VikramGovindarajuShakkottaiMDPhD(He/Him)

PubMed

• Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
  Ruo-Yah Lai, Christian Rummey, Christian J Amlang, Chi-Ying R Lin, Tiffany X Chen, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulso...> ;Movement Disorders Clinical Practice. 2024 Feb 29
• The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.
  Selvadurai, L., Perlman, S., Ashizawa, T., Wilmot, G., Onyike, C., Rosenthal, L., Shakkottai, V., Paulson, H., Subramony, S., Bushara, K., Kuo, S., Dietiker, C., Gesch...> ;Cerebellum. 2024 Jan 2
• 5 citations
  Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.
  Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer...> ;Neuron. 2024 Feb 7
• Deriving early single-rosette brain organoids from human pluripotent stem cells.
  Andrew M Tidball, Wei Niu, Qianyi Ma, Taylor N Takla, J Clayton Walker, Joshua L Margolis, Sandra P Mojica-Perez, Roksolana Sudyk, Lu Deng, Shannon J Moore, Ravi Chopr...> ;Stem Cell Reports. 2023 Dec 12
• Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1.
  Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, David D Bushart, Samuel S Pappas, Harry T Orr, Vikram G Shakkottai> ;Biorxiv. 2023 Oct 23
• 5 citations
  Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia.
  Haoran Huang, Vikram G Shakkottai> ;Life. 2023 Jun 8
• 1 citations
  Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding.
  Ahmed M Malik, Josephine J Wu, Christie A Gillies, Quinlan A Doctrove, Xingli Li, Haoran Huang, Elizabeth H M Tank, Vikram G Shakkottai, Sami Barmada> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr 11
• 4 citations
  The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications.
  Louisa P Selvadurai, Susan L Perlman, George R Wilmot, Sub H Subramony, Christopher M Gomez, Tetsuo Ashizawa, Henry L Paulson, Chiadi U Onyike, Liana S Rosenthal, Hari...> ;Cerebellum. 2023 Oct 1
• 6 citations
  Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia.
  Sharan R Srinivasan, Haoran Huang, Wei-Chih Chang, Joshua A Nasburg, Hai M Nguyen, Tim Strassmaier, Heike Wulff, Vikram G Shakkottai> ;Molecular Pharmacology. 2022 Jul 1
• 2 citations
  Preliminary Study of Vibrotactile Feedback during Home-Based Balance and Coordination Training in Individuals with Cerebellar Ataxia.
  Safa Jabri, David D Bushart, Catherine Kinnaird, Tian Bao, Angel Bu, Vikram G Shakkottai, Kathleen H Sienko> ;Sensors. 2022 May 5
• 1 citations
  Vulnerability of Human Cerebellar Neurons to Degeneration in Ataxia-Causing Channelopathies.
  David D Bushart, Vikram G Shakkottai> ;Frontiers in Systems Neuroscience. 2022 Jan 1
• 4 citations
  THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes.
  Dhananjay Yellajoshyula, Samuel S. Pappas, Abigail E Rogers, Biswa Choudhury, Xylena Reed, Jinhui Ding, Mark R. Cookson, Vikram G. Shakkottai, Roman J. Giger, William ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Aug 3
• 150 citations
  Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
  Ruth Chia, Marya S. Sabir, Sara Bandres-Ciga, Sara Saez-Atienzar, Regina H. Reynolds, Emil K. Gustavsson, Ronald L. Walton, Samreen Ahmed, Coralie Viollet, Jinhui Ding...> ;Nature Genetics. 2021 Feb 15
• 16 citations
  Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.
  Ravi Chopra, David D. Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M. Morrison, Haoran Huang, Hillary P Handler, Luke J. Man, Warunee Dansithong, Daniel R. S...> ;Human Molecular Genetics. 2020 Nov 25
• 17 citations
  A Chlorzoxazone-Baclofen Combination Improves Cerebellar Impairment in Spinocerebellar Ataxia Type 1
  David D. Bushart, Haoran Huang, Luke J. Man, Logan M. Morrison, Vikram G. Shakkottai> ;Movement Disorders. 2021 Mar 1
• 26 citations
  Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.
  Mercedes Prudencio, Hector Garcia-Moreno, Karen Jansen-West, Rana Hanna Al-Shaikh, Tania F. Gendron, Michael G. Heckman, Matthew R. Spiegel, Yari Carlomagno, Lillian M...> ;Science Translational Medicine. 2020 Oct 21
• 2 citations
  Dysphagia in spinocerebellar ataxias type 1, 2, 3 and 6.
  Chen Ya Yang, Ruo Yah Lai, Nadia Amokrane, Chi-Ying Lin, Karla P. Figueroa, Stefan M. Pulst, Susan Perlman, George Wilmot, Christopher M. Gomez, Jeremy D. Schmahmann, ...> ;Journal of the Neurological Sciences. 2020 Aug 15
• 13 citations
  Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel-Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3.
  David D. Bushart, Annie J. Zalon, Hongjiu Zhang, Logan M. Morrison, Yuanfang Guan, Henry L. Paulson, Vikram G. Shakkottai, Hayley S. McLoughlin> ;Cerebellum. 2021 Feb 1
• 2 citations
  Multiple system atrophy pathology is associated with primary Sjögren’s syndrome
  Kyle S. Conway, Sandra Camelo-Piragua, Amanda Fisher-Hubbard, William R. Perry, Vikram G. Shakkottai, Sriram Venneti> ;JCI Insight. 2020 Aug 6
• 18 citations
  In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3.
  Maria do Carmo Costa, Maria Radzwion, Hayley S. McLoughlin, Naila S. Ashraf, Svetlana Fischer, Vikram G. Shakkottai, Patrícia Maciel, Henry L. Paulson, Gülin Öz> ;Movement Disorders. 2020 Oct 1
• 14 citations
  The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3.
  Shi Rui Gan, Karla P. Figueroa, Hao Ling Xu, Susan Perlman, George Wilmot, Christopher M. Gomez, Jeremy D. Schmahmann, Henry L. Paulson, Vikram G. Shakkottai, Sarah H....> ;Parkinsonism & Related Disorders. 2020 Mar 1
• 45 citations
  Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
  Colleen A. Stoyas, David D. Bushart, Pawel M. Switonski, Jacqueline M. Ward, Akshay Alaghatta, Mi bo Tang, Chenchen Niu, Mandheer Wadhwa, Haoran Huang, Alex Savchenko,...> ;Neuron. 2020 Feb 19
• 155 citations
  Polyglutamine Repeats in Neurodegenerative Diseases.
  Andrew P. Lieberman, Vikram G. Shakkottai, Roger L. Albin> ;Annual Review of Pathology. 2019 Jan 24
• 17 citations
  Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases
  Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A Liu, Thaddeus J. Kunkel, Troy Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. Mc...> ;BMC Medicine. 2019 Nov 11
• 16 citations
  Alanyl-tRNA Synthetase 2 (AARS2)-Related Ataxia Without Leukoencephalopathy.
  Molly E. Kuo, Anthony Antonellis, Vikram G. Shakkottai> ;Cerebellum. 2020 Feb 1
• Join now to see all

Journal Articles

• Targeted Exome Analysis Identifies the Genetic Basis of Disease in over 50% of Patients with a Wide Range of Ataxia-Related Phenotypes  
  Christopher M Gomez, Vikram Shakkottai, Darrel J Waggoner, Nature