UnaDMcCannMD

Psychosomatic Medicine

Professor of Psychiatry and Behavioral Sciences, Professor of Neurology, Johns Hopkins University School of Medicine; Associate Program Director JHBMC GCRC, Director, Anxiety Disorders Program

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Office
5500 Lombard Street
Baltimore, MD 21224
Phone+1 410-550-1933
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Education & Training

National Capital ConsortiumResidency, Psychiatry, 1989 - 1990
Stanford Health Care-Sponsored Stanford UniversityResidency, Psychiatry, 1984 - 1988
Duke University School of MedicineClass of 1984

Certifications & Licensure

CA State Medical License 1985 - Present
MD State Medical License 1989 - 2025
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Preventing Long Term Psychiatric Disability Among Those With Major Burn Injuries Start of enrollment: 2007 Oct 16
Completed
Not Applicable
Mobile Acoustic Startle Reflex-monitoring System (MARS) Start of enrollment: 2020 Nov 28
Completed
Not Applicable
Evaluation of a Tai Chi Resilience Training Program on Objective and Subjective Measures of Post Traumatic Stress Disorder Severity Start of enrollment: 2021 Oct 15
Completed
Not Applicable

Publications & Presentations

PubMed

2 citations
Effect of a Tobacco Cessation Intervention Incorporating Weight Management for Adults With Serious Mental Illness: A Randomized Clinical Trial.
Gail L Daumit, A Eden Evins, Corinne Cather, Arlene T Dalcin, Faith B Dickerson, Edgar R Miller 3rd, Lawrence J Appel, Gerald J Jerome, Una McCann, Daniel E Ford, Jean...> ;JAMA Psychiatry. 2023 Sep 1
1 citations
Racial differences in platelet serotonin polymorphisms in acute coronary syndrome
Marlene S. Williams, Lisa R. Yanek, Roy C. Ziegelstein, Una D. McCann, Nauder Faraday> ;Thrombosis Research. 2021 Feb 6
36 citations
Low-frequency right repetitive transcranial magnetic stimulation for the treatment of depression after traumatic brain injury: A randomized sham-controlled pilot study
Vani Rao, Kathleen T. Bechtold, Una D. McCann, Durga Roy, Matthew E. Peters, Sandeep Vaishnavi, David M. Yousem, Susumu Mori, Haijuan Yan, Jeannie Marie Sheppard Leout...> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2019 Apr 25
16 citations
Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression.
Marlene S. Williams, Roy C. Ziegelstein, Una D. McCann, Neda F Gould, Tamara Ashvetiya, Dhananjay Vaidya> ;Psychosomatic Medicine. 2019 May 1
8 citations
Pathological Laughter and Crying and Psychiatric Comorbidity After Traumatic Brain Injury
Durga Roy, Una D. McCann, Dingfen Han, Vani Rao> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2015 Aug 10
6 citations
Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.
Aayushi Garg, Saloni Kapoor, Mishita Goel, Saurav Chopra, Manav Chopra, Anirudh Kapoor, Una D. McCann, Chittaranjan Behera> ;Current Drug Abuse Reviews. 2015 Mar 31
30 citations
Does acute TBI-related sleep disturbance predict subsequent neuropsychiatric disturbances?
Vani Rao, Una D. McCann, Dingfen Han, Alyssa Bergey, Michael T. Smith> ;Brain Injury. 2014 Jan 1
6 citations
Correlates of apathy during the first year after traumatic brain injury.
Vani Rao, Una D. McCann, Alyssa Bergey, Dingfen Han, Jason Brandt, David J. Schretlen> ;Psychosomatics. 2013 Jul 1
17 citations
Studies of (±)-3,4-Methylenedioxymethamphetamine (MDMA) Metabolism and Disposition in Rats and Mice: Relationship to Neuroprotection and Neurotoxicity Profile
Melanie Mueller, Concepcion Maldonado-Adrian, Jie Yuan, Una D. McCann, George A. Ricaurte> ;The Journal of Pharmacology and Experimental Therapeutics. 2013 Feb 1
9 citations
Single oral doses of (±) 3,4-methylenedioxymethamphetamine (‘ Ecstasy ’) produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and m...
Melanie Mueller, Jie Yuan, Una D. McCann, George Hatzidimitriou, George A. Ricaurte> ;The International Journal of Neuropsychopharmacology. 2013 May 1
17 citations
Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.
Vani Rao, Michelle M. Mielke, Xin Xu, Gwenn S. Smith, Una D. McCann, Alyssa Bergey, Vishal K. Doshi, Dzung L. Pham, David M. Yousem, Susumi Mori> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2012 Jul 1
21 citations
Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use.
Bethea A. Kleykamp, Roland R. Griffiths, Una D. McCann, Michael T. Smith, Miriam Z. Mintzer> ;Experimental and Clinical Psychopharmacology. 2012 Feb 1
4 citations
Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugs
Michael W. McLane, Una D. McCann, George A. Ricaurte> ;Synapse. 2011 Jun 17
74 citations
Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal.
Ryan Vandrey, Michael T. Smith, Una D. McCann, Alan J. Budney, Erin M. Curran> ;Drug and Alcohol Dependence. 2011 Aug 1
Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers.
McCann, U.D., Sgambati, F.P., Schwartz, A.R., Ricaurte, G.A.> ;Neurology. 2011-07-05
3 citations
Synthesis and Neurotoxicity Profile of 2,4,5-Trihydroxymethamphetamine and its 6-(N-Acetylcystein-S-yl) Conjugate
Anne Neudörffer, Melanie Mueller, Claire Marie Martinez, Annis O. Mechan, Una D. McCann, George A. Ricaurte, Martine Largeron> ;Chemical Research in Toxicology. 2011 Jun 20
398 citations
Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D Richards, Una D. McCann, Robert Jesse> ;Psychopharmacology. 2011 Jun 15
7 citations
Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Una D. McCann, Robert R. Edwards, Michael T. Smith, Kristen Kelley, Michael Wilson, Francis Sgambati, George A. Ricaurte> ;Psychopharmacology. 2011 May 21
11 citations
Metabolism and Disposition of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Baboons after Oral Administration: Comparison with Humans Reveals Marked Differences
Melanie Mueller, Amy K. Goodwin, Nancy A. Ator, Una D. McCann, George A. Ricaurte> ;The Journal of Pharmacology and Experimental Therapeutics. 2011 Jul 1
31 citations
Sleep Disturbance After Mild Traumatic Brain Injury: Indicator of Injury?
Vani Rao, Alyssa Bergey, Hugh Hill, David Thomas Efron, Una D. McCann> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2011 Apr 1
13 citations
Peritraumatic heart rate and posttraumatic stress disorder in patients with severe burns.
Neda F Gould, Jodi B. A. McKibben, Ryan C.W. Hall, Nida H. Corry, Nicole A. Amoyal, Shawn T. Mason, Una D. McCann, James A. Fauerbach> ;The Journal of Clinical Psychiatry. 2011 Apr 1
8 citations
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity:...
Melanie Mueller, Jie Yuan, Concepcion Maldonado Adrian, Una D. McCann, George A. Ricaurte> ;Synapse. 2011 Oct 1
9 citations
Dopamine is not essential for the development of methamphetamine‐induced neurotoxicity
Jie Yuan, Martin Darvas, Bethany N. Sotak, George Hatzidimitriou, Una D. McCann, Richard D. Palmiter, George A. Ricaurte> ;Journal of Neurochemistry. 2010 Jun 1
34 citations
Sleep apnea in young abstinent recreational MDMA (“ecstasy”) consumers
Una D. McCann, Francis P. Sgambati, Alan R. Schwartz, George A. Ricaurte> ;Neurology. 2009 Dec 8
1 citations
Traumatic burn injury: Neuropsychiatric perspectives on risk, outcomes and treatment
James A. Fauerbach, Una D. McCann> ;International Review of Psychiatry. 2009 Nov 17
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Press Mentions

What Doctors Want You to Know Before Trying Valerian Root for AnxietyFebruary 19th, 2021
CDC Opioid Prescribing Guidelines Unlikely to Affect Physicians' PracticesMarch 15th, 2016
CDC Opioid Prescribing Guidelines Unlikely to Effect ChangeMarch 15th, 2016
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Grant Support

PET Studies Of The SERT And DAT In METH UsersNational Institute On Drug Abuse2010–2012
PET Studies Of The Dopamine Transporter In Adult ADHDNational Center For Research Resources2006–2007
Sleep And Nocturnal Endocrine Function In MDMA UsersNational Center For Research Resources2005–2007
Neuroimaging MDMA Neurotoxicity: Dopamine StudiesNational Center For Research Resources2005–2007
Sleep And Nocturnal Endocrine Function In MDMA USERNational Institute On Drug Abuse2003–2007
PET Imaging MDMA NeurotoxicityNational Institute On Drug Abuse2002–2006
PET Studies Of Methamphetamine Neurotoxicity On HumansNational Center For Research Resources2000
MDMA Neurotoxicity In Humans-- Occurence &ConsequenceNational Center For Research Resources2000