Theresa Guerin, Tashinga E. Bapiro, Frances M. Richards, Vicky Chen, Keyur Talsania, Parimal Kumar, Debra J. Gilbert, Jerome J. Schlomer...> ;Molecular Cancer Therapeutics. 2021 Aug 10
4 citations
Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
Bogdan Domrachev, Sitanshu S. Singh, Dandan Li, Udo Rudloff> ;Journal of Cancer Treatment & Diagnosis. 2021 Apr 30
19 citations
Phase II study of selumetinib, an orally active inhibitor of MEK1 and MEK2 kinases, in KRASG12R-mutant pancreatic ductal adenocarcinoma.
Cara M. Kenney, Tricia F. Kunst, Santhana Webb, Devisser Christina, Christy Arrowood, Seth M. Steinberg, Niharika B. Mettu, Edward J. Kim, Udo Rudloff> ;Investigational New Drugs. 2021 Jan 6
17 citations
A Novel CD206 Targeting Peptide Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice.
Anghesom Ghebremedhin, Ahmad Bin Salam, Benjamin Adu-Addai, Steve Noonan, Richard Stratton, Shakir Uddin Ahmed, Chandra Khantwal, George R. Martin, Hui-Xian Lin, Chris...> ;Biorxiv. 2020 Jul 29
3 citations
Safety assessment of metarrestin in dogs: A clinical candidate targeting a subnuclear structure unique to metastatic cancer cells.
Mohammed Bourdi, Udo Rudloff, Samarjit Patnaik, Juan J. Marugan, Pramod S. Terse> ;Regulatory Toxicology and Pharmacology. 2020 Jun 30
2 citations
LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with app...
Maura O'Neill, King C. Chan, Jesse M. Jaynes, Zachary Knotts, Xia Xu, Abisola Abisoye-Ogunniyan, Theresa Guerin, Jerome J. Schlomer, Dandan Li, Jeffrey W. Cary, Kannia...> ;Journal of Pharmaceutical and Biomedical Analysis. 2020 Mar 20
5 citations
Metabolism and pharmacokinetics characterization of metarrestin in multiple species
Elias C. Padilha, Pranav Shah, Amy Wang, Marc Singleton, Emma Hughes, Dandan Li, Kelly A. Rice, Kylie M. Konrath, Samarjit Patnaik, Juan J. Marugan, Udo Rudloff, Xin Xu> ;Cancer Chemotherapy and Pharmacology. 2020 Mar 17
166 citations
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jesse M. Jaynes, Rushikesh Sable, Michael Ronzetti, Wendy Bautista, Zachary Knotts, Abisola Abisoye-Ogunniyan, Dandan Li, Raul Calvo, Myagmarjav Dashnyam, Anju Singh, ...> ;Science Translational Medicine. 2020 Feb 12
102 citations
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Adele Waters, J. Nathaniel Diehl, Bjoern ...> ;Cancer Discovery. 2020 Jan 1
13 citations
Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.
Yansong Bian, Yaroslav Teper, Lesley A. Mathews Griner, Taylor Aiken, Vivek Shukla, Rajarshi Guha, Paul Shinn, Hong-Wu Xin, Holger Pflicke, Astin Powers, Dandan Li, Ji...> ;Molecular Cancer Therapeutics. 2019 Nov 1
24 citations
Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC)
Winifred Lo, Bin Zhu, Arvind Sabesan, Ho-Hsiang Wu, Astin Powers, Rebecca A. Sorber, Sarangan Ravichandran, Ina Chen, Lucas A. McDuffie, Humair S. Quadri, Joal D. Bean...> ;Journal of Medical Genetics. 2019 Jun 1
31 citations
Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives
Udo Rudloff> ;Clinical and Experimental Gastroenterology. 2018 Dec 3
7 citations
Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancr...
Tomas Vilimas, Amy Wang, Samarjit Patnaik, Emma Hughes, Marc D. Singleton, Zachary Knotts, Dandan Li, Kevin J. Frankowski, Jerome J. Schlomer, Theresa Guerin, Stephani...> ;Cancer Chemotherapy and Pharmacology. 2018 Oct 10
18 citations
Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells.
Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew J. Anderson, Snorri S. Thorgeirsson, Itzhak Avital, Udo Rudloff> ;BMC Cancer. 2018 Jul 31
2 citations
Adjuvant intraperitoneal chemotherapy for the treatment of colorectal cancer at risk for peritoneal carcinomatosis: a systematic review.
Paul L. Feingold, Nicholas D. Klemen, Mei Li M. Kwong, Barry Hashimoto, Udo Rudloff> ;International Journal of Hyperthermia. 2018 Jul 4
47 citations
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
Kevin J. Frankowski, Chen Wang, Samarjit Patnaik, Frank J. Schoenen, Noel Southall, Dandan Li, Yaroslav Teper, Wei Sun, Irawati Kandela, Deqing Hu, Christopher R. Dext...> ;Science Translational Medicine. 2018 May 16
15 citations
The Changing Paradigm of Management of Liver Abscesses in Chronic Granulomatous Disease.
David M. Straughan, Kaitlin C. McLoughlin, John E. Mullinax, Beatriz E. Marciano, Alexandra F. Freeman, Victoria L. Anderson, Gulbu Uzel, Saïd C. Azoury, Rebecca Sorbe...> ;Clinical Infectious Diseases. 2018 Apr 17
20 citations
Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk.
Dandan Li, Winifred Lo, Udo Rudloff> ;Clinical and Translational Medicine. 2018 Feb 22
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Press Mentions

Mini-Review: PDPK1 (3-Phosphoinositide Dependent Protein Kinase-1), an Emerging Cancer Stem Cell TargetApril 12th, 2021
Combining the Antimesothelin Immunotoxin SS1P with the BH3-Mimetic ABT-737 Induces Cell Death in SS1P-Resistant Pancreatic Cancer CellsNovember 16th, 2020
Tumor Testing May Help Guide Pancreatic Cancer TreatmentApril 16th, 2020
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UdoRudloffMD

Dr. Rudloff is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

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