VirginiaLLeeMD

PubMed

• 16 citations
  Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.
  Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily S. Meymand, Modupe F. Olufemi, Pyry Koivula, Shaniy...> ;Acta Neuropathologica Communications. 2021 Sep 9
• 19 citations
  Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression a...
  Mandana Hunter, Krista Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Chris Roberts, Richard M. Ransohoff, John Q. Trojanow...> ;Acta Neuropathologica Communications. 2021 Aug 19
• 12 citations
  TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy
  Fei Mao, John L. Robinson, Travis L. Unger, Marijan Posavi, Defne A. Amado, Lauren Elman, Murray Grossman, David A. Wolk, Edward B. Lee, Vivianna M. Van Deerlin, Sílvi...> ;Acta Neuropathologica. 2021 Jun 21
• 13 citations
  Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples
  Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider, Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski, Rob...> ;Frontiers in Aging Neuroscience. 2021 Jun 18
• 26 citations
  Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
  Eli J. Cornblath, Howard L. Li, Lakshmi Changolkar, Bin Zhang, Hannah J. Brown, Ronald J. Gathagan, Modupe F. Olufemi, John Q. Trojanowski, Danielle S. Bassett, Virgin...> ;Science Advances. 2021 Jun 1
• 20 citations
  Distinct brain-derived TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo.
  Sílvia Porta, Yan Xu, Tagan Lehr, Bin Zhang, Emily S. Meymand, Modupe F. Olufemi, Anna Stieber, Edward B. Lee, John Q. Trojanowski, Virginia M.-Y. Lee> ;Neuropathology and Applied Neurobiology. 2021 May 21
• 66 citations
  The development and convergence of co-pathologies in Alzheimer's disease.
  John L. Robinson, Hayley Richardson, Sharon X. Xie, EunRan Suh, Vivianna M. Van Deerlin, Brian Alfaro, Nicholas Loh, Matias Porras-Paniagua, Jeffrey J. Nirschl, David ...> ;Brain. 2021 Apr 12
• 3 citations
  Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration.
  Jiasi Vicky Zhang, David J. Irwin, Kaj Blennow, Henrik Zetterberg, Edward B. Lee, Leslie M. Shaw, Katya Rascovsky, Lauren Massimo, Corey T. McMillan, Alice Chen-Plotki...> ;Neurology. Clinical Practice. 2021 Apr 1
• 7 citations
  LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons.
  Michael X. Henderson, Lakshmi Changolkar, John Q. Trojanowski, Virginia M.-Y. Lee> ;Journal of Parkinson's Disease. 2021 Jan 1
• 37 citations
  Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor
  Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Xiaoyun Zhou, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu, Daita Kaneda, Yosh...> ;Brain Communications. 2021 Jan 16
• 9 citations
  Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5- a ]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.
  Killian Oukoloff, Goodwell Nzou, Carmine Varricchio, Bobby Lucero, Thibault Alle, Jane Kovalevich, Ludovica Monti, Anne-Sophie Cornec, Yuemang Yao, Michael J. James, J...> ;Journal of Medicinal Chemistry. 2021 Jan 7
• 124 citations
  High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
  Kenji Tagai, Maiko Ono, Manabu Kubota, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinotoh, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuok...> ;Neuron. 2021 Jan 6
• 43 citations
  α-Synuclein modulates tau spreading in mouse brains
  Fares Bassil, Emily S. Meymand, Hannah J. Brown, Hong Xu, Timothy O. Cox, Shankar Pattabhiraman, Chantal M. Maghames, Qihui Wu, Bin Zhang, John Q. Trojanowski, Virgini...> ;The Journal of Experimental Medicine. 2021 Jan 4
• 28 citations
  In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics.
  Hong Xu, Mia O’Reilly, Garrett S. Gibbons, Lakshmi Changolkar, Jennifer D. McBride, Dawn M. Riddle, Bin Zhang, Anna Stieber, Jeffrey J. Nirschl, Soo-Jung Kim, Kevt’her...> ;Acta Neuropathologica. 2021 Jan 1
• 20 citations
  Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
  John J. Ferrie, Zsofia Lengyel-Zhand, Bieneke Janssen, Marshall G. Lougee, Sam Giannakoulias, Chia-Ju Hsieh, Vinayak Vishnu Pagar, Chi-Chang Weng, Hong Xu, Thomas J. A...> ;Chemical Science. 2020 Dec 16
• 17 citations
  Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
  Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle, Susan Leight, Lakshmi Changolkar, Hong Xu, Emily S. Meymand, Mia O’Reilly, Bin Zhang, Kurt R. Brunden, John...> ;Molecular Neurodegeneration. 2020 Nov 4
• 47 citations
  An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
  Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, ...> ;Nature Communications. 2020 Nov 2
• 29 citations
  Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
  Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah M. Moore, Timothy J. Hohman, Estrella Morenas-Rodríguez, Brigitte Nuscher, Leslie M. Shaw, John Q. Troj...> ;Molecular Neurodegeneration. 2020 Oct 8
• 31 citations
  Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo
  Qihui Wu, Muhammad A. Shaikh, Emily S. Meymand, Bin Zhang, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee> ;Acta Neuropathologica. 2020 Oct 6
• 11 citations
  Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition
  Yuemang Yao, Goodwell Nzou, Thibault Alle, Wangchen Tsering, Shaniya Maimaiti, John Q. Trojanowski, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden> ;Alzheimer's & Dementia. 2020 Sep 11
• 76 citations
  Cell-to-Cell Transmission of Tau and α-Synuclein.
  Norihito Uemura, Maiko T. Uemura, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski> ;Trends in Molecular Medicine. 2020 Oct 1
• 31 citations
  Characterization of tau binding by gosuranemab.
  Richelle Sopko, Olga Golonzhka, Joseph Arndt, Chao Quan, Julie Czerkowicz, Andrew Cameron, Benjamin Smith, Yogapriya Murugesan, Garrett S. Gibbons, Soo-Jung Kim, John ...> ;Neurobiology of Disease. 2020 Sep 28
• 48 citations
  Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
  Daichao Xu, Heng Zhao, Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic, Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Li...> ;Nature. 2020 Sep 23
• 7 citations
  Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo.
  Sarah A Weitzman, Sneha Narasimhan, Zhuohao He, Lakshmi Changolkar, Jennifer D. McBride, Bin Zhang, Gerard D. Schellenberg, John Q. Trojanowski, Virginia M.-Y. Lee> ;Journal of Neuropathology and Experimental Neurology. 2020 Sep 1
• 44 citations
  Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration.
  John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, EunRan Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, ...> ;Brain. 2020 Sep 1
• Join now to see all