WayneMatthewDanknerMD

Infectious Disease • Durham, NC

Adjunct Associate Professor in the Department of Pediatrics, Duke University School of Medicine

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Office
1000 Park Forty Plaza
Suite 360
Durham, NC 27713
Phone+1 919-439-3400
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Education & Training

University of California (San Diego) Medical CenterFellowship, Infectious Disease, 1984 - 1987
Stanford Health Care-Sponsored Stanford UniversityResidency, Pediatrics, 1981 - 1984
New York Medical CollegeClass of 1981

Certifications & Licensure

NC State Medical License 2000 - 2025
CA State Medical License 1982 - 2000
American Board of Pediatrics Pediatrics

Clinical Trials

The Safety and Effectiveness of Methylprednisolone in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Children With AIDS
Withdrawn
Phase 3
A Pharmacokinetic and Tolerance Study of Oral Ganciclovir in HIV-Infected Children With Asymptomatic Cytomegalovirus Infection and Low CD4 Cell Counts or Quiescent Cytomegalovirus Disease
Completed
Phase 1
A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
Completed
Phase 2
A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
Withdrawn
Phase 1
A Study on the Rate of Opportunistic (AIDS-Related) Infections Among HIV-Positive Children Who Have Stopped Taking Their OI Preventive Medications
Completed
Not Applicable
Growth Hormone Treatment of Children With HIV-Associated Growth Failure
Completed
Not Applicable
Long-Term Effects of HIV Exposure and Infection in Children
Completed
AZD9773 Dose Escalation Study Start of enrollment: 2008 Jan 01
Completed
Phase 2
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock Start of enrollment: 2010 Jul 01
Completed
Phase 2
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock Start of enrollment: 2010 Oct 01
Completed
Phase 2
Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Start of enrollment: 2015 Dec 01
Completed
Phase 3
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Publications & Presentations

PubMed

11 citations
Estimating the Impact of Necrotizing Soft Tissue Infections in the United States: Incidence and Re-Admissions.
Addison K. May, Victor B. Talisa, David A. Wilfret, Eileen M. Bulger, Wayne Dankner, Andrew C. Bernard, Sachin Yende> ;Surgical Infections. 2021 May 18
16 citations
A Novel Immune Modulator for Patients With Necrotizing Soft Tissue Infections (NSTI): Results of a Multicenter, Phase 3 Randomized Controlled Trial of Reltecimod (AB 103)
Eileen M. Bulger, Addison K. May, Bryce R.H. Robinson, David C. Evans, Sharon Henry, John M. Green, Eric A. Toschlog, Jason L. Sperry, Peter J. Fagenholz, Niels D. Mar...> ;Annals of Surgery. 2020 Jul 8
12 citations
Validation of a clinical trial composite endpoint for patients with necrotizing soft tissue infections.
Eileen M. Bulger, Addison K. May, Wayne Dankner, Gregory Maislin, Bryce R.H. Robinson, Anat Shirvan> ;The Journal of Trauma and Acute Care Surgery. 2017 Oct 1
16 citations
Impact and Progression of Organ Dysfunction in Patients with Necrotizing Soft Tissue Infections: A Multicenter Study.
Eileen M. Bulger, Addison K. May, Andrew C. Bernard, Stephen M. Cohn, David C. Evans, Sharon Henry, Jacob A. Quick, Leslie Kobayashi, Kevin Foster, Therese M. Duane, R...> ;Surgical Infections. 2015 Nov 23
Early viral suppression improves neurocognitive outcomes in HIV-infected children.
Crowell CS, Huo Y, Tassiopoulos K, Malee KM, Yogev R, Hazra R, Rutstein RM, Nichols SL, Smith RA, Williams PL, Oleske J, Muller WJ> ;AIDS. 2015 Jan 28
12 citations
A Randomized, Open-Label, Dose-Response Study of Losartan in Hypertensive Children
Nicholas J. A. Webb, Thomas G. Wells, Shahnaz Shahinfar, R. Massaad, Wayne M. Dankner, Chun Lam, Emanuela P. Santoro, Christine McCrary Sisk, Robert O. Blaustein> ;Clinical Journal of the American Society of Nephrology. 2014 Aug 7
59 citations
Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or se...
Gordon R. Bernard, Bruno Francois, Jean-Paul Mira, Jean Louis Vincent, R. Phillip Dellinger, James A. Russell, Steven P. LaRosa, Pierre-François Laterre, Mitchell M. L...> ;Critical Care Medicine. 2014 Mar 1
196 citations
Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era.
Michael T. Brady, James M. Oleske, Paige L. Williams, Carol Elgie, Lynne M. Mofenson, Wayne M. Dankner, Russell B. Van Dyke> ;Journal of Acquired Immune Deficiency Syndromes. 2010 Jan 1
150 citations
Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system
Sara Oliver, Gretchen A. Cloud, Pablo J. Sánchez, Gail J. Demmler, Wayne M. Dankner, Mark Shelton, Richard F. Jacobs, Wendy Vaudry, Robert F. Pass, Seng-Jaw Soong, Ric...> ;Journal of Clinical Virology. 2009 Dec 1
18 citations
Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treat...
Adriana Weinberg, Sharon Huang, Terence Fenton, Julie Patterson-Bartlett, Philimon Gona, Jennifer S. Read, Wayne M. Dankner, Sharon Nachman> ;Journal of Acquired Immune Deficiency Syndromes. 2009 Sep 1
33 citations
Incidence of Noninfectious Conditions in Perinatally HIV-Infected Children and Adolescents in The HAART Era
Sharon Nachman, Miriam Chernoff, Philimon Gona, Russell B. Van Dyke, Wayne M. Dankner, George R. Seage, James M. Oleske, Paige L. Williams> ;Archives of Pediatrics & Adolescent Medicine. 2009 Feb 2
7 citations
Simple Pediatric AIDS Severity Score (PASS): a pediatric severity score for resource-limited settings.
Kunjal Patel, Geoffrey A. Weinberg, Kate Buchacz, Kenneth McIntosh, Wayne M. Dankner, George R. Seage> ;Journal of Acquired Immune Deficiency Syndromes. 2006 Dec 15
5 citations
The Pediatric AIDS Severity Score (PASS): a multidimensional AIDS-severity adjustment for pediatric HIV infection.
George R. Seage, Kate Buchacz, Geoffrey A. Weinberg, Kunjal Patel, Kenneth McIntosh, Wayne M. Dankner> ;Journal of Acquired Immune Deficiency Syndromes. 2006 Dec 15
31 citations
Risk Factors for Opportunistic Illnesses in Children With Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Therapy
Nathalie Ylitalo, Susan B. Brogly, Michael Hughes, Sharon Nachman, Wayne M. Dankner, Russell B. Van Dyke, George R. Seage> ;Archives of Pediatrics & Adolescent Medicine. 2006 Aug 1
179 citations
Incidence of opportunistic and other infections in HIV-infected children in the HAART era.
Philimon Gona, Russell B. Van Dyke, Paige L. Williams, Wayne M. Dankner, Miriam Chernoff, Sharon Nachman, George R. Seage> ;JAMA. 2006 Jul 19
62 citations
Antibody Responses to Hepatitis A Virus Vaccine in HIV-Infected Children with Evidence of Immunologic Reconstitution while Receiving Highly Active Antiretroviral Therapy
Adriana Weinberg, Philimon Gona, Sharon Nachman, Patricia Defechereux, Ram Yogev, Walter T. Hughes, Diane W. Wara, Steven A Spector, Jennifer S. Read, Carol Elgie, Mar...> ;The Journal of Infectious Diseases. 2006 Jan 15
7 citations
GB virus C infection in children with perinatal human immunodeficiency virus infection
Susan Schuval, Jane C. Lindsey, Jack T. Stapleton, Russell B. Van Dyke, Paul Palumbo, Lynne M. Mofenson, James M. Oleske, Joseph S. Cervia, Andrea Kovacs, Wayne N. Dan...> ;The Pediatric Infectious Disease Journal. 2005 May 1
28 citations
The Rate of Serious Bacterial Infections Among HIV-Infected Children With Immune Reconstitution Who Have Discontinued Opportunistic Infection Prophylaxis
Sharon Nachman, Philimon Gona, Wayne M. Dankner, Adrianna Weinberg, Ram Yogev, Anne A. Gershon, Mobeen H. Rathore, Jennifer S. Read, Sharon Huang, Carol Elgie, Kim Hud...> ;Pediatrics. 2005 Apr 1
27 citations
Comparison of atovaquone and azithromycin with trimethoprim- sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection
Walter T. Hughes, Wayne M. Dankner, Ram Yogev, Sharon Huang, Mary E. Paul, Midnela Acevedo Flores, Mark W. Kline, Lee-Jen Wei> ;Clinical Infectious Diseases. 2005 Jan 1
14 citations
Hepatitis C Prevalence in Children With Perinatal Human Immunodeficiency Virus Infection Enrolled in a Long-term Follow-up Protocol
Susan Schuval, Russell B. Van Dyke, Jane C. Lindsey, Paul Palumbo, Lynne M. Mofenson, James M. Oleske, Joseph S. Cervia, Andrea Kovacs, Wayne N. Dankner, Elizabeth Smi...> ;Archives of Pediatrics & Adolescent Medicine. 2004 Oct 1
62 citations
Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents
Chang Heok Soh, James M. Oleske, Michael T. Brady, Stephen A. Spector, William Borkowsky, Sandra K. Burchett, Marc Foca, Edward Handelsman, Eleanor Jimenez, Wayne M. D...> ;Lancet. 2003 Dec 20
554 citations
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
David W. Kimberlin, Chin Yu Lin, Pablo J. Sánchez, Gail J. Demmler, Wayne M. Dankner, Mark Shelton, Richard F. Jacobs, Wendy Vaudry, Robert F. Pass, Jan Kiell, Seng-Ja...> ;The Journal of Pediatrics. 2003 Jul 1
61 citations
Pharmacokinetics and tolerance of zidovudine in preterm infants
Edmund V. Capparelli, Mark Mirochnick, Wayne M. Dankner, Suzette Blanchard, Lynne M. Mofenson, George D. McSherry, Gregory Ciupak, Betsy Smith, James D. Connor> ;The Journal of Pediatrics. 2003 Jan 1
383 citations
Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1.
Steven L. Gortmaker, Michael Hughes, J Cervia, Michael T. Brady, G M Johnson, G R Seage rd, L Y Song, Wayne M. Dankner, James M. Oleske> ;The New England Journal of Medicine. 2001 Nov 22
45 citations
Impact of Protease Inhibitor-Containing Combination Antiretroviral Therapies on Height and Weight Growth in HIV-Infected Children
Kate Buchacz, Joseph S. Cervia, Jane C. Lindsey, Michael Hughes, George R. Seage, Wayne M. Dankner, James Oleske, Jack Moye> ;Pediatrics. 2001 Oct 1
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