WilliamCDooleyMD

General Surgery • Oklahoma City, OK

Breast, Surgical Oncology (Other than Breast)

The G. Rainey Williams Professor and Chair Surgical Oncology

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Office
825 Ne 10th St
OUPB 4G
Oklahoma City, OK 73104
Phone+1 405-271-7867

Fax+1 405-271-4443
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Education & Training

The Johns Hopkins Universitypost grad, Surgery/ Surgical Oncology, 1982 - 1988
Johns Hopkins University School of MedicineFellowship, Complex General Surgical Oncology, 1988
Johns Hopkins UniversityResidency, Surgery, 1987
Oxford Universitypost grad, 1986 - 1986
Johns Hopkins UniversityInternship, Surgery, 1982 - 1983
Vanderbilt University School of MedicineClass of 1982

Certifications & Licensure

OK State Medical License 2001 - 2025
AL State Medical License 1984 - 2024
MD State Medical License 1987 - 2024
American Board of Surgery Surgery

Awards, Honors, & Recognition

Oklahoma Magazine Castle Connolly, 2008-2017
America's Top Doctors for Cancer Castle Connolly, 2005-2017
America's Top Doctors Castle Connolly, 2002-2017
Redbook Magazine: Top Breast Cancer Doctors Castle Connolly, 2001
Fellow (FACS) American College of Surgeons
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Clinical Trials

Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women Start of enrollment: 1999 May 01
Completed
Phase 3
Combination Chemotherapy With or Without Microwave Thermotherapy Before Surgery in Treating Women With Locally Advanced Breast Cancer Start of enrollment: 2001 Aug 01
Unknown status
Phase 2
Microwave Thermotherapy in Treating Women With Stage I or Stage II Breast Cancer Start of enrollment: 2001 Aug 01
Unknown status
Phase 2
Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women Start of enrollment: 2003 Jan 01
Completed
Phase 2
Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer Start of enrollment: 2004 Dec 03
Completed
Phase 3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) Start of enrollment: 2006 Apr 07
Active, not recruiting
Phase 3
Study of Breast Cancer Prevention by Letrozole in High Risk Women Start of enrollment: 2006 Oct 01
Completed
Phase 2
Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS) Start of enrollment: 2008 May 01
Unknown status
Phase 2
Bone Mineral Density in Postmenopausal Women at Increased Risk of Breast Cancer And Who Are Receiving Exemestane on MAP3 Start of enrollment: 2008 Jul 10
Completed
S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors Start of enrollment: 2010 Nov 01
Unknown status
Phase 3
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer Start of enrollment: 2011 Jan 01
Terminated
Phase 2
NBRST: Prospective Neo-adjuvant REGISTRY Trial Start of enrollment: 2011 Jul 01
Completed
MINT I Multi- Institutional Neo-adjuvant Therapy MammaPrint Project I Start of enrollment: 2011 Oct 01
Completed
Phase 4
Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer Start of enrollment: 2012 Jul 01
Completed
Phase 2
PRospective Study Of MammaPrint in Patients With an Intermediate Recurrence Score Start of enrollment: 2012 May 01
Completed
Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System® Start of enrollment: 2012 May 08
Active, not recruiting
Not Applicable
Measuring the Impact of MammaPrint on Adjuvant and Neoadjuvant Treatment in Breast Cancer Patients: A Prospective Registry Start of enrollment: 2015 Nov 01
Completed
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma Start of enrollment: 2019 Dec 17
Recruiting
Phase 3
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

ASO Visual Abstract: Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-...
Pat Whitworth, Peter D Beitsch, James V Pellicane, Paul L Baron, Laura A Lee, Carrie L Dul, Charles H Nash 3rd, Mary K Murray, Paul D Richards, Mark Gittleman, Raye Bu...> ;Annals of surgical oncology. 2022 Apr 19
5 citations
Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer.
Pat Whitworth, Peter D Beitsch, James V Pellicane, Paul L Baron, Laura A Lee, Carrie L Dul, Charles H Nash 3rd, Mary K Murray, Paul D Richards, Mark Gittleman, Raye Bu...> ;Annals of Surgical Oncology. 2022 Apr 4
3 citations
Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer.
Noah Rozich, Samara E Lewis, Sixia Chen, Kenneth Stewart, Michael B. Stout, William C. Dooley, Laura E. Fischer, Katherine T. Morris> ;Plos One. 2021 Apr 30
8 citations
Prolonged Time from Diagnosis to Breast-Conserving Surgery is Associated with Upstaging in Hormone Receptor-Positive Invasive Ductal Breast Carcinoma.
Natalie Hills, Macall Leslie, Rachel Davis, Marielle Crowell, Hiroyasu Kameyama, Hallgeir Rui, Inna Chervoneva, William C. Dooley, Takemi Tanaka> ;Annals of Surgical Oncology. 2021 Mar 21
ASO Author Reflections: Does Prompt Breast-Conserving Surgery Matter?
Natalie Hills, Macall Leslie, Rachel Davis, Marielle Crowell, Hiroyasu Kamemyama, Hallgeir Rui, Inna Chervoneva, William C. Dooley, Takemi Tanaka> ;Annals of Surgical Oncology. 2021 Mar 5
4 citations
A prospective single‐institution study of intraoperative radiotherapy (IORT) for early‐stage breast cancer
My-Lien Nguyen, Patricia Pius, William C. Dooley, Ronald A. Squires, Ozer Algan, Y Chen, D Johnson, Christina Henson> ;The Breast Journal. 2021 Mar 1
9 citations
Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer.
Carol J. Fabian, Seema A. Khan, Judy Garber, William C. Dooley, Lisa D. Yee, Jennifer R. Klemp, Jennifer L. Nydegger, Kandy R. Powers, Amy L. Kreutzjans, Carola M. Zal...> ;Cancer Prevention Research. 2020 Jul 1
3 citations
The importance of differentiating between qualitative, semi-quantitative, and quantitative imaging-close only counts in horseshoes.
Richard M Fleming, Matthew R Fleming, William C. Dooley, Tapan K Chaudhuri> ;European Journal of Nuclear Medicine and Molecular Imaging. 2020 Jan 17
Letter to the Editor: A response to Hruska's case study on molecular breast imaging and the need for true tissue quantification.
Richard M Fleming, Matthew R Fleming, Tapan K Chaudhuri, William C. Dooley, Andrew McKusick> ;Breast Cancer Research. 2019 Jan 29
377 citations
Plasma exosome microRNAs are indicative of breast cancer
Bethany N. Hannafon, Yvonne D. Trigoso, Cameron L. Calloway, Y. Daniel Zhao, David H. Lum, Alana L. Welm, Zhizhuang Joe Zhao, Kenneth E. Blick, William C. Dooley, Wei ...> ;Breast Cancer Research. 2016 Sep 8
163 citations
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)
Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley, Wei Qun Ding> ;Molecular Cancer. 2015 Jul 16
41 citations
Blocking the Adhesion Cascade at the Premetastatic Niche for Prevention of Breast Cancer Metastasis
Shin Ae Kang, Nafis Hasan, Aman P. Mann, Wei Zheng, Lichao Zhao, Lynsie Morris, Weizhu Zhu, Yan D. Zhao, K. Stephen Suh, William C. Dooley, David E. Volk, David G. Gor...> ;Molecular Therapy. 2015 Jun 1
Who Wants a Blind Breast Surgeon
William C. Dooley> ;Annals of Surgical Oncology. 2006 May 18
The optimization of breast conservation.
William C. Dooley, Mo Keshtgar, Tibor Tot, Daigo Yamamoto, Mahmoud B. El-Tamer> ;International Journal of Breast Cancer. 2011 Dec 12
13 citations
Tamoxifen Downregulates Ets Oncogene Family Members ETV4 and ETV5 in Benign Breast Tissue: Implications for Durable Risk Reduction
David M. Euhus, Dawei Bu, Xian Jin Xie, Venetia R. Sarode, Raheela Ashfaq, Kelly K Hunt, Weiya Xia, Joyce O'Shaughnessy, Michael Grant, Banu Arun, William C. Dooley, A...> ;Cancer Prevention Research. 2011 Nov 1
2 citations
Do the CMS proposed breast cancer quality measures actually predict improved outcomes
William C. Dooley, Ronald A. Squires, Jingu Bong, Jeanene Parker> ;American Journal of Surgery. 2011 Dec 1
3 citations
Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy
William C. Dooley, J. Bong, Jeanene Parker> ;International Journal of Breast Cancer. 2011 Jun 30
Exemestane for breast-cancer prevention in postmenopausal women.
Goss, P. E., Ingle, J. N., Ales-Martinez, J. E., Cheung, A. M., Chlebowski, R. T., Wactawski-Wende, J., McTiernan, A., Robbins, J., Johnson, K. C., Martin, L. W., Winq...> ;N Engl J Med. 2011 Jun 23
17 citations
An HLA-Presented Fragment of Macrophage Migration Inhibitory Factor Is a Therapeutic Target for Invasive Breast Cancer
Oriana E. Hawkins, Bhavna Verma, Stanley Lightfoot, Rinki Jain, Amit Rawat, Sandy McNair, Shannon Caseltine, Aleksandar Mojsilovic, Priyanka Gupta, Francisca Neethling...> ;Journal of Immunology. 2011 Jun 1
8 citations
Mechanisms of improved outcomes for breast cancer between surgical oncologists and general surgeons.
William C. Dooley, Jinju Bong, Jeanene Parker> ;Annals of Surgical Oncology. 2011 May 17
1 citations
Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of brea...
William C. Dooley, Ozer Algan, Kambiz Dowlatshahi, Darius Francescatti, Elizabeth P. Tito, J David Beatty, Art G. Lerner, Betsy Ballard, Susan K. Boolbol> ;World Journal of Surgical Oncology. 2011 Mar 7
8 citations
Electronic brachytherapy as adjuvant therapy for early stage breast cancer: a retrospective analysis
William C. Dooley, James C Wurzer, Mohamed Megahy, Gary Schreiber, Tapan Roy, Gary M. Proulx, Susan J. Laduzinsky, Steven C. Lane, James Dalzell, Kambiz Dowlatshahi, D...> ;Oncotargets and Therapy. 2011 Jan 12
7 citations
Use of electronic brachytherapy to deliver postsurgical adjuvant radiation therapy for endometrial cancer: a retrospective multicenter study
William C. Dooley, John P Thropay, Gary Schreiber, Mohamed Y Puthawala, Steven C. Lane, James C Wurzer, Charles E Stewart, Gordon L Grado, Harish G Ahuja, Gary M. Proulx> ;Oncotargets and Therapy. 2010 Oct 5
24 citations
Clinical series of oncoplastic mastopexy to optimize cosmesis of large-volume resections for breast conservation.
J. Bong, Jeanene Parker, R. Clapper, William C. Dooley> ;Annals of Surgical Oncology. 2010 Jun 12
32 citations
Focused Microwave Thermotherapy for Preoperative Treatment of Invasive Breast Cancer: A Review of Clinical Studies
William C. Dooley, Hernan I. Vargas, Alan J. Fenn, Mary Beth Tomaselli, Jay K. Harness> ;Annals of Surgical Oncology. 2010 Apr 1
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