VinaykumarK.PuduvalliMD

Neurooncology

Professor and Chair, Department of Neuro-oncology Beau Biden Endowed Chair for Brain Cancer Research Co-Director, Brain Tumor Center UT MD Anderson Cancer Center Houston TX 77030

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Office
1515 Holcombe Blvd
Unit 431
Houston, TX 77030
Phone+1 713-792-2883

Fax+1 713-794-4999
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Clinical Expertise

Neuro-oncology, Glioblastoma, Astrocytoma, Oligodendroglioma, Gliomas, Primary brain tumors, Metastatic brain tumors, Cancer Neurology

Education & Training

University of Texas M D Anderson Cancer CenterFellowship, Neuro-Oncology, 1996 - 1998
University of Texas Health Science Center at HoustonResidency, Neurology, 1993 - 1996
Texas Tech University (Amarillo)Internship, Internal Medicine, 1992 - 1993
Bangalore Medical CollegeClass of 1983

Certifications & Licensure

AZ State Medical License 2023 - 2026
WA State Medical License 2023 - 2025
TN State Medical License 2023 - 2025
GA State Medical License 2023 - 2024
TX State Medical License 1997 - 2024
MS State Medical License 2023 - 2024
OK State Medical License 2023 - 2024
LA State Medical License 2023 - 2024
AL State Medical License 2023 - 2024
OH State Medical License 2013 - 2022
PA State Medical License 1996 - 1998
American Board of Psychiatry and Neurology Neurology
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Awards, Honors, & Recognition

Beau Biden Endowed Chair in Brain Cancer Research UT MD Anderson Cancer Center, 2021
Top Doctors in Columbus Columbus Monthly
Newsweek Top Doctors in Cancer Newsweek
America's Top Doctors Castle Connolly
America's Top Doctors for Cancer Castle Connolly
Sanford and Rife Family Endowed Chair in Neuro-oncology The Ohio State University Wexner Medical Center, 2013
Top Doctors:SE Texas Castle Connolly, 2013
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Clinical Trials

Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM) Start of enrollment: 2007 Nov 28
Active, not recruiting
Phase 1, Phase 2
Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I Start of enrollment: 2008 Apr 29
Terminated
Phase 1
Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM) Start of enrollment: 2011 Jun 01
Terminated
Phase 1, Phase 2
Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma Start of enrollment: 2011 Jul 12
Completed
Phase 1, Phase 2
A Phase 1b/2 Study of PLX3397 + Radiation Therapy + Temozolomide in Patients With Newly Diagnosed Glioblastoma Start of enrollment: 2013 Jul 18
Completed
Phase 1, Phase 2
DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors Start of enrollment: 2014 Sep 11
Completed
Phase 1
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma Start of enrollment: 2020 Jun 08
Terminated
Phase 1, Phase 2
Roles: Principal Investigator, Contact
Randomized Study of Neo-adjuvant and Adjuvant Pembrolizumab With and Without Targeted Blood Brain Barrier Opening Using Exablate MRI-guided Focused Ultrasound (Exablate MRgFUS) for Recurrent Glioblastoma Start of enrollment: 2024 Jul 30
Not yet recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Final report of the phase II NEXT/CNS-GCT-4 trial: GemPOx followed by marrow-ablative chemotherapy for recurrent intracranial germ cell tumors.
Margaret Shatara, Megan Blue, Joseph Stanek, Yin A Liu, Daniel M Prevedello, Pierre Giglio, Vinay K Puduvalli, Sharon L Gardner, Jeffrey C Allen, Kenneth K Wong, Marvi...> ;Neuro-Oncology Practice. 2024 Apr 1
Pembrolizumab alters the tumor immune landscape in a patient with dMMR glioblastoma.
Bartkowiak, T., Brockman, A., Moots, P., Merrell, R., Thompson, R., Ihrie, R., Mobley, B., Harmsen, H., Johnson, D., Puduvalli, V.> ;Medrxiv. 2023 Dec 26
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis.
Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, ...> ;BMC Medicine. 2023 Dec 5
Characterization of industry relationships in oncology.
Rebecca A Harrison, Nazanin K Majd, Margaret O Johnson, Diana L Urbauer, Vinay Puduvalli, Mustafa Khasraw> ;Cancer. 2023 Sep 15
40 citations
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
Farshad Nassiri, Vikas Patil, Leeor S Yefet, Olivia Singh, Jeff Liu, Rachel M A Dang, Takafumi N Yamaguchi, Mariza Daras, Timothy F Cloughesy, Howard Colman, Priya U K...> ;Nature Medicine. 2023 Jun 1
Characterization of recurrence patterns and outcomes of medulloblastoma in adults: The University of Texas MD Anderson Cancer Center experience.
Timothy A Gregory, Maximilian Mastall, Heather Lin, Kenneth R Hess, Ying Yuan, Manuela Martin-Bejarano Garcia, Gregory N Fuller, Kristin D Alfaro, Maria K Gule-Monroe,...> ;Neuro-Oncology Advances. 2023 Apr 13
29 citations
Tumor microenvironment in glioblastoma: Current and emerging concepts.
Pratibha Sharma, Ashley Aaroe, Jiyong Liang, Vinay K Puduvalli> ;Neuro-Oncology Advances. 2023 Feb 23
1 citations
A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin.
Jiyong Liang, Dexing Fang, Joy Gumin, Hinda Najem, Moloud Sooreshjani, Renduo Song, Aria Sabbagh, Ling-Yuan Kong, Joseph Duffy, Irina V Balyasnikova, Seth M Pollack, V...> ;Cancers. 2023 Feb 8
1 citations
Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrentand-mutant Glioma.
Kristina Fanucci, Mary Jo Pilat, Derek Shyr, Yu Shyr, Scott Boerner, Jing Li, Diane Durecki, Jan Drappatz, Vinay Puduvalli, Frank Scott Lieberman, Javier Gonzalez, Pie...> ;Cancer Research Communications. 2023 Feb 1
An expedited strategy for accurate and timely integrated molecular diagnosis of gliomas.
Timothy A Gregory, Garret L Williford, Jacob M Maronge, Kristin Alfaro, Gregory N Fuller, John de Groot, Vinay K Puduvalli, Leomar Y Ballester, Nazanin K Majd> ;Neuro-Oncology. 2023 Apr 6
32 citations
NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.
Craig Horbinski, Louis Burt Nabors, Jana Portnow, Joachim Baehring, Ankush Bhatia, Orin Bloch, Steven Brem, Nicholas Butowski, Donald M Cannon, Samuel Chao, Milan G Ch...> ;Journal of the National Comprehensive Cancer Network. 2023 Jan 1
3 citations
HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia.
Tzung-Huei Lai, Hatice Gulcin Ozer, Pierluigi Gasparini, Giovanni Nigita, Rosario Distefano, Lianbo Yu, Janani Ravikrishnan, Selen Yilmaz, Juan Gallegos, Sachet Shukla...> ;Blood Advances. 2023 Jun 27
Patterns of failure after radiation therapy in primary spinal high-grade gliomas: A single institutional analysis.
Rituraj Upadhyay, Swapnil Khose, Halyna Pokhylevych, Arnold C Paulino, Mary Frances McAleer, Amol Ghia, Jing Li, Debra Nana Yeboa, Monica Loghin, Rebecca Harrison, Bar...> ;Neuro-Oncology Advances. 2022 Aug 20
24 citations
Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study.
Moran, S. E., Andrew B Lassman, Juan Manuel Sepúlveda-Sánchez, Timothy F Cloughesy, Miguel J Gil-Gil, Vinay K Puduvalli, Jeffrey J Raizer, Filip Y F De Vos, Patrick Y ...> ;Clinical Cancer Research. 2022 Jun 1
9 citations
Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy.
Jihong Xu, Pei-Jung Wu, Tzung-Huei Lai, Pratibha Sharma, Alessandro Canella, Alessandra M Welker, Christine E Beattie, J Brad Elder, Michelle Easley, Russell Lonser, N...> ;Clinical Cancer Research. 2022 May 2
1 citations
Prospective biomarker study in newly diagnosed glioblastoma: Cyto-C clinical trial.
Corinne E Griguer, Claudia R Oliva, Christopher S Coffey, Merit E Cudkowicz, Robin A Conwit, Anna L Gudjonsdottir, Dixie J Ecklund, Janel K Fedler, Tina M Neill-Hudson...> ;Neuro-Oncology Advances. 2021 Dec 24
3 citations
Targeted Therapy for BRAF Mutant Brain Tumors
Appaji Rayi, Iyad Alnahhas, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Current Treatment Options in Oncology. 2021 Oct 6
14 citations
Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma.
Kirit Singh, Kristen A. Batich, Patrick Y. Wen, Aaron Tan, Stephen J Bagley, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Susan M. Chang, Rifaquat Rah...> ;Clinical Cancer Research. 2021 Sep 24
13 citations
Inhibition of nicotinamide phosphoribosyltransferase, the rate-limiting enzyme of the nicotinamide adenine dinucleotide salvage pathway, to target glioma heterogeneity...
Pankaj Sharma, Jihong Xu, Katie Williams, Michelle Easley, J. Brad Elder, Russell R. Lonser, Frederick F. Lang, Rosa Lapalombella, Deepa Sampath, Vinay K. Puduvalli> ;Neuro-Oncology. 2021 Jul 14
Erratum to: Characterizing Benefit from Temozolomide in MGMT Promoter Unmethylated and Methylated Glioblastoma: A Systematic Review and Meta-analysis.
Iyad Alnahhas, Mouaz Alsawas, Appaji Rayi, Joshua D Palmer, Raju Raval, Shirley Ong, Pierre Giglio, Mohammad Hassan Murad, Vinay Puduvalli> ;Neuro-Oncology Advances. 2021 Jul 10
35 citations
Systematic review of combinations of targeted or immunotherapy in advanced solid tumors
Aaron Tan, Stephen J Bagley, Patrick Y. Wen, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Wolfgang Wick, Susan M. Chang, Evanthia Galanis, Alireza Man...> ;Journal for Immunotherapy of Cancer. 2021 Jul 1
8 citations
Tumor Treating Fields for Glioblastoma Therapy During the COVID-19 Pandemic
Na Tosha Gatson, Jill S. Barnholtz-Sloan, Jan Drappatz, Roger Henriksson, Andreas F. Hottinger, Piet Hinoul, Carol Kruchko, Vinay K. Puduvalli, David Tran, Eric T. Won...> ;Frontiers in Oncology. 2021 May 7
7 citations
Report of National Brain Tumor Society Roundtable Workshop on Innovating Brain Tumor Clinical Trials: Building on Lessons Learned from COVID-19 Experience.
Eudocia Q. Lee, Wendy Selig, Clair Meehan, Jeffrey A. Bacha, Amy Barone, Erik Bloomquist, Susan M. Chang, John de Groot, Evanthia Galanis, Islam Hassan, Chitkala Kalid...> ;Neuro-Oncology. 2021 Apr 2
2 citations
The role of VEGF receptor inhibitors in preventing cerebral radiation necrosis: a retrospective cohort study.
Iyad Alnahhas, Appaji Rayi, Joshua D. Palmer, Raju Raval, Edmund Folefac, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Neuro-Oncology Practice. 2021 Feb 25
5 citations
Management of gliomas in patients with Lynch syndrome
Iyad Alnahhas, Appaji Rayi, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Neuro-Oncology. 2021 Jan 30
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Grant Support

Characterization of Onalespib, A novel long acting Hsp90 inhibitor, as a chemo and radiosensitizer in Adults with Newly Diagnosed GlioblastomaNational Cancer institute2019–2025
Patient Oriented Research Program In Neuro-OncologyNational Cancer Institute2012
Efficacy And Toxicity Of Trail Against GliomasNational Cancer Institute2006–2010
Correlative Trial Of Fenretinide Against GlioblastomasNational Cancer Institute2002–2003

Hospital Affiliations

University of Texas M.D. Anderson Cancer CenterHouston, Texas