WilliamMichaelKavanaughMD

PubMed

• A Phase 1, First in Human Study of FP-1039 (GSK3052230), a Novel FGF Ligand Trap, in Patients with Advanced Solid Tumors.
  Tolcher, A. W.,Papadopoulos, K. P.,Patnaik, A.,Wilson, K.,Thayer, S.,Zanghi, J.,Gemo, A. T.,Kavanaugh, W. M.,Keer, H. N.,LoRusso, P. M.> ;Ann. Oncol.. 2015 Dec 10
• In vivo imaging of protease activity by Probody therapeutic activation.
  Wong, K. R.,Menendez, E.,Craik, C. S.,Kavanaugh, W. M.,Vasiljeva, O.> ;Biochimie. 2015 Nov 08
• Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
  Zhang, H.,Pao, L. I.,Zhou, A.,Brace, A. D.,Halenbeck, R.,Hsu, A. W.,Bray, T. L.,Hestir, K.,Bosch, E.,Lee, E.,Wang, G.,Liu, H.,Wong, B. R.,Kavanaugh, W. M.,Williams, L. T.> ;Proc. Natl. Acad. Sci. U.S.A.. 2014 Oct 22
• Semirational design of a potent, artificial agonist of fibroblast growth factor receptors.
  Ballinger, M. D., Shyamala, V., Forrest, L. D., Deuter-Reinhard, M., Doyle, L. V., Wang, J. X., Panganiban-Lustan, L., Stratton, J. R., Apell, G., Winter, J. A., Doyle...> ;Nat Biotechnol. 1999 Dec
• A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and ...
  Wisniewski, D., Strife, A., Swendeman, S., Erdjument-Bromage, H., Geromanos, S., Kavanaugh, W. M., Tempst, P., Clarkson, B.> ;Blood. 1999 Apr 15
• An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.
  Vollenweider, P., Clodi, M., Martin, S. S., Imamura, T., Kavanaugh, W. M., Olefsky, J. M.> ;Mol Cell Biol. 1999 Feb
• High-throughput screening for ligand-induced c-fos mRNA expression by branched DNA assay in Chinese hamster ovary cells.
  Shyamala, V., Khoja, H., Anderson, M. L., Wang, J. X., Cen, H., Kavanaugh, W. M.> ;Anal Biochem. 1999 Jan 1
• Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation.
  Klippel, A., Escobedo, M. A., Wachowicz, M. S., Apell, G., Brown, T. W., Giedlin, M. A., Kavanaugh, W. M., Williams, L. T.> ;Mol Cell Biol. 1998 Oct
• 3-Phosphohistidine cannot replace phosphotyrosine in high-affinity binding to phosphotyrosine binding or Src homology 2 domains.
  Senderowicz, L., Wang, J. X., Wang, L. Y., Yoshizawa, S., Kavanaugh, W. M., Turck, C. W.> ;Biochemistry. 1997 Aug 26
• SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase.
  Deuter-Reinhard, M., Apell, G., Pot, D., Klippel, A., Williams, L. T., Kavanaugh, W. M.> ;Mol Cell Biol. 1997 May
• A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
  Klippel, A., Kavanaugh, W. M., Pot, D., Williams, L. T.> ;Mol Cell Biol. 1997 Jan
• Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways.
  Klippel, A., Reinhard, C., Kavanaugh, W. M., Apell, G., Escobedo, M. A., Williams, L. T.> ;Mol Cell Biol. 1996 Aug
• Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
  Kavanaugh, W. M., Pot, D. A., Chin, S. M., Deuter-Reinhard, M., Jefferson, A. B., Norris, F. A., Masiarz, F. R., Cousens, L. S., Majerus, P. W., Williams, L. T.> ;Curr Biol. 1996 Apr 1
• Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors.
  Laminet, A. A., Apell, G., Conroy, L., Kavanaugh, W. M.> ;J Biol Chem. 1996 Jan 5
• Tyrosine 508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth factor receptor.
  Kavanaugh, W. M., Turck, C. W., Klippel, A., Williams, L. T.> ;Biochemistry. 1994 Sep 13
• PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine.
  Kavanaugh, W. M., Turck, C. W., Williams, L. T.> ;Science. 1995 May 26
• An alternative to SH2 domains for binding tyrosine-phosphorylated proteins.
  Kavanaugh, W. M., Williams, L. T.> ;Science. 1994 Dec 16
• Sequence homologies between A subunits of Escherichia coli and Vibrio cholerae enterotoxins.
  Spicer, E. K., Kavanaugh, W. M., Dallas, W. S., Falkow, S., Konigsberg, W. H., Schafer, D. E.> ;Proc Natl Acad Sci U S A. 1981 Jan
• Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells.
  Kavanaugh, W. M., Harsh, G. R., Starksen, N. F., Rocco, C. M., Williams, L. T.> ;J Biol Chem. 1988 Jun 15
• Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway.
  Kavanaugh, W. M., Williams, L. T., Ives, H. E., Coughlin, S. R.> ;Mol Endocrinol. 1988 Jul
• Cyclic AMP blocks expression of the c-sis gene in tumor cells.
  Harsh, G. R., Kavanaugh, W. M., Starksen, N. F., Williams, L. T.> ;Oncogene Res. 1989
• cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.
  Escobedo, J. A., Navankasattusas, S., Kavanaugh, W. M., Milfay, D., Fried, V. A., Williams, L. T.> ;Cell. 1991 Apr 5
• A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine.
  Escobedo, J. A., Kaplan, D. R., Kavanaugh, W. M., Turck, C. W., Williams, L. T.> ;Mol Cell Biol. 1991 Feb
• Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells.
  Kavanaugh, W. M., Klippel, A., Escobedo, J. A., Williams, L. T.> ;Mol Cell Biol. 1992 Aug
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