William E Kraus MD FACC, FAHA, FASCM

Cardiology•Durham, NC

Preventive Cardiology, Exercise Physiology and Cardiac Rehabilitation

Professor of Medicine, School of Medicine Professor, Bioengineering

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2100 Erwin RdDurham, NC 27705
Phone+1 919-620-4467

Education & Training

Duke University HospitalFellowship, Cardiovascular Disease, 1988
Duke University HospitalResidency, Internal Medicine, 1983 - 1986
Duke University HospitalInternship, Internal Medicine, 1983 - 1984
Duke University School of MedicineClass of 1983
Harvard CollegeAB, Astronomy and Astrophysics, 1973 - 1977

Certifications & Licensure

NC State Medical License 1985 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I) Start of enrollment: 1998 Sep 01
Completed
Phase 2
Effects of Resistance and Aerobic Exercise on Cardiovascular Health Start of enrollment: 2004 May 01
Completed
Phase 2
CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy Start of enrollment: 2007 May 01
Completed
Not Applicable
Exercise Dose-Response Effects in Prediabetes Start of enrollment: 2009 Jul 01
Completed
Not Applicable
Stress Management and Biomarkers of Risk in Cardiac Rehabilitation Start of enrollment: 2009 Sep 01
Completed
Not Applicable
Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes Start of enrollment: 2012 Jun 01
Completed
Not Applicable
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure Start of enrollment: 2014 Feb 01
Terminated
Phase 1, Phase 2
Effects of Ranolazine and Exercise on Daily Physical Activity Trial Start of enrollment: 2013 Dec 01
Completed
Phase 4
Medication Therapy Management With Pharmacogenetic Testing Start of enrollment: 2013 Nov 01
Completed
Not Applicable
Exercise, Heart Failure, and Type 2 Diabetes Start of enrollment: 2012 Feb 01
Withdrawn
Not Applicable
The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function Start of enrollment: 2014 Jun 01
Completed
Not Applicable
Gene-by-Stress Interactions in Intervention Studies Significance Start of enrollment: 2018 May 24
Terminated
Phase 1
Rejuvenation of Aged Muscle Stem Cells Through Exercise Start of enrollment: 2021 Jan 01
Withdrawn
Not Applicable
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Publications & Presentations

PubMed

Author Correction: Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake.
Rania Bajunaid, Chaoqun Niu, Catherine Hambly, Zongfang Liu, Yosuke Yamada
Nature Food. 2025-04-23
Differential response of tissue engineered skeletal muscle from rheumatoid arthritis patients and healthy controls.
Catherine E Oliver, Jonathan L Carter, James S Hong, Mingzhi Xu, William E Kraus
Communications Biology. 2025-04-09
Sex-specific skeletal muscle gene expression responses to exercise reveal novel direct mediators of insulin sensitivity change.
Sisi Ma, Monica J Hubal, Matthew C Morris, Leanna M Ross, Kim M Huffman
NAR Molecular Medicine. 2025-04-01

Journal Articles

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia After Coronary Artery Bypass Surgery
Alan M Smeltz, Svati H Shah, Mihai V Podgoreanu, William E Kraus, Miklos D Kertai, Joseph P Mathew, Thrombosis and Haemostasis
Multi‐Ethnic Comparisons of Diabetes in Heart Failure with Reduced Ejection Fraction: Insights from the HF‐ACTION Trial and the ASIAN‐HF Registry
William E Kraus, Robert J Mentz, European Journal of Heart Failure
Ten Weeks of High-Intensity Interval Walk Training Is Associated with Reduced Disease Activity and Improved Innate Immune Function in Older Adults with Rheumatoid Arth...
Kim M Huffman, Jennifer Moss, Virginia B Kraus, William E Kraus, BioMed Central
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood
William E Kraus, Virginia B Kraus, Harvey Jay Cohen, James R Bain, L Kristin Newby, The Journals of Gerontology
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Press Mentions

IT PAYS TO KNOW: Keep Moving!!!April 14th, 2023
Pandemic Intensifies Push for Home-Based CardiacOctober 11th, 2021
Modest Calorie Reduction plus Exercise Linked with Improved Vascular HealthAugust 2nd, 2021
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Grant Support

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYDUKE UNIVERSITY2021–2026
Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic HealthDUKE UNIVERSITY2021–2025
MoTrPAC CPET Core LabDUKE UNIVERSITY2016–2025
MoTrPAC CPET Core LabDUKE UNIVERSITY2016–2025
Molecular Transducers of Physical Activity and Health: NC Consortium Clinical SiteDUKE UNIVERSITY2016–2025
Molecular Transducers of Physical Activity and Health: NC Consortium Clinical SiteDUKE UNIVERSITY2016–2025
MoTrPAC CPET Core LabDUKE UNIVERSITY2016–2025
Molecular Transducers of Physical Activity and Health: NC Consortium Clinical SiteDUKE UNIVERSITY2016–2025
Exercise Dose-Response Effects In Prediabetes: Responses And MechanismsNational Institute Of Diabetes And Digestive And Kidney Diseases2011–2012
Calerie Competitive RenewalNational Institute On Aging2010–2012
Exercise Dose-Response Effects In Prediabetes:Responses And MechanismsNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
Genetic Mediators Of Metabolic Cardiovascular Disease RiskNational Heart, Lung, And Blood Institute2009–2010
Peripheral Effects Of Exercise On Cardiovascular HealthNational Heart, Lung, And Blood Institute1998–2008
Comparative Approach To Genomics Of Complex TraitsNational Heart, Lung, And Blood Institute2005–2006
Molecular Signaling In Muscular Adaption To ExerciseNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1993–1996