WarrenLe EricAlexanderMD

PubMed

• 22 citations
  The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
  Yuqing Yang, Andrew J. Kueh, Zoe L. Grant, Waruni Abeysekera, Alexandra L. Garnham, Stephen Wilcox, Craig D. Hyland, Ladina Di Rago, Donald Metcalf, Warren S. Alexande...> ;Blood. 2021 Nov 1
• 4 citations
  Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency.
  Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, ...> ;Iscience. 2021 Oct 22
• 3 citations
  Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.
  Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah D. Coughlan, Pedro L. Baldoni, Nicolas Jacquelot, Wang H. J. Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pelleg...> ;Science Immunology. 2021 Sep 17
• 3 citations
  Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9
  Jarrod J. Sandow, Andrew I. Webb, Dina Stockwell, Nadia J. Kershaw, Cyrus Tan, Satoshi Ishido, Warren S. Alexander, Douglas J. Hilton, Jeffrey J. Babon, Nicos A. Nicola> ;Proteomics. 2021 Jun 1
• 7 citations
  The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis
  Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S. Alexander,...> ;Cell Death & Disease. 2021 Jan 28
• 4 citations
  T-ALL can evolve to oncogene independence
  Hesham Abdulla, Anh Vo, Benjamin J. Shields, Tenae J. Davies, Jacob T. Jackson, Raed Alserihi, Elizabeth M. Viney, Tin Wong, Feng Yan, Nicholas C. Wong, Lisa Demoen, D...> ;Leukemia. 2021 Jan 22
• 25 citations
  Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice
  Silvia Alvarez-Diaz, Adele Preaudet, Andre L. Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L. Garnham, Warren S. Alexander, Andreas Strasser, Matthias Ernst, Tracy L ...> ;Cell Death and Differentiation. 2021 May 1
• 3 citations
  Downregulation of the GHRH/GH/IGF1 axis in a mouse model of Börjeson-Forssman-Lehman syndrome.
  Helen M McRae, Samantha Eccles, Lachlan Whitehead, Warren S Alexander, Jozef Gécz, Tim Thomas, Anne K Voss> ;Development. 2020 Oct 23
• 14 citations
  A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics
  Daniela Amann-Zalcenstein, Luyi Tian, Jaring Schreuder, Sara Tomei, Dawn S. Lin, Kirsten A. Fairfax, Jessica E. Bolden, Mark D. McKenzie, Andrew Jarratt, Adrienne A. H...> ;Nature Immunology. 2020 Oct 19
• 37 citations
  Membrane budding is a major mechanism of in vivo platelet biogenesis.
  Kathryn S. Potts, Alison Farley, Caleb A. Dawson, Joel S. Rimes, Christine Biben, Carolyn A. de Graaf, Margaret A Potts, Olivia Stonehouse, Amandine Carmagnac, Pradnya...> ;The Journal of Experimental Medicine. 2020 Sep 7
• 60 citations
  A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
  Joanne M Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatt...> ;Nature Communications. 2020 Jun 19
• 48 citations
  An Erg-driven transcriptional program controls B cell lymphopoiesis
  Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. ...> ;Nature Communications. 2020 Jun 15
• 5 citations
  Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma.
  Stephanie R. Hyslop, Marliese Alexander, Alesha A. Thai, Ariena Kersbergen, Andrew J. Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P. Ng, Benjamin J...> ;Oncogene. 2020 Jun 13
• 2 citations
  Correction: NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
  Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian B D'Silva, Tobias Kratina, Laura F. Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth L. Masters, Mel...> ;The Journal of Experimental Medicine. 2020 May 4
• 51 citations
  NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS
  Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian B D'Silva, Tobias Kratina, Laura F. Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth L. Masters, Mel...> ;The Journal of Experimental Medicine. 2020 May 4
• 8 citations
  miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells
  Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf, Ladina Di Rago, Craig D. Hyland, Eugenio Morelli, Jai Rautela, Nicholas D. Huntington, Andreas Strasser, Warren S...> ;Cell Death and Differentiation. 2020 May 1
• 7 citations
  Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome
  Keiichi Ishihara, Ryohei Shimizu, Kazuyuki Takata, Eri Kawashita, Kenji Amano, Atsushi Shimohata, Donovan Low, Takeshi Nabe, Haruhiko Sago, Warren S. Alexander, Floren...> ;Brain Pathology. 2020 Jan 1
• 7 citations
  Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Rα)
  Jeffrey J. Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose A Villadangos, Alan Ching, Satoshi Ishido, Douglas J. Hilton, Warren S. Alexand...> ;The Biochemical Journal. 2019 Oct 15
• 29 citations
  PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
  Helen M. McRae, Alexandra L. Garnham, Yifang Hu, Matthew T. Witkowski, Mark A. Corbett, Mathew P. Dixon, Rose E. May, Bilal N. Sheikh, William Chiang, Andrew J. Kueh, ...> ;Blood. 2019 Apr 18
• 80 citations
  Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans.
  Jarny Choi, Tracey M. Baldwin, Mae Wong, Jessica E. Bolden, Kirsten A. Fairfax, Erin C. Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A. Ramsay, Ashley P. ...> ;Nucleic Acids Research. 2019 Jan 8
• 50 citations
  Cytokine control of megakaryopoiesis.
  Kira Behrens, Warren S. Alexander> ;Growth Factors. 2018 Aug 1
• 77 citations
  MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML
  Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S.A. Al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara J....> ;Blood. 2018 Oct 4
• 10 citations
  Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.
  Ewa M. Michalak, Michael J. G. Milevskiy, Rachel Joyce, Johanna F. Dekkers, Paul R. Jamieson, Bhupinder Pal, Caleb A. Dawson, Yifang Hu, Stuart H. Orkin, Warren S. Ale...> ;Plos Biology. 2018 Aug 6
• 7 citations
  Identification of a Siglec‐F+ granulocyte‐macrophage progenitor
  Jessica E. Bolden, Erin C. Lucas, Geyu Zhou, Jeremy A. O'Sullivan, Carolyn A. de Graaf, Mark D. McKenzie, Ladina Di Rago, Tracey M. Baldwin, Jake Shortt, Warren S. Ale...> ;Journal of Leukocyte Biology. 2018 Jul 1
• 58 citations
  Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted.
  Michael D. Stutz, Samar Ojaimi, Cody C. Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J. Sandow, Andrew I. Webb, John Silke, Warren S. Alexa...> ;Cell Death and Differentiation. 2018 May 1
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