WilliamGCanceMD

General Surgery • Phoenix, AZ

Endocrine, Surgical Oncology (Other than Breast)

Deputy Director University of Arizona Cancer Center at Dignity St. Joseph's

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Office
625 N. 6th Street
Phoenix, AZ 85004
Phone+1 602-827-2692
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Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1982 - 1987
Duke University School of MedicineClass of 1982

Certifications & Licensure

AZ State Medical License 2016 - 2025
GA State Medical License 2020 - 2025
NY State Medical License 1988 - 2019
FL State Medical License 2004 - 2011
NC State Medical License 1990 - 2009
American Board of Surgery Surgery

Awards, Honors, & Recognition

Buffalo Spree Magazine Castle Connolly, 2010-2014
America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Fellow (FACS) American College of Surgeons
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Publications & Presentations

PubMed

Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk.
Lik Hang Lee, Lindy Davis, Lourdes Ylagan, Angela R Omilian, Kristopher Attwood, Canan Firat, Jinru Shia, Philip B Paty, William G Cance> ;Journal of the National Cancer Institute. 2022 May 9
7 citations
Impact of COVID-19 Pandemic on Cancer Research
Leonard I. Zon, Ana P. Gomes, William G. Cance, Antoni Ribas, David A. Tuveson, Sophie Postel-Vinay, Christophe Massard, Fabrice Barlesi> ;Cancer Cell. 2020 Nov 9
6 citations
Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling.
Erik Stahl, Rohini Nott, Karissa Koessel, William G. Cance, Timothy Marlowe> ;Chemical Biology & Drug Design. 2020 Mar 13
5 citations
Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK-Paxillin Interaction
Timothy Marlowe, Carlos Alvarado, Andrew Rivera, Felicia L. Lenzo, Rohini Nott, Dena Bondugji, Justin J. Montoya, Alana Hurley, Matthew E. Kaplan, Andrew P. Capaldi, W...> ;SLAS Discovery. 2020 Jan 1
7 citations
Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR.
Carlos Alvarado, Erik Stahl, Karissa Koessel, Andrew Rivera, Brian R. Cherry, Surya V.S.R.K. Pulavarti, Thomas Szyperski, William G. Cance, Timothy Marlowe> ;Molecules. 2019 Sep 14
5 citations
High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site
Timothy Marlowe, Alexey Dementiev, Sheila Figel, Andrew Rivera, Michael T. Flavin, William G. Cance> ;BMC Molecular and Cell Biology. 2019 May 20
4 citations
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein.
Felicia L. Lenzo, William G. Cance> ;Translational Cancer Research. 2017 Jun 23
3 citations
Surgeon-Authored Virtual Laparoscopic Adrenalectomy Module Is Judged Effective and Preferred Over Traditional Teaching Tools:
Juan C. Cendan, Saleh Dindar, Kristopher Attwood, James M. Hassett, Ruth Nawotniak, Gregory S. Cherr, William G. Cance, Jörg Peters> ;Surgical Innovation. 2017 Feb 1
20 citations
Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors
Timothy Marlowe, Felicia L. Lenzo, Sheila Figel, Abigail T. Grapes, William G. Cance> ;Molecular Cancer Therapeutics. 2016 Dec 1
29 citations
Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways
Huanjie Shao, Vita M. Golubovskaya, Hongbin Chen, William G. Cance, Alex A. Adjei, Grace K. Dy> ;British Journal of Cancer. 2016 Jul 12
18 citations
In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride)
Vita M. Golubovskaya, Leslie Curtin, Adrienne Groman, Sandra Sexton, William G. Cance> ;Archives of Toxicology. 2015 Jul 1
Synthesis and bioactivity of a Goralatide analog with antileukemic activity.
Zhiliang Li, Iryna O. Lebedyeva, Vita M. Golubovskaya, William G. Cance, Khalid A. Alamry, Hassan M. Faidallah, C. Dennis Hall, Alan R. Katritzky> ;Bioorganic & Medicinal Chemistry. 2015 Aug 1
20 citations
Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15
Vita M. Golubovskaya, Shalana O’Brien, Baotran Ho, Melissa Heffler, Jeffrey M. Conroy, Quang Hu, Dan Wang, Song Liu, William G. Cance> ;Journal of Cancer Research and Clinical Oncology. 2015 Feb 6
38 citations
The Use of Modified Four-Dimensional Computed Tomography in Patients with Primary Hyperparathyroidism: An Argument for the Abandonment of Routine Sestamibi Single-Posi...
Moshim Kukar, Timothy A. Platz, Timothy J. Schaffner, Rania Elmarzouky, Adrienne Groman, Shicha Kumar, Ahmed Abdelhalim, William G. Cance> ;Annals of Surgical Oncology. 2015 Jan 1
18 citations
Inhibition of FAK and VEGFR‐3 binding decreases tumorigenicity in neuroblastoma
Jerry E. Stewart, Xiaojie Ma, Michael L. Megison, Hugh C. Nabers, William G. Cance, Elena Kurenova, Elizabeth A. Beierle> ;Molecular Carcinogenesis. 2015 Jan 1
4 citations
Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs.
John Wilton, Elena Kurenova, Laura Pitzonka, Allison Gaudy, Leslie Curtin, Sandra Sexton, William G. Cance, Gerald J. Fetterly> ;European Journal of Drug Metabolism and Pharmacokinetics. 2016 Feb 1
14 citations
A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells
Elena Kurenova, Deniz A. Ucar, Jianqun Liao, Michael Yemma, Priyanka N. Gogate, Wiam Bshara, Ulas Sunar, Mukund Seshadri, Steven N. Hochwald, William G. Cance> ;Cell Cycle. 2014 Oct 30
12 citations
Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer.
Priyanka N. Gogate, Elena Kurenova, Manivannan Ethirajan, Jianqun Liao, Michael Yemma, Arindam Sen, Ravindra K. Pandey, William G. Cance> ;Cancer Letters. 2014 Oct 28
40 citations
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype
Vita M. Golubovskaya, Lourdes Ylagan, Austin Miller, Melissa Hughes, Jason P. Wilson, David Wang, Elizabeth Brese, Wiam Bshara, Stephen B. Edge, Carl Morrison, William...> ;BMC Cancer. 2014 Oct 17
3 citations
Low dose four-dimensional computerized tomography with volume rendering reconstruction for primary hyperparathyroidism: How I do it?
Timothy A. Platz, Moshim Kukar, Rania Elmarzouky, William G. Cance, Ahmed Abdelhalim> ;World Journal of Radiology. 2014 Sep 28
4 citations
FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted ther...
Shalana O'Brien, Vita M Golubovskaya, Jeffrey Conroy, Song Liu, Dan Wang, Biao Liu, William G Cance> ;Oncotarget. 2014 Sep 15
17 citations
The prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancer.
Grace K. Dy, Lourdes Ylagan, Saraswati Pokharel, Austin Miller, Elizabeth Brese, Wiam Bshara, Carl Morrison, William G. Cance, Vita M. Golubovskaya> ;Journal of Thoracic Oncology. 2014 Sep 1
19 citations
Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction
Priyanka N. Gogate, Manivannan Ethirajan, Elena Kurenova, Andrew T. Magis, Ravindra K. Pandey, William G. Cance> ;European Journal of Medicinal Chemistry. 2014 Jun 10
3 citations
Inhibition of the Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor-3 Interaction Leads to Decreased Survival in Human Neuroblastoma Cell Lines
Elizabeth A. Beierle, Xiaojie Ma, Jerry E. Stewart, Michael L. Megison, William G. Cance, Elena Kurenova> ;Molecular Carcinogenesis. 2014 Mar 1
3 citations
Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.
Vita M. Golubovskaya, Baotran Ho, Jeffrey M. Conroy, Song Liu, Dan Wang, William G. Cance> ;Cancers. 2014 Jan 21
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Press Mentions

National Quality Improvement Initiative Led by the American College of Surgeons Successfully Helped Address Pandemic-Related Cancer Screening DeficitsNovember 16th, 2022
Could a Stool Test Help Spot Pancreatic Cancer?March 9th, 2022
The American Cancer Society and Flatiron Health Announce Recipients of Real-World Data Impact AwardOctober 25th, 2021
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Grant Support

Postdoctoral Research Training In Surgical OncologyNational Cancer Institute2011
Focal Adhesion Kinase - Tumor Biology And TherapeuticsNational Cancer Institute2010–2011
Focal Adhesion Kinase-Tumor Biology And TherapeuticsNational Cancer Institute2009
Surgical Oncology Research TrainingNational Cancer Institute2005–2008
Focal Adhesion Kinase-Tumor Biology And TherapeuticsNational Cancer Institute2005–2008
Focal Adhesion Kinase--Tumor Biology And TherapeuticsNational Cancer Institute2003–2004
Surgical Oncology Research Training ProgramNational Cancer Institute2002
Focal Adhesion Kinase--Tumor Biology And TherapeuticsNational Cancer Institute2000–2002
Calgb Laboratory Studies In The ElderlyNational Cancer Institute1999–2002
Core--Tissue Procurement And AnalysisNational Cancer Institute1997–2002
Core--Tissue Procurement And AnalysisNational Cancer Institute1995–2001
Surgical Oncology Research Training Grant (T32)National Cancer Institute1993–2001
Focal Adhesion Kinase Tumor Biology And TherapeuticsNational Cancer Institute1996–1998
Cancer Education ProgramNational Cancer Institute1993–1997
Novel Protein Kinases In Human Breast CarcinomaNational Cancer Institute1992–1995