WilliamGradisharMD

Oncology • Chicago, IL

Breast Cancer, Hematologic Oncology

Betsy Bramsen Professorship of Breast Oncology, Northwestern University Medical School

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Office
250 E Superior St
Chicago, IL 60611
Phone+1 312-695-0990

Fax+1 312-472-4784
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Education & Training

University of ChicagoFellowship, Hematology and Medical Oncology, 1986 - 1989
Michael Reese Hospital and Medical CenterResidency, Internal Medicine, 1982 - 1986
University of Illinois College of MedicineClass of 1982

Certifications & Licensure

IL State Medical License 1982 - 2026
FL State Medical License 2013 - 2015
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
Chicago Magazine: Top Doctors Castle Connolly, 2006, 2008, 2010, 2012, 2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
Fellow (FASCO) American Society of Clinical Oncologists, 2008
Fellow (FACP) American College of Physicians, 1996
Super Doctor SuperDoctors.com
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Clinical Trials

Chemotherapy in Treating Women With Previously Treated Metastatic Breast Cancer Start of enrollment: 1998 Jul 13
Completed
Phase 2
Docetaxel, Doxorubicin, and Cyclophosphamide in Treating Women With Stage III Breast Cancer Start of enrollment: 1998 Nov 01
Completed
Phase 2
Irinotecan in Treating Patients With Metastatic or Recurrent Breast Cancer Start of enrollment: 1999 Oct 01
Completed
Phase 2
Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer Start of enrollment: 2000 Feb 01
Terminated
Phase 2
Paclitaxel and Capecitabine in Treating Women With Metastatic Breast Cancer Start of enrollment: 1998 Jul 01
Completed
Phase 2
PS-341 in Treating Women With Metastatic Breast Cancer Start of enrollment: 2001 Aug 01
Completed
Phase 2
Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer Start of enrollment: 2004 May 01
Completed
Phase 2
In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer Start of enrollment: 2003 Jul 01
Completed
Phase 1, Phase 2
High-Dose Esterified Estrogens in Treating Postmenopausal Women With Metastatic Breast Cancer That Has Failed Previous Hormone Therapy Start of enrollment: 2004 Mar 01
Terminated
Phase 2
Lapatinib and Doxorubicin Hydrochloride Liposome in Treating Patients With Metastatic Breast Cancer Start of enrollment: 2006 May 01
Completed
Phase 1
Study of Satraplatin With Capecitabine to Treat Advanced Solid Malignancies Start of enrollment: 2006 May 01
Terminated
Phase 1
Phase 2b Study of Taxol Plus Sorafenib or Placebo in Patients With Advanced Breast Cancer Start of enrollment: 2007 Jun 01
Active, not recruiting
Phase 2
Cyclosporine A in Combination With Nab-Paclitaxel in Patients With Metastatic Breast Cancer Start of enrollment: 2010 Feb 01
Completed
Phase 1
Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Neuropathy Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast Cancer Start of enrollment: 2013 Mar 07
Completed
Phase 2
Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women Start of enrollment: 2014 Mar 11
Completed
Phase 2
A Study to Assess the Safety and Efficacy of the VEGFR-FGFR-PDGFR Inhibitor, Lucitanib, Given to Patients With Metastatic Breast Cancer Start of enrollment: 2014 Sep 09
Terminated
Phase 2
Study of MT-5111 in HER2-positive Solid Tumors Start of enrollment: 2019 Nov 12
Terminated
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Pharmacological suppression of the OTUD4-CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.
Yueming Zhu, Anupam Banerjee, Ping Xie, Andrey A Ivanov, Amad Uddin, Qiao Jiao, Junlong J Chi, Lidan Zeng, Ji Young Lee, Yifan Xue, Xinghua Lu, Massimo Cristofanilli, ...> ;The Journal of Clinical Investigation. 2024 Mar 26
Treatment of residual disease following neoadjuvant therapy in breast cancer.
Natalie K Heater, Khyati Somayaji, William Gradishar> ;Journal of Surgical Oncology. 2024 Jan 1
Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circu...
Lorenzo Gerratana, Andrew A Davis, Marko Velimirovic, Katherine Clifton, Whitney L Hensing, Ami N Shah, Charles S Dai, Carolina Reduzzi, Paolo D'Amico, Firas Wehbe, Ar...> ;Breast Cancer Research. 2023 Oct 2
Coping strategies and psychosocial resources among women living with metastatic breast cancer: A qualitative study.
Blanca S Noriega Esquives, Emily A Walsh, Frank J Penedo, Jessica L Thomas, Fiona S Horner, Joanna B Torzewski, William J Gradishar, David E Victorson, Patricia I Moreno> ;Journal of Psychosocial Oncology. 2023 Sep 12
1 citations
Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes.
Lauren Lenz, Chris Neff, Cara Solimeno, Elizabeth S Cogan, Vandana G Abramson, Judy C Boughey, Carla Falkson, Matthew P Goetz, James M Ford, William J Gradishar, Rache...> ;Breast Cancer Research and Treatment. 2023 Nov 1
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.
R C Coombes, Sacha Howell, Simon R Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason ...> ;Nature Communications. 2023 Aug 7
4 citations
Identification of metabolic pathways contributing to ERbreast cancer disparities using a machine-learning pipeline.
Ashlie Santaliz-Casiano, Dhruv Mehta, Oana C Danciu, Hariyali Patel, Landan Banks, Ayesha Zaidi, Jermya Buckley, Garth H Rauscher, Lauren Schulte, Lauren Ro Weller, De...> ;Scientific Reports. 2023 Jul 26
4 citations
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.
R C Coombes, Sacha Howell, Simon R Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason ...> ;Nature Communications. 2023 Jul 24
1 citations
Safety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer.
Elena Shagisultanova, William Gradishar, Pavani Chalasani, Andrew J Brenner, Alison Stopeck, Hannah Parris, Dexiang Gao, Jose Mayordomo, Peter Kabos, Virginia F Borges...> ;Clinical Cancer Research. 2023 Dec 15
2 citations
Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer.
Nurmaa K Dashzeveg, Yuzhi Jia, Youbin Zhang, Lorenzo Gerratana, Priyam Patel, Asif Shajahan, Tsogbadrakh Dandar, Erika K Ramos, Hannah F Almubarak, Valery Adorno-Cruz,...> ;Cancer Discovery. 2023 Sep 6
10 citations
Randomized Phase II Trial of Endocrine Therapy With or Without Ribociclib After Progression on Cyclin-Dependent Kinase 4/6 Inhibition in Hormone Receptor-Positive, Hum...
Kevin Kalinsky, Melissa K Accordino, Codruta Chiuzan, Prabhjot S Mundi, Elizabeth Sakach, Claire Sathe, Heejoon Ahn, Meghna S Trivedi, Yelena Novik, Amy Tiersten, Geor...> ;Journal of Clinical Oncology. 2023 Aug 20
2 citations
Margetuximab in HER2-positive metastatic breast cancer.
William J Gradishar, Ruth O'Regan, Mothaffar F Rimawi, Jeffrey L Nordstrom, Minori K Rosales, Hope S Rugo> ;Future Oncology. 2023 May 1
1 citations
Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Metastatic Breast Cancer: A Retrospective Real-World Biomarker Analysis.
Lorenzo Gerratana, Andrew A Davis, Marko Velimirovic, Carolina Reduzzi, Katherine Clifton, Leslie Bucheit, Whitney L Hensing, Ami N Shah, Tania Pivetta, Charles S Dai,...> ;JCO Precision Oncology. 2023 May 1
A multi-site trial of an electronic health integrated physical activity promotion intervention in breast and endometrial cancers survivors: MyActivity study protocol.
Lisa Cadmus-Bertram, Payton Solk, Megan Agnew, Julia Starikovsky, Christian Schmidt, Whitney A Morelli, Vanessa Hodgson, Hannah Freeman, Laura Muller, Abby Mishory, So...> ;Contemporary Clinical Trials. 2023 Jul 1
6 citations
Risk of Recurrence in Patients With HER2+ Early-Stage Breast Cancer: Literature Analysis of Patient and Disease Characteristics.
Joyce O'Shaughnessy, William Gradishar, Ruth O'Regan, Vijayakrishna Gadi> ;Clinical Breast Cancer. 2023 Jun 1
2 citations
Characterizing unique supportive care needs among women living with metastatic breast cancer: A qualitative study.
Patricia I Moreno, Blanca Noriega Esquives, Jessica L Thomas, Fiona S Horner, Joanna B Torzewski, William Gradishar, David Victorson, Frank J Penedo> ;Journal of Psychosocial Oncology Research and Practice. 2023 Jan 23
5 citations
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
Ziyi Fu, Siqi Chen, Yueming Zhu, Donghong Zhang, Ping Xie, Qiao Jiao, Junlong Chi, Shipeng Xu, Yifan Xue, Xinghua Lu, Xinxin Song, Massimo Cristofanilli, William J Gra...> ;Science Advances. 2023 Jan 6
2 citations
A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metas...
Ami N Shah, Cesar A Santa-Maria, Dhruvika Mukhija, Nikita Shah, Anthony K Kang, Priya Kumthekar, Kirsten Burdett, Shruti Chandra, Jenny Chang, Dean Tsarwhas, Jill Wood...> ;Clinical Breast Cancer. 2023 Apr 1
20 citations
Margetuximab Versus Trastuzumab in Patients With Previously Treated HER2-Positive Advanced Breast Cancer (SOPHIA): Final Overall Survival Results From a Randomized Pha...
Hope S Rugo, Seock-Ah Im, Fatima Cardoso, Javier Cortes, Giuseppe Curigliano, Antonino Musolino, Mark D Pegram, Thomas Bachelot, Gail S Wright, Cristina Saura, Santiag...> ;Journal of Clinical Oncology. 2023 Jan 10
4 citations
Circulating tumour DNA characterisation of invasive lobular carcinoma in patients with metastatic breast cancer.
Andrew A Davis, Lorenzo Gerratana, Katherine Clifton, Arielle J Medford, Marko Velimirovic, Whitney L Hensing, Leslie Bucheit, Ami N Shah, Paolo D'Amico, Carolina Redu...> ;Ebiomedicine. 2022 Dec 1
22 citations
A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, effic...
Priya U Kumthekar, Michael J Avram, Andrew B Lassman, Nancy U Lin, Eudocia Lee, Sean A Grimm, Margaret Schwartz, Kirsten L Bell Burdett, Rimas V Lukas, Karan Dixit, Is...> ;Neuro-Oncology. 2023 Mar 14
A spotlight on avoidance coping to manage fear of recurrence among breast cancer survivors in an eHealth intervention.
Daniel L Hall, Beverly J Levine, Elizabeth Jeter, Allison Chandler, Janet A Tooze, Jenna Duffecy, David Victorson, William Gradishar, Joseph Leach, Thomas Saphner, Mar...> ;Journal of Behavioral Medicine. 2022 Oct 1
1 citations
Using ecological momentary assessment to understand associations between daily physical activity and symptoms in breast cancer patients undergoing chemotherapy.
Madelyn Whitaker, Whitney A Welch, Jason Fanning, Cesar A Santa-Maria, Lisa A Auster-Gussman, Payton Solk, Seema A Khan, Swati A Kulkarni, William Gradishar, Juned Sid...> ;Supportive Care in Cancer. 2022 Aug 1
8 citations
Genomic Landscape of Advanced Solid Tumors in Circulating Tumor DNA and Correlation With Tissue Sequencing: A Single Institution's Experience.
Lorenzo Gerratana, Michael Movarek, Firas Wehbe, Neelima Katam, Devalingam Mahalingam, Jeannine Donahue, Ami Shah, Young K Chae, Mary Mulcahy, Dean Tsarwhas, Victoria ...> ;JCO Precision Oncology. 2022 Jun 1
293 citations
Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Elias, A., Savur Moran, M. S., William J Gradishar, Meena S Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H Allison, Bethany Anderson, Harold J Burstein, H...> ;Journal of the National Comprehensive Cancer Network. 2022 Jun 1
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Journal Articles

Efficacy of Margetuximab vs Trastuzumab in Patients with Pretreated ERBB2-Positive Advanced Breast Cancer
Denise A Yardley, William J Gradishar, JAMA Oncology
From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing
William J Gradishar, Al B Benson, Massimo Cristofanilli, Allison W Kurian, Value in Health

Lectures

Predicting expected absolute chemotherapy treatment benefit in women with early-stage breast cancer using a 12-gene expression assay.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
Pros and Cons of Extended Adjuvant Endocrine Therapy
2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018

Other

Breast cancer in men
Gradishar WJ
http://www.uptodate.com/contents/breast-cancer-in-men
UpToDate, Wolters Kluwer Health - 2013-02-20
Axillary node metastases with occult primary breast cancer
Gradishar WJ, Kaklamani V
http://www.uptodate.com/contents/axillary-node-metastases-with-occult-primary-breast-cancer
UpToDate, Wolters Kluwer Health - 2012-08-07

Authored Content

From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor SequencingAugust 2018

Press Mentions

NCCN Publishes New Resource to Help Patients Understand Quick-Moving Type of Breast CancerApril 24th, 2023
Treatment in HR+ Early Breast Cancer May Be Best Guided by Risk of RecurrenceMarch 23rd, 2023
1 NCCN Guidelines for Patients® Inflammatory Breast Cancer, 2023March 23rd, 2023
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