WayneHTsujiMD

PubMed

• 36 citations
  Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study
  Christophe Cellier, Gerd Bouma, Tom van Gils, Sherine Khater, Georgia Malamut, Laura Crespo, Pekka Collin, Peter H.R. Green, Sheila E. Crowe, Wayne Tsuji, Eric Butz, N...> ;The Lancet. Gastroenterology & Hepatology. 2019 Dec 1
• 6 citations
  Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data
  Bdm Tom, Deborah P M Symmons, Sarah Brockbank, Claudio Carini, Andrew P. Cope, Ehrenstein, Benjamin A Fisher, Carl S. Goodyear, Neil Gozzard, Ray Harris, K Hicks, Sall...> ;RMD Open. 2018 Oct 25
• 46 citations
  Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and...
  Laurence E. Cheng, Zahir Amoura, Benjamin Cheah, Falk Hiepe, Barbara A. Sullivan, Lei Zhou, Gregory E. Arnold, Wayne Tsuji, Joan T. Merrill, James B. Chung> ;Arthritis & Rheumatology. 2018 May 25
• 2 citations
  Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration.
  Andrew P. Cope, Michael R. Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S. Goodyear...> ;Nature Reviews. Rheumatology. 2018 Jan 24
• 11 citations
  The RA-MAP Consortium: a working model for academia-industry collaboration
  Andrew P. Cope, Michael R. Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S. Goodyear...> ;Nature Reviews. Rheumatology. 2018 Jan 1
• 52 citations
  Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus
  Barbara A. Sullivan, Wayne Tsuji, Alan Kivitz, Joanna Z. Peng, Gregory E. Arnold, Michael Boedigheimer, Kit Chiu, Cherie Green, Arunan Kaliyaperumal, Christine Wang, J...> ;Lupus Science & Medicine. 2016 Apr 1
• 1 citations
  Modeling the pharmacokinetic-pharmacodynamic relationship of the monoclonal anti-macaque-IL-15 antibody Hu714MuXHu in cynomolgus monkeys.
  Wei. J. Pan, Hong Li, Jim J. Xiao, Michelle Horner, Herve Lebrec, Eric A. Butz, Arunan Kaliyaperumal, Tsui C. Cheah, Robert Ortiz, Samantha P. Prokop, Sabina Buntich, ...> ;Pharmacology Research & Perspectives. 2015 Dec 1
• 18 citations
  Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers a...
  Jason M. Gow, Wayne Tsuji, Gary J. Williams, Daniel T. Mytych, David Sciberras, Shawn L. Searle, Tim Mant, John P. Gibbs> ;Arthritis Research & Therapy. 2015 Oct 8
• 40 citations
  Treatment of systemic lupus erythematosus patients with the BAFF antagonist "peptibody" blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and ...
  William Stohl, Joan T. Merrill, R. John Looney, Jill P. Buyon, Daniel J. Wallace, Michael H. Weisman, Ellen M. Ginzler, Blaire Cooke, Donna Holloway, Arunan Kaliyaperu...> ;Arthritis Research & Therapy. 2015 Aug 20
• 22 citations
  Preclinical development of AMG 139, a human antibody specifically targeting IL-23.
  Kathleen Köck, Wei-Jian Pan, Jason M. Gow, Michelle Horner, John P. Gibbs, Alexander Colbert, T J Goletz, Kathryn J. Newhall, William A. Rees, Yu Sun, Yu Zhang, J C O'...> ;British Journal of Pharmacology. 2015 Jan 1
• 32 citations
  Homeostasis of human NK cells is not IL-15 dependent
  Herve Lebrec, Michelle Horner, Kevin S. Gorski, Wayne Tsuji, Dong Xia, Wei Jian Pan, Gary Means, Greg Pietz, Nianyu Li, Marc W. Retter, Kathy Shaffer, Neha Patel, Padm...> ;Journal of Immunology. 2013 Dec 1
• 14 citations
  Magnetic resonance imaging in rheumatoid arthritis clinical trials: emerging patterns based on recent experience.
  Charles Peterfy, Peter Countryman, Annarita Gabriele, T. Shaw, Andrew Anisfeld, Wayne Tsuji, Ewa Olech, Norman Gaylis, Philip G. Conaghan, Vibeke Strand, Julie C DiCarlo> ;The Journal of Rheumatology. 2011 Sep 1
• 16 citations
  A review of current animal models of osteoarthritis pain.
  Warren N. D'Souza, Gordon Y. Ng, Bradley D. Youngblood, Wayne Tsuji, Sonya G. Lehto> ;Current Pharmaceutical Biotechnology. 2011 Sep 30
• 128 citations
  Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates
  Robin K. Dore, Stanley Cohen, Nancy E Lane, William R Palmer, William Shergy, L. Zhou, H. Wang, Wayne Tsuji, Richard Newmark> ;Annals of the Rheumatic Diseases. 2010 May 1
• 40 citations
  Patient-reported outcomes in a randomized trial of etanercept in psoriatic arthritis.
  Philip J. Mease, J. Michael Woolley, Amitabh Singh, Wayne Tsuji, Meleana Dunn, Chiun Fang Chiou> ;The Journal of Rheumatology. 2010 Jun 1
• 43 citations
  Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis.
  John T. Sharp, Wayne Tsuji, P Ory, Cristina Harper-Barek, H. Wang, Richard Newmark> ;Arthritis Care & Research. 2010 Apr 1
• 84 citations
  Denosumab‐mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patients
  A. Deodhar, R. K. Dore, D. Mandel, J. Schechtman, W. Shergy, R. Trapp, P Ory, Charles Peterfy, T. Fuerst, H. Wang, L. Zhou, Wayne Tsuji, Richard Newmark> ;Arthritis Care & Research. 2010 Apr 1
• 7 citations
  Assessing single joints in arthritis clinical trials.
  Helen I Keen, Clifton O Bingham 3rd, Laurence A Bradley, Philip G Conaghan, Alison E Heald, Gurjit S Kaeley, Walter P Maksymowych, Roland W Moskowitz, H Ralph Schumach...> ;The Journal of Rheumatology. 2009 Sep 1
• 408 citations
  Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blin...
  Stanley Cohen, Robin K. Dore, Nancy E Lane, Peter A. Ory, Charles G. Peterfy, John T. Sharp, Désirée Van Der Heijde, L. Zhou, Wayne Tsuji, Richard Newmark> ;Arthritis and Rheumatism. 2008 May 1
• 397 citations
  Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept
  D. van der Heijde, Robert Landewé, S. Einstein, P Ory, D Vosse, L. Ni, Shao Lee Lin, Wayne Tsuji, John C. Davis> ;Arthritis and Rheumatism. 2008 May 1
• 28 citations
  Rapid and sustained improvement in health-related quality of life and utility for 72 weeks in patients with ankylosing spondylitis receiving etanercept.
  Annelies Boonen, Vaishali Patel, Shana Traina, Chiun Fang Chiou, Andreas Maetzel, Wayne Tsuji> ;The Journal of Rheumatology. 2008 Apr 1
• 124 citations
  Efficacy and safety of up to 192 weeks of etanercept therapy in patients with ankylosing spondylitis
  John C. Davis, D. van der Heijde, Jürgen Braun, Maxime Dougados, Daniel O. Clegg, Alan Kivitz, Roy Fleischmann, Robert D. Inman, L. Ni, S. L. Lin, Wayne Tsuji> ;Annals of the Rheumatic Diseases. 2007 Oct 29
• 47 citations
  A placebo-controlled, randomized, double-blinded study evaluating the safety of etanercept in patients with rheumatoid arthritis and concomitant comorbid diseases
  Michael H. Weisman, Harold E. Paulus, Francis X. Burch, Alan Kivitz, Joshua Fierer, Meleana Dunn, David R. Kerr, Wayne Tsuji, Scott Baumgartner> ;Rheumatology. 2007 Jul 1
• 78 citations
  Standardizing Assessment and Reporting of Adverse Effects in Rheumatology Clinical Trials II: the Rheumatology Common Toxicity Criteria v.2.0
  Thasia G. Woodworth, Daniel E. Furst, Rieke Alten, Clifton O. Bingham, David E. Yocum, Victor S. Sloan, Wayne Tsuji, Randall Stevens, James F. Fries, James Witter, Ken...> ;The Journal of Rheumatology. 2007 Jun 1
• 202 citations
  Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis.
  Esther Jimenez-Boj, Iris Nöbauer-Huhmann, Beatrice Hanslik-Schnabel, Ronald Dorotka, Axel Wanivenhaus, Franz Kainberger, Siegfried Trattnig, Roland Axmann, Wayne Tsuji...> ;Arthritis and Rheumatism. 2007 Apr 1
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Journal Articles

• Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus  
  Sullivan, BA, Tsuji, W, Kivitz, A, et al, Lupus Sci & Med, 1/1/2016
• Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers a...  
  Gow, JM., Tsuji, WH., Williams, GJ., et al, Arth Res Ther, 1/1/2015
• Treatment of systemic lupus erythematosus patients with the B cell-activating factor (BAFF) antagonist "peptibody" blisibimod (AMG 623): Results from randomized, doubl...  
  Stohl, W., Merrill, JT., Looney, RJ., et al (Tsuji W), Arth Res Ther, 1/1/2015
• Preclinical development of AMG 139, a human antibody specifically targeting IL-23  
  Kock, K., Pan, W. J., Gow, J. M., et al (Tsuji W), Br J Pharmacol, 1/1/2015
• Modeling the pharmacokinetic-pharmacodynamic relationship of the monoclonal antimacaque-IL-15 antibody Hu714MuXHu in cynomolgus monkeys  
  Pan, WJ., Li, H., Xiao,JJ., et al (Tsuji W), Pharmacol Res Perspect, 1/1/2015
• Homeostasis of human NK cells is not IL-15 dependent  
  Lebrec, H., M. J. Horner, K. S. Gorski, et al (Tsuji W), J Immunol, 1/1/2013
• OARSI-FDA initiative: defining the disease state of osteoarthritis  
  Lane, N. E., K. Brandt, et al (Tsuji W), Osteoarthritis Cartilage, 1/1/2011
• Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-bli...  
  Cohen, Dore, Lane, Ory, Peterfy, Sharp, van der Heijde, Zhou, Tsuji, Newmark; Denosumab Rheumatoid Arthritis Study Group, Nat Clin Pract Rheumatol, 10/2008
• Rapid and sustained improvement in health-related quality of life and utilityfor 72 weeks in patients with ankylosing spondylitis receiving etanercept  
  Boonen, Patel, Traina, Chiou, Maetzel, Tsuji, J Rheumatol, 4/2008
• Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept  
  van der Heijde, D., R. Landewe, et al (Tsuji W), Ann Rheum Dis, 1/1/2008
• Sustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks  
  Davis, van der Heijde, Braun, Dougados, Cush, Clegg, Inman, Kivitz, Zhou, Solinger, Tsuji, Ann Rheum Dis, 11/2005
• Baseline factors that influence ASAS 20 response in patients with ankylosing spondylitis treated with etanercept  
  Davis, van der Heijde, Dougados, Braun Cush, Clegg, Inman, de Vries, Tsuji, J Rheumatol, 9/2005
• Magnetic Resonance imaging examinations of the spine in patients with ankylosing spondylitis before and after therapy with the tumor necrosis factor alpha receptor fus...  
  Baraliakos X, Davis J, Tsuji W, Braun J, Arthritis Rheum, 4/2005
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Abstracts/Posters

• A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus A...
  L. E. Cheng, Z. Amoura, B. Cheah, F. Hiepe, B. A. Sullivan, L. Zhou, G. E. Arnold, W. H. Tsuji, J. T. Merrill, J. B. Chung, EULAR, 1/1/2017
• Administration of AMG 557, a Human Anti- Sequential, Rising, Multiple-dose Study.
  Sullivan B, Tsuji WH, Chindalore VL, Geppert TD, Rudinskaya A, Pardo P, Kivitz A, Neuwelt CM, Mackay M, Looney RJ, Thorne JC, Andrew M, Arnold G, Boedigheimer M, Chiu ..., Arth Rheum, 1/1/2013
• Safety, Pharmacokinetics and Pharmacodynamics of AMG 557 (anti-B7RP-1) in Subjects with Systemic Lupus Erythematosus: Results of a Phase 1 Multicenter, Randomized, Dou...
  Sullivan BA, Tsuji W, Kivitz A, Weisman M, Wallace DJ, Boyce M, Mackay M, Looney RJ, Cohen S, Andrew MA , Arnold GE, Boedigheimer MJ, Chiu K, Ferbas J, Green CL, Kaliy..., Lupus; 10th International Congress on SLE, 1/1/2013
• Discriminative Power of Different Combinations of Bones and Joints for Assessing Change in Rheumatoid Arthritis with MRI: Results Based on Pooled Data from Four Multis...
  Peterfy C, Countryman P, DiCarlo J, Gabrielle A, Shaw T, Anisfeld A, Tsuji W, Olech E, Gaylis N, Arthritis & Rheumatism; ACR, 1/1/2010
• The Effect of Denosumab on Metacarpal Shaft Cortical Bone Loss in Patients With Erosive Rheumatoid Arthritis
  Sharp J, Tsuji W, Ory P, Harper-Barek C, Wang H, Newmark R, EULAR; Annals of the Rheumatic Diseases, 1/1/2009
• Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis
  Sharp JT, Tsuji W, Harper-Barek C, Wang H, Newmark R, Arthritis & Rheumatism; ACR, 1/1/2008
• Denosumab increases bone mineral density in patients with rheumatoid arthritis: results at 12 months
  Dore R, Hurd E, Palmer W, Shergy W, Lane N, Cohen S, Zhou L, Tsuji W, Newmark R, ECCEO, 1/1/2008
• Increase in hand bone mineral density in patients with rheumatoid arthritis is associated with decreased progression of bone erosion after denosumab therapy
  Deodhar A, Dore R, Sharp J, Mandel D, Schechtman J, Shergy W, Trapp R, Ory P, Peterfy C, Feurst T, Zhou L, Tsuji W, Newmark R, EULAR; Annals of the Rheumatic Diseases, 1/1/2008
• Bone mineral density improved in patients with rheumatoid arthritis treated with denosumab, with or without glucocorticoids
  Lane N, Cohen S, Dore R, Zhou L, Tsuji W, Newmark R, EULAR; Annals of the Rheumatic Diseases, 1/1/2008
• Inhibiting RANKL with denosumab decreases progression of bone erosions in patients with rheumatoid arthritis: MRI results at 6 months
  Cohen SB, Valen P, Ritchlin C, Schechtman J, Peterfy C, van der Heijde D, Zhou L, Newmark R, Tsuji W, Annals of the Rheumatic Diseases; EULAR, 1/1/2007
• Efficacy and safety of up to 192 weeks of etanercept therapy in patients with ankylosing spondylitis
  Davis JC Jr, van der Heijde D, Braun J, Dougados M, Clegg DO, Kivitz A, Fleischmann R, Inman R, Ni L, Lin S-L, Tsuji W, Annals of the Rheumatic Diseases; EULAR, 1/1/2007
• Inhibiting RANKL with denosumab increases bone mineral density in patients with rheumatoid arthritis: 6-month results from a randomized, placebo-controlled trial
  Dore R, Hurd E, Palmer W, Shergy W, Zhou L, Newmark R, Tsuji W, Annals of the Rheumatic Diseases; EULAR, 1/1/2007
• Inhibiting RANKL with denosumab reduces markers of bone and cartilage turnover in patients with rheumatoid arthritis
  Lane N, Iannini M, Atkins C, Haraoui R, Zhou L, Tsuji W, Newmark R, Annals of the Rheumatic Diseases; EULAR, 1/1/2007
• The RANKL inhibitor denosumab reduces progression of the total Sharp score and bone erosions in patients with rheumatoid arthritis: x-ray results at 12 months
  Van Der Heijde D, Cohen S, Sharp J, Ory P, Zhou L, Tsuji W, Newmark R, Annals of the Rheumatic Diseases; EULAR, 1/1/2007
• Denosumab-mediated increase of hand bone mineral density in patients with rheumatoid arthritis is associated with decreased bone erosion
  Deodhar A, Dore R, Sharp J, Mandel D, Schechtman J, Shergy W, Trapp R, Zhou L, Tsuji W, Newmark R, Arthritis & Rheumatism; ACR, 1/1/2007
• Denosumab increases bone mineral density in patients with glucocorticoid-induced osteoporosis and rheumatoid arthritis
  Lane N, Cohen S, Dore R, Zhou L, Tsuji W, Newmark R, Arthritis & Rheumatism; ACR, 1/1/2007
• Population analysis of denosumab pharmacokinetics (PK) and pharmacodynamics (PD) in patients with rheumatoid arthritis (RA)
  Peterson M, Tsuji W, Newmark R, Arthritis & Rheumatism; ACR, 1/1/2007
• Denosumab inhibits RANKL, reducing progression of the total Sharp score and bone erosions in patients with rheumatoid arthritis: 12-month x-ray results
  Van Der Heijde D,Cohen S, Sharp J, Ory P, Zhou L, Tsuji W, Newmark R, Arthritis & Rheumatism; ACR, 1/1/2007
• RANKL inhibition with denosumab decreases progression of bone erosions in patients with rheumatoid arthritis: MRI results at 6 months
  Cohen SB, Valen P, Ritchlin C, Schechtman J, Peterfy C, van der Heijde D, Zhou L, Newmark R, Tsuji W, ECCEO, 1/1/2007
• RANKL inhibition with denosumab increases bone mineral density in patients with rheumatoid arthritis
  Dore R, Hurd E, Palmer W, Shergy W, Zhou L, Newmark R, Tsuji W, ECCEO, 1/1/2007
• Assessing patient-reported outcomes of patients with psoriatic arthritis treated with etanercept
  Mease PJ, Woolley JM, Singh A, Tsuji W, Dunn M, Chiou CF, AMCP, Fall, 1/1/2006
• Etanercept in ankylosing spondylitis results in a rapid and sustained improvement in quality of life and utility: 72-week results from an open-label extension trial
  Boonen A, Maetzel A, Patel V, Traina S, Chiou F, Tsuji W, Annals of the Rheumatic Diseases; EULAR, 1/1/2006
• A phase IV registry of etanercept in children with juvenile rheumatoid arthritis
  Giannini EH, Ilowite NT, Lovell DJ, Wallace CA, Rabinovich EC, Reiff AO, Bevirt T, Chen C-Y, Tsuji WH, Annals of the Rheumatic Diseases; EULAR, 1/1/2006
• US and UK EQ-5D scoring algorithms result in different utility estimates: Results from an etanercept open-label extension trial in ankylosing spondylitis
  Maetzel A, Boonen A, Patel V, Traina S, Chiou F, Tsuji W, Annals of the Rheumatic Diseases; EULAR, 1/1/2006
• Patient-reported outcomes in a randomized comparison of etanercept and placebo for treatment of psoriatic arthritis
  Mease PJ, Woolley M, Singh A, Tsuji WH, Dunn M, Chiou CF, Annals of the Rheumatic Diseases; EULAR, 1/1/2006
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Lectures

• IL-17 and IL-23: Targets with Complex Underlying Biology 
  Univerisity of Washington, 2014 - 1/1/2014
• Th17 Cells in Rheumatic Diseases 
  Univerisity of Washington - 1/1/2010
• TNF Inhibition: A Quantum Leap in Therapy of Rheumatic Diseases 
  1/1/2009
• RANKL and Denosumab in Rheumatoid Arthritis 
  Univerisity of Washington - 1/1/2007
• The clinical development history of etanercept 
  1/1/2004
• Etanercept (Enbrel) for the Treatment of Ankylosing Spondylitis 
  1/1/2003
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Other

• A randomized, double-blind, parallel-group, placebo-controlled, multiple-dose study to evaluate AMG557 in patients with systemic lupus erythematosus and active lupus a... 
  Cheng LE, Amoura Z, Cheah B, et al (Tsuji W), Arth Rheumatol Online
  1/1/2018
• The RA-MAP Consortium: a working model for academia-industry collaboration. 
  Cope, AP, Barnes, MR, Belson, A, et al (Tsuji W), Nat Rev Rheumatol Online
  1/1/2017