W. KimrynRathmellMDPhD

PubMed

• 14 citations
  Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus.
  Kelsey Voss, Allison E Sewell, Evan S Krystofiak, Katherine N Gibson-Corley, Arissa C Young, Jacob H Basham, Ayaka Sugiura, Emily N Arner, William N Beavers, Dillon E ...> ;Science Immunology. 2023 Jan 13
• 4 citations
  Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.
  Naira Baregamian, Konjeti R Sekhar, Evan S Krystofiak, Maria Vinogradova, Giju Thomas, Emmanuel Mannoh, Carmen C Solórzano, Colleen M Kiernan, Anita Mahadevan-Jansen, ...> ;Surgery. 2023 Jan 1
• 8 citations
  A global view of the aspiring physician-scientist.
  Christopher S Williams, W Kimryn Rathmell, John M Carethers, Diane M Harper, Y M Dennis Lo, Peter J Ratcliffe, Mone Zaidi> ;Elife. 2022 Sep 13
• 12 citations
  Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection.
  Connor J Beebout, Gabriella L Robertson, Bradley I Reinfeld, Alexandra M Blee, Grace H Morales, John R Brannon, Walter J Chazin, W Kimryn Rathmell, Jeffrey C Rathmell,...> ;Nature Microbiology. 2022 Sep 1
• 6 citations
  Ligand-independent integrin β1 signaling supports lung adenocarcinoma development.
  Scott M Haake, Erin J Plosa, Jonathan A Kropski, Lindsay A Venton, Anupama Reddy, Fabian Bock, Betty T Chang, Allen J Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A P...> ;JCI Insight. 2022 Aug 8
• 5 citations
  The Association between a Decrease in On-Treatment Neutrophil-to-Eosinophil Ratio (NER) at Week 6 after Ipilimumab Plus Nivolumab Initiation and Improved Clinical Outc...
  Yu-Wei Chen, Matthew D Tucker, Landon C Brown, Hesham A Yasin, Kristin K Ancell, Andrew J Armstrong, Kathryn E Beckermann, Nancy B Davis, Michael R Harrison, Elizabeth...> ;Cancers. 2022 Aug 7
• 87 citations
  Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
  W Kimryn Rathmell, R Bryan Rumble, Peter J Van Veldhuizen, Hikmat Al-Ahmadie, Hamid Emamekhoo, Ralph J Hauke, Alexander V Louie, Matthew I Milowsky, Ana M Molina, Trac...> ;Journal of Clinical Oncology. 2022 Sep 1
• 9 citations
  Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer.
  Evan B Glass, Alyssa A Hoover, Kennady K Bullock, Matthew Z Madden, Bradley I Reinfeld, Whitney Harris, Dominique Parker, Demetra H Hufnagel, Marta A Crispens, Dineo K...> ;BMC Cancer. 2022 May 6
• 4 citations
  Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.
  Emily J Gallagher, Don C Rockey, Christopher D Kontos, Jatin M Vyas, Lawrence F Brass, Patrick J Hu, Carlos M Isales, Olujimi A Ajijola, W Kimryn Rathmell, Paul R Conl...> ;JCI Insight. 2022 Mar 22
• 52 citations
  From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit.
  Choueiri, T., Albiges, L., Atkins, M., Bakouny, Z., Bratslavsky, G., Braun, D., Haas, N., Haanen, J., Hakimi, A., Jewett, M., Jonasch, E., Kaelin, W., Kapur, P., Labak...> ;Clinical Cancer Research. 2022 Mar 1
• 1 citations
  Spatial models of tumour evolution.
  Dakim K Gaines, W Kimryn Rathmell> ;Nature Ecology & Evolution. 2022 Jan 1
• 2 citations
  SETD2 regulates the methylation of translation elongation factor eEF1A1 in clear cell renal cell carcinoma.
  Robert Hapke, Lindsay Venton, Kristie Lindsay Rose, Quanhu Sheng, Anupama Reddy, Rebecca Prather, Angela Jones, W Kimryn Rathmell, Scott M Haake> ;Kidney Cancer Journal. 2022 Jan 1
• 16 citations
  Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.
  Benjamin J. Reisman, Hui Guo, Haley E. Ramsey, Madison T. Wright, Bradley I. Reinfeld, P. Brent Ferrell, Gary A. Sulikowski, W. Kimryn Rathmell, Michael R. Savona, Lar...> ;Nature Chemical Biology. 2021 Dec 2
• 212 citations
  Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
  Eric Jonasch, Frede Donskov, Othon Iliopoulos, W. Kimryn Rathmell, Vivek Narayan, Benjamin L. Maughan, Stéphane Oudard, Tobias Else, Jodi K. Maranchie, Sarah J. Welsh,...> ;The New England Journal of Medicine. 2021 Nov 25
• Upcycling the TCA cycle-rewiring tumour-associated fibroblasts.
  Zachary A. Bacigalupa, W. Kimryn Rathmell> ;Nature Metabolism. 2021 Nov 1
• 17 citations
  Association of baseline neutrophil-to-eosinophil ratio with response to nivolumab plus ipilimumab in patients with metastatic renal cell carcinoma.
  Matthew D. Tucker, Landon C. Brown, Yu-Wei Chen, Chester Kao, Nathan Hirshman, Emily N. Kinsey, Kristin Kathleen Ancell, Kathryn E. Beckermann, Nancy B. Davis, Renee M...> ;Biomarker Research. 2021 Nov 3
• 5 citations
  Integrative computational immunogenomic profiling of cortisol-secreting adrenocortical carcinoma
  Jordan J. Baechle, David N. Hanna, Konjeti R. Sekhar, Jeffrey C. Rathmell, W. Kimryn Rathmell, Naira Baregamian> ;Journal of Cellular and Molecular Medicine. 2021 Oct 19
• 10 citations
  Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.
  Gennady Bratslavsky, Neil Mendhiratta, Michael Daneshvar, James Brugarolas, Mark W. Ball, Adam R. Metwalli, Katherine L. Nathanson, Phillip M. Pierorazio, Ronald S. Bo...> ;Cancer. 2021 Nov 1
• 34 citations
  The therapeutic implications of immunosuppressive tumor aerobic glycolysis.
  Bradley I. Reinfeld, W. Kimryn Rathmell, Tae Kon Kim, Jeffrey C. Rathmell> ;Cellular & Molecular Immunology. 2021 Jul 8
• 7 citations
  Molecular determinants for α-tubulin methylation by SETD2.
  Sarah Kearns, Frank M. Mason, W. Kimryn Rathmell, In Young Park, Cheryl Walker, Kristen J. Verhey, Michael A. Cianfrocco> ;The Journal of Biological Chemistry. 2021 Jun 19
• 4 citations
  Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma.
  Aaron R. Lim, Benjamin G. Vincent, Alissa M. Weaver, W. Kimryn Rathmell> ;Cancer Gene Therapy. 2021 Jun 4
• 127 citations
  Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages
  Aleksandar Obradovic, Nivedita Chowdhury, Scott M. Haake, Casey Ager, Vinson Wang, Lukas Vlahos, Xinzheng V. Guo, David H. Aggen, W. Kimryn Rathmell, Eric Jonasch, Joy...> ;Cell. 2021 May 27
• 12 citations
  Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.
  Matthias Koenning, Xianlong Wang, Menuka Karki, Rahul K. Jangid, Sarah Kearns, Durga Nand Tripathi, Michael A. Cianfrocco, Kristen J. Verhey, Sung Yun Jung, Cristian C...> ;Brain. 2021 Sep 4
• 229 citations
  Cell-programmed nutrient partitioning in the tumour microenvironment
  Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf, Anna Chytil, Jackie E. Bader, Andrew R. Patterson, Ayaka Sugiura, Allison S. Cohen, Ahmed Ali, Brian T. Do, Al...> ;Nature. 2021 Apr 7
• 16 citations
  A cytoskeletal function for PBRM1 reading methylated microtubules
  Menuka Karki, Rahul K. Jangid, Ramakrishnan Anish, Riyad N.H. Seervai, Jean-Philippe Bertocchio, Takashi Hotta, Pavlos Msaouel, Sung Yun Jung, Sandra L. Grimm, Cristia...> ;Science Advances. 2021 Apr 1
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Journal Articles

• Publisher Correction: Clinical Activity and Molecular Correlates of Response to Atezolizumab Alone or in Combination with Bevacizumab Versus Sunitinib in Renal Cell Ca...  
  Michael B Atkins, Mario Sznol, Robert J Motzer, Richard W Joseph, Thomas Hutson, John Hainsworth, W Kimryn Rathmell, Brian I Rini, David F McDermott, Toni K Choueiri, ..., Nature
• Epigenetic Modifiers: Activities in Renal Cell Carcinoma  
  W. Kimryn Rathmell, MD, Nature
• VHL Substrate Transcription Factor ZHX2 as an Oncogenic Driver in Clear Cell Renal Cell Carcinoma  
  Eric Jonasch, Xian Chen, William Y Kim, W Kimryn Rathmell, Science Magazine
• Clinical Activity and Molecular Correlates of Response to Atezolizumab Alone or in Combination with Bevacizumab Versus Sunitinib in Renal Cell Carcinoma  
  Michael B Atkins, Thomas Hutson, Mario Sznol, Toni K Choueiri, Sumanta K Pal, Richard W Joseph, John Hainsworth, W Kimryn Rathmell, David F McDermott, Robert J Motzer,..., Nature
• A case report of severe type B lactic acidosis following first dose of nivolumab in a VHL-mutated metastatic renal cell carcinoma  
  Nakajima, E, Leger, P, Mauer, IA, Neuss, MN, Chism, DD, Rathmell, WK, Kidney Cancer, 1/1/2017
• Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas  
  Campbell JD, Alexandrov A, Kim J, Wala J, Berger AH, Pedamallu CS, Shukla SA, Guo G, Brooks AN, Murray BA, Imielinski M, Hu X, Ling S, Akbani R, Rosenberg M, Cibulskis..., Nat Genet, 1/1/2016
• Characterization of HPV and host genome interactions in primary head and neck cancers  
  Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tan..., Proc. Natl Acad. Sci. U S A., 1/1/2014
• The somatic genomic landscape of chromophobe renal cell carcinoma  
  Davis, CF*, Ricketts, C*, Wang, M*, Yang, L*, Cherniack, AD, Shen, H, Buhay, C, Kim, SC, Fahey, CC, Hacker, KE, Bhanot, G, Gordenin, DA, Chu, A, Gunaratne, PH, Biehl, ..., Cancer Cell., 1/1/2014
• Comprehensive molecular characterization of gastric adenocarcinoma  
  Cancer Genome Atlas Research Network., Nature, 1/1/2014
• ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma  
  Brooks SA, Brannon AR, Parker JS, Fisher JC, Sen O, Kattan MW, Hakimi AA, Hsieh JJ, Choueiri TK, Tamboli P, Maranchie JK, Hinds P, Miller CR, Nielsen ME, Rathmell, WK, Eur Urol., 1/1/2014
• HIF1 and HIF2 exert differential preferences on nutrient utilization  
  Arreola, A, Cowey, CL, Coloff, J, Rathmell, JC, and Rathmell, WK., PLoS One., 1/1/2014
• Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects  
  Simon, J*, Hacker, KE*, Brannon, AR, Parker, JS, Weiser, M, Ho, TH, Kuan PF, Jonasch E, Furey TS, Prins JF, Lieb, JD**, Rathmell, WK**, Davis, IJ, Genome Research., 1/1/2014
• Seeing the Forest for the Trees: Kidney Oncogenomes Relate to Therapeutic Outcomes  
  Chism, DD, Rathmell, WK., Clin Cancer Res, 1/1/2014
• Ror2 creates a poised signal for Wnt signaling in renal cell carcinoma  
  Rasmussen, N, Wright, T,Debebe, Z, Hacker, KE, Sen, O, Major, MB, Green, J., Wahl, G, Rathmell, WK, J Biol Chemistry, 1/1/2013
• Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis and ATM-Mediated DNA Damage Response  
  DeSimone, M, Rathmell, WK*, Threadgill, D*, J. Natl. Cancer Inst, 1/1/2013
• Racial Difference in Histologic Subtype of Renal Cell Carcinoma  
  Olshan, AF, Kuo, T, Meyer, A-M, Nielsen, ME, Purdue, MP, and Rathmell, WK, Cancer Med., 1/1/2013
• FDG-PET as a Predictive Biomarker for Therapy with Everolimus in Metastatic Renal Cell Cancer (mRCC)  
  Chen, J, Appelbaum, D, Kocherginsky, M, Cowey, CL, Rathmell, WK, McDermott, D, Stadler, W, Cancer Med, 1/1/2013
• In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation  
  Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O., Cell Metabolism, 1/1/2013
• Survival prediction in everolimus-treated patients with metastatic renal cell carcinoma incorporating tumor burden response in the RECORD-1 trial  
  Stein A, Bellmunt J, Escudier B, Kim D, Stergiopoulos SG, Mietlowski W, Motzer RJ; RECORD-1 Trial Study Group., Eur Urol, 1/1/2013
• Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors  
  Cancer, 1/1/2010
• The importance of HIF in clear cell renal cell carcinoma  
  Rathmell, WK, Kidney Cancer Journal., 1/1/2009
• Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial  
  Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N, Urbanowitz G, Berg WJ, Kay A, Lebwohl D, Ravaud A; R..., Lancet, 1/1/2008
• Biomarkers guide choice in systemic treatment  
  Rathmell, WK., Kidney Cancer Journal., 1/1/2008
• Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies  
  Rathmell KW*, Chen F, Creighton CJ, Oncoscience, 1/20/2015
• Integrated genomic characterization of oesophageal carcinoma  
  Cancer Genome Atlas Research Network, Nature, 1/12/2017
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Books/Book Chapters

• Renal Cell Carcinoma: Principles and Practice 
  Chapter: Biomarkers for Renal Cell Carcinoma 
  Rose, T and Rathmell, WKEditors: Primo Lara and Eric Jonasch.Edition 2nd,2015
• 9th Manual of Clinical Oncology 
  Chapter: Kidney Cancer 
  Ferguson, JE, Wallen, EM, and Rathmell, WK2014
• Renal Cell Carcinoma 
  Chapter: Prognostic and Predictive Biomarkers in Renal Cell Carcinoma (RCC) 
  Chism, DD and Rathmell, WKEditors: Nizar Tannir.2014
• Renal Cell Carcinoma: Biology, Prognostic Factors, and Therapeutic Targets. 
  Chapter: HIF biology in renal cell carcinoma 
  Rathmell, WK.Editors: Robert Figlin, Brian Rini, and W. Kimryn Rathmell.2012
• Renal cell carcinoma: clinical management 
  Chapter: Biology of RCC (VEGF, mTOR, immune aspects). 
  Arreola, A and Rathmell, WK.Editors: Brian Rini and Stephen Campbell..2012
• ASCO Education Book 
  Chapter: Biomarkers in renal cell carcinoma 
  Li, M and Rathmell, WK2011
• Emerging Cancer Therapeutics: Renal Cancer. 
  Chapter: The biology of renal cell carcinoma. 
  Page 1.0 - 20.0Haake, SM and Rathmell, WKEditors: Walter Stadler and Jame Abraham.2011
• Renal cell carcinoma: Principles and Practice. 
  Chapter: Biomarkers for renal cell carcinoma. 
  Li, M and Rathmell, WKEditors: Primo Lara and Eric Jonasch.2011
• Kidney Cancer. 
  Chapter: Basic Research in Kidney Cancer. 
  Oosterwijk, E, Belldegrun, A, Brannon, AR, Finley, DS, Junker, K, Pouliot, F, Rathmell, WK and Uemura, H.Editors: Z. Kirkali and P. Mulders.1st EAU-ICUD International Consultation on Kidney Cancer, Barcelona2010
• Medical Biostatistics for Complex Diseases 
  Chapter: Predicting Cancer Survival Using Expression Patterns 
  Page 305.0 - 330.0Reddy, A, Kronek, L-P, Brannon, AR, Seiler, M, Ganesan, S, Rathmell, WK, Bhanot, G.Editors: Emmert-Streib, F. and Dehmer, M..2010
• Renal Cell Carcinoma 
  Chapter: Vascular Endothelial Growth Factor Ligand-Binding Agents. 
  Page 203.0 - 210.0Rini, BI and Rathmell, WKEditors: Rini, B. and Campbell, S..2009
• Renal Cell Carcinoma 
  Chapter: Angiogenesis Biology in Metastatic Renal Cell Carcinoma. 
  Page 191.0 - 202.0Amin, C and Rathmell, WKEditors: Rini, B. and Campbell, S..2009
• Renal Cell Carcinoma 
  Chapter: Biologic and Clinical Implications of VEGF Activity in Renal Cell Carcinoma. 
  Page 99.0 - 118.0Rathmell, WK and Rini, BI.Editors: Bukowski, R., Motzer, R., and Figlin, R..2008
• Netter’s Internal Medicine 
  Chapter: Testicular Cancer. 
  Page 614.0 - 622.0Rathmell, WK and Godley, PEditors: Runge, M. and Greganti, A..Edition 2nd,2008
• ASCO Education Book 
  Chapter: Rational Therapeutic Choices and Strategies for Patients with Metastatic Renal Cancer 
  Rathmell, WK, Stadler, WM, Rini, BI.2008
• ASCO Education Book 
  Chapter: VHL Gene: Clinical Implications 
  Rathmell, WK2007
• DNA damage and repair, Vol. 2: DNA repair in higher eukaryotes 
  Chapter: Mechanisms for DNA double-strand break repair in eukaryotic cells. 
  Page 299.0 - 316.0Rathmell, WK, Chu, G.Editors: Nickolof, J.A., Hoekstra, M.F..Humana Press1998
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Lectures

• Renal Cell Carcinoma. 
  Nashville, TN - 1/1/2016
• Translational Research at the Bioinformatic Edge. 
  Schloss Dagstuhl, Wadern, Germany - 1/1/2016
• Renal Medullary Carcinoma 
  Nashville, TN - 1/1/2016
• Chromatin and transcriptional regulation in RCC 
  Duke-NUS Singapore. - 1/1/2016
• ClearCode34, is it ready for prime time? 
  St. Andrews, Scotland. - 1/1/2016
• Translational Studies in RCC. 
  Vanderbilt University. - 1/1/2016
• Alterations in angiogenesis related to VHL mutation. 
  Houston, TX - 1/1/2016
• What Nephrologists should know about kidney cancer 
  Sand Diego, CA - 1/1/2015
• New Directions in RCC 
  Lake Geneva, WI - 1/1/2015
• Balancing the career of an MD-PhD 
  Wrightsville Beach, NC. - 1/1/2015
• Targeting Notch pathway to overcome resistance to anti-angiogenic therapy in RCC 
  MD Anderson Cancer Center, Ann, Houston, TX - 1/1/2015
• Epigenetics in Kidney Cancer. 
  New Orleans, LA - 1/1/2015
• Comparison of kidney cancers using The Cancer Genome Atlas. 
  Chapel Hill, NC - 1/1/2015
• Angiogenic and Metabolic Phenotypes in RCC 
  ChongQing, China. - 1/1/2015
• Using Kidney tissue to make disease assessment. 
  NIDDK, Bethesda, MD - 1/1/2015
• SETD2 Mutations in Clear Cell RCC. 
  Bethesda, MD - 1/1/2014
• Transcriptomics of VHL disease 
  Madrid, Spain - 1/1/2014
• Renal Cell Carcinoma Translational Opportunities 
  Weissman Institute, Rehovot, Israel - 1/1/2014
• A Predictor for Survival in Intermediate Grade Clear Cell Renal Cell Carcinoma. 
  1/1/2009
• Renal cell carcinoma: update 2009 
  Reno, NV. - 1/1/2009
• Renal Cell Carcinoma: a new era of targeted therapy 
  Maine Medical Center. Silver Springs MD, Birmingham, AL, Laurinberg, NC, Hendersonville, NC - 1/1/2008
• Focus on Fellows and Junior Faculty, Participation in the annual meeting. 
  1/1/2005
• Animal Modeling of RCC 
  University of North Carolina - 1/1/2005
• VHL: Oxygen sensing and molecular targeting 
  Hilton Head, SC - 1/1/2004
• Multidisciplinary Advances in the Treatment of Genitourinary Cancers 
  University of North Carolina at Chapel Hill - 1/1/2004
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Other

• Tumor Genomics Program 
  Rathmell, WK
  http://university.asco.org/tumor-genomics-program
  ASCO University. - 1/1/2014
• Comment on autophagy related to VHL gene as a strategy to develop cancer treatments 
  Rathmell, WK, NPR Morning Edition.
  1/1/2008
• mTOR: An Emerging Pathway in Cancer 
  Rathmell, WK. and Shaw R., Novartis Internal Training Module.
  1/1/2008
• Kidney cancer. An Interview with Dr. Kimryn Rathmell 
  Draznin, J.
  www.Oncolink.com
  1/1/2004
• Keystone Symposia, Mouse Models of Human Cancer Meeting Review. 
  Rathmell, WK., and Van Dyke, T., Investigational Drugs Database. Thomson Current Drugs Online
  1/1/2004
• Thesis, Ku and DNA/PK in the repair of DNA double strand breaks 
  Rathmell, WK, Stanford University
  1/1/1996
• Making Strides Against a Rare Disease: Renal Medullary Carcinoma in Focus. 
  Rathmell, WK, OncLive.
  1/8./2017
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