WilburH.ChenMD, MS, FACP, FIDSA

Infectious Disease • Baltimore, MD

International Health, Travel & Tropical

Professor of Medicine, University of Maryland School of Medicine

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Office
Center for Vaccine Development
685 W. Baltimore Street, suite 480
Baltimore, MD 21201
Phone+1 410-706-5328

Fax+1 410-706-6205
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Summary

Dr. Wilbur Chen is the Frank M. Calia, MD Endowed Professor of Medicine, an infectious disease physician-scientist at the University of Maryland School of Medicine, affiliated with the University of Maryland Medical Center. He received his medical degree from Howard University College of Medicine and has been in practice 18 years. He specializes in international health, travel & tropical and is the Director of the University of Maryland, Baltimore Travel Medicine Practice. He conducts vaccine research on diarrheal diseases, influenza, and tropical medicine.

Education & Training

University of Maryland School of MedicineMS, Clinical Research, 2004 - 2008
University of Maryland School of MedicinePost-Doctoral Fellowship, NIH T32 Vaccinology, 2004 - 2006
University of MarylandFellowship, Infectious Disease, 2002 - 2004
Johns Hopkins UniversityResidency, Internal Medicine, 1999 - 2002
Howard University College of MedicineClass of 1999

Certifications & Licensure

MD State Medical License 2004 - 2024

Clinical Trials

H5N1 (Clade 2) Vaccination of Adults and Elderly Start of enrollment: 2008 Nov 01
Completed
Phase 1, Phase 2
Booster Trial to 07-0019 With A/Anhui/05 With and Without MF59 Start of enrollment: 2010 Jun 01
Completed
Phase 1
Sanofi H1N1 Influenza Vaccine Administered at Two Dose Levels in Adult and Elderly Populations Start of enrollment: 2009 Aug 01
Completed
Phase 2
Sanofi H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations Start of enrollment: 2009 Sep 01
Completed
Phase 2
Phase I STEBVax in Healthy Adults Start of enrollment: 2011 Feb 01
Completed
Phase 1
Safety and Efficacy of Investigational Anti-Influenza Immune Plasma in Treating Influenza Start of enrollment: 2010 Dec 01
Completed
Phase 2
Phase II Tularemia Vaccine Comparison Start of enrollment: 2010 Sep 01
Completed
Phase 2
H5N1 Mix and Match With AS03 Start of enrollment: 2011 May 01
Completed
Phase 1
Maternal Flu Vaccine Trial in Bamako, Mali Start of enrollment: 2011 Sep 12
Completed
Phase 4
Safety and Immunogenicity of the Live Oral Cholera Vaccine Candidate PXVX0200 Start of enrollment: 2012 Apr 01
Completed
Phase 1
Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera Start of enrollment: 2013 Sep 01
Completed
Phase 3
PXVX0200 (CVD103-HgR) vs Shanchol in Mali Start of enrollment: 2014 Jul 01
Completed
Phase 2
Study of Meninigococcal Conjugate Vaccine Containing Serogroups A,C,Y,W and X (MCV5) in Healthy Adults Start of enrollment: 2016 Aug 01
Completed
Phase 1
Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults Start of enrollment: 2017 Aug 01
Withdrawn
Phase 2
A Double-Blind Placebo-Control Dose Escalating Study to Evaluate the Safety and Immunogenicity of dmLT by Oral, Sublingual and Intradermal Vaccination in Adults Residing in an Endemic Area Start of enrollment: 2019 Mar 10
Terminated
Phase 1
Meningococcal Serogroup ACYWX Conjugate Vaccine in Comparison With MenACWY-TT Conjugate Vaccine Start of enrollment: 2022 Mar 24
Active, not recruiting
Phase 3
Roles: Principal Investigator
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Publications & Presentations

PubMed

Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.
Marco Cavaleri, David Kaslow, Eric Boateng, Wilbur H Chen, Christopher Chiu, Robert K M Choy, Rodrigo Correa-Oliveira, Anna Durbin, Moses Egesa, Malick Gibani, Melissa...> ;Biologicals. 2024 Feb 1
7 citations
Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond.
Hyung-Joon Kwon, Martina Kosikova, Weichun Tang, Uriel Ortega-Rodriguez, Peter Radvak, Ruoxuan Xiang, Kelly E Mercer, Levan Muskhelishvili, Kelly Davis, Jerrold M Ward...> ;Iscience. 2022 Dec 22
6 citations
The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination.
Johannes B Goll, Aarti Jain, Travis L Jensen, Rafael Assis, Rie Nakajima, Algis Jasinskas, Lynda Coughlan, Sami R Cherikh, Casey E Gelber, S Khan, D Huw Davies, Philip...> ;NPJ Vaccines. 2022 Aug 30
2 citations
Shigella-Controlled Human Infection Models: Current and Future Perspectives.
Kristen A Clarkson, Chad K Porter, Kawsar R Talaat, Melissa C Kapulu, Wilbur H Chen, Robert W Frenck Jr, A Louis Bourgeois, Robert W Kaminski, Laura B Martin> ;Current Topics in Microbiology and Immunology. 2022 May 27
3 citations
Safety and immunogenicity of monovalent H7N9 influenza vaccine with AS03 adjuvant given sequentially or simultaneously with a seasonal influenza vaccine: A randomized ...
Justin R Ortiz, Paul W Spearman, Paul A Goepfert, Kaitlyn Cross, C Buddy Creech, Wilbur H Chen, Susan Parker, Edgar T Overton, Michelle Dickey, Heather L Logan, Ashley...> ;Vaccine. 2022 May 20
7 citations
Functional and structural modifications of influenza antibodies during pregnancy.
Madeleine F Jennewein, Martina Kosikova, Francesca J Noelette, Peter Radvak, Carolyn M Boudreau, James D Campbell, Wilbur H Chen, Hang Xie, Galit Alter, Marcela F Pasetti> ;Iscience. 2022 Apr 15
6 citations
Use of Ebola Vaccine: Expansion of Recommendations of the Advisory Committee on Immunization Practices To Include Two Additional Populations - United States, 2021.
Jason H Malenfant, Allison Joyce, Mary J Choi, Caitlin M Cossaboom, Amy N Whitesell, Brian H Harcourt, Robert L Atmar, Julie M Villanueva, Beth P Bell, Christine Hahn,...> ;MMWR. Morbidity and Mortality Weekly Report. 2022 Feb 25
36 citations
Dengue Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021.
Gabriela Paz-Bailey, Laura Adams, Joshua M Wong, Katherine A Poehling, Wilbur H Chen, Veronica McNally, Robert L Atmar, Stephen H Waterman> ;MMWR. Recommendations and Reports. 2021 Dec 17
4 citations
A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea i...
Rahsan Erdem, Gwen Ambler, Mohamed S. Al-Ibrahim, Katarzyna Fraczek, Steven D Dong, Chris Gast, Laina D. Mercer, Michael Raine, Sharon M. Tennant, Wilbur H. Chen, Euge...> ;Plos Neglected Tropical Diseases. 2021 Nov 18
A site assessment tool for inpatient controlled human infection models for enteric disease pathogens.
Chad K. Porter, Katherine J Detizio, Nicole Maier, Kayla J. Testa, Kawsar R. Talaat, Wilbur H. Chen, Caroline E. Lyon, Ramiro L. Gutierrez, Robert W. Frenck, Sandra D....> ;Clinical Trials. 2021 Oct 28
5 citations
Linked vaccination coverage surveys plus serosurveys among Ethiopian toddlers undertaken three years apart to compare coverage and serologic evidence of protection in ...
James D. Campbell, Marcela F. Pasetti, Lisa Oot, Zenaw Adam, Mesfin Tefera, Berhane Beyane, Nigisti Mulholland, Robert Steinglass, Rebecca Krey, Wilbur H. Chen, Willia...> ;Vaccine. 2021 Aug 28
2 citations
The operational feasibility of vaccination programs targeting influenza risk groups in the WHO African and South-East Asian Regions.
Justin R. Ortiz, Stephen Yu, Amanda J. Driscoll, Sarah R. Williams, Joanie Robertson, Jui-Shan Hsu, Wilbur H. Chen, Robin Biellik, Samba O. Sow, Sonali Kochhar, Kathle...> ;Clinical Infectious Diseases. 2021 May 5
18 citations
National routine adult immunisation programmes among World Health Organization Member States: an assessment of health systems to deploy COVID-19 vaccines
Sarah R. Williams, Amanda J. Driscoll, Hanna M. LeBuhn, Wilbur H. Chen, Kathleen M. Neuzil, Justin R. Ortiz> ;Euro Surveillance. 2021 Apr 29
7 citations
The potential effects of deploying SARS-Cov-2 vaccines on cold storage capacity and immunization workload in countries of the WHO African Region.
Justin R. Ortiz, Joanie Robertson, Jui-Shan Hsu, Stephen Yu, Amanda J. Driscoll, Sarah R. Williams, Wilbur H. Chen, Meagan C. Fitzpatrick, Samba O. Sow, Robin Biellik,...> ;Vaccine. 2021 Apr 8
7 citations
Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents.
Rajiv S. Jumani, Johanne Blais, Hanns-Christian Tillmann, Florencia Segal, Dean Wetty, Christian Ostermeier, Natko Nuber, Jay Parthiban Lakshman, Natasha Aziz, Richa C...> ;ACS Infectious Diseases. 2021 Apr 6
2 citations
Immunogenicity and safety of different dose schedules and antigen doses of an MF59-adjuvanted H7N9 vaccine in healthy adults aged 65 years and older
Patricia L. Winokur, Hana M. El Sahly, Mark J. Mulligan, Sharon E. Frey, Richard E. Rupp, Evan J. Anderson, Kathryn M. Edwards, David I. Bernstein, Kenneth E. Schmader...> ;Vaccine. 2021 Jan 21
3 citations
Vaccine‐related major cutaneous reaction size correlates with cellular‐mediated immune responses after tularaemia immunisation
Rosangela Salerno-Goncalves, Wilbur H. Chen, Mark J. Mulligan, Sharon E. Frey, Jack T. Stapleton, Wendy A. Keitel, Jason A. Bailey, Eli A. Sendra, Heather Hill, Robert...> ;Clinical & Translational Immunology. 2021 Jan 1
51 citations
Understanding immunosenescence and its impact on vaccination of older adults.
Jessica C Allen, Franklin R. Toapanta, Wilbur H. Chen, Sharon M. Tennant> ;Vaccine. 2020 Nov 21
29 citations
Opinion: For now, it's unethical to use human challenge studies for SARS-CoV-2 vaccine development.
Jeffrey P. Kahn, Leslie Meltzer Henry, Anna C. Mastroianni, Wilbur H. Chen, Ruth Macklin> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 17
4 citations
Pre-existing Helicobacter pylori serum IgG enhances the vibriocidal antibody response to CVD 103-HgR live oral cholera vaccine in Malian adults
Khitam Muhsen, Samba O. Sow, Milagritos D. Tapia, Fadima Cheick Haidara, Mardi Reymann, Valeria Asato, Wilbur H. Chen, Marcela F. Pasetti, Myron M. Levine> ;Scientific Reports. 2020 Oct 9
7 citations
The operational impact of deploying SARS-CoV-2 vaccines in countries of the WHO African Region.
Justin R Ortiz, Joanie Robertson, Jui-Shan Hsu, Stephen Yu, Amanda J. Driscoll, Sarah R. Williams, Wilbur H. Chen, Meagan C. Fitzpatrick, Samba O. Sow, Robin Biellik, ...> ;Medrxiv. 2020 Nov 1
6 citations
COVID-19 and Lessons to Be Learned from Prior Coronavirus Outbreaks.
Meagan E Deming, Wilbur H. Chen> ;Annals of the American Thoracic Society. 2020 Jul 1
30 citations
Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlle...
Saad B. Omer, Dayna R Clark, Shabir A. Madhi, Milagritos D. Tapia, Marta C. Nunes, Clare L. Cutland, Eric A. F. Simões, Anushka R. Aqil, Joanne Katz, James M. Tielsch,...> ;The Lancet. Respiratory Medicine. 2020 Jun 1
23 citations
Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies.
Kawsar R. Talaat, A. Louis Bourgeois, Robert W. Frenck, Wilbur H. Chen, Calman A. MacLennan, Mark S. Riddle, Akamol E. Suvarnapunya, Jessica Brubaker, Karen L. Kotloff...> ;Clinical Infectious Diseases. 2019 Dec 9
21 citations
Consensus Report on Shigella Controlled Human Infection Model: Clinical Endpoints
Calman A. MacLennan, Mark S. Riddle, Wilbur H. Chen, Kawsar R. Talaat, Varsha K. Jain, A. Louis Bourgeois, Robert W. Frenck, Karen L. Kotloff, Chad K. Porter> ;Clinical Infectious Diseases. 2019 Dec 9
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Journal Articles

Responses of the Human Gut Escherichia Coli Population to Pathogen and Antibiotic Disturbances
Wilbur Chen, MD, mBio

Press Mentions

Incredible Medical Advances of 2022December 23rd, 2022
Vaccines for RSV, the Illness That's Been Sickening Babies Across the US, Are Poised to Become Available in 2023November 11th, 2022
Strong RSV Vaccine Data Lifts Hopes After Years of FutilityNovember 2nd, 2022
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