ValentinaShakhnovichMD

PubMed

• Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children.
  Kathryn E Kyler, Andrea Gaedigk, Susan Abdel-Rahman, Vincent S Staggs, Robin E Pearce, Paul Toren, J Steven Leeder, Valentina Shakhnovich> ;Clinical and Translational Science. 2024 Apr 1
• 1 citations
  Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug-Gene Pairs to Know.
  Tracy Sandritter, Rachel Chevalier, Rebecca Abt, Valentina Shakhnovich> ;Pharmaceuticals. 2023 Jun 16
• 2 citations
  Nonanaphylactic Variant of Alpha-Gal Syndrome as an Etiology for Chronic Gastrointestinal Symptoms in Children.
  De'mond Glynn, Hannah Welch, Valentina Shakhnovich, Craig Friesen, Halma, J.> ;The Journal of Pediatrics. 2023 Aug 1
• 2 citations
  A fresh look at proton pump inhibitor (PPI)-associated adverse events through a CYP2C19 pharmacogenetic lens.
  Rachel Chevalier, Sara L Van Driest, Valentina Shakhnovich, Attard, T. M., Thomas Attard> ;Expert Opinion on Drug Metabolism & Toxicology. 2023 Feb 1
• Impact of Duodenal Pathology on Oral Drug Bioavailability and Disease Outcomes in Pediatric Crohn's Disease.
  Rebecca Casini, Carrie A Vyhlidal, Julia M Bracken, Ashley K Sherman, Atif Ahmed, Vivekanand Singh, Veronica Williams, Valentina Shakhnovich> ;Pharmaceuticals. 2023 Feb 28
• 1 citations
  Effects of obesity on the pharmacology of proton pump inhibitors: current understanding and future implications for patient care and research.
  Zachary L Taylor, Daniel Gonzalez, Valentina Shakhnovich, Farwa Jafri> ;Expert Opinion on Drug Metabolism & Toxicology. 2023 Jan 1
• Novel OncogenicVariant in Severe Infantile Myofibromatosis With Response to Imatinib Using Therapeutic Drug Monitoring.
  Abbey Elsbernd, Boutaina Boulouadnine, Atif Ahmed, Midhat Farooqi, Tracy Sandritter, Valentina Shakhnovich, Darius Blanding, Jean-Baptiste Demoulin, Joel Thompson> ;JCO Precision Oncology. 2022 Oct 1
• 1 citations
  Characterization of the Mucosally-Adherent Duodenal Microbiome in Children with and without Crohn's Disease.
  Kenneth Schmidt, Janelle Noel-MacDonnell, Carrie Vyhlidal, Daniel P Heruth, Vivekanand Singh, Atif A Ahmed, Taina Hudson, Veronica Williams, Valentina Shakhnovich> ;Pharmaceuticals. 2022 Jul 11
• Utility of theC-pantoprazole breath test as a CYP2C19 phenotyping probe for children.
  Keith Feldman, Gregory L Kearns, Robin E Pearce, Susan M Abdel-Rahman, James Steven Leeder, Vincent S Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich, Fr...> ;Clinical and Translational Science. 2022 May 1
• 2 citations
  Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
  Chelsea M Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, J Steven Leeder> ;Clinical and Translational Science. 2022 Apr 1
• 6 citations
  A population physiologically-based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab
  Hsuan Ping Chang, Valentina Shakhnovich, Adam Frymoyer, Ryan S. Funk, Mara L. Becker, K.T. Park, Dhaval K. Shah> ;British Journal of Clinical Pharmacology. 2021 Jul 19
• 4 citations
  Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
  Chelsea Hosey-Cojocari, Sherwin S Chan, Chance S. Friesen, Amie L Robinson, Veronica Williams, Erica Swanson, Daniel O'Toole, Neil J Mardis, Trevor N. Johnson, J Steve...> ;Clinical and Translational Science. 2021 May 31
• 3 citations
  Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease.
  Ryan Morrow, Ryan S. Funk, Mara L. Becker, Ashley K. Sherman, Leon van Haandel, Taina Hudson, Rebecca Casini, Valentina Shakhnovich> ;Pharmaceuticals. 2021 May 14
• 5 citations
  Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study.
  Ryan S. Funk, Valentina Shakhnovich, Yu Kyoung Cho, Kishore Polireddy, Taina Jausurawong, Kyle Gress, Mara L. Becker> ;Pediatric Rheumatology Online Journal. 2021 May 1
• 9 citations
  Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy.
  Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke Sweeney, Alec S. Friesen, Jason D. Fraser, Valentina Shakhnovich> ;Frontiers in Endocrinology. 2021 Apr 13
• 1 citations
  Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma.
  Kathryn E. Kyler, Jessica L. Bettenhausen, Matthew Hall, Earl F. Glynn, Mark A. Hoffman, Valentina Shakhnovich, Kim G. Smolderen, Ann M. Davis> ;Hospital Pediatrics. 2021 Mar 1
• 3 citations
  Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective.
  Chance S. Friesen, Sherwin S Chan, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Iván L. Csanaky, Valentina Shakhnovich> ;Clinical and Translational Science. 2021 May 1
• 8 citations
  Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine.
  Carrie A. Vyhlidal, Brian D. Chapron, Atif A. Ahmed, Vivekanand Singh, Rebecca Casini, Valentina Shakhnovich> ;Clinical and Translational Science. 2021 Mar 1
• 126 citations
  Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
  John J. Lima, Cameron D. Thomas, Julia M. Barbarino, Zeruesenay Desta, Sara L. Van Driest, Nihal El Rouby, Julie A. Johnson, Larisa H. Cavallari, Valentina Shakhnovich...> ;Clinical Pharmacology and Therapeutics. 2021 Jun 1
• 3 citations
  Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease.
  Kyle Gress, Julie A. Bass, Ryan S. Funk, Ryan Morrow, Rachel Hasenkamp, Valentina Shakhnovich> ;Frontiers in Immunology. 2020 Jun 9
• Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity.
  Valentina Shakhnovich, Kathryn E. Kyler> ;Obesity. 2020 Jun 1
• 10 citations
  Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
  Valentina Shakhnovich, Bernd Meibohm, Amy S. Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. van der Graaf, Yow Ming C. Wan...> ;Clinical and Translational Science. 2020 Mar 1
• 14 citations
  Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children.
  Kathryn E. Kyler, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Kevin M. Watt, Valentina Shakhnovich> ;Paediatric Drugs. 2019 Oct 1
• 6 citations
  #Science: The Potential and the Challenges of Utilizing Social Media and Other Electronic Communication Platforms in Health Care
  Violette Gijsen, Michele H Maddux, Adam Lavertu, Graciela Gonzalez-Hernandez, Nilam Ram, Byron Reeves, Thomas N. Robinson, Victoria C. Ziesenitz, Valentina Shakhnovich...> ;Clinical and Translational Science. 2020 Jan 1
• 2 citations
  Handheld Indirect Calorimetry as a Clinical Tool for Measuring Resting Energy Expenditure in Children with and without Obesity.
  David A. White, Vincent S. Staggs, Veronica Williams, Trent C Edwards, Robin P. Shook, Valentina Shakhnovich> ;Childhood Obesity. 2019 Apr 22
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Journal Articles

• Rare Presentation of pancreatitis secondary to intussusceptions of duodenal duplication cyst: a pediatric case report.  
  V. Shakhnovich; J. Colombo; A. Desai; S. St. Peter, Journal of Pediatric Surgery Case Reports, 12/1/2014

Books/Book Chapters

• Pediatric Formulations: a roadmap 
  Chapter: General considerations for pediatric oral drug formulations 
  Page 89 - 104Valentina Shakhnovich & Susan Abdel-RahmanEditors: Daniel Bar-Shalom & Klaus Rose.American Association of Pharmaceutical Scientists/Springer2014

Lectures

• 49th Annual Arden Conference-American Association of Pharmaceutical Scientists: Development of Pediatric Formulations: Challenges and Opportunities. 
  Rockville, MD - 2/24/2014