WaelAssadSakrMD

Pathology • Detroit, MI

Genitourinary Pathology, Anatomic Pathology, Clinical Pathology, Surgical Pathology

Professor & Chairman Pathology Department Wayne State University School of Medicine

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Office
3990 John R St
Harper Hospital Pathology
Detroit, MI 48201
Phone+1 313-745-8555

Fax+1 313-745-9299
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Education & Training

Detroit Medical Center/Wayne State UniversityResidency, Pathology-Anatomic and Clinical, 1985 - 1987
New York-Presbyterian/QueensResidency, Pathology-Anatomic and Clinical, 1982 - 1985
Damascus University Faculty of MedicineClass of 1980

Certifications & Licensure

MI State Medical License 1986 - 2026
IA State Medical License 1985 - 1988
American Board of Pathology Anatomic Pathology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com
Top MD Consumers Checkbook

Publications & Presentations

PubMed

The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin.
Shijie Sheng, Margarida Bernardo, Sijana H Dzinic, Kang Chen, Wael A Sakr> ;Cancer Metastasis Reviews. 2022 Dec 1
12 citations
p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis.
Su Hyun Lee, Won Jin Cho, Abdo J. Najy, Allen-Dexter Saliganan, Tri Pham, Joseph T. Rakowski, Brian Loughery, Chang Hoon Ji, Wael Sakr, Seongho Kim, Ikuko Kato, Weon K...> ;Cell Death & Disease. 2021 Oct 25
41 citations
Recurrent KRAS mutations in papillary renal neoplasm with reverse polarity.
Khaleel I Al-Obaidy, Mehdi Nassiri, Liang Cheng, Mohammad K. Eldomery, Sean R. Williamson, W. A. Sakr, Nilesh S. Gupta, Oudai Hassan, Muhammad T. Idrees, David J. Grig...> ;Modern Pathology. 2020 Jun 1
7 citations
Should all prostate needle biopsy Gleason score 4 + 4 = 8 prostate cancers be high risk? Implications for shared decision-making and patient counselling
Kevin Ginsburg, Adam I. Cole, Michael E. Silverman, Joan Livingstone, Daryn Smith, Lance K. Heilbrun, Dongping Shi, Rohit Mehra, Wael Sakr, Todd M. Morgan, Michael L. ...> ;Urologic Oncology. 2020 Mar 1
51 citations
Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study.
Khaleel I Al-Obaidy, Liang Cheng, Sean R. Williamson, W. A. Sakr, Nilesh S. Gupta, Muhammad T. Idrees, David J. Grignon, John N. Eble> ;The American Journal of Surgical Pathology. 2019 Jan 1
15 citations
Tackling tumor heterogeneity and phenotypic plasticity in cancer precision medicine: our experience and a literature review
Shijie Sheng, M. Margarida Bernardo, Sijana H. Dzinic, Kang Chen, Elisabeth I. Heath, Wael Sakr> ;Cancer Metastasis Reviews. 2018 Nov 27
15 citations
Overexpression of the Pluripotent Stem Cell Marker Podocalyxin in Prostate Cancer
Elisabeth I. Heath, Lance K. Heilbrun, Daryn Smith, William M. Schopperle, Yawen Ju, Susan Bolton, Quratulain Ahmed, Wael Sakr> ;Anticancer Research. 2018 Nov 1
13 citations
Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells
Emily A. Teslow, Bin Bao, Greg Dyson, Christophe Legendre, Cristina Mitrea, Wael Sakr, John D. Carpten, Isaac J. Powell, Aliccia Bollig-Fischer> ;Molecular Oncology. 2018 May 24
27 citations
Phase III Intergroup Trial of Adjuvant Androgen Deprivation With or Without Mitoxantrone Plus Prednisone in Patients With High-Risk Prostate Cancer After Radical Prost...
Maha Hussain, Catherine M. Tangen, Ian M. Thompson, Gregory P. Swanson, Wael Sakr, Nancy A. Dawson, Naomi B. Haas, Thomas W. Flaig, Tanya B. Dorff, Daniel W. Lin, E. D...> ;Journal of Clinical Oncology. 2018 Apr 6
38 citations
Early Surgery Confers 1-Year Mortality Benefit in Hip-Fracture Patients.
Kamal Maheshwari, Jeffrey Planchard, Jing You, Wael Ali Sakr, Jaiben George, Carlos A. Higuera-Rueda, Leif Saager, Alparslan Turan, Andrea Kurz> ;Journal of Orthopaedic Trauma. 2017 Oct 1
3 citations
An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Response.
Ming Zhang, Mary J.C. Hendrix, Philip A. Pemberton, Wael Sakr, Shijie Sheng> ;Cancer Research. 2017 Sep 15
33 citations
HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer.
Young-Suk Jung, Abdo J. Najy, Wei Huang, Seema Sethi, Michael Snyder, Wael Sakr, Gregory Dyson, Maik Hüttemann, Icksoo Lee, Rouba Ali-Fehmi, Silvia Franceschi, Linda S...> ;Oncotarget. 2017 May 16
17 citations
An Essential Role of Maspin in Embryogenesis and Tumor Suppression.
Sijana H. Dzinic, M. Margarida Bernardo, Xiaohua Li, Rodrigo Fernandez-Valdivia, Ye Shih Ho, Qing Sheng Mi, Sudeshna Bandyopadhyay, Fulvio Lonardo, Semir Vranic, Danie...> ;Cancer Research. 2017 Feb 15
9 citations
Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients
Clara Hwang, Seema Sethi, Lance K. Heilbrun, Nilesh S. Gupta, Dhananjay Chitale, Wael Sakr, Mani Menon, James O. Peabody, Daryn Smith, Fazlul H. Sarkar, Elisabeth I. H...> ;American Journal of Translational Research. 2016 Jan 15
9 citations
Tumor suppressor maspin as a modulator of host immune response to cancer
Sijana H. Dzinic, M. Margarida Bernardo, Daniel S. M. Oliveira, Marian Wahba, Wael Sakr, Shijie Sheng> ;Bosnian Journal of Basic Medical Sciences. 2015 Oct 25
19 citations
Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity
M. Margarida Bernardo, Alexander Kaplun, Sijana H. Dzinic, Xiaohua Li, Jonathan C. Irish, Adelina Mujagic, Benjamin Jakupovic, Jessica B. Back, Eric Van Buren, Xiang H...> ;Cancer Research. 2015 Sep 15
88 citations
Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes.
Dejuan Kong, Seema Sethi, Yiwei Li, Wei Chen, Wael Sakr, Elisabeth I. Heath, Fazlul H. Sarkar> ;The Prostate. 2015 Feb 1
17 citations
Maspin expression in prostate tumor elicits host anti-tumor immunity
Sijana H. Dzinic, Kang Chen, Archana Thakur, Alexander Kaplun, R. Daniel Bonfil, Xiaohua Li, Jason Liu, M. Margarida Bernardo, Allen Saliganan, Jessica B. Back, Hirosh...> ;Oncotarget. 2014 Oct 22
35 citations
Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG Fusions
Rajareddy Singareddy, Louie Semaan, M. Katie Conley-LaComb, Jason St. John, Katelyn Powell, Matthew K. Iyer, Daryn Smith, Lance K. Heilbrun, Dongping Shi, Wael Sakr, M...> ;Molecular Cancer Research. 2013 Nov 1
99 citations
SWOG S0353: Phase II Trial of Intravesical Gemcitabine in Patients with Nonmuscle Invasive Bladder Cancer and Recurrence after 2 Prior Courses of Intravesical Bacillus...
Eila C. Skinner, Bryan Goldman, Wael Sakr, Daniel P. Petrylak, Heinz-Josef Lenz, Cheryl T. Lee, Shandra Wilson, Mitchell C. Benson, Seth P. Lerner, Catherine M. Tangen...> ;The Journal of Urology. 2013 Oct 1
39 citations
Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer.
Seema Sethi, Dejuan Kong, Sue Land, Gregory Dyson, Wael Sakr, Fazlul H. Sarkar> ;American Journal of Translational Research. 2013 Jan 1
30 citations
3, 3′-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells
Aamir Ahmad, Shadan Ali, Alia Ahmed, Azfur S. Ali, Avraham Raz, Wael Sakr, KM Wahidur Rahman> ;Plos One. 2013 Jan 22
4 citations
The Therapeutic Value of Natural Agents to Treat miRNA Targeted Breast Cancer in African-American and Caucasian-American Women
KM Wahidur Rahman, Wael Sakr> ;Current Drug Targets. 2012 Nov 30
160 citations
Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM
Dejuan Kong, Elisabeth I. Heath, Wei Chen, Michael L. Cher, Isaac J. Powell, Lance K. Heilbrun, Yiwei Li, Shadan Ali, Seema Sethi, Oudai Hassan, Clara Hwang, Nilesh S....> ;Plos One. 2012 Mar 19
65 citations
Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.
Dejuan Kong, Elisabeth I. Heath, Wei Chen, Michael L. Cher, Isaac J. Powell, Lance K. Heilbrun, Yiwei Li, Shadan Ali, Seema Sethi, Oudai Hassan, Clara Hwang, Nilesh S....> ;American Journal of Translational Research. 2012 Jan 5
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Press Mentions

Jinping Xu, M.D., Appointed Chair of Department of Family Medicine and Public Health SciencesFebruary 24th, 2023
The Year in Review: Our Top Stories of 2022 at the School of MedicineJanuary 7th, 2023
Medical Students Create Mask to Share Implicit Biases and Professional IdentitiesAugust 17th, 2022
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Hospital Affiliations

DMC Children's Hospital of MichiganDetroit, Michigan
DMC Detroit Receiving Hospital & University Health CenterDetroit, Michigan
DMC Harper University HospitalDetroit, Michigan
DMC Sinai-Grace HospitalDetroit, Michigan
Karmanos Cancer CenterDetroit, Michigan