WilliamJefferyEdenfieldMD

Oncology • Greenville, SC

Breast Cancer, Hematologic Oncology, Hospice & Palliative, Neuro-Oncology

Medical Director, Institute for Translational Oncology Research Greenville Health System Cancer Institute

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Office
900 W Faris Road
3rd Floor
Greenville, SC 29605
Phone+1 864-404-2010

Fax+1 864-404-2015
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Education & Training

National Capital ConsortiumFellowship, Hematology and Medical Oncology, 1995 - 1998
National Capital ConsortiumResidency, Internal Medicine, 1992 - 1995
University of Miami Leonard M. Miller School of MedicineClass of 1992

Certifications & Licensure

SC State Medical License 2003 - 2025
FL State Medical License 1994 - 2005
NC State Medical License 1999 - 2004
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012-2013

Clinical Trials

A Study of Intravenous XMT-1001 in Patients With Advanced Solid Tumors Start of enrollment: 2011 Mar 01
Completed
Phase 1
Gemzar, Cisp, Sunitinib Urothelial Ca Start of enrollment: 2008 Aug 01
Completed
Phase 2
Study of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell Carcinoma Start of enrollment: 2011 Mar 01
Completed
Phase 3
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Start of enrollment: 2011 Jan 11
Terminated
Phase 3
A Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies Start of enrollment: 2011 Apr 01
Completed
Phase 1, Phase 2
Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer Start of enrollment: 2012 Apr 01
Terminated
Phase 2
A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate Cancer Start of enrollment: 2012 Dec 01
Terminated
Phase 2
A Study of BBI608 in Adult Patients With Advanced Malignancies Start of enrollment: 2009 Mar 01
Completed
Phase 1
A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer Start of enrollment: 2012 Mar 01
Completed
Phase 2
A Study of BBI503 in Adult Patients With Advanced Solid Tumors Start of enrollment: 2012 Feb 01
Completed
Phase 1
A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer Start of enrollment: 2014 Jan 01
Completed
Phase 1, Phase 2
Durvalumab in Combination With Tremelimumab in Subjects With Advanced Rare Solid Tumors Start of enrollment: 2016 Dec 01
Recruiting
Phase 2
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Publications & Presentations

PubMed

1 citations
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.
Mats Någård, Mei-Lin Ah-See, James Strauss, Trisha Wise-Draper, Howard P Safran, Laura Nadeau, William J Edenfield, Lionel D Lewis, Lone H Ottesen, Yan Li, Ganesh M Mu...> ;Cancer Chemotherapy and Pharmacology. 2023 Sep 1
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.
Mats Någård, Mei-Lin Ah-See, James Strauss, Trisha Wise-Draper, Howard P Safran, Laura Nadeau, William J Edenfield, Lionel D Lewis, Dinko Rekić, Corina Dota, Lone H Ot...> ;Cancer Chemotherapy and Pharmacology. 2023 Aug 1
6 citations
Development and validation of an integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit.
Tomlins, S., Khazanov, N., Bulen, B., Hovelson, D., Shreve, M., Lamb, L., Matrana, M., Burkard, M., Yang, E., Edenfield, W., Dees, E., Onitilo, A., Thompson, M., Buchs...> ;Communications Medicine. 2023 Feb 7
11 citations
BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extraterminal Domain Proteins, in Patients with Selected Advanced Solid Tumors: Results from a Phase 1/2a...
John Hilton, Mihaela Cristea, Sophie Postel-Vinay, Capucine Baldini, Mark Voskoboynik, William Edenfield, Geoffrey I Shapiro, Michael L Cheng, Jacqueline Vuky, Bradley...> ;Cancers. 2022 Aug 23
3 citations
A Phase 1/2 Study of the Oral Janus Kinase 1 Inhibitors INCB052793 and Itacitinib Alone or in Combination With Standard Therapies for Advanced Hematologic Malignancies.
Amer M Zeidan, Rachel J Cook, Rodolfo Bordoni, James R Berenson, William J Edenfield, Sanjay Mohan, Gongfu Zhou, Ekaterine Asatiani, Nithya Srinivas, Michael R Savona> ;Clinical Lymphoma, Myeloma & Leukemia. 2022 Jul 1
12 citations
Mutations Correlate with Higher Galectin Levels and Brain Metastasis in Breast and Non-Small Cell Lung Cancer.
Avery T Funkhouser, Alexander M Strigenz, Bailey B Blair, Andrew P Miller, Jonah C Shealy, Joseph A Ewing, Julie C Martin, Christopher R Funk, William J Edenfield, Ann...> ;Cancers. 2022 Jun 3
18 citations
Increased Circulating Levels of Galectin Proteins in Patients with Breast, Colon, and Lung Cancer.
Bailey B. Blair, Avery T. Funkhouser, Jane L Goodwin, Alexander M Strigenz, Basil H Chaballout, Julie C. Martin, Connie M Arthur, Christopher Ronald Funk, W Jeffery Ed...> ;Cancers. 2021 Sep 26
18 citations
Trilaciclib prior to chemotherapy reduces the usage of supportive care interventions for chemotherapy-induced myelosuppression in patients with small cell lung cancer:...
Renata Ferrarotto, Ian Anderson, Balazs Medgyasszay, Maria Rosario García-Campelo, William Jeffery Edenfield, Trevor M. Feinstein, Jennifer Johnson, Sujith Kalmadi, Ph...> ;Cancer Medicine. 2021 Sep 1
10 citations
A Phase II Study of Durvalumab in Combination with Tremelimumab in Patients with Rare Cancers.
William Jeffery Edenfield, Ki Y. Chung, Mark Allen O'Rourke, Elizabeth H. Cull, Julie C. Martin, Heather Bowers, Wesley M. Smith, William Larry Gluck> ;The Oncologist. 2021 Sep 1
13 citations
Real-World Performance of a Comprehensive Genomic Profiling Test Optimized for Small Tumor Samples.
Scott A. Tomlins, Daniel H. Hovelson, Jennifer Marie Suga, Daniel M. Anderson, Han A. Koh, Elizabeth Claire Dees, Brendan McNulty, Mark E. Burkard, Michael Guarino, Ja...> ;JCO Precision Oncology. 2021 Aug 19
2 citations
Effects of Rovalpituzumab Tesirine on Ventricular Repolarization in Patients With Small-Cell Lung Cancer
Jonathan W. Goldman, Minal A. Barve, Jyoti D. Patel, Antoinette J. Wozniak, Afshin Dowlati, Alexander Starodub, Taofeek K. Owonikoko, William Jeffery Edenfield, Scott ...> ;Clinical and Translational Science. 2021 Mar 1
7 citations
Trilaciclib dose selection: an integrated pharmacokinetic and pharmacodynamic analysis of preclinical data and Phase Ib/IIa studies in patients with extensive-stage sm...
Chao Li, Lowell L. Hart, Taofeek K. Owonikoko, Raid Aljumaily, Caio Max Sao Pedro Rocha Lima, Paul Conkling, Roy Timothy Webb, Robert M. Jotte, Steven R. Schuster, Wil...> ;Cancer Chemotherapy and Pharmacology. 2021 Feb 17
57 citations
Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors
Albiruni Ryan Abdul Razak, James M. Cleary, Victor Moreno, Michael Boyer, Emilliano Calvo Aller, William Jeffery Edenfield, Jeanne Tie, R. Donald Harvey, Annemie Rutte...> ;Journal for Immunotherapy of Cancer. 2020 Oct 1
47 citations
Randomized Trial of Text Messaging to Reduce Early Discontinuation of Adjuvant Aromatase Inhibitor Therapy in Women With Early-Stage Breast Cancer: SWOG S1105
Dawn L. Hershman, Joseph M. Unger, GC Hillyer, Anna Moseley, Kathryn B. Arnold, Shaker R. Dakhil, Benjamin Esparaz, Ming C. Kuan, Mark L. Graham, Douglas M. Lackowski,...> ;Journal of Clinical Oncology. 2020 May 5
Correction to: Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer (Cancer Chemo...
Hani M. Babiker, Mohammed M. Milhem, Joseph Aisner, William Jeffery Edenfield, Dale R. Shepard, Michael R. Savona, Swaminathan P. Iyer, Maen Abdelrahim, C.L. Beach, Ba...> ;Cancer Chemotherapy and Pharmacology. 2020 May 1
3 citations
Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer.
Hani M Babiker, Mohammed Milhem, Joseph Aisner, William Edenfield, Dale Shepard, Michael Savona, Swaminathan Iyer, Maen Abdelrahim, C L Beach, Barry Skikne, Eric Laill...> ;Cancer Chemotherapy and Pharmacology. 2020 Mar 1
68 citations
Parsaclisib, a potent and highly selective PI3Kδ inhibitor, in patients with relapsed or refractory B-cell malignancies.
Andres Forero-Torres, Radhakrishnan Ramchandren, Abdulraheem Yacoub, Michael S. Wertheim, William Jeffery Edenfield, Paolo Caimi, Martin Gutierrez, Luke P. Akard, Caro...> ;Blood. 2019 Apr 18
489 citations
Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study.
Luc Dirix, István Takács, Guy Jerusalem, Petros Nikolinakos, Hendrik Tobias Arkenau, Andres Forero-Torres, Ralph V. Boccia, Marc E. Lippman, Robert Somer, Martin Smaka...> ;Breast Cancer Research and Treatment. 2018 Oct 23
15 citations
Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors
Daniel D. Von Hoff, Drew W. Rasco, Elisabeth I. Heath, Pamela N. Munster, Jan H.M. Schellens, Nicolas Isambert, Christophe Le Tourneau, Bert H. O'Neil, Ron H.J. Mathij...> ;Clinical Cancer Research. 2018 Sep 1
6 citations
Quality of life of irradiated brain tumor survivors treated with donepezil or placebo: Results of the WFU CCOP research base protocol 91105.
Michelle J. Naughton, L. Douglas Case, Ann M. Peiffer, Michael D. Chan, Volker W. Stieber, Dennis F. Moore, Steven Charles Falchuk, James Piephoff, William Jeffery Ede...> ;Neuro-Oncology Practice. 2018 May 10
3 citations
Safety and Pharmacokinetics of Bendamustine Rapid-Infusion Formulation
Eric Cheung, William Jeffery Edenfield, Bassam Mattar, Stephen P. Anthony, Peter J. Mutch, Brian Chanas, Mark S. Smith, Adrian Hepner> ;Journal of Clinical Pharmacology. 2017 May 31
231 citations
Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-la...
James L. Gulley, Arun Rajan, David R. Spigel, Nicholas Iannotti, Jason C. Chandler, Deborah J.L. Wong, Joseph Leach, W. Jeff Edenfield, Ding Wang, Hans Juergen Grote, ...> ;The Lancet. Oncology. 2017 May 1
90 citations
PD-L1 Expression by Two Complementary Diagnostic Assays and mRNA In Situ Hybridization in Small Cell Lung Cancer
Hui Yu, Cory Batenchuk, Andrzej Badzio, Theresa A. Boyle, Piotr Czapiewski, Daniel C. Chan, Xian Lu, Dexiang Gao, Kim Ellison, Ashley Kowalewski, Christopher J. Rivard...> ;Journal of Thoracic Oncology. 2017 Jan 1
Phase 1 study evaluating the safety and pharmacokinetics of pralatrexate in relapsed/refractory advanced solid tumors and lymphoma patients with mild, moderate, and se...
Kevin R. Kelly, Nashat Y. Gabrail, Steven D. Weitman, John Sarantopoulos, Anthony J. Olszanski, William Jeffery Edenfield, Jürgen Venitz, Guru Reddy, Allen Yang, Steve...> ;Cancer Chemotherapy and Pharmacology. 2016 Sep 16
86 citations
Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes
G. Garcia-Manero, Steven D. Gore, Suman Kambhampati, Bart L. Scott, A Tefferi, Christopher R. Cogle, William Jeffery Edenfield, Joel Hetzer, Keshava Kumar, Eric Laille...> ;Leukemia. 2016 Apr 1
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Lectures

Selected reaction monitoring mass spectrometry (SRM-MS) evaluation of HER2 equivocal breast cancer.
ASCO Annual Meeting 2019 - Chicago, IL - 5/31/2019