William Ted Brown MD

PubMed

• 5 citations
  Involvement of Type 10 17β-Hydroxysteroid Dehydrogenase in the Pathogenesis of Infantile Neurodegeneration and Alzheimer's Disease.
  Xue-Ying He, Jannusz Frackowiak, Carl Dobkin, William Ted Brown, Song-Yu Yang
  International Journal of Molecular Sciences. 2023-12-18
• Editorial for the Fragile X Syndrome Genetics Special Issue: May 2023.
  David E Godler, William T Brown
  Genes. 2023-05-25
• 5 citations
  The role of reduced expression of fragile X mental retardation protein in neurons and increased expression in astrocytes in idiopathic and syndromic autism (duplicatio...
  Jarek Wegiel, W. Ted Brown, Giuseppe La Fauci, Tatyana Adayev, Richard J. Kascsak
  Autism Research. 2018-10-01

Journal Articles

• Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults  
  Weigel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Frackowiak J, Mazur-Kolecka B, Wierzba-Bobrowicz T, London E, Wisniewski T, Hof PR, Brown WT, Acta Neuropathologica Communications, 1/1/2015
• Viral infection-induced differential expression of LncRNAs associated with collagen in mouse placentas and amniotic sacs  
  Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins EC, Brown WT, Zhong N, American Journal of Reproductive Immunology, 1/1/2015
• Epigenetic regulation of IncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes  
  Luo X, Pan J, Wang L, Wang P, Zhang M, Liu M, Dong Z, Meng Q, Tao X, Zhao X, Zhong J, Ju W, Gu Y, Jenkins EC, Brown W, Shi Q, Zhong N, BMC Pregnancy and Childbirth, 1/1/2015
• Microarray analysis reveals higher gestational folic acid alters expression of genes in the cerebellum of mice offspring – A pilot study  
  Barua S, Kuizon S, Chadman KK, Brown WT, Junaid MA, Brain Sciences, 1/1/2015
• Fragile X full mutation expansions are inhibited by one or more AGG interruptions in premutation carriers  
  Nolin SL, Glicksman A, Ersalesi N, Dobkin C, Brown WT, Cao R, Blatt E, Sah S, Latham GJ, Hadd AG, Genet Med, 1/1/2015
• LncRNA-regulated infection and inflammation pathways associated with pregnancy loss: genome wide differential expression of IncRNAs in early spontaneous abortion  
  Wang H, Cao Q, Ge J, Liu C, Ma Y, Meng Y, Wang Y, Zhao X, Liu R, Li C, Wang Y, Zhong J, Ju W, Jenkins EC, Brown WT, Zhong N, American Journal of Reproductive Immunology, 1/1/2014
• Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the stri...  
  J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Wisniewski T, Brown WT, Acta Neuropathologica Communications, 1/1/2014
• Brain-region-specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism  
  Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Brown WT, Wisniewski T, Acta Neuropathologica Communications, 1/1/2014
• Fragile X protein in newborn dried blood spots  
  Adayev T, LaFauci G, Dobkin C, Caggana M, Wiley V, Field M, Wotton T, Kascsak R, Nolin SL, Glicksman A, Hosmer N, Brown WT, BMC Medical Genetics, 1/1/2014
• Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome  
  Gordon LB, Massaro J, D’Agostino RB Sr, Campbell SE, Brazier J, Brown WT, Kleinman ME, Kieran MW and the Progeria Clinical Trials Collaborative, Circulation, 1/1/2014
• Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid  
  Barua S, Kuizon S, Chadman KK, Flory MJ, Brown WT, Junaid MA, Epigenetics & Chromatin, 1/1/2014
• Hypermethylation of the enolase gene (EN02) in autism  
  Wang Y, Fang Y, Zhang F, Xu M, Zhang J, Yan J, Ju W, Brown WT, Zhong N, European Journal of Pediatrics, 1/1/2014
• Novel epigenetic regulation of alpha-synuclein expression in Down syndrome  
  Ramakrishna N, Meeker HC, Brown WT, Molecular Neurobiology, 1/1/2014
• Substrate reduction therapy in four patients with milder CLN1 mutations and juvenile-onset Batten disease using cysteamine bitartrate  
  Gavin M, Wen GY, Messing J, Adelman S, Logush A, Jenkins EC, Brown WT, Velinov M, Journal of Inherited Metabolic Disease Reports, 1/16/2013
• Autoantibodies against neuronal progenitors in sera from children with autism  
  Mazur-Kolecka B, Cohen IL, Gonzalez M, Jenkins EC, Kaczmarski W, Brown WT, Flory M, Frackowiak J, Brain and Development, 1/6/2013
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  Frackowiak J, Mazur-Kolecka B, Schanen CN, Brown WT, Wegiel J, Acta Neuropathologica Communications, 1/1/2013
• Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles  
  Nolin SL, Sah S, Glicksman A, Sherman SL, Allen E, Berry-Kravis E, Tassone F, Yrigollen C, Cronister A, Jodah M, Ersalesi N, Dobkin C, Brown WT, Shroff R, Latham GJ, H..., American Journal of Medical Genetics, 1/1/2013
• Transcription start sites and epigenetic analysis of the HSD17B10 proximal promoter  
  Yang SY, Dobkin C, He XY, Brown WT, BMC Biochem, 1/1/2013
• Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism  
  Wegiel J, Kuchna I, Nowicki K, Imaki H, Wegiel J, Ma SY, Azmitia EC, Banarjee P, Flory M, Cohen IL, London E, Brown WT, Hare CK, Wisniewski T, Brain Research, 1/1/2013
• Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development  
  Yang K, Cao F, Sheikh AM, Malik M, Wen G, Wei H, Brown WT, Li X, Brain Structure Function, 1/1/2013
• A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome  
  Kover ST, Pierpont EI, Kim J-S, Brown WT, Abbeduto L, Developmental Neuropsychology, 1/1/2013
• Prevalence of psychotropic drug use in adults with intellectual disability: positive and negative findings from a large scale study  
  Tsiouris JA, Kim SY, Brown WT, Pettinger J, Cohen IL, Journal of Autism Developmental Disorders, 1/1/2013
• Quantitative 3D evaluation of step ascent and descent in individuals with Down syndrome –analysis of a daily challenging task  
  Galli M, Cimolin V, Ferrario D, Patti P, Heaney G, Freedland R, Albertini G, Brown WT, Journal of Intellectual Disability Research, 1/1/2013
• Fragile X screening by quantification of FMRP in dried blood spots by a Luminex immunoassay  
  LaFauci G, Adayev T, Kascsak R, Kascsak R, Nolin S, Mehta P, Brown WT, Dobkin C, Journal of Molecular Diagnostics, 1/1/2013
• LncRNA pathway involved in premature preterm rupture of membrane (PPROM): an epigenomic approach to study the pathogenesis of reproductive disorders  
  Luo X, Shi Q, Gu Y, Pan J, Hua M, Liu M, Dong Z, Zhang M, Wang L, Gu Y, Zhong J, Zhao X, Jenkins EC, Brown WT, Zhong N, Plos ONE, 1/1/2013
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Books/Book Chapters

• Branched Chain Amino Acids in Clinical Nutrition: Volume 1. 
  Chapter: Mental Retardation and Isoleucine Metabolism. 
  Page 157 - 169Yang S-Y, He X-Y, Dobkin C, Isaacs C, Brown WTEditors: Rajendram R, Preedy VR, Patel VB.Humana Press, Springer, New York, NY2015
• The Claustrum, Structural, Functional, and Clinical Neuroscience. 
  Chapter: Delayed Development of the Claustrum in Autism. 
  Page 225 - 235Editors: Smythies JR, Edelstein LR, Ramachandran VS.Academic Press2014
• The Neuroscience of Autism Spectrum Disorders. 
  Chapter: Clinicopathological stratification of idiopathic autism and autism with 15q11.2-q13 duplications. 
  Page 347 - 359Wegiel J, Schanen NC, Cook EH, Brown WT, Kuchna I, Nowicki K, Wegiel J, Imaki H, Ma SY, London E, Wisniewski TEditors: Hof PR, Buxbaum JD.Academic Press2013
• The Neuroscience of Autism Spectrum Disorders. 
  Chapter: Fragile X syndrome and autism spectrum disorders. 
  Page 409 - 419Brown WT, Cohen ILEditors: Hof PR, Buxbaum JD.Academic Press2013
• Modeling Fragile X Syndrome. 
  Chapter: Neuroendocrine alterations in the fragile X mouse. Clinical aspects of the fragile X syndrome. (Results and Problems in Cell Differentiation, 54). 
  Page 201 - 221El Idrissi A, Yan X, L’Amoreaux W, Brown WT and Dobkin CEditors: Denman RB.Springer, Dordrecht, Netherlands2012
• Modeling Fragile X Syndrome. 
  Chapter: Clinical aspects of the fragile X syndrome. (Results and Problems in Cell Differentiation, 54). 
  Page 273 - 279Brown WTEditors: Denman RB.Springer, Dordrecht, Netherlands2012
• Contemporary Issues in Intellectual Disabilities. 
  Chapter: Biomarkers of aggressive and self-abusive behavior. 
  Page 111 - 112Brown WT, Cohen IL, Freedland R, Flory M, Yoo JH, Petting J, Tsiouris JAEditors: Prasher VP.Nova Publishers, New York, NY2010
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  Editors: Chauhan A, Chauhan V, Brown WT.Taylor & Francis/CRC Press, Boca Raton, FL2009
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  Chapter: Type, topography, and sequelae of neuropathological changes shaping clinical phenotype of autism. 
  Page 1 - 34Wegiel J, Wisniewski T, Chauhan A, Chauhan V, Kuchna I, Nowicki K, Imaki H, Wegiel J, Ma SY, Bobrowicz TW, Cohen IL, London E, Brown WTEditors: Chauhan A, Chauhan V, Brown WT.Taylor & Francis/CRC Press, Boca Raton, FL2009
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  Chapter: Genetics of Autism. 
  Page 61 - 72Brown WTEditors: Chauhan A, Chauhan V, Brown WT.Taylor & Francis/CRC Press, Boca Raton, FL2009
• Handbook of Neurochemistry and Molecular Neurobiology 
  Chapter: Protein Alterations in Mental Retardation. 
  Page 259 - 282Junaid MA, Brown WTKluwer Publishing Corp, New York, NY2007
• Encyclopedia of Diagnostic Genomics and Proteomics 
  Chapter: Prader-Willi Syndrome. 
  Page 1060 - 1064Velinov M, Jenkins EC, Brown WTMarcel Dekker, Inc., New York, NY2005
• Elsevier’s Encyclopedia of Neuroscience 
  Chapter: The Fragile X Syndrome. 
  Brown WT, Jenkins ECEditors: BSG, Adelman and BH Smith.Elsevier ScienceEdition 3rd,2004
• Genetic Disorders and the Fetus 
  Chapter: Prenatal diagnosis of the fragile X syndrome. 
  Page 375 - 394Jenkins EC, Brown WTEditors: Milunsky, Ed.Johns Hopkins University Press, Baltimore, MDEdition 5th,2004
• Nelson’s Textbook of Pediatrics 
  Chapter: Progeria. 
  Page 494 - 495Brown WTEditors: Behrman RE, Kliegman R, Arvin AM.W.B. Saunders Publishing Co., Orlando, FLEdition 17th,2003
• Chromosomal Instability and Aging. 
  Chapter: Hutchinson-Gilford Progeria Syndrome. 
  Page 245 - 261Brown WTEditors: FM Hisama, SM Weissman, GM Martin.Marcel Dekker, Inc., New York, NY2003
• The NORD Guide to Rare Disorders. 
  Chapter: Progeria. 
  Page 724 - 725Brown WTLippincott, Williams & Wilkins, Philadelphia, PA2003
• Current Protocols in Human Genetics 
  Chapter: Molecular Analysis of Fragile X Syndrome 
  Nolin S, Dobkin C, Brown WTEditors: Dracopoli NC, Haines JL, Korf BR.Wiley, New York, NY2003
• Fragile X Syndrome: Diagnosis, Treatment and Research. 
  Chapter: The Molecular Biology of the Fragile X Mutation. 
  Page 110 - 135Brown WTEditors: RJ Hagerman, PJ Hagerman.Johns Hopkins University Press, Baltimore, MDEdition 3rd,2002
• The Genetic Basis of Common Diseases. 
  Chapter: Mental Retardation. 
  Page 914 - 919Brown WTEditors: RA King, JI Rotter, AG Motulsky.Oxford University Press, New York, NYEdition 2nd,2002
• Elsevier’s Encyclopedia of Neuroscience 
  Chapter: Fragile X Syndrome. 
  Page 732 - 734Brown WT, Jenkins ECEditors: BSG. Adelman and BH Smith.Elsevier ScienceEdition 2nd,1999
• Diagnosis and Treatment of the Unborn Child. 
  Chapter: Fragile X Syndrome. 
  Page 17 - 26Brown WTEditors: MI New.Idelson-Gnocchi, Reddick, FL1999
• Genetic disorders of the fetus. 
  Chapter: Prenatal diagnosis of the fragile X syndrome. 
  Page 314 - 331Jenkins EC, Shapiro LR, Brown WTEditors: A. Milunsky.Johns Hopkins University Press, Baltimore, MD1998
• Nelson's Textbook of Pediatrics 
  Chapter: Progeria 
  Page 1996 - 1997DeBusk F, Brown WTEditors: Behrman RE, Kliegman R, Arvin AM.W.B. Saunders Publishing Co, Orlando, FLEdition 15th,1997
• Down's Syndrome Psychological, Psychobiological and Socio-Educational Perspectives 
  Chapter: Consequences of Genetic Abnormalities in Down's Syndrome on Brain Structure and Function. Chapter 1 
  Page 3 - 19Wisniewski K, Kida E, Brown WTEditors: JA Rondal, J Perera, L. Nadel, A. Comblain.Athenaeum Press Ltd.1996
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Other

• Hutchinson-Gilford Progeria Syndromes. 
  Gordon LB, Brown WT, Collins FS, Pagon RA, Adam MP, Ardinger HH, et al., editors. Gene Reviews® [Internet]
  http://www.ncbi.nlm.nih.gov/books/NBK1121/
  University of Washington, Seattle, WA - 1/8/2015
• Hutchinson-Gilford Progeria Syndrome 
  Gordon LB, Brown WT, Collins FS, GeneReviews at GeneTests: Medical Genetics Information Resource.
  http://www.genetests.org
  1/1/2011
• Hutchinson-Gilford Progeria Syndrome. 
  Brown WT, Gordon LB, Collins FS, GeneReviews at GeneTests: An Online Medical Genetics Information Resource
  http://www.genetests.org
  1/1/2003
• The Caudal Thalamus of the Frog: A Microelectrode Study, Ph.D. Thesis 
  Brown WT, Department of Biophysics, The Johns Hopkins University
  1/1/1973
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