
William Timothy Lester MD
Assistant Professor in Medicine, Massachusetts General Hospital, Harvard Medical School
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15 Parkman StSte 625Boston, MA 02114
Phone+1 617-726-2375
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Summary
- As a physician-engineer and clinical informatics executive at Massachusetts General Hospital and Harvard Medical School, I bring a unique, multidisciplinary perspective to healthcare transformation. For over 25 years, I have stood at the intersection of medicine, engineering, and health IT-turning complex clinical challenges into actionable, scalable solutions that drive real-world results.
What sets me apart is the breadth and depth of my roles:
• Practicing Clinician: I deliver primary and urgent care on the front lines, giving me firsthand understanding of the needs of patients and providers.
• Engineering System Designer: My background in systems engineering enables me to architect robust, user-centered clinical information systems that truly work in practice.
• Informatics Leader: I have led the design, implementation, and optimization of EMRs and decision support tools across diverse care settings, always with an eye toward measurable impact.
Signature achievements:
• Spearheaded the modernization of MGH’s Organ Transplantation EMR, launching advanced analytics and workflow platforms now adopted hospital-wide.
• Advanced national standards for clinical quality measurement and published research that shapes the future of digital health.
• Built and led high-performing, multidisciplinary teams, secured competitive grant funding, and mentored the next generation of informatics leaders.
My passion lies in bridging clinical care and technology-creating data-driven, innovative solutions that improve outcomes, enhance efficiency, and empower healthcare teams. I am always eager to connect with those who share a vision for impactful health IT strategy, innovation, and leadership.
Let’s connect and redefine what’s possible in healthcare together.
Education & Training
- Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1997 - 2000
- McGovern Medical School at UTHealthClass of 1997
- The University of Texas at AustinMS, Electrical and Biomedical Engineering, 1991 - 1993
Certifications & Licensure
- MA State Medical License 2000 - 2027
- American Board of Internal Medicine Internal Medicine
Clinical Trials
- The Impact of a "Serious Game" on Improving Patient's Medication Knowledge Start of enrollment: 2014 Mar 01
Publications & Presentations
PubMed
- 1 citationsDedicated AI Expert System vs Generative AI With Large Language Model for Clinical Diagnoses.Mitchell J Feldman, Edward P Hoffer, Jared J Conley, Jaime Chang, Jeanhee A Chung
JAMA Network Open. 2025-05-01 - 1 citationsPharmacogenomic testing and prescribing patterns for patients with cancer in a large national precision medicine cohort.Jay G Ronquillo, William T Lester
Journal of Medical Genetics. 2023-01-01 - 4 citationsPrecision Medicine Landscape of Genomic Testing for Patients With Cancer in the National Institutes of Health All of Us Database Using Informatics Approaches.Jay G Ronquillo, William T Lester
JCO Clinical Cancer Informatics. 2022-01-01
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