WayneShrefflerMDPhD

PubMed

• TCF1-LEF1 co-expression identifies a multipotent progenitor cell (T2-MPP) across human allergic diseases.
  Radomir Kratchmarov, Sarah Djeddi, Garrett Dunlap, Wenqin He, Xiaojiong Jia, Caitlin M Burk, Tessa Ryan, Alanna McGill, Jessica R Allegretti, Raghu P Kataru, Babak J M...> ;Nature Immunology. 2024 Apr 8
• Who are the potential patients for omalizumab for food allergy?
  Hugh A Sampson, J Andrew Bird, David Fleischer, Wayne G Shreffler, Jonathan M Spergel> ;Annals of Allergy, Asthma & Immunology. 2024 Mar 11
• Varying Doses of Epicutaneous Immunotherapy With Viaskin Milk vs Placebo in Children With Cow's Milk Allergy: A Randomized Clinical Trial.
  Daniel Petroni, Philippe Bégin, J Andrew Bird, Terri Brown-Whitehorn, Hey J Chong, David M Fleischer, Rémi Gagnon, Stacie M Jones, Stephanie Leonard, Melanie M Makhija...> ;JAMA Pediatrics. 2024 Apr 1
• 1 citations
  Omalizumab for the Treatment of Multiple Food Allergies.
  Robert A Wood, Alkis Togias, Scott H Sicherer, Wayne G Shreffler, Edwin H Kim, Stacie M Jones, Donald Y M Leung, Brian P Vickery, J Andrew Bird, Jonathan M Spergel, Ah...> ;The New England Journal of Medicine. 2024 Mar 7
• Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.
  Megha Lal, Caitlin M Burk, Ravi Gautam, Zoe Mrozek, Tina Trachsel, Jarad Beers, Margaret C Carroll, Duncan M Morgan, Amanda B Muir, Wayne G Shreffler, Melanie A Ruffner> ;Biorxiv. 2024 Jan 30
• Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
  Wood, L. F., Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S Kane, Zoe Swank, Jameson P Davis, Melina Demokritou, ...> ;Nature Communications. 2024 Jan 30
• 1 citations
  Utility of food allergy thresholds.
  Rotter, N., Stieb, E., Stockbridge, J., Theodorakakis, M., Li, J., Shreffler, W.> ;Annals of Allergy, Asthma & Immunology. 2024 Mar 1
• Antigen-specific T cell responses in SARS-CoV-2 mRNA-vaccinated children.
  Jordan D Philpott, Jordan Miller, Brittany P Boribong, Saeina Charles, Jameson P Davis, Simon Kazimierczyk, Brittany Jimena, Maureen M Leonard, Wayne G Shreffler, Ales...> ;Cell Reports. Medicine. 2023 Dec 19
• Frequency and predictors of multisystem reactions to peanut in infant oral food challenges.
  Corinne A Keet, Robert A Wood, Jennifer Dantzer, Mihaela Plesa, Isha Taneja, Mharlove Andre, Wayne Shreffler, Alkis Togias, Michael Pistiner> ;The Journal of Allergy and Clinical Immunology. in Practice. 2024 Jan 1
• Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Ast...
  Mirna Chehade, Benjamin L Wright, Dan Atkins, Seema S Aceves, Steven J Ackerman, Amal H Assa'ad, Maureen Bauer, Margaret H Collins, Scott P Commins, Carla M Davis, Eva...> ;The Journal of Allergy and Clinical Immunology. 2023 Dec 1
• 2 citations
  The SunBEAm birth cohort: Protocol design.
  Corinne Keet, Scott H Sicherer, Supinda Bunyavanich, Cynthia Visness, Patricia C Fulkerson, Alkis Togias, Wendy Davidson, Susan Perry, Sanaz Hamrah, Agustin Calatroni,...> ;The Journal of Allergy and Clinical Immunology. Global. 2023 Aug 1
• 1 citations
  Longitudinal assessment of early growth in children with IgE- and non-IgE-mediated food allergy in a healthy infant cohort.
  Rachael Rosow, Yamini V Virkud, Victoria M Martin, Marielle Young, Kuan-Wen Su, Neelam Phadke, Wayne G Shreffler, Qian Yuan> ;Annals of Allergy, Asthma & Immunology. 2023 Sep 1
• Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
  Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail Kane, Zoe Swank, Jameson Davis, Melina Demokritou, Anagha P Chitnis,...> ;Research Square. 2023 Apr 6
• 2 citations
  Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years' Time?
  Nandinee Patel, Wayne G Shreffler, Adnan Custovic, Alexandra F Santos> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Apr 1
• 3 citations
  Plant-based enveloped Ara h 2 bioparticles display exceptional hypo-allergenicity.
  C Castenmiller, M Stigler, M E Kirpas, S Versteeg, J H Akkerdaas, G Pena-Castellanos, B R Blokhuis, S C Dreskin, L Auger, R Desgagnés, C Martel, L Mirande, B Morel, J ...> ;Clinical and Experimental Allergy. 2023 May 1
• 1 citations
  Efficacy and safety of peanut epicutaneous immunotherapy in patients with atopic comorbidities.
  Carla M Davis, Lars Lange, Kirsten Beyer, David M Fleischer, Lara Ford, Gordon Sussman, Roxanne C Oriel, Jacqueline A Pongracic, Wayne Shreffler, Katharine J Bee, Dian...> ;The Journal of Allergy and Clinical Immunology. Global. 2023 Feb 1
• 5 citations
  Retail Food Equivalents for Post-Oral Immunotherapy Dosing in the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food-Allergi...
  Marion Groetch, Kim Mudd, Margaret Woch, Allison Schaible, Brianna E Gray, Denise C Babineau, J Andrew Bird, Stacie Jones, Edwin H Kim, Bruce J Lanser, Julian Poyser, ...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Feb 1
• 7 citations
  Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy.
  Nicole A LaHood, Jungki Min, Tarun Keswani, Crystal M Richardson, Kwasi Amoako, Jingjia Zhou, Orlee Marini-Rapoport, Hervé Bernard, Stéphane Hazebrouck, Wayne G Shreff...> ;The Journal of Clinical Investigation. 2023 Jan 17
• 4 citations
  Early infancy dysbiosis in food protein-induced enterocolitis syndrome: A prospective cohort study.
  Kuan-Wen Su, Murat Cetinbas, Victoria M Martin, Yamini V Virkud, Hannah Seay, Renata Ndahayo, Rachael Rosow, Michael Elkort, Brinda Gupta, Eileen Kramer, Tetiana Pronc...> ;Allergy. 2023 Jun 1
• Factors influencing age of common allergen introduction in early childhood.
  Michael Marget, Yamini V Virkud, Wayne G Shreffler, Victoria M Martin, Qian Yuan> ;Frontiers in Pediatrics. 2023 Jan 1
• 6 citations
  Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.
  Elise G Liu, Biyan Zhang, Victoria Martin, John Anthonypillai, Magdalena Kraft, Alexander Grishin, Galina Grishina, Jason R Catanzaro, Sharon Chinthrajah, Tina Sindher...> ;Science Translational Medicine. 2022 Nov 16
• 6 citations
  Protocol design and synopsis: Omalizumab as Monotherapy and as Adjunct Therapy to Multiallergen OIT in Children and Adults with Food Allergy (OUtMATCH).
  Robert A Wood, R Sharon Chinthrajah, Amanda K Rudman Spergel, Denise C Babineau, Scott H Sicherer, Edwin H Kim, Wayne G Shreffler, Stacie M Jones, Donald Y M Leung, Br...> ;The Journal of Allergy and Clinical Immunology. Global. 2022 Nov 1
• 2 citations
  Revealing the heterogeneity of CD4T cells through single-cell transcriptomics.
  Duncan M Morgan, Wayne G Shreffler, J Christopher Love> ;The Journal of Allergy and Clinical Immunology. 2022 Oct 1
• 6 citations
  Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis.
  Victoria M Martin, Yamini V Virkud, Ehud Dahan, Hannah L Seay, Dvir Itzkovits, Hera Vlamakis, Ramnik Xavier, Wayne G Shreffler, Qian Yuan, Moran Yassour> ;Microbiome. 2022 Sep 23
• 24 citations
  SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children.
  Yannic C Bartsch, Kerri J St Denis, Paulina Kaplonek, Jaewon Kang, Evan C Lam, Madeleine D Burns, Eva J Farkas, Jameson P Davis, Brittany P Boribong, Andrea G Edlow, A...> ;Science Translational Medicine. 2022 Nov 23
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Journal Articles

• Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children with Peanut Allergy  
  Todd D Green, David M Fleischer, Hey Chong, R Sharon Chinthrajah, Edwin H Kim, Stacie M Jones, Robert Wood, Bruce J Lanser, Lynda Schneider, Jacqueline A Pongracic, Wa..., JAMA
• Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children  
  Thyagarajan A, Jones S, Calatroni A Pons L, Kulis M, Woo C, Kamalakannan M, Vickery B, Scurlock A, Burks AW, Shreffler WG, Clin Exp Allergy, 1/1/2012
• Consortium for Food Allergy Research (CoFAR). Oral immunotherapy for treatment of egg allegry in children  
  Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, Stablein D, Henning AK, Vickery BP, Liu AH, Scurlock AM, Shreffler WG, Plaut M, Sampson HA, N Engl J Med, 1/1/2012
• Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation  
  Patil S, Shreffler WG, Clin Exp Immunol, 1/1/2012
• The role of dendritic cells in food allergy  
  Ruiter B, Shreffler WG, J All Clin Immunol, 1/1/2012
• Innate immunostimulatory properties of allegens and their relevance to food allergy  
  Ruiter B, Shreffler WG, Semin Immunopathol, 1/1/2012
• Determinants of food allergy  
  Masilamani, M., Commins, S., & Shreffler, W, Immunology and Allergy Clinics of North America, 1/1/2012
• Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization  
  Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler WG, Steele P, Kamilaris J, Vickery B, Burks AW, J Allergy Clin Immunol, 1/1/2011
• Both variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility  
  Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, Benson C, Shreffler WG, Matsui EC, J Allergy Clin Immunol, 1/1/2011
• Walnut Allergy in Peanut-Allergic Patients: Significance of Sequential Epitopes of Walnut Homologous to Linear Epitopes of Ara h 1, 2 and 3 in Relation to Clinical Rea...  
  Rosenfeld L, Shreffler W, Bardina L, Niggeman B, Wahn U, Sampson HA, Beyer K, Int Arch Allergy Immunol, 1/1/2011
• Microarrayed recombinant allergens for diagnostic testing  
  Shreffler WG, J All Clin Immunol, 1/1/2011
• Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  
  Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzayn A, Shreffler WG, Sampson HA, J Allergy Clin Immunol, 1/1/2010
• Immunologic features of infants with milk or egg allergy enrolled in an observational study (CoFAR) of food allergy  
  Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DYM, Grishin A, Mayer L, Shreffler WG, Lindblad R, Sampson HA, J Allergy Clin Immunol, 1/1/2010
• Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay  
  Vereda A, Andreae DA, Lin J, Shreffler WG, Ibanez MD, Cuesta-Herranz J, Bardina L, Sampson HA, J Allergy Clin Immunol, 1/1/2010
• The association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein  
  Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA, J All Clin Immunol, 1/1/2009
• Allergen-specific basophil activation associated with clinical tolerance in patients with milk allergy  
  Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG, J All Clin Immunol, 1/1/2009
• The Urban Environment and Childhood Asthma (URECA) birth cohort study; design, methods, and study population  
  Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O’Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ Jr, Busse WW, BMC Pulm Med, 1/1/2009
• Clinical efficacy and immune regulation with peanut oral immunotherapy  
  Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW, J All Clin Immunol, 1/1/2009
• Development of a novel peptide microarray for large-scale epitope mapping of food allergens  
  Lin J, Bardina L, Shreffler WG, Andreae DA, Ge Y, Wang J, Bruni FM, Fu Z, Han Y, Sampson HA, J Allergy Clin Immunol, 1/1/2009
• Epinephrine treatment is infrequent and biphasic reactions are rare in food- induced reactions during oral food challenges in children  
  Jarvinen KM, Amalanayagam S, Shreffler WG, Noone S, Sicherer SH, Sampson HA, Nowak- Wegrzyn A, J Allergy Clin Immunol, 1/1/2009
• The perfectly potent peanut  
  Shreffler WG, J All Clin Immunol, 1/1/2009
• Microarrayed allergen molecules for diagnostics of allergy  
  Lin J, Bardina L, Shreffler WG, Methods Mol Biol, 1/1/2009
• Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy  
  Flinterman AE, Knol EF, Andreae DA, Bardina L, den Hartog Jager CF, Pasmans SG, Bruijnzeel- Koomen CA, Sampson HA, van Hoffen E, Shreffler WG, J All Clin Immunol, 1/1/2008
• Tolerance to extensively heated milk in children with cow’s milk allergy  
  Nowak-Wegrzyn A, Bloom K, Sicherer SH, Shreffler WG, Noone S, Wanich N, Sampson HA, J All Clin Immunol, 1/1/2008
• Immunologic changes in children with egg allergy ingesting extensively heated egg  
  Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A, J All Clin Immunol, 1/1/2008
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Abstracts/Posters

• Tolerance of Baked Milk in a Subset of Patients with Cow’s Milk-Mediated Eosinophilic Esophagitis
  J Leung, A Katz, Q Yuan, S Iyengar, P Permaul, JE Walter, J Ramakrishna, WG Shreffler, P Hesterberg, 2013 AAAAI Annual Meeting, San Antonio, TX, 1/1/2013
• Increase in Antigen-specific B Cells During Peanut Oral Immunotherapy Using Novel Tetramer-based Approach
  SU Patil, S Kubala, A Brennan, A Ma, J Moon, WG Shreffler, 2013 AAAAI Annual Meeting, San Antonio, TX, 1/1/2013
• Human basophils internalize antigen in an IgE-dpendent fashion and express costimulatory molecules
  S Patil, A Ma, G Lund, WG Shreffler, 2012 EAACI Congress, Geneva, Switzerland, 1/1/2012
• Human dendritic cells stimulated with peanut express high levels of ALDH1A2 and induce RA-sensitive genes in naïve T cells
  B Ruiter, G Grishina, HA Sampson, WG Shreffler, 2011 EAACI-GA2LEN 9th Immunology Winter School, Davos, Switzerland, 1/1/2011
• CS Woo, A Ma, S Yoo, W Chan, HA Sampson, WG Shreffler, 2010 AAAAI Annual Meeting, New Orleans, LA, 1/1/2010
• Human dendritic cells stimulated with peanut allergen express high levels of ALDH1A2 and induce RA-sensitive genes in naïve T cells
  B Ruiter, HA Sampson, WG Shreffler, 2010 AAAAI Annual Meeting, New Orleans, LA, 1/1/2010
• Further characterization of putative basophil nanotubes by confocal microscopy
  A Praslick, M Masilimani, M Gross, WG Shreffler, 2010 AAAAI Annual Meeting, New Orleans, LA, 1/1/2010
• IgE sensitization to milk and peanut are associated with increased IL-4 but not GATA-3. Oral Abstract Session 5604
  Shreffler WG, AAAAI Annual Meeting, New Orleans, LA, 1/1/2010
• Literature review abstracts
  Shreffler WG, Pediatrics, 1/1/2005
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Lectures

• Update on Food Allergy and Immunotherapy / Therapeutic Vaccines: Reprogramming Immunity in Infectious Diseases, Allergy and Cancer 
  Annecy, France - 1/1/2013
• Food Allergy and Immunotherapy 
  Milan, Italy - 1/1/2013
• Dendritic cells in sickness and in health; arbiters of allergy versus tolerance 
  San Fransisco, CA - 1/1/2013
• Future Directions in Food Allergen Immunotherapy 
  San Antonio, TX - 1/1/2013
• Identifying and Developing Great Mentors and Great Projects 
  San Antonio, TX - 1/1/2013
• Mechanisms of Activation and Desensitisation Underlying Spontaneous Tolerance in Food Allergy 
  Geneva, Switzerland - 1/1/2012
• Overview of food allergies in pediatrics 
  Boston MA - 1/1/2012
• Anaphylaxis and food allergy in the pediatric population 
  Boston MA - 1/1/2012
• Guidelines for the Diagnosis and Management of Food Allergy 
  Lowell MA - 1/1/2012
• Implementing Peanut Oral Immunotherapy 
  Boston MA - 1/1/2012
• Eosinophilic Esophagitis and its Relation to Food Allergy 
  Marlborough MA - 1/1/2012
• Summary of the NIAID Food Allergy Guidelines 
  Boston MA - 1/1/2012
• Update on Food Allergy 
  Boston MA - 1/1/2012
• Eosinophilic GI Disease, Brigham and Women’s Hospital Board Review Course 
  Boston, MA - 1/1/2012
• Mechanisms of OIT-induced Tolerance in the Setting of Food Allergy; Immuno- inflammation Therapeutic Strategy Unit 
  Bridgewater, NJ - 1/1/2012
• The Role of Humoral Immunity in Food Allergy/ Allergy & Immunology Seminar Series 
  Boston, MA - 1/1/2012
• Dissecting Mechanisms of Oral Tolerance in Food Allergy 
  Orlando, FL - 1/1/2012
• Cellular Assays for Monitoring Allergen Immunotherapy 
  Orlando, FL - 1/1/2012
• Update on Food Allergy and the Use of Molecular Allergen Testing 
  Berkeley, CA - 1/1/2012
• Promising New Treatments for Food Allergies 
  1/1/2011
• Update on Best Treatment Practices for Food Allergy 
  Beacon Hill - 1/1/2011
• 21st Century: What’s Good? What’s Bad? And What is Just Plain Confusing? 
  1/1/2011
• Patient handout sheets on: Food Allergies; Treatment of Anaphylaxis; Eosinophilic Esophagitis; Allergen Avoidance 
  1/1/2011
• Clinical Spectrum of Food Allergy MGH Pediatrics Chief’s Conference 
  Boston MA - 1/1/2011
• NIAID Guidelines on Food Allergy: What is new and what do you need to know? 
  Newton MA - 1/1/2011
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Other

• OpenWetWare 
  Shreffler WG
  http://openwetware.org/index.php?title=Shreffler&oldid=312635
• Future diagnostic tools for food allergy 
  Shreffler WG, Andreae DA
  http://www.uptodate.com/contents/future-diagnostic-tools-for-food-allergy
  UpToDate, Wolters Kluwer Health - 2013-04-18