WadeHBerrettiniMDPhD in Pharmacology

PubMed

• Clinical stakeholders' perceptions of patient engagement in outpatient medication treatment for opioid use disorder: A qualitative study.
  Melissa N Poulsen, Sophie A Roe, Patrick B Asdell, Alanna Kulchak Rahm, Wade Berrettini> ;Journal of Substance Use and Addiction Treatment. 2024 Mar 1
• Editorial Expression of Concern: Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia.
  Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, R...> ;Nature Medicine. 2024 Mar 1
• 15 citations
  GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.
  Anna R Docherty, Niamh Mullins, Allison E Ashley-Koch, Xuejun Qin, Jonathan R I Coleman, Andrey Shabalin, JooEun Kang, Balasz Murnyak, Frank Wendt, Mark Adams, Adrian ...> ;The American Journal of Psychiatry. 2023 Oct 1
• 1 citations
  Identification of opioid use disorder using electronic health records: Beyond diagnostic codes.
  Melissa N Poulsen, Cara M Nordberg, Vanessa Troiani, Wade Berrettini, Patrick B Asdell, Brian S Schwartz> ;Drug and Alcohol Dependence. 2023 Oct 1
• 4 citations
  Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder.
  Himanshu K Mishra, Heather Wei, Kayla E Rohr, Insu Ko, Caroline M Nievergelt, Adam X Maihofer, Paul D Shilling, Martin Alda, Wade H Berrettini, Kristen J Brennand, Jos...> ;European Neuropsychopharmacology. 2023 Sep 1
• 8 citations
  Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis.
  Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M Nievergelt, Adam X Maihofer, Maria C Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Y...> ;Molecular Psychiatry. 2023 Mar 29
• 1 citations
  Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome.
  Uppala Radhakrishna, Swapan K Nath, Lavanya V Uppala, Avinash Veerappa, Ariadna Forray, Srinivas B Muvvala, Raghu P Metpally, Richard C Crist, Wade H Berrettini, Lori ...> ;Frontiers in Genetics. 2023 Jan 1
• 4 citations
  Application of the COM-B model to patient barriers and facilitators of retention in medication treatment for opioid use disorder in rural Northeastern United States: A...
  Melissa N Poulsen, Patrick B Asdell, Wade Berrettini, Kortney McBryan, Alanna K Rahm> ;SSM. Mental Health. 2022 Dec 1
• 23 citations
  Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
  Nathan Gaddis, Ravi Mathur, Jesse Marks, Linran Zhou, Bryan Quach, Alex Waldrop, Orna Levran, Arpana Agrawal, Matthew Randesi, Miriam Adelson, Paul W Jeffries, Nichola...> ;Scientific Reports. 2022 Oct 7
• 7 citations
  Common Genetic Variation and Age of Onset of Anorexia Nervosa.
  Hunna J Watson, Laura M Thornton, Zeynep Yilmaz, Jessica H Baker, Jonathan R I Coleman, Roger A H Adan, Lars Alfredsson, Ole A Andreassen, Helga Ask, Wade H Berrettini...> ;Biological Psychiatry Global Open Science. 2022 Oct 1
• 3 citations
  Single Nucleus Transcriptome Data from Alzheimer's Disease Mouse Models Yield New Insight into Pathophysiology.
  Andrew E Weller, Thomas N Ferraro, Glenn A Doyle, Benjamin C Reiner, Richard C Crist, Wade H Berrettini> ;Journal of Alzheimer's Disease. 2022 Jan 1
• 16 citations
  Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake.
  Benjamin C Reiner, Yafang Zhang, Lauren M Stein, Emilie Dávila Perea, Gabriella Arauco-Shapiro, Jennifer Ben Nathan, Kael Ragnini, Matthew R Hayes, Thomas N Ferraro, W...> ;Translational Psychiatry. 2022 Sep 8
• 8 citations
  Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer's Disease.
  Ray O Bahado-Singh, Uppala Radhakrishna, Juozas Gordevičius, Buket Aydas, Ali Yilmaz, Faryal Jafar, Khaled Imam, Michael Maddens, Kshetra Challapalli, Raghu P Metpally...> ;Cells. 2022 May 25
• 12 citations
  Correction of depression-associated circadian rhythm abnormalities is associated with lithium-response in bipolar disorder.
  Monica Federoff, Michael McCarthy, Amit Anand, Wade H. Berrettini, Holli Bertram, Abesh Kumar Bhattacharjee, Cynthia V. Calkin, Carla Conroy, William Coryell, Nicole D...> ;Bipolar Disorders. 2021 Nov 26
• 2 citations
  Analysis of differential gene expression and transcript usage in hippocampus of Apoe null mutant mice: Implications for Alzheimer's disease.
  Andrew E. Weller, Glenn A. Doyle, Benjamin C. Reiner, Richard C. Crist, Wade H. Berrettini> ;Neuroscience Research. 2021 Oct 29
• 4 citations
  Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescri...
  Vanessa Troiani, Richard C. Crist, Glenn A. Doyle, Thomas N. Ferraro, Donielle Beiler, Stephanie Ranck, Kortney McBryan, Margaret A. Jarvis, Jordan S. Barbour, John J....> ;BMC Medical Genomics. 2021 Oct 26
• 28 citations
  Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition.
  Xiaolei Liu, Anurag Verma, Gustavo Garcia, Holly Ramage, Anastasia Lucas, Rebecca L. Myers, Jacob J. Michaelson, William Coryell, Arvind Kumar, Alexander W. Charney, M...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Oct 19
• Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1
  Richard C. Crist, Gabriella Arauco-Shapiro, Alexander Zhang, Benjamin C. Reiner, Wade H. Berrettini, Glenn A. Doyle> ;The American Journal of Drug and Alcohol Abuse. 2021 Aug 18
• 10 citations
  Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome.
  Uppala Radhakrishna, Swapan K. Nath, Sangeetha Vishweswaraiah, Lavanya V. Uppala, Ariadna Forray, Srinivas B. Muvvala, Nitish K. Mishra, Siddesh Southekal, Chittibabu ...> ;Genomics. 2021 Nov 1
• 411 citations
  Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
  Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon J. Coombes, Jonathan R. I. Coleman, Zhen Qiao, Thomas Damm Als, Tim B. Bigdeli, Sigrid Børte, Julien Br...> ;Nature Genetics. 2021 May 17
• 5 citations
  Investigation of long interspersed element-1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy.
  Glenn A. Doyle, Benjamin C. Reiner, Richard C. Crist, Aditya M Rao, Nkechi S Ojeah, Gabriella Arauco-Shapiro, Rachel N Levinson, Lokesh D Shah, Michael R. Sperling, Th...> ;Epilepsia. 2021 Apr 7
• 14 citations
  Clinical predictors of non-response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study
  Yian Lin, Adam X. Maihofer, Emma K. Stapp, Megan Ritchey, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman, Wade H. Berrettini, Holli Bertram, Abesh Kumar Bhattachar...> ;Bipolar Disorders. 2021 Apr 2
• 12 citations
  Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.
  Ray O. Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu Metpally, David J. Carey, Richard C. Crist, Wade H. Berrettini, George S. Wilson, Khalid ...> ;Plos One. 2021 Mar 31
• 14 citations
  Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome.
  Uppala Radhakrishna, Sangeetha Vishweswaraiah, Lavanya V. Uppala, Marta Szymanska, Jacqueline Macknis, Sandeep Kumar, Fozia Saleem-Rasheed, Buket Aydas, Ariadna Forray...> ;Genomics. 2021 Mar 9
• 24 citations
  Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies
  Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, J...> ;Molecular Psychiatry. 2021 Mar 5
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Journal Articles

• Detecting Significant Genotype–Phenotype Association Rules in Bipolar Disorder: Market Research Meets Complex Genetics  
  John Kelsoe, Melvin McInnis, James Potash, William Lawson, John Rice, Evaristus Nwulia, William Byerley, Francis J McMahon, John Nurnberger, Wade Berrettini, Cinnamon ..., Springer Open
• Psychiatric pharmacogenetics: a developing science.  
  Berrettini WH, Neuropsychopharmacology 70: 787-92
• Accuracy of CNV Detection from GWAS Data.  
  D, Qian Y, Akula N, Alliey-Rodriguez N, Tang J, The Bipolar Genome Study, Gershon ES, and Liu C, PLoS ONE 6(1): e14511
• Measurement of CSF dynorphin A1-8 in anorexia nervosa and normal-weight bulimia.  
  Lesem, M.D., Berrettini, W.H., Kaye, W.H. and Jimerson D.C, Biological Psychiatry 29:244-252
• Serotonin transporter polymorphisms and measures of impulsivity, aggression and sensation seeking among African-American cocaine abusers.  
  Patkar AA, Berrettini WH, Hoehe M, Thornton CC, Gottheil E, Weinstein SP, Psychiatry Research 110: 103-115
• A case of erythromycin-induced carbamazepine toxicity.  
  Berrettini, W.H, Journal of Clinical Psychiatry 46:147
• Diagnostic and Genetic Issues of Depression and Bipolar Illness.  
  Berrettini WH, Pharmacotherapy 15: 69S-75S
• Opioid peptides in Parkinson's disease: Effects of dopamine repletion.  
  Baronti, F., Conant, K.E., Giuffra, M., Davis, T.L., Brughitta, G., Iadarola, M.J., Berrettini, W.H., Chase, T.N. and Mouradian, M.M, Brain Research 560:92-96
• Personality, perfectionism and attitudes towards eating in parents of individuals with eating disorders.  
  Woodside DB, Bulik CM, Halmi KA, Fichter MM, Kaplan A, Berrettini WH, Strober M, Treasure J, Lilenfeld L, Klump K, Kaye WH, Int. J Eating Disorders 31:290-99
• Changes in food reward following smoking cessation: a pharmacogenetic investigation.  
  Lerman C, Berrettini WH, Pinto A, Patterson F, Crystal-Mansour F, Wileyto EP, Restine SL, Leonard DGB, Berkowitz R, Shields PG, Epstein LH, Psychopharmacology 174:571-6
• Editorial: Is investment in molecular genetics worthwhile?.  
  Berrettini, W.H, Biological Psychiatry 30(3):213-215
• The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts response to nicotine replacement therapy in a clinical trial.  
  Lerman C, Wileyto P, Patterson F, Rukstalis, M, Audrain-McGovern, J, Restine S, Shields PG, Kaufmann V, Redden D, Benowitz N, Berrettini WH, Pharmacogenomics Journal 4:184-92
• No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals.  
  Patkar AA Berrettini WH, Hoehe M, Hill KP, Gottheil E, Thornton CC, Weinstein SP, Psychiatric Genetics 12:161-4
• Loci on chromosome 6q and 6p interact in increase susceptibility to bipolar affective disorder in the NIMH Genetics Initiative pedigrees.  
  Schulze TG, Buervenich S, Badner JA, Steele cJM, Detera-Wadleigh SD, Dick D, Foroud T, Cox NJ, MacKinnon DF, Potash JB, Berrettini WH, Byerley W, Coryell W, DePaulo JR..., Biol Psychiatry 56: 18-23
• Relationship between platelet serotonin uptake sites and measures of impulsivity, aggression and sensation seeking among cocaine abusers.  
  Patkar AA, Gottheil E, Berrettini, WH, Hill KP, Thornton C, Weinstein SP, J Addictive Diseases 22: 79-92
• Review of bipolar molecular linkage and association studies.  
  Berrettini WH, Curr Psychiatry Reports 4:124-9
• Candidate genes for anorexia nervosa in the 1p34-36 linkage region: both serotonin 1D and delta opioid receptors display significant association to anorexia nervosa.  
  Bergen AW, van den Bree MBM, Yeager M, Genjei JK, Welch R, Haque, K, Becanu S-A, Berrettini WH, Grice D, Bulik CM, Fichter MM, Halmi KA, Kaplan A, Strober M, Treasure ..., Mol Psychiatry 8: 397-406
• Genomic screening for genes predisposing to bipolar disease.  
  Berrettini, W.H., Detera-Wadleigh, S.D., Goldin, L.R., Martinez, M., Hsieh, W-T., Hoehe, M., Choi, H., Muniec, D., Ferraro, T.N., Guroff, J.J., Kazuba, D., Harris, N.,..., Psychiatric Genetics 2:191-208
• Differences in platelet serotonin transporter sites between tobacco smokers and nonsmokers.  
  Patkar AA, Weinstein SP, Berrettini WH, Gopalakrishnan R, Vergare MJ and Leone FT, Psychopharmacology 166:221-7
• A bipolar pedigree series for genomic mapping of disease genes: Diagnostic and analytic considerations.  
  Berrettini, W.H., Goldin, L.R., Martinez, M.M., Maxwell, M.E., Smith, A.L., Guroff, J.J., Kazuba, D.M., Nurnberger, Jr., J.I., Hamovit, J., Simmons-Alling, S., Robb, A..., Psychiatric Genetics 2(2):125-160
• Cerebrospinal fluid neurochemistry of children and adolescents with obsessive compulsive disorder.  
  Swedo, S.E., Leonard, H.L., Kruesi, M.J.P., Rettew D.C., Listwak, S.J., Berrettini, W., Stipetic M, Hamburger, S., Gold, P.W., Potter W.Z. and Rapoport, J.L, Archives of General Psychiatry 49:29-36
• Cerebrospinal fluid galanin and neuropeptide Y immunoreactivity in progressive supranuclear palsy patients.  
  Litvan, I., Berrettini, W.H., Atack, J.R. and Chase, T.N, Acta Neurologica Scandinavica 86:204-206
• A systematic search for a bipolar predisposing locus on chromosome 5.  
  Detera-Wadleigh, S.D., Berrettini, W.H., Goldin, L.R., Martinez, M., Hsieh, W-T., Hoehe, M., Encio, I.J., Coffman, D., Rollins, D.Y., Muniec, D., Choi, H., Guroff, J.J..., Neuropsychopharmacology 6(4): 219-229
• A genetic association study of the mu opioid receptor gene and severe opioid dependence.  
  Crowley JJ, Oslin DW, Patkar AA, Gottheil E, DeMaria PA, Jr., Obrien CP, Berrettini WH, Grice DE, Psychiatric Genetics 13:169-74
• Enhanced genetic maps from family-based disease studies: population-specific comparisons.  
  He C, Weeks, DE, Buyske, S, Abecasis GR, Stewart WC, Matise TC, the enhanced map consortium, BMC Medical Genetics 12:15
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Books/Book Chapters

• Biological Psychiatry. Vol. 2 
  Chapter: A non-Kraepelinian continuity of affective disorders and schizophrenia is suggested by twin and family studies. 
  Page 510 - 512Gershon, E.S., Berrettini, W.H., Robb, A., Martinez, M. and Goldin, L.REditors: G. Racagni, N. Brunello, T. Fukuda.Elsevier Science Publishing Co. Inc., New York, NY
• Genetic Approaches to Mental Disorders, American Psychopathological Association Annual Series. 
  Chapter: A systematic search for vulnerability genes in manic-depressive illness. 
  Page 273 - 289Berrettini, W.H., Detera-Wadleigh, S.D., Goldin, L.R., Martinez, M.M., Hsieh, W-T., Hoehe, M.R., Choi, H., Muniec, D., Ferraro, T.N., Guroff, J.J., Kazuba, D., Harris,...Editors: E.S. Gershon, C.R. Cloninger.American Psychiatric Press, Inc., Washington, D.C
• Antidepressants and Receptor Function. 
  Chapter: Beta-adrenergic receptor function in human adult skin fibroblasts: A study of manic-depressive illness. 
  Page 30 - 42Berrettini, W.H., Bardakjian, J., Barnett, A.L., Nurnberger, J.I. and Gershon, E.SEditors: R. Porter, et al.John Wiley and Sons, New York, NY
• The Biology of Depressive Disorders. Part A: A Systems Perspective (The Depressive Illness Series, vol. 3). 
  Chapter: The Molecular Genetics of Bipolar Disease. 
  Page 189 - 204Berrettini, W.HEditors: J. Mann.Plenum Publishing Corp., New York, NY
• The Genetic Basis of Common Disease. 
  Chapter: The major affective disorders: bipolar, unipolar, and schizoaffective. 
  Goldin, L.R., Gershon, E.S., Nurnberger, Jr., J.I. and Berrettini, W.HEditors: R.A. King, J.A. Rotter, A.G. Motulsky.University Press, New York, NY
• Handbook of Psychogenetics. 
  Chapter: Molecular linkage studies of manic-depressive illness 
  Page 161 - 167Berrettini WHEditors: K Blum and EP Noble.CRC Press, Boca Raton, FL
• 61st Symposium on Quantitative Biology. 
  Chapter: Quantitative trait loci mapping in mouse models of complex behavior. 
  Page 771 - 778Ferraro TN, BerrettiniWHCold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
• Bipolar Disorder: Biological Models and their Clinical Application. 
  Chapter: Linkage studies of bipolar syndromes. 
  Page 219 - 233Berrettini WHEditors: LT Young, RT Joffe.Marcel Dekker, Inc, New York, NY
• Directions in Psychiatry. 
  Chapter: Genetic factors in Anorexia Nervosa. 
  Page 53 - 58Berrettini WHEditors: Frederic Flach.The Hatherleigh Company, New York, NY
• Genetic Influences on Neural and Behavioral Functions. 
  Chapter: The search for susceptibility genes in bipolar disorder. 
  Page 31 - 47Berrettini WHEditors: Don Pfaff.CRC Press, Boca Raton, FL
• Annual Review of Medicine. 
  Chapter: Genetics of psychiatric disease. 
  Page 465 - 479Berrettini, WHEditors: CH Coggins.Annual Reviews, Palo Alto, CA
• Current Diagnosis and Treatment in Psychiatry. 
  Chapter: Psychiatric genetics 
  Page 61 - 79Nurnberger JI, Berrettini WHEditors: Ebert MH, Loosen PT, Nurcombe B.Lange Medical Books, New York, NY
• Emery and Rimoin’s Principles and Priactice of Medical Genetics vol. III. 
  Chapter: Addictive Disorders 
  Page 2949 - 2974Faroud T, Berrettini WHEditors: DL Rimoin, JM Connor, RE Pyerlitz, BR Korf.Churchill Livingstone, London
• GABA and Mood Disorders. 
  Chapter: Cerebrospinal fluid GABA in manic-depressive illness. 
  Page 187 - 193Joffe, R.T., Post, R.M., Rubinow, D.R., Berrettini, W.H., Hare, T.A., Ballenger, J.C. and Roy-Byrne, P.PEditors: G. Bartholini.Raven Press, New York, NY
• Neuropsychopharmacology, The Fifth Generation of Progress. 
  Chapter: Bipolar disorders: review of molecular genetic studies. 
  Page 1027 - 1038Berrettini WHEditors: KL Davis, D Charney, JT Coyle, C Nemeroff.Lippincott, Philadelphia, PA
• Advanced Methods in Psychobiology. 
  Chapter: Genetic methods in neuropsychiatric disorders. 
  Page 221 - 235Nurnberger, J.I., Jr., Berrettini, W.H., Goldin, L.R. and Gershon, E.SEditors: J.N. Hingtgen, et al.C.J. Hogrefe, Inc., Toronto
• The Neurobiology of Mental Illness. 
  Chapter: Genetic studies of bipolar disorder. 
  Page 369 - 379Berrettini WHEditors: D Charney and E Nestler.Oxford University Press, New York, NYEdition 2,
• Psychopharmacology: The Third Generation of Progress. 
  Chapter: Genetics of Affective Illness. 
  Page 481 - 491Gershon, E.S., Berrettini, W.H., Nurnberger, J.I., Jr. and Goldin, L.REditors: H.Y. Meltzer.Raven Press, New York, NY
• Textbook of Mood Disorders. 
  Chapter: Genetics of Bipolar and Unipolar Disorders. 
  Page 235 - 250Berrettini WHEditors: DJ Stein, DJ Kupfer, AF Schatzberg.American Psychiatric Publishing, Boulevard Arlington, VA
• Neurobehavioral Genetics. 
  Chapter: Genetics of Major Affective Disorders 
  Page 127 - 246Berrettini WHEditors: BC Jones and P Mormede.CRC Press, Boca Raton, FL
• Current Diagnosis and Treatment in Psychiatry. 
  Chapter: Psychiatric Genetics 
  Page 15 - 34Nurnberger JI and Berrettini WHMcGraw-Hill, New York, NY
• The Neurobiology of Mental Illness. 
  Chapter: Genetics of mood disorders. 
  Page 360 - 377Lohoff FW and Berrettini WHEditors: D Charney and E Nestler.Oxford University Press, New York, NYEdition 3,
• Bipolar Disorder. 
  Chapter: Genetics of bipolar disorder. 
  Page 110 - 123Lohoff FW, Berrettini WHEditors: LN Yatham and M. Maj.Wiley-Blackwell, Hoboken, NJ
• Psychiatric Genetics. 
  Nurnberger JI, Jr, and Berrettini WHChapman and Hall, London
• Comprehensive Textbook of Psychiatry. 
  Chapter: Affective Disorders: Genetics. 
  Page 879 - 888Gershon, E.S., Berrettini, W.H. and Goldin, L.REditors: H.I. Kaplan, B.J. Saddock.Williams and Wilkins, Baltimore, MDEdition 5,
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Abstracts/Posters

• Further evidence for an endogenous inhibitor of platelet MAO in chronic schizophrenia.
  Vogel, W.H., Berrettini, W.H. and Ladman, R.K, Schizophrenia Bulletin 6:232-234
• Platelet MAO in families of chronic schizophrenics.
  Berrettini, W.H., Benfield, T.C., Schmidt, A.O., Ladman, R.K. and Vogel, W.H, Schizophrenia Bulletin 6:235-237
• Effects of oxygen, pH, and toluene on the activity of platelet MAO obtained from healthy and chronic schizophrenic individuals.
  Vogel, W.H., Berrettini, W.H., Weiss, K.J. and Benfield, T.C, Psychopharmacology Bulletin l7:28-31