WilliamGHumphreysMD

PubMed

• Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
  Shen, H.,Holenarsipur, V. K.,Mariappan, T. T.,Drexler, D. M.,Cantone, J. L.,Rajanna, P.,Singh Gautam, S.,Zhang, Y.,Gan, J.,Shipkova, P. A.,Marathe, P.,Humphreys, W. G.> ;J. Pharmacol. Exp. Ther.. 2018 Oct 27
• 8 citations
  Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data.
  Jiachang Gong, Lisa Iacono, Ramaswamy A. Iyer, William G. Humphreys, Ming Zheng> ;British Journal of Clinical Pharmacology. 2018 Jun 1
• Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1...
  Shen, H.,Christopher, L.,Lai, Y.,Gong, J.,Kandoussi, H.,Garonzik, S.,Perera, V.,Garimella, T.,Humphreys, W. G.> ;Drug Metab. Dispos.. 2018 May 20
• 8 citations
  Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.
  Yaofeng Cheng, Lifei Wang, Lisa Iacono, Donglu Zhang, Weiqi Chen, Jiachang Gong, William G. Humphreys, Jinping Gan> ;British Journal of Clinical Pharmacology. 2018 Jan 1
• 58 citations
  Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
  Bhagwat Prasad, Deepak Kumar Bhatt, Kate M Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Sunyong Lee, Cornelis E. C. A. Hop, Anita Ma...> ;Drug Metabolism and Disposition. 2018 Jan 1
• 6 citations
  In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094.
  Wenying Li, Kevin J Trouba, Li Ma, Jae Kwagh, C. W. Storck, Yongxin Zhu, Oliver P. Flint, William G. Humphreys, Jian Wang, Ang Liu, Bonnie Wang, Michael J. Graziano, M...> ;International Journal of Toxicology. 2017 Jan 5
• 89 citations
  Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics
  Li Wang, Carol Collins, Edward J. Kelly, Xiaoyan Chu, Adrian S. Ray, Laurent Salphati, Guangqing Xiao, Caroline Sunyong Lee, Yurong Lai, Mingxiang Liao, Anita Mathias,...> ;Drug Metabolism and Disposition. 2016 Jan 1
• 114 citations
  Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide In...
  Yurong Lai, Sandhya Mandlekar, Hong Shen, Vinay K. Holenarsipur, Robert Langish, Prabhakar Rajanna, Senthilkumar Murugesan, Nilesh Gaud, Sabariya Selvam, Onkar Date, Y...> ;The Journal of Pharmacology and Experimental Therapeutics. 2016 Jan 1
• High-Resolution Mass Spectrometry-Based Background Subtraction for Identifying Protein Modifications in a Complex Biological System: Detection of Acetaminophen-Bound M...
  Zhang, H.,Gan, J.,Shu, Y. Z.,Humphreys, W. G.> ;Chem. Res. Toxicol.. 2015 Feb 06
• Quantitative Analysis of Polyethylene Glycol (PEG) and PEGylated Proteins in Animal Tissues by LC-MS/MS Coupled with In-Source CID.
  Gong, J.,Gu, X.,Achanzar, W. E.,Chadwick, K. D.,Gan, J.,Brock, B. J.,Kishnani, N. S.,Humphreys, W. G.,Iyer, R. A.> ;Anal. Chem.. 2014 Jul 09
• 89 citations
  The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus
  Sreeneeranj Kasichayanula, Xiaoni Liu, Melanie Pe Benito, Ming Yao, Marc Pfister, Frank LaCreta, William G. Humphreys, David W. Boulton> ;British Journal of Clinical Pharmacology. 2013 Sep 1
• 5 citations
  A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds.
  Mary F. Grubb, William G. Humphreys, Jonathan L. Josephs> ;Bioanalysis. 2012 Aug 9
• 15 citations
  Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabo...
  Xiaohui Xu, Roger Demers, Huidong Gu, Lisa J. Christopher, Hong Su, Laura Cojocaru, David W. Boulton, Mark S. Kirby, Bruce Stouffer, William G. Humphreys, Mark E. Arnold> ;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2012 Mar 15
• Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats. Use of Radioprofiling, Modulation of Metabolism and Adrenocortical Cell Lines to Evaluate Adrenal Tox...
  Zhang, D., Flint, O., Wang, L., Gupta, A., Westhouse, R., Zhao, W., Raghavan, N., Caceres-Cortes, J., Marathe, P.H., Shen, G., Zhang, Y., Allentoff, A., Josephs, J., G...> ;Chem Res Toxicol. 2012 Mar 19
• A Strategy and its Implications of Protein Bioanalysis Utilizing High Resolution Mass Spectrometric Detection of Intact Protein.
  Ruan, Q., Ji, Q.C., Arnold, M.E., Humphreys, W.G., Zhu, M.> ;Anal Chem. 2011 Dec 1
• In Vitro Characterization of the Metabolic Pathways and P450 Inhibition and Induction Potential of BMS-690514, an ErbB/VEGFR Inhibitor.
  Hong, H., Su, H., Ma, L., Yao, M., Iyer, R.A., Humphreys, W.G., Christopher, L.J.> ;Drug Metab Dispos. 2011 Sep
• Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design.
  Humphreys, W. G.> ;Chem. Biol. Interact.. 2011 Jan 18
• 25 citations
  Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism
  Jinping Gan, Weiqi Chen, Hong Shen, Ling Gao, Yang Hong, Yuan Tian, Wenying Li, Yueping Zhang, Yuwei Tang, Hongjian Zhang, William G. Humphreys, A. David Rodrigues> ;British Journal of Clinical Pharmacology. 2010 Dec 1
• 15 citations
  Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans
  Lisa J. Christopher, Haizheng Hong, Blisse Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin N. Heller, Christopher T. Harbi...> ;Drug Metabolism and Disposition. 2010 Nov 1
• 20 citations
  Algorithm for thorough background subtraction of high-resolution LC/MS data: application to obtain clean product ion spectra from nonselective collision-induced dissoc...
  Haiying Zhang, Mary F. Grubb, Wei Wu, Jonathan L. Josephs, William G. Humphreys> ;Analytical Chemistry. 2009 Apr 1
• 15 citations
  Prediction of human oral pharmacokinetics using nonclinical data: examples involving four proprietary compounds
  Aberra Fura, Viral Vyas, William G. Humphreys, Anjaneya Chimalokonda, David Rodrigues> ;Biopharmaceutics & Drug Disposition. 2008 Nov 1
• 40 citations
  Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats.
  Kan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys, Lisa J. Christopher> ;Drug Metabolism and Disposition. 2008 Dec 1
• 39 citations
  Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2.
  Bruce A. Ellsworth, Wei Meng, Manorama Patel, Ravindar N. Girotra, Gang Wu, Philip M. Sher, Deborah Hagan, Mary T. Obermeier, William G. Humphreys, James G. Robertson,...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Sep 1
• 6 citations
  (D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.
  Jun Li, Stephanie Y. Chen, Brian J. Murphy, Neil Flynn, Ramakrishna Seethala, Dorothy Slusarchyk, Mujing Yan, Paul G. Sleph, Hongjian Zhang, William G. Humphreys, Will...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Jul 15
• 7 citations
  Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.
  Jun Li, Stephanie Y. Chen, Shiwei Tao, Haixia Wang, James J. Li, Steve Swartz, Christa M. Musial, Andres A. Hernandez, Neil Flynn, Brian J. Murphy, Blake C. Beehler, K...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Mar 15
• Join now to see all