William Gradishar MD

Oncology•Chicago, IL

Breast Cancer, Hematologic Oncology

Betsy Bramsen Professorship of Breast Oncology, Northwestern University Medical School

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675 N Saint Clair St# GalterChicago, IL 60611
Phone+1 312-695-0990
Fax+1 312-695-1106

Education & Training

University of ChicagoFellowship, Hematology and Medical Oncology, 1986 - 1989
Michael Reese Hospital and Medical CenterResidency, Internal Medicine, 1982 - 1986
University of Illinois College of MedicineClass of 1982

Certifications & Licensure

IL State Medical License 1983 - 2026
FL State Medical License 2013 - 2015
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
Chicago Magazine: Top Doctors Castle Connolly, 2006, 2008, 2010, 2012, 2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
Fellow (FASCO) American Society of Clinical Oncologists, 2008
Fellow (FACP) American College of Physicians, 1996
Super Doctor SuperDoctors.com
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Clinical Trials

Chemotherapy in Treating Women With Previously Treated Metastatic Breast Cancer Start of enrollment: 1998 Jul 13
Completed
Phase 2
Docetaxel, Doxorubicin, and Cyclophosphamide in Treating Women With Stage III Breast Cancer Start of enrollment: 1998 Nov 01
Completed
Phase 2
Irinotecan in Treating Patients With Metastatic or Recurrent Breast Cancer Start of enrollment: 1999 Oct 01
Completed
Phase 2
Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer Start of enrollment: 2000 Feb 01
Terminated
Phase 2
Paclitaxel and Capecitabine in Treating Women With Metastatic Breast Cancer Start of enrollment: 1998 Jul 01
Completed
Phase 2
PS-341 in Treating Women With Metastatic Breast Cancer Start of enrollment: 2001 Aug 01
Completed
Phase 2
Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer Start of enrollment: 2004 May 01
Completed
Phase 2
In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer Start of enrollment: 2003 Jul 01
Completed
Phase 1, Phase 2
High-Dose Esterified Estrogens in Treating Postmenopausal Women With Metastatic Breast Cancer That Has Failed Previous Hormone Therapy Start of enrollment: 2004 Mar 01
Terminated
Phase 2
Lapatinib and Doxorubicin Hydrochloride Liposome in Treating Patients With Metastatic Breast Cancer Start of enrollment: 2006 May 01
Completed
Phase 1
Study of Satraplatin With Capecitabine to Treat Advanced Solid Malignancies Start of enrollment: 2006 May 01
Terminated
Phase 1
Phase 2b Study of Taxol Plus Sorafenib or Placebo in Patients With Advanced Breast Cancer Start of enrollment: 2007 Jun 01
Active, not recruiting
Phase 2
Cyclosporine A in Combination With Nab-Paclitaxel in Patients With Metastatic Breast Cancer Start of enrollment: 2010 Feb 01
Completed
Phase 1
Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Neuropathy Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast Cancer Start of enrollment: 2013 Mar 07
Completed
Phase 2
Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women Start of enrollment: 2014 Mar 11
Completed
Phase 2
A Study to Assess the Safety and Efficacy of the VEGFR-FGFR-PDGFR Inhibitor, Lucitanib, Given to Patients With Metastatic Breast Cancer Start of enrollment: 2014 Sep 09
Terminated
Phase 2
Study of MT-5111 in HER2-positive Solid Tumors Start of enrollment: 2019 Nov 12
Terminated
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Accuracy and Reproducibility of ChatGPT Responses to Breast Cancer Tumor Board Patients.
Ning Liao, Cheukfai Li, William J Gradishar, V Suzanne Klimberg, Joshua A Roshal
JCO Clinical Cancer Informatics. 2025-06-01
Expert consensus on treating HR+/HER2- metastatic breast cancer based on real-world practice patterns observed in the RETRACT survey of US oncologists.
Hope S Rugo, Aditya Bardia, William J Gradishar, Erika P Hamilton, Sara A Hurvitz
Breast. 2025-05-03
MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer.
Junlong Jack Chi, Ping Xie, Mary Hongying Cheng, Yueming Zhu, Xin Cui
Nature Communications. 2025-04-15

Journal Articles

Efficacy of Margetuximab vs Trastuzumab in Patients with Pretreated ERBB2-Positive Advanced Breast Cancer
Denise A Yardley, William J Gradishar, JAMA Oncology
From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing
William J Gradishar, Al B Benson, Massimo Cristofanilli, Allison W Kurian, Value in Health

Lectures

Predicting expected absolute chemotherapy treatment benefit in women with early-stage breast cancer using a 12-gene expression assay.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
Pros and Cons of Extended Adjuvant Endocrine Therapy
2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018

Other

Breast cancer in men
Gradishar WJ
http://www.uptodate.com/contents/breast-cancer-in-men
UpToDate, Wolters Kluwer Health - 2013-02-20
Axillary node metastases with occult primary breast cancer
Gradishar WJ, Kaklamani V
http://www.uptodate.com/contents/axillary-node-metastases-with-occult-primary-breast-cancer
UpToDate, Wolters Kluwer Health - 2012-08-07

Authored Content

From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor SequencingAugust 2018

Press Mentions

Sequencing HER2-Targeted Therapies: What Comes After THP?June 4th, 2025
Dr. Gradishar on Managing Toxicities and Tailoring Treatment in HER2+ mBCJune 4th, 2025
Greenwich LifeSciences Provides Global Update on FLAMINGO-01April 3rd, 2025
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