VipulKPatelMD

PubMed

• Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.
  Li, M., Luraghi, P., Amour, A., Qian, X., Carter, P.S., Clark, C.J., Deakin, A., Denyer, J., Hobbs, C.I., Surby, M., Patel, V.K., Schaefer, E.M.> ;Anal Biochem. 2009 Jan 1
• Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
  Sierra, M. L., Beneton, V., Boullay, A. B., Boyer, T., Brewster, A. G., Donche, F., Forest, M. C., Fouchet, M. H., Gellibert, F. J., Grillot, D. A., Lambert, M. H., La...> ;J Med Chem. 2007 Feb 22
• Syk kinase inhibitors in allergic diseases.
  Denyer, J., Patel, V.> ;Drug News Perspect. 2009 Apr 01
• N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
  Bamborough, P., Angell, R. M., Bhamra, I., Brown, D., Bull, J., Christopher, J. A., Cooper, A. W., Fazal, L. H., Giordano, I., Hind, L., Patel, V. K., Ranshaw, L. E., ...> ;Bioorg Med Chem Lett. 2007 Aug 1
• Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
  Liddle, J., Atkinson, F. L., Barker, M. D., Carter, P. S., Curtis, N. R., Davis, R. P., Douault, C., Dickson, M. C., Elwes, D., Garton, N. S., Gray, M., Hayhow, T. G.,...> ;Bioorg Med Chem Lett. 2011 Oct 15
• p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
  Aston, N. M., Bamborough, P., Buckton, J. B., Edwards, C. D., Holmes, D. S., Jones, K. L., Patel, V. K., Smee, P. A., Somers, D. O., Vitulli, G., Walker, A. L.> ;J Med Chem. 2009 Oct 22
• Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.
  Watson, N. S., Brown, D., Campbell, M., Chan, C., Chaudry, L., Convery, M. A., Fenwick, R., Hamblin, J. N., Haslam, C., Kelly, H. A., King, N. P., Kurtis, C. L., Leach...> ;Bioorg Med Chem Lett. 2006 Jul 15
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