Wade H Berrettini MD PhD in Pharmacology

Addiction, Psychopharmacology, Psychosomatic Medicine

Professor of Psychiatry, Perelman School of Medicine at the University of Pennsylvania

113 Cherry LaneWynnewood, PA 19096
Phone+1 484-432-5836
Fax+1 610-642-2740

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Summary

Wade Berrettini, MD, PhD, is a board-certified psychiatrist and pharmacologist, based in Wynnewood, PA. He is expert in the pharmacotherapy of those patients with treatment-resistant mood disorders. He completed his medical education at Jefferson Medical College (1977) and then received a Ph.D. in Pharmacology (1979) from Thomas Jefferson University. Dr. Berrettini is a professor of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania. He has contributed to several noteworthy publications in the field, focusing on bipolar disorder genetics and pharmacogenetics. His research work has been recognized with multiple awards, including a Research Award from Caron Foundation and a Distinguished Investigator Award from the National Alliance for Research on Schizophrenia and Depression.

Education & Training

Clinical Center at the National Institutes of HealthFellowship, Psychosomatic Medicine, 1982 - 1983
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Psychiatry, 1977 - 1980
Thomas Jefferson UniversityPh.D, Pharmacology, 1977 - 1979
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1977, MD
Dickinson CollegeBS, Cum Laude, 1969 - 1973

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Certifications & Licensure

PA State Medical License 1978 - 2026
MD State Medical License 1980 - 1990
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Research Award Caron Foundation, 2009
National Alliance for Research on Schizophrenia and Depression Distinguished Investigator Award 1999, 2004, 2009
GlaxoSmithKline Fellowship in Genetics of Disease 2007

Clinical Trials

Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD)
COMPLETED

Publications & Presentations

PubMed

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.
Tracey van der Veen, Markos Tesfaye, Jessica Mei Kay Yang, Toni Boltz, Friederike S David
Research Square. 2026-08-26
3 citations
Acute opioid responses are modulated by dynamic interactions ofand.
Paige M Lemen, Yanning Zuo, Alexander S Hatoum, Price E Dickson, Guy Mittleman
Elife. 2026-07-29
Influence of residential greenness and season on discontinuation of medication treatment for opioid use disorder across rural to urban community types.
Melissa N Poulsen, Cara M Nordberg, Karen Bandeen-Roche, Joseph DeWalle, Wade Berrettini
Addictive Behaviors Reports. 2026-06-01

Journal Articles

Detecting Significant Genotype–Phenotype Association Rules in Bipolar Disorder: Market Research Meets Complex Genetics
John Kelsoe, Melvin McInnis, James Potash, William Lawson, John Rice, Evaristus Nwulia, William Byerley, Francis J McMahon, John Nurnberger, Wade Berrettini, Cinnamon ..., Springer Open
Platelet monoamine oxidase in chronic schizophrenia.
Berrettini, W.H., Vogel, W.H. and Clouse, R, American Journal of Psychiatry 134:805-806
Decreased platelet monoamine oxidase activity in chronic schizophrenia demonstrated with novel substrates.
Berrettini, W.H., Prozialeck, W. and Vogel, W.H, Archives of General Psychiatry 35:600-605

Books/Book Chapters

Neuropsychopharmacology, The Fifth Generation of Progress.
Chapter: Bipolar disorders: review of molecular genetic studies.
Page 1027 - 1038Berrettini WHEditors: KL Davis, D Charney, JT Coyle, C Nemeroff.Lippincott, Philadelphia, PA
Handbook of Psychogenetics.
Chapter: Molecular linkage studies of manic-depressive illness
Page 161 - 167Berrettini WHEditors: K Blum and EP Noble.CRC Press, Boca Raton, FL
61st Symposium on Quantitative Biology.
Chapter: Quantitative trait loci mapping in mouse models of complex behavior.
Page 771 - 778Ferraro TN, BerrettiniWHCold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

Abstracts/Posters

Further evidence for an endogenous inhibitor of platelet MAO in chronic schizophrenia.
Vogel, W.H., Berrettini, W.H. and Ladman, R.K, Schizophrenia Bulletin 6:232-234
Platelet MAO in families of chronic schizophrenics.
Berrettini, W.H., Benfield, T.C., Schmidt, A.O., Ladman, R.K. and Vogel, W.H, Schizophrenia Bulletin 6:235-237
Effects of oxygen, pH, and toluene on the activity of platelet MAO obtained from healthy and chronic schizophrenic individuals.
Vogel, W.H., Berrettini, W.H., Weiss, K.J. and Benfield, T.C, Psychopharmacology Bulletin l7:28-31

Press Mentions

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia NervosaDecember 5th, 2018
Genome-Wide Association Study of Seasonal Affective DisorderSeptember 14th, 2018
Yes, You Can Inherit Depression—Here’s What That Means if You're StrugglingMay 16th, 2018

Grant Support

Genetics Of Nicotine DependenceNational Institute On Drug Abuse2009–2012
MU Opioid Receptor In AddictionNational Institute On Drug Abuse2008–2011
Linkage Disequilibrium Studies Of Morip Genes In Opiod DependenceNational Institute On Drug Abuse2008–2011
Administrative CoreNational Institute On Drug Abuse2008–2011
MU Receptor Interacting Proteins In Opiate DependenceNational Institute On Drug Abuse2007–2011